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관상동맥 질환에서 도플러 심초음파도로 측정한 확장기 좌심실기능의 지표와 혈역학적 소견과의 비교 검토
임헌관,기신영,유창범,최태명,김성구,권영주 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1
Background : Left ventricular diastolic dysfunction is now recognized as a significant cause of cardiac symptoms even in patient with normal systolic ventricular function. During the last several years, the use of Doppler echocardiography for assessing left ventricular diastolic function has attracted increased attention. Doppler study have demonstrated that patients with ischemic heart disease have abnormal diastolic filling pattern suggesting impaired relaxation. Methods : This study was designed to correlate Doppler mitral flow velocity patterns and measuared variance with hemodynamic findings in 33 patients: 10 with myocardial infarction(group 1), 10 with angina pectoris(group 2) and 13 with no coronary disease(group 3). Results: 1. E/A ratio (0.87±0.24 m/sec versus 1.09±0.91 m/sec, P<0.05) was lower in group 1 than in group 3. 2. Significant correlation were demonstrated between pulmonary capillary wedge pressure (PCWP) and isovolumic relaxation time(IVRT) (r=-0.58; p<0.001), and E velocity (r=0.61; p<0.005). 3. IVRT was (61±30msec versus 92±35msec, p<0.05) shorter in patients with PCWP>10mmHg than in patients with PCWP≤10mmHg. Conclusion: Doppler mitral flow recordings have partially clinical potentiality in assessing left ventricalar diastolic function in patient with ischmic heart disease.
김태훈,유선열 전남대학교 치의학연구소 2001 구강과학 Vol.13 No.3
The purpose of the present study was to investigate the effect of absorbable membrane (BioMesh®) on bone regeneration in the rabbit by evaluating biodegradability, biocompatibility and bone regenerative capacity. Eight rabbits, weighing about 2kg, were used. Two bone defects, 8 mm in diameter and 7 mm in depth, were made. In the experimental group, the bone defect was covered with BioMesh® absorbable membrane. In the control group, induced spontaneous healing. The rabbits were sacrificed at 2, 4, 6, and 8 weeks after the operation. Radiographic and microscopic examination were performed. Results obtained were as follows: After 2 weeks, proliferation of the fibrous tissue was observed in the control group, but the newly formed cartilage and more active bone formation were noted in the experimental group. After 4 weeks, the new bone formation appeared in the control group, and in the experimental group, the bone trabeculi were densely aligned and matured. After 6 weeks, complete resorption of the BioMesh® membrane occurred in the experimental group. Both experimental and control group acquired dense osseous coverage, after 8 weeks. These results suggest that the BioMesh® absorbable membrane contributes new bone formation by guiding bone regeneration in the early stage.
미국의 식물유래약용물질(Plant-Made Pharmaceuticals, PMPs)의 안전성 규제
김태산,원소윤,이근표,류태훈,진용문,이길복,김현준 한국국제농업개발학회 2005 韓國國際農業開發學會誌 Vol.17 No.1
1. 식물유래 약용물질 (PMP)은 살아있는 식물에서 생산된 치료용 단백질로, 발효조에서 세포계통을 이용하는 것보다 적은 비용으로 높은 순도의 단백질을 생산할 수 있어 이에 대한 연구개발이 확대될 전망이다. 2. 식물유래 약용물질의 재배시험을 감독하는 주관부서는 미농무부(USDA)의 동식물 검역청(APHIS)이다. 3. PMP의 생산에는 알팔파. 옥수수, 벼 잇꽃과 담배 등이 이용되고 있다. 4. 현재 상업화된 PMP는 없으나 ProdiGene, Inc사 등 몇몇 생명공학 회사에서 이들의 연구개발이 진행되고 있다. 5. 2002년에 PMP 재배시험은 130에이커 규모로 34개 시험장에서 20건이 허가 되었으며 주별로는 애리조나, 네브라스카 등 14주에서 시험이 이루어 졌다. 6. 미국 USDA의 PMP 재배 지침에 의하면 PMP의 재배생산에는 안전성확보를 위한 별도의 전용장비를 필요로 하며 파종에서 생산까지 엄격하게 관리된다. 7. 미국 USDA의 APHIS는 2002년 PMP 옥수수를 생산하는 ProdiGene, Inc사에 대하여 2건의 포장시험허가 위반사항을 적발하여 벌금 조치를 한바있다. Plant-made pharmaceuticals(PMPs) are therapeutic agents(pharmaceutical proteins) produced in genetically engineered plants. To yield these valuable products plants offer several advantages that include large-scale production capacity at a reduced cost, equivalent purity/activity to other manufacturing systems, and freedom from contamination with animal pathogens, prions, or disease-causing germs. But there are risks of contamination of the food supply and unintended effects on ecosystems. In the U.S. PMPs are regulated under stringent requirement of the U.S. Department of Agriculture(USDA) and the Food and Drug Administration(FDA). In this article, contamination incident with PMP corn engineered by ProdiGene, Inc will be briefly introduced and regulations of PMPs will be discussed.
수증기 활성화법으로 제조된 영월 석탄계 활성탄의 특성 연구
이송우,권태훈,나영수,최동훈,류동춘,송승구 한국환경과학회 2000 한국환경과학회지 Vol.9 No.4
Activated carbons were prepared from Youngwall coal by steam activation in this study. The feasibility of the Youngwall coal to commercial activated carbon was examined. The variation of pore structures and the development of porosity in activated carbons were investigated by changing activation conditions in batch type apparatus. The values of BET surface area and adsorption capacity of iodine and methylene blue of the resulting activated carbons were obtained as high as 1,000㎡/g, 900㎎/g, 150㎖/g, respectively. Youngwall activated carbon prepared in this study showed much higher pore volume in pore diameter over l0Å than that of commercial reference activated carbon(Ningxia Taihua ZJ-15C) produced from China anthracite.
전승정,김태헌,류민선,오다연,송명은,이신아,류재인,김혜인,문일환,유권 이화여자대학교 의과학연구소 2011 EMJ (Ewha medical journal) Vol.34 No.2
The causes of pyogenic liver abscess has been known as biliary tract disease or intrabadominal infection but the large proportions of the patients has no apparent underlying disorders. Recently colonic mucosal lesions were reported in patients with cryptogenic liver abscess and it has been suggested that colonic mucosal break may play a role in developing liver abscess in otherwise healthy patients. We experienced a patient of severe recurrent liver abscess complicated with endophthalmitis only 3 months after successful treatment of initial cryptogenic liver abscess and a polypoid colon cancer was discovered by chance. It seems prudent to proceed colonoscopic examination in patients with cryptogenic liver abscess especially when it is recurrent.
선천성 Long QT 증후군 환자의 경흉부 교감신경절제술을 위한 마취관리
김두식,김승수,이석우,김세환,장태호,박세훈,류시정,김경한 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.39 No.3
A 23-year-old female patient was diagnosed with congenital long QT syndrome, discovered when she visited our cardiac department due to chest discomfort, because she had a prolonged QTc interval on ECG, history of syncopal attacks and seizures several times every year, and ingestion of anticonvulsants for several yeam. It is well known that the long QT syndrome is associated with sudden death secondary to ventricular tachyarrhythmia or fibrillation at a young age. Moreover cardiac artests during induction, maintenance, and awakening of anesthesia of these patients have been reported, and may be due to asymmetrical adrenergic stimuli in the heart, especially in the unrecognised case. This case report describes the anesthetic management of a patient with congenital long QT syndrome, who presented for cervicothoracic sympathectomy for a more permanent control of life-threatening ventricular arrhytbmias, and reviews the related literature.
Tae Hun Ryu,Seung In Yi,Yong Sham Kwon,Byung Dong Kim 한국유전학회 2007 Genes & Genomics Vol.29 No.4
In this study, microsatellite DNA markers were utilized to characterize somaclonal variation in regenerated plants from cultured cotyledons of Capsicum annuum L. cv Subicho. Twenty five microsatellite primer pairs were utilized in the screening of 41 regenerated plants derived from the cotyledons. Microsatellite DNA variation was detected among the regenerated plants at two SSR loci. The primer pairs for the SSR loci HpmsF15 and HpmsF037 revealed somaclonal variation in 5 out of the 41 plantlets (12%). However, 23 microsatellite markers evidenced no nuclear DNA polymorphisms. Nevertheless, the microsatellite marker technique can be successfully employed to assess genetic variations in somaclonal variants of the hot pepper.
Ryu, Chung Hun,Kim, Sae-Woong,Lee, Kyu Hwa,Lee, Joo Yong,Kim, Hongtae,Lee, Woon Kyu,Choi, Byung Hyune,Lim, Young,Kim, Young Hoon,Lee, Kweon-Haeng,Hwang, Tae-Kon,Jun, Tae-Youn,Rha, Hyoung Kyun Nature Publishing Group 2005 Oncogene Vol.24 No.34
Neurofibromatosis type 2 (NF2) is the most commonly mutated gene in benign tumors of the human nervous system such as schwannomas and meningiomas. The NF2 gene encodes a protein called schwannomin or merlin, which is involved in regulating cell growth and proliferation through protein–protein interactions with various cellular proteins. In order to better understand the mechanism by which merlin exerts its function, yeast two-hybrid screening was performed and Ral guanine nucleotide dissociation stimulator (RalGDS), a downstream molecule of Ras, was identified as a merlin-binding protein. The direct interaction between merlin and RalGDS was confirmed both in vitro and in the NIH3T3 cells. The domain analyses revealed that the broad C-terminal region of merlin (aa 141–595) is necessary for the interaction with the C-terminal Ras-binding domain (RBD) of RalGDS. Functional studies showed that merlin inhibits the RalGDS-induced RalA activation, the colony formation and the cell migration in mammalian cells. These results suggest that merlin can function as a tumor suppressor by inhibiting the RalGDS-mediated oncogenic signals.Oncogene (2005) 24, 5355–5364. doi:10.1038/sj.onc.1208633; published online 27 June 2005