Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

고등학생과 대학생의 기체의 성질에 관한 오개념 비교

윤회정,우애자 이화여자대학교 교과교육연구소 2007 교과교육학연구 Vol.11 No.2

본 연구의 목적은 고등학생과 대학생의 기체의 확산과 온도변화에 따른 부피변화에 대한 개념을 살펴보고, 학생들이 가지고 있는 오개념의 종류와 학년 간에 나타나는 오개념의 차이점을 조사하는 것이다. 본 연구를 통해 얻은 결론은 다음과 같다. 전반적으로 대학생은 고등학생에 비하여 기체의 성질을 올바르게 이해하고 있는 것으로 나타났고, 대학생의 경우 학년에 따른 이해도 차이는 거의 없는 것으로 보인다. 대학생은 고등학생보다 적은 종류의 오개념을 가지고 있는데 이는 학습을 통하여 일부 오개념이 수정되기 때문으로 판단된다. 기체에 관한 입자적 수준에서의 이해에 대한 부족으로 생긴 오개념은 학습에 의해 일부 올바른 개념으로 전환되기도 하지만 고등학생과 대학생에게 공통적으로 나타나는 것으로 보아 쉽게 수정되는 것은 아님을 알 수 있다. 또한 학생들은 수업에서 많이 사용되는 익숙한 내용의 문항에는 공식이나 암기한 지식들을 그대로 이용하여 설명하는 경향이 있고, 이런 경향은 고등학생들보다 대학생들에게 더 많이 나타난다.

자가 면역성 간염에서 자가항체의 발현 양상과 스테로이드 치료의 효과

박기오,채경훈,허원석,강윤세,정재훈,김연수,문희석,이엄석,김선문,이병석,김남재,이헌영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

목적 : 최근 8년간 본원에서 경험한 자기면역성 간염의 혈액학적 특징과 스테로이드의 치료효과를 알아보고자 본 연구를 시행하였다. 방법 : 1996년 이후부터 2002년까지 충남대학교 병원에서 1999년 International Autoimmune Hepatitis Group(LAHG)에서 제시한 수정 진단 기준안에 의거하여 총 진단점수가 probable 이상에 해당하는 환자들을 대상으로 임상적 특징, 검사실 및 조직 소견과 스테로이드와 azathioprine의 치료 효과를 후향적으로 조사하였다. 결과 : 9예의 환자들은 여성이 78%, 40대가 많았고, 급성 발병이 33.3%, 피로감, 식욕부진 및 황달 등이 나타났으며, 항핵항체가 55.6%에서 그리고 항평활근 항체가 77.8%에서 양성이었고, 동반 질환은 류마치스 관절염이 2예, 특발성 혈소판 감소증 1예, Henoch-Sch nlein 자반증 및 그레브스병이 각각 1예 씩이었다. 7예에 대해서 스테로이드와 azathioprine으로 치료하여 생화학적 임상적 완해가 이루어져서 유효한 치료 결과를 얻었다. 결론 : 자가면역성 간염은 우리 나라에서 원인을 찾을 수 없는 만성 간질환의 경우, 특히 중년여성에서 다른 자가면역성 질환이 동반되었을 때 자가면역성 간염을 의심하여 자가항체 선별검사를 시행해 보아야 할 것으로 생각된다. 향후 다기관 연구를 통하여 좀 더 많은 증례를 모으고 전향적인 연구를 시행하여야 할 필요가 있다. Although autoimmune hepatitis(AIH) is common in western contries, some studties have been reported in Korea. The aim of the study was to analyze the clinical and histological features and expression pattern of the autoantibody and to examine clinical course of AIH in Korea. For 9 patients diagnosed as having AIH in our hospital since 1996, we reviewed medical records and analyzed clinical and laboratory findings retrospectively. They had a probable or definite AIH according to the revised criteria of International AIH group. The mean age was 42.7(21∼68)years and 7(77.8%) were female. Three of them(33.3%) showed acute hepatitis and five of them showed cirrhosis. Fatigue and anorexia were the most frequently complained symptoms(55.6%). Four patients(44.4%) were accompanied with other autoimmune diseases. Antinuclear antibody was detected in 5(55.6%) and anti-smooth muscle antibody was detected in 7(77.8%). Three patients showed focal picemeal necrosis and four showed periportal fibrosis. Among 7 patients who received immunosuppressive therapy, six patients(85.7%) showed initial response. and biochemical and serologic remission were achived in 5(71.4%) and 3(42.8%) patients, AIH seems to be partly responsible for chronic liver disease of unknown etiology in Korea. AIH should be suspected in female patients with unknown chronic liver disease of unknown etiolgy, especially accompanied with other autoimmune disease. The clinical characteristics of AIH may not be quite different from those of Western countries.

Methionine sulfoxide reductase B1 deficiency does not increase high-fat diet-induced insulin resistance in mice

Heo, Jung-Yoon,Cha, Hye-Na,Kim, Ki Young,Lee, Eujin,Kim, Suk-Jeong,Kim, Yong-Woon,Kim, Jong-Yeon,Lee, In-Kyu,Gladyshev, Vadim N.,Kim, Hwa-Young,Park, So-Young Harwood Academic 2017 Free radical research Vol.51 No.1

Bariatric surgery versus conventional therapy in obese Korea patients

Yoon-Seok Heo,Joong-Min Park,Yong-Jin Kim,Seong-Min Kim,Do-Joong Park,Sang-Kuon Lee,Sang-Moon Han,Kyung-Won Shim,Yeon-Ji Lee,Ja-Youn Lee,Jin-Won Kwon 대한외과학회 2012 Annals of Surgical Treatment and Research(ASRT) Vol.83 No.6

Purpose: In Korea, the results of bariatric surgery have not been compared with those of nonsurgical treatment. The purpose of this study was to evaluate the effectiveness and safety of bariatric surgery vs. conventional nonsurgical treatment in severely obese Koreans. Methods: In this retrospective cohort study, we reviewed the medical charts of 261 consecutive subjects who underwent bariatric surgery and 224 subjects who were treated with weight control medication and lifestyle modification therapy between January 2008 and February 2011. Measures of clinical effectiveness, including change in weight (%) and comorbid diseases, and occurrence of complications, were investigated for 18 months after bariatric surgery. Results: Body mass index (BMI) was higher in the surgery group than in the conventionally treated group (mean ± standard deviation, 39.0 ± 6.2 vs. 34.3 ± 3.8). Diabetes was more prevalent in the surgery group than in the conventionally treated group (39.1% vs. 12.9%). The change in weight (%) between baseline and 18 months posttreatment was significantly greater in the surgery group (22.6%) than in the conventional therapy group (6.7%). While 57%, 47%, and 84% of subjects recovered from diabetes, hypertension, and dyslipidemia, respectively, in the surgery group, 10%, 20%, and 24% of subjects recovered from these conditions in the conventional group. Fifty-one subjects (19.5%) in the surgery group reported 61 complications (23.4%). Conclusion: Bariatric surgery in Korea was significantly more effective than conventional treatment for weight loss and recovery from comorbidities such as diabetes, hypertension, and dyslipidemia, with a reasonable complication rate.

Immediate Effects of Lumbar Rotational Mobilization on the One-Legged Standing Ability in Healthy Individuals: A Randomized Controlled Trial

Heo, Seo Yoon,Kim, Bo Kyung,Moon, Ok Kon,Choi, Wan Suk International Academy of Physical Therapy Research 2018 Journal of International Academy of Physical Ther Vol.9 No.3

The original focus of this study was to investigate the immediate effects of lumbar rotational mobilization on the one-legged standing ability. Fifteen subjects (6 men and 9 women, mean age = 22.77 (SD = 1.21), mean height = 165.46cm (SD = 11.65), mean weight = 61.46kg (SD = 8.29) volunteers from healthy individuals were recruited and randomized to a lumbar rotational mobilization (LRM) group and a trunk rotational exercise (TRE) group. Mobilization (grade 3 or 4) was applied to the LRM group on the lumbar spine (L1 to L5) in a side-lying, and trunk twist exercise (left and right side) was applied the to the TRE group with lunge position. Center of pressure (COP) and the velocity of the center of pressure (VCOP) of each participant were measured as a balance ability through one leg standing position. Results are as follows. In within-group difference, the COP of the LRM group reduced during standing with the right foot, but the VCOP change of the LRM was not statistically significant. In between-groups difference, COP of TRE group was decreased compared with LRM group only during left leg standing in the eyes (p <.05). The results of this study suggest that LRM is more effective than TRE in improving balance ability.

Anti-asthmatic activities in mycelial extract and culture filtrate of Cordyceps sphecocephala J201.

Heo, Jin-Chul,Nam, Sung-Hee,Nam, Dong-Yoon,Kim, Jong-Guk,Lee, Kwang-Gil,Yeo, Joo-Hong,Yoon, Cheol-Sik,Park, Chul-Hong,Lee, Sang-Han D.A. Spandidos 2010 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.26 No.3

<P>This study investigated the effects of mycelial extract and culture filtrate of Cordyceps sphecocephala J201 on airway hyper-responsiveness, pulmonary immune cell infiltration, and Th2 cytokine expression in animal models of asthma. After Concanavalin A (Con A) activation of mouse primary spleen cells, the IL-4 and IL-13 cytokine expression were significantly decreased in the presence of the mycelial extract and culture filtrate of Cordyceps sphecocephala J201. The asthma model was induced by sensitization to ovalbumin by intraperitoneal (i.p.) injection treatment in mice. The Cordyceps sphecocephala J201 mycelial extract was injected in order to assess the effects of anti-asthmatic activity by comparing lung cell infiltration in ovalbumin-induced asthmatic mice. The results revealed that the increased IL-4, IL-13 and IL-25 expression were controlled by the mycelial extract and culture filtrate of Cordyceps sphecocephala J201, indicating that the extracts reduced the undesirable immune responses and/or cytokine expression exhibited in asthma.</P>

Efficacy and safety of bariatric surgery for Korean morbidly obese patients

Yoon Seok Heo 대한외과학회 2016 대한외과학회 학술대회 초록집 Vol.2016 No.11

Torque Balancing for Power Assisted Wheelchair based on Torque and Temporal Similarity

Heo, Yoon,Hong, Eung-Pyo,Mun, Mu-Sung,Choi, Tae-Ho Korean Society for Precision Engineering 2015 International Journal of Precision Engineering and Vol.16 No.8

In this study, a new torque balancing technique is proposed to improve the driving performance of power assisted wheelchairs (PAWs). For a PAW to maintain a straight driving direction, the same force must be delivered to both the right and the left push-rims. However, humans typically have different strength in the right and left arms, and therefore, they cannot control the force uniformly at all times. As a result, the driving direction may need frequent corrections during PAW operation. Toward this end, appropriate assist torques need to be generated to compensate for unbalanced human torque inputs by detecting the driving intention in order to maintain a uniform direction in straight sections or to quickly change direction in curved sections. We propose an assist torque balancing control scheme that estimates the human driving intention by considering the temporal similarity between the right and the left torque signals as well as the proportion of both torques. Simulation results show that the proposed balancing control scheme has better performance than the existing method for straight and circular driving conditions.

Machine Learning-Based Model for Prediction of Outcomes in Acute Stroke

Heo, JoonNyung,Yoon, Jihoon G.,Park, Hyungjong,Kim, Young Dae,Nam, Hyo Suk,Heo, Ji Hoe Ovid Technologies Wolters Kluwer -American Heart A 2019 Stroke Vol.50 No.5