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Ryu, Tae-Kyung,Baek, Seung-Woon,Kang, Rae-Hyung,Jeong, Ki-Young,Jun, Dae-Ryong,Choi, Sung-Wook Elsevier 2018 Journal of controlled release Vol.270 No.-
<P><B>Abstract</B></P> <P>This paper describes the fabrication and evaluation of phase-change material (PCM) nanoparticles containing chlorin e6 (Ce6) and nanodiamonds (NDs) for photodynamic and photothermal approaches for tumor therapy, respectively. The temperature of the PCM nanoparticles containing NDs (ND/PCM, 0.5mg/mL in water) is increased to 45°C during laser exposure for 5min. The singlet oxygen generation intensity of PCM nanoparticles containing Ce6 and NDs (Ce6/ND/PCM) is gradually increased with respect to the laser exposure time. Also, the release of Ce6 from Ce6/ND/PCM can be controlled in an on-and-off manner using laser. Cell ablation tests reveal that Ce6/ND/PCM greatly ablates KB cells upon laser exposure, which is attributed to both the temperature increase in the media and singlet oxygen generation by the released Ce6. In an animal model, tumor volume is notably reduced over time after the intratumoral injection of Ce6/ND/PCM and subsequent laser exposure with a higher efficiency compared to ND/PCM. The Ce6/ND/PCM can be a promising nanomedicine for tumor therapy.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Effects of piperlongumine on cognitive function and amyloid pathology
Jun Go,Thi-Kim-Quy Ha,Ji Yeon Seo,Tae-Shin Park,Young-Kyoung Ryu,Hye-Yeon Park,Jung-Ran Noh,Yong-Hoon Kim,Jung Hwan Hwang,Dong-Hee Choi,Sang Hee Kim,Chul-Ho Lee,Won Keun Oh,Kyoung-Shim Kim 한국실험동물학회 2018 한국실험동물학회 학술발표대회 논문집 Vol.2018 No.1
( Jun Soo Kwak ),( Sung-il Kim ),( Jong Tae Song ),( Si Wan Ryu ),( Hak Soo Seo ) 한국육종학회 2017 Plant Breeding and Biotechnology Vol.5 No.3
There is a growing preference for using doubled haploids (DHs) in maize breeding programs because they reduce the time required to generate and evaluate new lines to 2 years or less. However, there is an urgent need for efficient techniques that accurately discriminate between haploid and diploid maize kernels. Here, we investigate the effects of several hormones and chemicals on the germination of haploid and diploid maize kernels, including auxin, cytokinin, ethylene, abscisic acid (ABA) biosynthesis inhibitor (fluridone), ABA catabolism inhibitor (diniconazole), methyl jasmonate (MeJA), and NaCl. Ethylene effectively stimulated the germination of both haploid and diploid maize kernels. The ABA biosynthesis inhibitor fluridone, the ABA catabolism inhibitor diniconazole, and MeJA selectively stimulated the germination of haploid maize kernels. By contrast, gibberellin, 1-naphthaleneacetic acid (NAA), kinetin, and NaCl inhibited the germination of both haploid and diploid maize kernels. These results indicate that the germination of haploid maize kernels is selectively stimulated by fluridone and diniconazole, and suggest that ABA-mediated germination of haploid maize kernels differs from that of diploid maize kernels and other plant seeds.
Time and Crack Effect on Chloride Diffusion for Concrete with Fly Ash
Sang-Hwa Jung,Hwa-Sung Ryu,Subbiah Karthick,Seung-Jun Kwon 한국콘크리트학회 2018 International Journal of Concrete Structures and M Vol.12 No.2
Nuclear power plants are constructed very close to the marine environments for cooling water and the structures are more susceptible to chloride induced corrosion. Cracking in RC structures in mass concrete is unavoidable when they are exposed to chloride contaminated chemical environments. This study is focused on the evaluation of crack and time effect on chloride diffusion rate. Two types of concrete strength grade were taken for nuclear power plant construction and the crack was induced with varying from 0.05 to 1.35 mm of width. The tests for chloride diffusion coefficients from steady-state condition were performed. The influence of crack width on the chloride transmission behavior was discussed and analyzed over an exposure period to one year. The diffusion coefficients due to growing crack width increase in crack width but they decrease with increasing curing period, which yields 57.8–61.6% reduction at the age of 180 days and 21.5–26.6% of reduction at 365 days. Through the parameters of age and crack width which are obtained from regression analysis, the evaluation technique which can consider the effect of crack and time on diffusion is proposed for nuclear power plant concrete.
Sang hun Jeon,Sunggyun Jang,Jeong Hyun Lee,Jun Ki An,Jin Ryu,Si On Kim,Won-Seok Kim 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.2
CYPRUS is a web-based waste disposal research comprehensive information management program developed by the Korea Atomic Energy Research Institute over three years from 2004. This program is stored as existing quality assurance documents and data, and the research results can be viewed at any time. In addition, it helps to perform all series of tasks related to the safety evaluation study of the repository in accordance with the quality assurance system. In the future, it is necessary to improve the user convenience by clarifying the relationship between FEP and scenarios and upgrading output functions such as visualization and automatic report generation. This purpose of this study is to research and develop the advanced program of CYPRUS. This study is based on building FEP, DIM and scenario databases. It is necessary to develop an algorithm to analyze and visualize the FEP, DIM and scenario relationship. This project is an integrated information processing platform for DB management and visualization considering user convenience. The first development goal is to build long-term evolutionary FEP, DIM, and scenarios as a database. The linkage by FEP item was designed in consideration of convenience by using a mixed delimiter of letters and numbers. This design provides information on detailed interactions and impacts between FEP items. Scenario data lists a series of events and characteristic change information for performance evaluation in chronological order. In addition, it includes information on FEP occurrence and mutual nutrition by period, and information on whether or not the repository performance is satisfied by item. The second development goal is to realize the relationship analysis and visualization function of FEP and scenario based on network analysis technique. Based on DIM, this function analyzes and visualizes interactions between FEPs in the same way as PID, RES, etc. In addition, this function analyzes FEP and DIM using network analysis technique and visualizes it as a diagram. The developed platform will be used to construct and visualize the FEP DB covering research results in various disposal research fields, to analyze and visualize the relationship between core FEP and scenarios, and finally to construct scenarios and calculation cases that are the evaluation target of the comprehensive performance evaluation model. In addition, it is expected to support the knowledge exchange of experts based on the FEP and scenario integrated information processing platform, and to utilize the platform itself as a part of the knowledge transfer system for knowledge preservation.