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Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions
Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8
Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.
Alternative Treatment of Osteoma Using an Endoscopic Holmium-YAG Laser
Han, Ba Leun,Shin, Ho Seong Korean Society of Plastic and Reconstructive Surge 2012 Archives of Plastic Surgery Vol.39 No.4
Osteoma is one of the most common tumors of the cranial vault and the facial skeleton. For osteoma in the facial region, endoscopic resection is widely used to prevent surgical scarring. Tumors in a total of 14 patients were resected using an endoscopic holmium-doped yttrium aluminium garnet (Ho:YAG) laser with a long flexible fiber. Aside from having the advantage of not leaving a scar due to the use of endoscopy, this procedure allowed resection at any position, was minimally invasive, and caused less postoperative pain. This method yielded excellent cosmetic results, so the endoscopic Ho:YAG laser is expected to emerge as a good treatment option for osteoma.
신승권,이한석,조영호,안두수 成均館大學校 科學技術硏究所 1998 論文集 Vol.49 No.1
Overhead crane systems are widely used for material transportation in many industrial fields. However, undesired swing can always be found during the moving progress, especially at the end location of the transport. The swing may increase the carrying time and cause safety problems. In order to achieve the target position, this paper used a PD controller and used a fuzzy controller to reduce swing angles found during the moving progress. The performance of controller was verified through the experimental results and the simulation results by MATLAB.
지구성 트레이닝의 최대 산소섭취량과 혈중 유산농도에 미치는 영향
신호주,김부환 명지대학교 예체능연구소 1995 藝體能論集 Vol.5 No.-
The purpose of this study was to determine the effect of endurance training on maximal oxygen uptake and blood lactate levels. The number of training group was seven, the work intensity equivalent to lactate threshold, administered thirty minutes a day, three days a week, for eight weeks. The conclusions of the study are as follow; 1. The lactate threshold is greatly advanced by the endurance training(p<.05). 2. Under the same conditions, the training reduces the blood lactate levels where as it increases oxygen uptake(p<.05). 3. During the training, it shows the retardation of apperance of maximum lactate, but shows the maximum blood lactate levels during relaxation(p<.05). 4. When the blood lactate level is 4.0mm/ℓ, which appears before and after the training, the lactate threshold happens.
서울시의 재건축 추진현황에 대한 분석 : 관련 법령의 개정을 중심으로 Focused on the revision of the law related
한수진,박신영,윤영호 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(계획계)
The aim of this study is to offer the fundamental resources that would guide us for more stable reconstruction in future, using the method of analyzing the relation between present situation of reconstruction and the law the related to it. However, this also represents over 1,115 cases of reconstructions in the city of Seoul, as well as revision of the law that related after the year 1987 As the result of this analysis, in spite of the idea for reconstruction should be based on solving the deteriorated building, in Seoul's case, it was repeating instable of the reconstructions caused by revision of the law related that had influenced the great deal of business. Now, although on December of 2002, for more efficient management on the reconstruction business, the integrated law has passed, much more of analyses well as researches need to be done.
신종익,이정한,송한범,강대언,오상훈,차승렬,이용재,김상대,이원호 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)
This study investigates the performance of the reinforced concrete frame with the steel plate slit damper. The test was carried out to investigate the structural behavior between the reinforced concrete bare frame and the reinforced concrete frame with the steel plate slit damper. The test results showed that the energy absorption capacity of the damped-frame was several times larger than that of the bare frame. For the damage by the input energy is concentrated on the steel plate slit damper, the ductilities of the former structure were increased and the damaged frame can be reused after exchange the steel plate slit damper.
한수진,박신영,윤영호 대한건축학회 2004 대한건축학회논문집 Vol.20 No.6
The aim of this study is to prove that reconstruction policy has more effect on reconstruction projects than market by analysing the characteristics of reconstruced projects in Seoul from 1987 to 2002. The average of the expected life span of reconstructed housing is only 20.5 year. 296,637 housing unit was newly constructed where 163,485 housing unit was demolished in the case of Seoul. According to the change of reconstruction policy of housing, the number of reconstruction union and cases has been changed, The less regulated, the number of them increased while the more regulated, the number of them decreased.
시상부위에 발생한 단일성 뇌농양 : 증례 보고 및 문헌고찰 Report of Two Cases and Review of the Literature
곽호신,김동규,이상형,정희원,이현구,김현집,한대희 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.12
The authors present two cases of solitary thalamic abscess which were intially diagnosed as malignant thalamic glioma. After treatment with steroids and osmotic agents, the patients' clinical conditions improved after two to three days. However, sudden deterioration of consciousness level developed and the CT scan showed acute hydrocephalus with increment of thalamic low-density lesions. We performed extraventricular drainage and obtained CSF containing numerous inflammatory cells. This suggested the possibility that the lesion was a pyogenic abscess. which progressed to ventriculitis, rather than a malignant glioma. Stereotactic aspiration of the lesion confirmed thalamic abscess. These findings and review of previous reports of thalamic abscess suggested that early diagnosis and stereotactic drainage of the thalamic abscess is of primary importance.