Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

대장-직장암에서 Cyclooxygenase-2의 발현

강원경,천준성,장세진,조현민,천성원,안창혁,오승택 대한대장항문학회 2004 Annals of Coloproctolgy Vol.20 No.2

전국체육고등학교 투척선수들의 운동 상해에 관한 연구

배성완,강주혁,문주흠 목포대학교 스포츠산업 연구소 2006 스포츠 산업연구소 논문집 Vol.5 No.-

The purpose of this research is to work out the injury time, injury place, injury part, cause of injury, medical treatment, preventions against weight throwers at national physical education high schools and management and protection of them and advance of competence. As a result of questioning total 148 persons of shot putters (M20, F17), discus throwers(M21, F20), javelin throwers(M22, F20) and hammer throwers(M18, F10) who are registered at the Korean Amateur Athletic Federation, we come to the following conclusions. 1. As a result of comparison and analysis of the training programme where weight throwers were frequently injured by the event, the meaningful difference was obtained. Javelin throwers were injured most frequently while throwing training. 2. As a result of comparison and analysis of the meaningful difference of part which injury happened most frequently while throwers trained usually, the meaningful difference was obtained. Javelin throwers’ elbow injury was very frequent. 3. As a result of comparison and analysis of most frequently injured part by the event while weight throwing, the meaningful difference was obtained. Discus throwers’ waists were mostly injured while throwing. 4. As a result of comparison and analysis of frequently injured part by the event while weigh throwing training, the meaningful difference was obtained. Injury in waist part happened more frequently in rotary motion event than rectilineal motion event while weight throwing. 5. As a result of comparison and analysis of the event that throwers were injured frequently by sex while weight training, the meaningful difference was obtained. Women weight throwers were injured while jump squat training. 6. As a result of comparison and analysis of treatment period after injury by sex, the meaningful difference was obtained. It took women 4 weeks more to cure up and it was not short. 7. That difference that keep in mind method that can protect Shanghai when saw as exercise injury experience according to comparative analysis result by item appeared and rectilineal movement item selected most by method that mental power can protect Shanghai both item beam egg number It Eotda. 8. As a result of comparison and analysis of the season when thrower were injured frequently by experience, the meaningful difference was obtained. Throwers with below 1-4 year experience were injured frequently in summer. 9. As a result of comparison and analysis of the training time when weight throwers were injured frequently by result, the meaningful difference was obtained. Weight throwers who have never won the prize were injured frequently while training in the afternoon. 10. As a result of comparison and analysis of throwing motion when weight throwers were injured frequently by experience while throwing training, the meaningful difference was obtained. Throwers with below 1-4 year experience were injured frequently on waist twisting motion in the finish motion.

항암화학요법을 받는 암 환자에 대한 Nucare^R의 영양지지효과

조덕연,김현수,곽상혁,강정현,김철희,배광봉,김종숙,박상준,윤환중,김삼용 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

Purpose : The purpose of this study was to evaluate the effect of nutritional support with enteral liquid supplement in cancer patients receving chemotherapy for possible benefit in nutritional, immunologic and golbal function of patients. Patients and Methods : From October 1995 to February 1997, 30 advanced cancer patients receving chemotherapy were divided two roups. The Nycare group, in addition to normal diet, Nucare^R enteral supplement was given for 1week right after chemotherapy for the duration of 2 chemotherapy cycles. Control group received only normal diet without parenteral fluid supplement for 2 chemotherapy cycles. Results : Median ages were 53 end 56 years for Nucare group and Contrl group respectively. Performance scores was less than 2 by ECOG scale. All patients were stage Ⅲ or Ⅳ. The physical parameters, such as weight, arm muscle circumference(AMC) and triceps skin fold(TSF) were decreased in both groups after 2 cycles of anticancer therapy. but it was less severe in Nucare group(p<0.05). Serum transferrin was maintained in mild deficit state in Nucare group, whereas it aggravated form mild to moderate deficit in Control group(p<0.05). Serum albumin level increased in Nucare group without statistical significance. but it decreased from normal to mild deficit in Control group. Serum total protein did not change significantly in Nucare group. but in Control group, serum total protein was decreased from 7.24±0.9 to 6.52±0.5(P<0.05). Total lymphocyte count did not change significantly in both groups. Conclusion : This study shows that the nutritional support with Nucare^R was effective in the prevention of nutritional deficit status in patients receving a nticancer chemotherapy.

Azathioprine에 반응을 보인 류마티양 관절염에 의한 경막염(Pachymeningitis)1예

배광봉,이정호,이정찬,곽상혁,강정현,김철희,김현수,김종숙,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

Rheumatoid arthritis frequently involves the cervical spine and may lead to neurologic impairement. However, direct involvement of CNS structures by inflammatory cells has been reported infrequently. The prevalence of this complication of rheumatoid arthritis is unknown. Inflammatory CNS involvement in rheumatoid arthritis reportedly occurs in the setting of longstanding, active, erosive articular disease and is accompanied by extracranial and extraspinal nodules and vasculitis. This is diagnosed by radiologic finding of CNS nodules or meningeal thickening and by biopsy or autopsy. Treatment with corticosteroid, cytotoxic agent or surgical decompression is helpful. But the majority of patients die within several months of onset of neurologic symptom. Recently, we experienced a case of pachymeningitis caused by rheumatoid arthritis, which resolved repeatedly with azathioprine treatment.

2D Flood Simulation for Estimating the Economic Loss in the Building Areas

Kang, Sang-Hyeok Korea Spatial Information Society 2007 한국공간정보학회지 Vol.15 No.4

도시지역의 2차원 모형은 홍수침수과정에 있어서 아직 선구적인 분야이며 이러한 모형은 지형 및 불충분한 지형계수 및 자료로 인하여 제한적으로 이용되고 있다. 본 연구에서는 도시지역의 DEM에 기초한 제방 붕괴로 인한 표면수의 침수를 재현하고자 한다. 도시지역에 있어서 표면수의 흐름은 Saint-Venant의 방정식을 통해 모형을 구성하였다. 2002년 삼척시에서 발생한 홍수를 재현하기 위하여 추적자를 이용한 수리모형실험을 수행하여 모형을 보정하였다. 본 연구는 향후 홍수지도 제작이나 도시지역에서 침수에 따른 경제적 손실을 평가하는데 유용하게 이용될 것이다. 2D hydraulic models of urban areas are at the forefront of current research of flood inundation mechanisms, but they are constrained by inadequate parameters of topography and insufficient data. In this paper a numerical model based on DEMs is presented to represent overflow waters due to bank break in urban areas. The surface flow in the building areas is assumed to be properly modeled by solving Saint-Venant equation. In order to represent flooding broken out in Samcheok city, 2002, hydraulic model test using tracer has been carried out and validated. These efforts will serve for making flood hazard map and for estimating economic loss due to inundation of personal properties in urban areas.

Index of Biological Integrity for Water Environmental Assessment of Nature-Friendly River Work

Sang Hyeok Kang 대한환경공학회 2004 Environmental Engineering Research Vol.9 No.4

APPLICATION OF IT TO REDUCE FLOOD DAMAGE DURING HEAVY RAINFALL DISASTER IN JAPAN

Kang, Sang-Hyeok,Motoyuki ushiyama, Motoyuki-Ushiyama Korea Water Resources Association 2003 Water engineering research Vol.4 No.4

The rainfall observation systems have largely been improved in Japan. The Japan Meteorological Agency, prefecture governments, and other administrative bodies have also increased the number of rain gauges thru out the country. The density of observatories is now one per several $\km^2$. Heavy rainfall information systems have been improved. Besides it, the Internet was popularized in the late 1990s, and has been used to transmit data of heavy rainfall. Internet accessible cellular phones have been popular in Japan since 1999. Such phones are expected to be useful in the field of disaster warning announcements, because they can automatically notify users bye-mail of pending disasters. The use of the Internet during natural disasters is groundbreaking in Japan today. However, in order to use disaster information effectively on Internet it is necessary to investigate how to use the information during the rainfall disaster. Therefore in our study we suggest methods on the effective construction and their use of information technology on Internet.

Residue Patterns of the Fungicides Bitertanol and Chlorothalonil in Korean Cabbage

Sang-Oh Jeon,Jeong-In Hwang,Sang-Hyeob Lee,Min-Su Kang,Hye-Hyeon Jung,Jun-Sang Ryu,Se-Yeon Kwak,Ja-Gun Kang,Chan-Hyeok Kwon,Yeong-Uk Son,Dong-Sool Kim,Jang-Eok Kim 한국농약과학회 2015 한국농약과학회 학술발표대회 논문집 Vol.2015 No.10

River Water Environmental Management System by Construction of Early Warning System - A Comparative Study on Korea and Japan.

Kang Sang-Hyeok Korea Spatial Information Society 2004 한국공간정보학회지 Vol.12 No.4

강원도 및 경상남도 지역은 2002년 태풍 루사 및 2003년 태풍 매미로 인하여 1927년 기상관측이래 가장 큰 규모의 홍수 피해를 입었다. 호우로 인하여 많은 도시가 침수되었고 도시기능은 마비되었으며 또한 막대한 도시기반 시설의 파괴와 인명 피해가 발생하였다. 이러한 호우피해는 지금까지 경험한 것 중에서 최악의 자연재해였다. 홍수피해를 줄이기 위해서는 호우기간 중 하천 수 환경에 대한 정보를 어떻게 이용할 것인가에 대한 조사가 필요하다. 따라서 본 연구에서는 홍수피해를 줄이기 위한 효과적인 대응과 정보전달에 관한 방안이 논의되었으며 일본의 광 정보를 이용한 수 환경 관리 조기 경보시스템에 대하여 토의하였다. Typhoons Rusa (2002) and Maemi (2003) struck Kangwon and Gyeongnam provinces of Korea and caused the most extensive flood damages ever blown since the foundation of Meteorological Agency in 1927. Many cities are inundated, crippling the critical facilities and resulting In high irreversible losses of human lives, and damages to infrastructures. These kinds of flood damages were among the worst natural disaster that Korean people experienced. In order to reduce flood damage, it is necessary to investigate how to use the information of water environment during the rainfall disaster. Therefore as per the result of this study, we have suggested few but effective countermeasures for controlling the flooding damages and also the advancements in the areas of disaster information dissemination and early warning system for water environmental management by using optical fiber system in Japan are discussed.