상아질 형성 부전증에 대한 증례보고

백병주,이승영,이두철,이승익,김재곤 大韓小兒齒科學會 2000 大韓小兒齒科學會誌 Vol.27 No.1

상아질 형성 부전증은 상아질 형성에 이상을 초래하느 유전성 질환으로, 주로 상염색체 우성의 양상으로 유전된다. 제1형의 상아질 형성 부전증은 골 형성 부전증 환자에서 나타난다. 제2형 상아질 형성 부전증은 골 형성 부전증과 연관되지 않고 단독으로 나타난다. 제3형 상아질 형성 부전증은 brandywine type이라고도 하는데. 이 유형은 매우 드물며 상염색체 우성에 의해 유전되고, Maryland주에 사는 한정된 민족에서 관찰된다. 세가지 모든 유형에서 유치열과 영구치열 모두 다양한 임상 양상을 나타낸다. 치아는 유백색을 띠고, 청회색에서 황갈색까지 다양하게 변색되어 있다. 상아질은 비정상적으로 연하고, 상부의 법랑질을 기능적으로 지지하지 못한다. 비록 법랑질이 정상이라고 해도, 쉽게 파절되어 떨어져나가, 교합면이나 절단면쪽 상아질이 노출된다. 노출된 유약 상아질은 쉽고, 빠르고 심한 교모를 일으킨다. 치아는 구형의 치관과 협소화된 백악-법랑 경계 그리고 가는 치근을 나타낸다. 치수강과 치근관은 다양한 정도의 폐쇄상을 나타낸다. 백악질, 치주인대, 그리고 치조골은 정상 소견을 나타낸다. 상아질 형성 부전증에서 법랑질은 정상이다. 법랑질은 직하방의 mantle dentin은 거의 정상적이나, 나머지 상아질은 심각한 정도의 이형성을 나타낸다. 상아세관은 방향성을 상실하여 불규칙적이며, 정상보다 더 크고 공간도 넓다. Dentinogenesis imperfecta is an inherited disorder of dentin formation, usually exhibiting an autosomal dominant mode of transmission. Type I dentinogenesis imperfecta occurs in patients afflicted with osteogenesis imperfecta. Type Ⅱ dentinogenesis imperfecta is not associated with osteogenesis imperfecta. Type Ⅲdentinogenesis imperfecta (Brandywine type) occurs in a racial isolate area in the state of Maryland. In all three types, teeth of both dentitions are affected with variable clinical appearances. The teeth are opalescent with the color ranging from bluish-gray to brown to yellowish. The dentin is abnormally soft, providing inadequate functional support to the overlying enamel. Although the enamel is normal, it fractures or chips away easily, exposing the occlusal and incisal dentin. The exposed soft dentin often undergoes rapid and severe functional attrition. The teeth exhibit bulb-shaped crowns with constricted cementoenamel junctions and thin roots. The teeth will exhibit varying stages of obliteration of the coronal and root pulpal chambers. The cementum, periodontal ligament and supporting alveolar bone appear normal. The enamal is normal. The mantle dentin remains nearly normal, whereas the remaining dentin is severely dysplastic. The dentinal tubules are disoriented, irregular, widely spaced, and usually larger than normal.

좌전하행지 관동맥 개구부위의 망사형의 관(Slotted Tube)스텐트와 나선형 코일(Coil)스텐트 삽입후 단기 및 장기 암상 경과의 비교

박훈기,박성욱,이일수,이상곤,김진우,이근,정상식,이철환,홍명기,김재중,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.6

Thermal cycling 과 시효처리가 Glass-Ionomer수복재의 인장강도에 미치는 영향

이승익,백병주,김재곤,이승영,김문현 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.4

본 연구에서는 구강환경과 유사한 액상의 조건하에서의 온도변화가 광중합형 글래스아이오노머계 수복재의 인장강도에 미치는 영향을 평가하기 위해 대조군으로 2종의 재래형 glass ionomer를 선택하고 실험군으로 2종의 광중합형의 resin-modified glass ionomer와 2종의 polyacid-modified resin composite을 선택한 다음 수중에서의 thermal cycling과 시효처리를 행하였으며, 다음과 같은 결론을 얻었다. 1. 글래스아이오노머 수복재의 인장강도를 측정한 결과, polyacid-modified resin composite, resin-modified glass ionomer 그리고 재래형 glass ionomer의 순으로 나타났다. 2. 인장강도는 30일간의 시효처리로 증가되는 경향을 보였다. 3. 재래형 glass ionomer 수복재의 인장강도는 thermal cycling 처리로 증가되는 경향을 보였으며, 37℃의 증류수 중에 1시간 침적한 군과 10,000회의 thermal cycling을 비교한 결과 유의한 차이로서 강도의 증가를 나타냈다(P<0.01). 4. thermal cycling 군의 인장강도는 DR군이 45.4MPa로 최대치를, FL군이 13.4MPa로 최소치를 나타냈으며, 각 군간의 통계적 유의성을 검증한 결과 polyacid-modified resin composite의 인장강도가 나머지 군과 유의한 차이를 보였다(p<0.05). 5. 특성강도는 DR군이 48.6MPa로 가장 높은 강도치를 보였으나, Weibull 계수는 CG군이 8.9로 가장 높은 값을 보여 시험재료 중에서 가장 작은 강도의 분산을 나타냈다. This study was performed to evaluate the effect of aging and thermal cycling on the tensile strength of six commercially available glass-ionomer materials: two chemically set glass-ionomer materials(Fuji Ⅱ, fuji Ⅸ), two resin-modified glass-ionomer materials(Fuji Ⅱ LC, Vitremer), and two polyacid-modified composite resins(Compoglass, Dyract). Rectangular tension test specimens were fabricated in a teflon mold giving 5mm in gauge length and 2mm in thickness. All samples were divided into 3 groups. Group 1 was immersed in a 37℃ distilled water for 1 hour. Group 2 was immersed in a 37℃ distilled water for 30 days. Group 3 was subjected to 10,000 thermal cycles between 5℃ and 55℃, and the immersion time in each bath was 15 seconds per cycle. Tensile testing was carried out at a cross-head speed of 0.5mm/min and fracture surfaces were examined with scanning electron microscope. The results obtained were summarized as follows; 1. The polyacid-modified composite resins were stronger than the resin-modified glass-ionomer materials, which were much stronger than the conventional glass-ionomer materials. 2. Tensile strengths were slightly increased after aging treatments for 30days. 3. Tensile strengths of conventional glass ionomers were significantly increased after thermal cycling treatment(p<0.01). 4. The highest tensile strength value of 45.4MPa was observed in the Dyract group and the lowest value of 13.3MPa was observed in the Fuji Ⅱ LC group after the thermal cycling test, and the strengths of polyacid-modified composite groups were significantly higher than those of other groups. 5. The highest characteristic strength value of 48.6MPa was obtained in the Dyract group, however the highest Weibull modulus value of 8.9MPa was obtained in the Compoglass group after thermal cycling test.

우라늄 오염 금속표면의 제염을 위한 UO_2 용해특성 연구

이성열,최왕규,오원진,유승곤 한국공업화학회 2003 공업화학 Vol.14 No.3

국내의 가동 중지된 우라늄 변환시설의 해체 시 대량으로 발생될 탱크류 및 배관 등 공정 계통 부품으로 이루어진 금속 폐기물의 재팔용 또는 자체처분을 위한 현장 제염기술로 질산 제염공정을 선정하였다. 오염 물질로써 UO_2를 대상으로 UO_2 입자의 용해 거동을 통해 우라늄 화합물로 오염된 금속 폐기물에 대한 질산 용액의 표면제염 적용성을 평가하였고, 우라늄 변환시설 내에서 직접 인출한 UO_2 오염 시편의 제염 실증실험을 통해 제염 공정의 성능을 검증하였다. 질산 제염 용액에서 UO_2 입자의 용해속도는 질산의 농도 및 용액의 온도에 크게 의존하였으며, 산화제로 H_2O_2를 첨가함에 의해서 상온의 저 농도 질산 제염 용액 내에서도 H_2O_2가 첨가되지 않은 경우에 비해서 속도가 현저하게 증가되었다 UO_2로 오염된 시편의 제염에 있어서, H_2O_2가 첨가되지 않은 질산 용액 내에서의 제염계수는 α 방사능에 대해서는 1.8~2.7, β 방사능에 대해서는 1.8~2.3인 반면에 질산 용액에 H_2O_2를 첨가한 경우에는 α 방사능에 대해서 61.7~338.5, β 방사능에 대해서는 20.1~92.4를 나타냄으로써 H_2O_2를 첨가함에 의해서 상온, 저농도 질산 용액 내에서도 UO_2 오염된 금속표면을 효과적으로 제염할 수 있음을 확인하였다. In this study, a decontamination process using nitric acid was selected as an in-situ technology for recycle or disposal of large amount of metallic wastes, which includes process system components such as tanks, piping, etc that are generated as a result of dismantling retired uranium conversion facility in Korea. The applicability of nitric acid solution for surface decontamination of metallic wastes that are contaminated with uranium compounds was evaluated through dissolution of UO_2 powder. The decontamination decontamination performance are verified using UO_2 contaminated specimen that came from an uranium conversion facility. Dissolution rate of UO_2 powder was dependant considerably upon nitric acid concentration and solution temperature. Notable enhancement of dissolution rate was achieved by addition of H_2O_2 as an oxidant even in the condition of low concentration of nitric acid and low temperature. The results for decontamination of the specimen contaminated with UO_2 showed that the decontamination factors (DFs) for nitric acid solution without H_2O_2 were 1.8~2.7 and 1.8~2.3 for α and β-radioactivity. respectively, while DFs for nitric acid solution containing H_2O_2 were 61.7~338.5 and 20.1 ~92.4 for α and β-radioactivity, respectively. Thus, the metallic surfaces contaminated with UO_2 can be decontaminated effectively with low concentration of nitric acid at mom temperature in the presence of H_2O_2.

위장관을 침범한 Henoch-Soho¨nlein purpura 1예

이승곤,김채규,서종옥,이호영,이호준,정회상,박유환,정춘해 조선의대 1996 The Medical Journal of Chosun University Vol.21 No.2

위장관을 침범한 Henoch-Sch o¨nlein purpura 1예

이승곤,김채규,서종옥,이호영,이호준,정회상,박유환,정춘해 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.2

Henoch-Scho¨nlein purpura(H-S purpura) is a systemic necrotizing vasculitis of small vessels that is characterized by nonthrombocytopenic palpable purpura on the buttocks and extremities, arthritis of knees and ankles, glomerulonephritis, and colicky abdominal pain, histologically characterized by leukocytoclastic vasculitis. Gastrointestinal involvement with colicky abdominal pain and GI bleeding, most frequently in jejunum and ileum, occurs in above a half of all patients, but common in children. We performed GI endoscopy in a case of H-S Purpura. Gastroduodenoscopic findings showed erythemas and erosions in gastric antrum, and mucosal edema and petechiae in duodenal 2nd portion. Colonoscopic findings showed 5-10㎜ sized multiple shallow hemorrhagic ulcers in transverse and descending colons We report a case of H-S purpura involving colon with literatural review.

매복 견치 및 저위교합 제 1대구치의 자가 이식에 의한 치험례

이승익,김재곤,권선자,백병주 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.2

In orthodontic treatment of certain cases of tooth loss, aplasia, or ectopia, autotransplantation is sometimes valid treatment alternative often provides and improved result, compared to conventional orthodontic treatment, an apprporiate donor tooth is available and the anatomic circumstances permit it. Clinically, successful transplants must show a radiolucent space between the roots and surroundings bone. There must be no evidence of ankylosis, no permanent root resorption, and no inflammation. Histologically, the criterion of success is a normal and functional periodontal ligament between the root surfaces of transplants and the bone, or gingival connective tissues. The successful autotransplantation of a impacted maxillary canine and infraoccluded mandibular 1st molar is reported. In case Ⅰ, impacted canine with incompletely developed root apex was maintained pulp vitality due to appropriate root development and short extraoral time, atraumatic surgical procedure. In case Ⅱ, infraoccluded molar was started endodontic treatment after 3 weeks. Because of closed apex, possibility of revasculization is rare. Both case Ⅰ, Ⅱ did not ankylosis and the periodontal and periapical tissues appears to be normal after 3 months. In autotransplantation cases it is important to transplant the tooth as quickly and as atraumatically as possible to dimish the chance of ankylosis and root resorption. In all cases of transplantation, patient selection minimal operating time, and good oral hygine will increase the chance for a successful prognosis.

담도폐쇄증 환아의 치과치료 : 증례보고

김재곤,양연미,백병주,이승익 大韓小兒齒科學會 2000 大韓小兒齒科學會誌 Vol.27 No.1

Intra-& extra-hepatic duct system의 경화를 야기하는 Biliary atresia는 출생시 1:10,000의 발생빈도를 보이며, 5년 이하의 생존율을 나타내는 예후가 좋지 않은 질환이다. 담도폐쇄증의 원인은 아직 명확하지 않으나, 유전적인 요소나 발육성 원인으로 믿고 있다. 임상적 특징으로 두드러진 황달, 간비증대, 가려움증, 지방변, 황색종, 성장지연, 문맥압항진증, 출혈, 골연하증, 복수 그리고 호흡기계 감염 등을 나타낸다. 구강내 소견으로 녹색을 띄는 변색치아, 유치의 확장된 치수강과 치근관, 치아맹출지연, 법랑질 형성부전, 그리고 심한 치아 우식 등이다. 담도폐쇄증은 조기진단과 수술에 의해 사망률이 감소되고, 성장과 발달이 정상으로 돌아오며 생존율도 향상되었으나 여전히 그 원인과 치료에 대한 연구가 계속되어야 할 것이다. 이에 저자는 전북대학교 치과병원에 내원한 2명의 담도폐쇄증환아에 대해 임상, 방사선학적 특징 및 적합한 처치에 대하여 보고하고자 한다. Congenital biliary atresia with pregressive sclerosis of the intra-and extra-hepatic duct system occurs in 1:10,000 live births, and has a poor prognosis with an expected survival of less than 5 years. Etiology of biliary atresia is unclear, however, it is believed a genetic or developmental cause. The clinical characteristics include pronounced jaundice, hepatosplenomegaly, pruritus, steatorrhea, xanthomas, growth retardation, portal hypetension, bleedings, ascites and respiratory infections. Oral manifestations have seldom been reported in patients with biliary atresia, but there may be enamel hypoplasia, delayed tooth eruption, and green teeth. Early diagnosis and surgical intervention have decreased morbidity, returned growth and development to normal and improved the prognosis for survival. Authors report the clinical and radiologic characteristics, proper managements about two cases with biliary atresia.

프레탈^(R)정(실로스타졸 50mg)에 대한 실로졸^(R)정의 생물학적 동등성

최한곤,권기철,이승호,김학미,박병주,유봉규,이종달,이경희,하정희,우종수,박인숙,최진석,용철순 한국병원약사회 2003 병원약사회지 Vol.20 No.1

Bioequivalence of two cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and the Cilozol^(R)(Hanmi Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA, Sixteen normal male volunteers(age 20~29 years old) were divided into two groups and a randomized 22 cross-over study was employed. After two tablets containing 50㎎ of cilostazol were orally administered. blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_(t) between two tablets were 4.99%, 1.74% and 7.68%, respectively. The powers(1-β) for C_(max), T_(max) and AUC_(t) were83.92%, 80.12% and 85.03%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilozol^(R) tablet is bioequivalent to Pletaal^(R) tablet.

Ⅱ급 와동에서 각종 구치용 수복물의 파절강도에 관한 실험적 연구

조영곤,허승면,이계혁 大韓齒科保存學會 1993 Restorative Dentistry & Endodontics Vol.18 No.2

The purpose of this study was to evaluate the fracture strength of class Ⅱ restored premolars with amalgam, posterior composite, amalgam-Ketac silver, resin-Ketac silver restorations at marginal ridge. Fifty extacted maxillary and mandibular premolar teeth that were caries free, fracture free, and restoration free were selected and randomly divided into five groups : Group 1:10 intact teeth, Group 2:10 teeth with class Ⅱ cavities and restored with, amalgam, Group 3:10 teeth with class Ⅱ cavities and restored with posterior resin, Group 4:10 teeth with class Ⅱ cavities and restored with amalgam-ketac silver, Group 5:10 teeth with class Ⅱ cavities and restored with resin-Katac silver. All teeth were mounted in base of dental stone within metal rings of 2cm diameter, exposing only the crown portion. Class Ⅱ mesio-occlusal or disto-occlusal cavities were prepared into specimens of Group 2 throung 5 by using a No. 710 fissure bur. The occlusal portion was prepared to a faciolingual width of 1.5mm and a pulpal depth of 1.5mm. The proximal protion was prepared to a faciolingual width of 4mm, a occlusogingival height of 4mm, and a gingival floor of 1.5mm. The teeth in Group 2 and 3 were resotored with silver amalgam and posterior resin respectively. In Group 4 and 5, proximal portions were first filled with Ketac silver 1.5mm gingivally and remaining cavities were restored with amalgam and posterior resin respectively. All specimens were stored in 100% relative humidity at 37℃ for 48 hours before testing. All teeth were subjected to a compressive load in a Universal Instron Testing Machine at marginal ridges. The loads required to fracture the restorations were recorded in killograms and the data obtained were subjected to statisticall analysis. The results were all follow: 1. The fracture strength of Group 1 which were unprepared were 100±10.0 kg and the higher values than Group 2, 3, 4, 5 which were prepared and resotred. 2. In restored groups, Group 2 had the higher fracture strength(81.8±12.4 kg) than other groups and Group 4 had the lowest fracture strength(66.8±9.2kg). 3. There were significant differences between fracture strength of between Group 1 and Group 3, 4, 5(P<0.05), but not significant difference between fracture strength of Group 2, 3, 4, 5(P>0.05).