Prazosin의 항고혈압 효과에 대한 임상적 관찰

서세웅,이균태,김연호,조성락,신영우,신영기 최신의학사 1984 最新醫學 Vol.27 No.8

기울어진 채널을 흐르는 초임계 질소의 열유체적 수치해석 연구

강호균(Ho Gyun Kang),소현수(Hyun Soo Soh),신재석(Jae Seok Shin),신정헌(Jeong-Heon Shin) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.4

Effects of online hemodiafiltration on anemia and nutritional status in chronic hemodialysis patients

( Yu Ho Lee ),( Yoon Soo Shin ),( So-young Lee ),( Yang Gyun Kim ),( Sang Ho Lee ),( Ju Young Moon ),( Kyung Hwan Jeong ),( Hyeon Seok Hwang ),( Shin Young Ahn ),( Hong Joo Lee ),( Dong-young Lee ),( 대한신장학회 2020 Kidney Research and Clinical Practice Vol.39 No.1

Background: Online hemodiafiltration (OL-HDF) offers considerable advantages in clearance of molecules of various sizes. However, evidence of clinical effects of OL-HDF is scarce in Korea. In this study, we investigated changes in laboratory values over more than 12 months after switching to OL-HDF. Methods: Adult patients with end-stage renal disease undergoing hemodialysis (HD) were prospectively enrolled in a K-cohort (CRIS no. KCT0003281) from 6 tertiary hospitals in South Korea. We recruited 435 patients, 339 of whom were on HD at enrollment. One hundred eighty-two patients were followed for more than 24 months. Among them, 44 were switched to OL-HDF for more than 12 months without conversion to HD. We used a paired t test to compare baseline and 24-month follow-up results. Results: The mean age of the subjects was 61.2 ± 12.2 years, and 62.6% were male. The baseline hemoglobin level was not significantly different between HD and OL-HDF group (10.61 ± 1.15 vs. 10.46 ± 1.03 g/dL, P = 0.437). However, the baseline serum protein and albumin levels were significantly lower in the OL-HDF group (6.82 ± 0.49 vs. 6.59 ± 0.48 g/dL, P = 0.006; 3.93 ± 0.28 vs. 3.73 ± 0.29 g/dL, P < 0.001). In patients switched to OL-HDF, levels of hemoglobin and serum albumin significantly increased (10.46 ± 1.03 vs. 11.08 ± 0.82 g/dL, P = 0.001; 3.73 ± 0.29 vs. 3.87 ± 0.30 g/dL, P = 0.001). The normalized protein catabolic rate decreased after 24 months, but the change was not significant (1.07 ± 0.25 vs. 1.03 ± 0.21 g/kg/day, P = 0.433). Although the dose of erythropoiesis-stimulating agent was lower in patients who converted to HDF, it was not significantly different (-115.7 ± 189.7 vs. -170.5 ± 257.1 P = 0.206). Conclusion: OL-HDF treatment over more than 12 months was associated with no harmful effects on anemia and nutritional status.

소득분포 양극화의 특성과 경제,사회적 영향 / 논평 / 일반토론

신관호 ( Kwan Ho Shin ),신동균 ( Dong Gyun Shin ),강석훈,임경묵,오영균,박종규,전성인,송의영,윤창현,신관호 한국금융연구원 2007 韓國經濟의 分析 Vol.13 No.1

전체 평균으로부터의 산포도만을 강조하는 전통적인 소득불평등 지수에 비해 지역평균값들을 중심으로 집단화 내지 집락화되어 가는(clustered) 현상을 반영하는 양극화 지수는 사회가 지니고 있는 잠재적 갈등의 수위와 더욱 밀접한 관계를 갖는다. 본 연구는 Esteban, Gradin, and Ray(1999)가 개발한 양극화 지수를 이용하여 다음과 같은 분석을 하였다. 첫째, 신동균 · 전병유(2005)를 보다 확장하여, 외환위기 이후 한국경제의 소득분포의 변화양상을 외국과 비교함으로써, 최근 한국의 양극화 지수가 매우 빠르게 진행되고 있다는 사실을 보다 강화하였다. 둘째, 최근의 양극화 진전에 대한 일차적인 원인분석을 시도하였다. 이를 통해 최근의 양극화의 진전은 저학력자 및 고연령층들에게 보다 불리한 방향으로 진전되었음을 알 수 있었다. 나아가 최근 금융위기 이후의 양극화 진전의 이면에는 소득의 편차가 상대적으로 작은 제조업의 비중이 위축되는 과정에서 방출된 가구주들이 편차가 큰 비제조업으로 유입된 사실과 무관하지 않은 것으로 나타났다. 마지막으로, 소득 양극화의 진행이 사회적 영향을 주는지 여부를 실제로 검증하는 차원에서 Park and Shin(2006)의 결과를 한국경제에 적용하였고, 이를 통해 양극화의 진전과 범죄율의 변화 사이의 관계에서 부분적으로 유의한 결과를 도출하였다. The level of social unrest associated with the income distribution is better represented by bi-polarization than inequality. This article uses the bi-polarization index developed by Esteban, Gradin, and Ray(1999) to analyze how the income distribution has evolved in Korea for the 1997-2003 period. First, comparison of Korea with several OECD countries in the speed of polarization confirms the Shin and Cheon`s(2005) conclusion that the problem associated with the income distribution in Korea lies in polarization rather than in rising inequality. Second, we attempt to characterize the dramatic bi-polarization process of the income distribution. Our calculations show that the mobility from the low to the upper class is reduced as the distribution becomes more bi-polarized. Polarization has more unfavorable effects on the low education group or older household heads(45+) than on the high education group or younger ones(44-). It is further observed that income dispersion is typically greater in the non-manufacturing than in the manufacturing sector and that the rising level of polarization is associated with the great exodus of workers from manufacturing to non-manufacturing. Finally, variation of labor force participation rates across regions and over time is better explained by bi-polarization than by rising inequality.

PDIPM을 이용한 최적조류계산 기법개발

신욱호(Wook-ho Shin),김지훈(Ji-hun Kim),김태균(Tae-gyun Kim),이병준(Byongjun Lee),이재걸(Jae-gul Lee),신정훈(Jeong-hoon Shin) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.11

최적조류계산을 위한 사용 툴은 비선형 방법 및 선형해법 알고리즘을 이용하여 다양하게 개발되어 왔다. 최적조류계산은 조류계산에서 계산하지 못하는 제어변수의 최적 값을 결정할 수 있는 알고리즘으로서 비용 및 효율성 측면에서 반드시 고찰되어야 할 것이다. 본 논문에서는 PDIPM 기법을 이용한 최적조류계산 알고리즘을 개발하였으며 대규모 계통에 적용하기 위하여 수렴성 및 수행속도 향상을 위한 모선변호 ordering 및 고성능 LU분해 기법 등을 개발하여 적용하였다. 또한 실제 전력계통을 현실적으로 검토하기 위해 필요한 발전기 단자전압 고정 방안에 대하여 수렴성 높은 알고리즘을 제안하였다. 개발된 알고리즘은 수행속도 및 정확성을 검증하기 위하여 2006, 2007, 2009년도 한전계통을 통하여 PSS/E OPF 모듈과의 비교 검증을 수행하였다.

강수기 양자강 하구 주변 표층해역의 해양환경과 식물플랑크톤 군집 분포 특성

윤양호(Yang Ho Yoon),박종식(Jong Sick Park),노일현(Il Hyeon Noh),박영균(Yeong Gyun Park),김동영(Dong Yeung Kim),서호영(Ho Young Soh),황두진(Doo Jin Hwang),정순범(Sun Beom Jeong),김용주(Yong Ju Kim),신형호(Hyeong Ho Shin) 전남대학교 수산과학연구소 2006 수산과학연구소논문집 Vol.14 No.2

We investigated the characteristics of the marine environment and phytoplankton community of surface in the adjoining sea of Yangtze river of the East China Sea in June 2005. According to the analysis of a T-S diagram, three characteristic of water masses were identified. We classified them into the mixed water mass by the Chinese continental coastal waters and Taiwan/Tsushima warm current, Chinese continental coastal waters and Taiwan/Tsushima warm current. The first water mass was characterized by high water temperature, low salinity, low density and very high Chl-a concentration. The second one was characterized by high water temperature, low salinity, low density and high Chl-a concentration and the last one was characterized by low water temperature, high salinity, high density and low Chl-a concentration. The phytoplankton community identified a total of 95 species belonging to 43 genera. The dominant species was 3 species, that is, mainly centric diatom, Skeletonema costatum in the Chinese continental coastal waters. The others one, one dinoflagellates, Prororcentrum donghaiense and one silicoflagellates, Dictyocha speculum var. otonaria in warm current regions. Standing crops of phytoplankton and Chl-a concentration were very high with ranged from 5.9 x 103 cells/L to 1.1 x 106 cells/L, and 2.90 ㎍/L to 26.40 ㎍/L, respectively. Phytoplankton productivity in the East China Sea was controlled by the discharge of Yangtze river waters which include a high concentrations of nutrients.

Treatment-Plan Evaluation Using the Dose Quality Factor (DQF) for Dynamic Conformal Arc (DCA)-based Radiosurgery on Patients Presenting with an Intracranial Tumor

Seung Hoon Yoo,Byung Jun Min,Kum Bae Kim,Sungho Cho,Eun Ho Kim,Jeong Hoon Park,Won-Gyun Jung,Geun Beom Kim,Seung Young Ko,Hyun Soo Shin,Sei Kyung Chang,Ho Jin Jeong,Dong Ho Shin,Kwan Ho Cho 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.12

The aim of the present study was to find the optimum dynamic conformal arc (DCA)-based radiosurgery conditions for treatment of patients with intracranial tumors. DCA plans were generated on a commercial treatment-planning system (BrainSCAN v.5.31) for various beam-number and gantry-angle combinations by using computed tomography (CT) scans to delineate the planning target volume (PTV) and the organs at risk (OARs). To evaluate planning quality related to the various planning conditions, we analyzed the dose quality factors (DQFs) for 22 patients as a function of the number and the total angle of arcs related to the target volume, which were determined on the basis of patient-specific features. When the total angle of arcs was less than 250, the DQF values were under 0.98 (worst group). When the total angle of arcs was more than 350 degrees, the DQF values were maximized, and the highest DQF values (best group, DQF > 0.995) occurred in the range between 50 and 120/cm3 for the total angle/target volume condition. In this optimal range of angle/volume, the asymmetric distribution of the arcs resulted in decreased DQF values. For a relatively large target volume (more than 10 cm3), the DQF values were lower than these for a relatively small target volume (less than 10 cm3). Re-planning results showed that the planning quality could be improved using optimized planning conditions. We expect that this study will provide a basis for the evaluation of various DCA conditions prior to actual planning and treatment.

Short-term effect of growth hormone treatment in childhood leukemia survivors with growth hormone deficiency

Shin Chungwoo,Jang Min Jeong,Kim Seongkoo,Lee Jae Wook,Chung Nack-Gyun,Cho Bin,Jung Min Ho,Suh Byung-Kyu,Ahn Moon Bae 대한소아내분비학회 2023 Annals of Pediatirc Endocrinology & Metabolism Vol.28 No.2

Purpose: Survivors of childhood leukemia are at risk of growth impairment due to intensive chemotherapy and radiation treatments. This study investigated the auxological and biochemical characteristics of childhood leukemia survivors diagnosed with growth hormone deficiency (GHD) and the changes in these parameters after 1 year of growth hormone (GH) treatment. Methods: A total of 24 children diagnosed with GHD after leukemia treatment was analyzed. Clinical and biochemical data were collected retrospectively at leukemia diagnosis, GHD diagnosis, and 1 year after GH treatment. Standard deviation score (SDS) was calculated based on the age- and gender-adjusted population. Results: Of the 24 children included in this study, 19 received GH treatment. The median age at GHD diagnosis was 12.3 years, and the median delay in bone age was 1.46 years. Height SDS decreased from -0.69 at leukemia diagnosis to -2.58 at GHD diagnosis (P<0.001). The change in height SDS with and without GH for 1 year was 0.35 and -0.21, respectively (P=0.044). In regression analyses, higher height SDS at GHD diagnosis and a smaller decrease of the height SDS between leukemia and GHD diagnoses were positively correlated with height SDS after GH treatment. Conclusion: GH treatment could be beneficial and safe for improving height in childhood leukemia survivors with GHD. Height SDS at GHD diagnosis and reduction of height SDS between leukemia and GHD diagnosis could be potential factors in predicting the therapeutic effects. Close auxological monitoring is recommended for any childhood leukemia survivors who experience posttreatment height decline.

Physical Activity Level of Korean Adults with Chronic Diseases: The Korean National Health and Nutritional Examination Survey, 2010–2012

Ho-Seong Jin,Ah-Reum An,Ho-Chun Choi,Sang-Hyun Lee,Dong-Heon Shin,Seung-Min Oh,Young-Gyun Seo,Be-Long Cho 대한가정의학회 2015 Korean Journal of Family Medicine Vol.36 No.6

Background: Proper physical activities are known to be helpful in the prevention and management of chronic diseases. However, the physical activity level of patients with chronic diseases is low. Therefore, this study aimed to investigate the physical activity compliance of patients with hypertension, diabetes, and dyslipidemia in Korea. Methods: This study analyzed the 2010–2012 Fifth Korean National Health and Nutrition Examination Survey data. We included 13,873 individuals in the analysis. The level of physical activity compliance was measured by performing multivariate logistic regression analyses. Results: In the univariate analysis, the subjects with hypertension or diabetes tended to comply with the physical activity guidelines less faithfully than their healthy counterparts. The proportion of subjects with hypertension who were insufficiently physically active was 65.4% among the men and 75.8% among the women. For diabetes, the proportions were 66.7% and 76.8%, respectively. No significant difference was found between the subjects with dyslipidemia and their healthy counterparts. In the multivariate logistic regression analysis, no significant difference in physical activity compliance was observed between the subjects with hypertension, diabetes, or dyslipidemia and their healthy counterparts for both sexes. Conclusion: The patients with hypertension or diabetes tended to have lower physical activity prevlaence than their healthy counterparts. However, for dyslipidemia, no significant difference was found between the two groups. Given the significance of physical activities in the management of chronic diseases, the physical activities of these patients need to be improved.

CALS의 추진현황 및 발전방안에 관한 연구

신호균,강해중 한국정보시스템학회 2000 情報시스템硏究 Vol.9 No.1

CALS(Commerce At Light Speed) which originated in the early 1980's in the military sector is now an integral component in our global strategy to further heighten competitiveness. Through integration and streamlining of production, distribution, technical information and management, CALS will certainly lead the world out of these economically challenging times and into new global prosperity. However, not much effort have been focused on the development and diffusion issues of component technologies such as ERP/SCM(Enterprise Resourses Planning/Supply Chain Management), PDM(Product Data Management), and BPR(Business Process Reengineering) related with the CALS in electronic industry. Therefore, the purpose of this study is to analyze the advancing status and to present suggestions for the development of the GALS in electronic industry. In order to achieve the purpose, the case study has been conducted using the questionaries on the end-users and the interviews on the managers in the GALS area. The case study cover 57 users of the GALS for the three outstanding electronics(L, S, and D Electronics) in Korea. The questionaries include five success measures and eleven diffusion factors for the component technologies such as ERP/SCM, PDM, and BPR. In summary, the CALS will serve as the bases for exciting corporated innovations and the common business framework which facilitates the realization of Virtual Enterprise and Electronic Commerce in the 21st century