ICR 웅성 마우스에서 BisphenoI A가 면역계에 미치는 영향

조경혜,박효영 서울여자대학교 자연과학연구소 2003 자연과학연구논문집 Vol.15 No.-

Bisphenol A (2, 2-bis-(4-hydoxyphenyl) propane; BPA) is a widely used endocrine disrupters and has estrogenic activities. Although interests on biological effect of BPA are rising, evidences of its effect on immune system are lacking. We investigated the effects of BPA on immune parameters, and on interruptions between neuroendocrine and immune system in order to elucidate the mechanism. BPA was orally administrated to mice (as a drinking water) at doses of 0.015, 1.5 and 30 mg/ml for 4 weeks. The BPA treatment did not show changes in body weight, spleen weight and distribution of spleen lymphocyte subpopulation. BPA exposure induced prolactin production in the spleen and hypothalamic pituitary adrenal, and increased the activity of splenocyte proliferation in response to Con A (p<0.001). The production of a strong Th-1 type cytokine (IFN-γ) was induced while Th-2 type (IL-4) was suppressed by BPA treatment. These were consistent with RT-PCR results of transcription factor GATA-3 and IRF-1. These findings suggest that stimulation of prolactin production by estrogenic effects of BPA affects cytokine profiles, and lead to the imbalanced cellular immune response. In addition, we hypothesized that prolactin and cytokines are important mediators involved in the network between neuroendocrine and immune systems after exposure of BPA to mice.

청소년의 부모폭행에 대한 연구

이호분,전여숙,민성길,오강섭,이시형 대한소아ㆍ청소년정신의학회 1997 소아청소년정신의학 Vol.8 No.2

대학 배구선수들의 10일간의 Detraining이 식행동, 체력 및 혈중 지질농도에 미치는 영향

김지현,조미란,조여원,선우섭,김희규 慶熙大學校 社會體育硏究所 1998 體育科學論叢 Vol.- No.11

The purpose of this study was to investigate the effects of detraining for 10 days after season on food pattern, physique, physical fitness and serum lipid concentration to provide basic data for preparing an effective fitness control program for volleyball players in detraining period after season. The results were summarized as follows: 1. Total daily energy intake was increased by 10% owing to intake alcohol and so forth. In addition, triglyceride and very low density lipoprotein were increased because of disorder of food pattern. 2. Any physique factor did not changed except for skinfold thickness in subscapular. 3. The relative value of leg extension power was decreased of decine of strengh factor in power and leg extension time. Muscular endurance was significantly decreased , too. 4. Basal metabolic rate was significantly increased after season and diastolic blood pressure was decreased in rest. In conclusion, our results suggest that the detraining of volleyball players for 10 days after season affects serum lipids concentration, power and muscular endurance by disorder of food pattern. Therefore, for improvement of performance in new season, the leaders of sports should present more reasonable program of food pattern and personal voluntary training in detraining period.

반응성 애착장애 아동의 애착유형

신의진,이순행,이경숙,전여숙,노경선,민성길 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

This study aims at examining examine the quality of attachment in children with Reactive Attachment Disorder(RAD). The subjects of this study were 26 chidren with RAD and 22 normal children as control group. The diagnosis of RAD was made according to DSM-Ⅳ and ICD-10 criteria of reactive attachment disorder. Attachment of each children was classified by using the Strange Situation Procedure(SSP). The data was statistically processed through Fisher's exact test and t-test. The results were as follows : Among the RAD children, 61.5% were classified as disorganized(D) type, 26.9% as anxious-avoidant(A) type, 11.6% as anxious-avoidant(C) type. Among the normal children, 63.5% were classified as secure attachment(B) type, 18.3% as anxious-avoidant(A) type, 13.6% as anxious-avoidant(C) type, 4.5% as disorganized(D) type. And RAD children had sifnigicantly higher proportion of disorganized(D) type and lower proportion of secure(B) type than that normal children. The above results suggest that RAD children has serious problems in their attachment relationship and there must be some consideration on serious attachment problems to make diagnosis and intervention of RAD children.

주의산만을 주소로 소아정신과를 내원한 아동의 인지적 특성 : T.O.V.A. 양상을 중심으로

신의진,이수진,이혜란,고려원 대한소아청소년정신의학회 2000 소아청소년정신의학 Vol.11 No.2

본 연구에서는 주의산만을 주소로 내원하는 아동을 진단 준거에 따라 분류하고 각 진단 집단을 설명할 수 있는 인지적 특성을 T.O.V.A. 양상을 중심으로 설명하였다. 소아정신과를 방문한 65명의 아동을 각각 주의력결핍 과잉행동장애(38명), 틱장애(17명), 그리고 기타 정서장애(10명) 집단으로 분류한 후 주의산만의 정도에 영향을 미칠 수 있는 집단의 연령 및 지능(전체 지능, 동작성 지능, 언어성 지능)을 먼저 파악한 후 T.O.V.A.의 중다구인(누락오류, 오경보오류, 정반응시간, 반응시간 표준편차, 예기반응, 다중반응)을 통해 주의산만의 양상을 살펴보았다. 세 집단 간에 연령에서 집단 간에 유의미한 차이가 나타나 연령 수준의 차이에서 기인한 효과를 배제한 결과, 언어성 지능에서 세 집단 간에 유의미한 차이가 나타났다. 또한, T.O.V.A.의 정반응 시간(전반부, 후반부, 전체)에서 세 집단간에 유의미한 차이가 있는 것으로 나타났다. 주의력결핍 과잉행동장애 집단은 틱장애 및 기타 정서장애 집단보다 T.O.V.A.의 정반응 시간이 길어 정보처리의 지연을 시사해 주었다. 한편 주의산만을 주소로 내원하는 아동의 경우 T.O.V.A. 양상과 더불어 연령과 지능의 효과에 대해 신중히 고려해야 할 필요가 있겠다. 중심 단어 : 인지적 특성ㆍ주의산만ㆍT.O.V.A.ㆍ정반응시간ㆍ주의력결핍 과잉행동장애ㆍ틱장애ㆍ기타 정서장애. Objective : This study aims to investigate the cognitive characteristics of clinically referred children with symptoms of inattention, cash as having ADHD, tic disorder, and emotional disorder. Methods : 65 boys(38 with ADHD, 17 with Tic disorder, and 10 with Emotional disorder) were individually assessed using the KEDI-WISC(FIQ, VIQ, PIQ) and T.O.V.A.(errors of omission, errors of commission, reaction time, variability, anticipatory response, multiple response), and the results of those tests were analyzed. Results : There was significant difference among three diagnostic groups of the VIQ of KEDI-WISC and the reaction time of T.O.V.A. after the correction of the effect of age difference. Conclusion : The finding suggest that the reaction time of T.O.V.A. might be the useful variable to differentiate the ADHD from other psychiatric disorders and the effect of age and IQ difference should be considered carefully to diagnose in clinical setting. KEY WORDS : Cognitive characteristicㆍInattentionㆍT.O.V.A.ㆍReaction time.

유병기간에 따른 한국인 파킨슨병 환자의 영양소 섭취 상태 및 식사의 질에 관한 연구

이주연,안태범,전범석,김윤영,조여원 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.4

Both genetic and environmental factors play important roles in the pathogenesis of Parkinson Disease (PD). The contribution of many environmental factors including dietary factor remains unproven. The purpose the study was to investigate the dietary habits, nutrient intake and dietary quality of Korean PD patients according to the duration of disease. PD patients were recruited from K and S university hospitals from May 2005 to January 2006. This study was carried out after approval by the Institute Review Board (IRB). British Brain Bank criteria was used to diagnose PD. The subjects were classified into 2 groups based on the duration of PD: < 25 months and ≥ 25 months groups. General characteristics, anthropometric measurements, food habits and dietary intakes were investigated. The results of this study were as follows: 1) The mean age of < 25 months group (66.9 ± 8.0 yr) was significantly higher than that of ≥ 25 months group (62.2 ± 8.8 yr) (p < 0.05). No significant differences were found for academic background, occupation, living status and social activity, however, numbers of diseases, exercise and family history of PD were significantly different. 2) Anthropometric measurements were not different between the two groups. 3) The frequency of taking snacks was significantly higher in < 25 months group and the amounts of alcohol consumption were significantly higher in ≥ 25 months group. 4) Daily intakes of most nutrients were very low compared with DRI. 5) The MAR score was significantly lower in < 25 months group (p < 0.05;) however, the scores of DVS, DDS and DQI were not significantly different. As a conclusion an overall nutrient intake and dietary quality of the Parkinson's Disease patients need to be improved regardless of duration of the disease and a well-balanced diet should be emphasized.

SoundLab and Electroacoustic Music in Hong Kong

Ryo Ikeshiro(료 이케시로),PerMagnus Lindborg(퍼마그너스 린드보르그) 한국전자음악협회 2021 에밀레 Vol.19 No.-

이 글은 퍼마그너스 린드보르그와 료 이케시로가 공동감독한 홍콩성시대학교 크리에이티브 미디어 대학의 3차원 공간 오디오 연구 및 실습 부서인 사운드실험실을 소개하고, 진행보고서로서의 역할을 한다. 연구물과 예술작품, 교육 및 지원활동에 대한 설명과 목표로 논의를 시작한다. 이어, 사운드실험실의 활동과 기여할 목표인 학계와 독립음악을 포함한 예술계의 현장, 두 곳 모두에서 홍콩의 전자음악의 지역적 위상과 면모에 대하여 간략히 이야기한다. 개괄한다면, 부분적으로 지역의 음악가와 예술가들과의 인터뷰를 기반으로 진행중인 연구에서 예비조사한 결과에 바탕을 두었다. 그리고 나서, 필적할만한 시설과 프로그램을 갖춘 많은 학술기관과 협의를 거쳐 개발한 고해상도의 오디오에 사용되는 반구형 스피커 어레이를 고안한 것에 대하여 논의한다. 공간과 장비, 용도에 대한 세부적 내용도 감안하였다. 목표에 관련된 향후 계획으로 마무리한다. The paper introduces SoundLab, a 3D spatial audio research and practice unit at the School of Creative Media, City University of Hong Kong, co-directed by PerMagnus Lindborg and Ryo Ikeshiro, and serves as a progress report. It begins with a description and its objectives involving research, artwork, teaching and outreach. It then gives a brief account of the local context of electroacoustic music in Hong Kong both in academia and in independent music and art scenes to which SoundLab aims to contribute through its activities. The overview is partly based on preliminary findings from an ongoing study based on interviews with local musicians and artists. It is followed by the design of a hemispherical loudspeaker array dedicated to high spatial resolution audio, developed after consulting a number of academic institutions with comparable facilities and programmes. Details concerning the space, equipment and usage are considered. Future plans in relation to its objectives are given in closing.

Purification and Characterization of Farnesyl Protein Transferase from Bovine Testis

Ryo, Kwon-Yul,Baik, Young-Jin,Yang, Chul-Hak Korean Society for Biochemistry and Molecular Biol 1995 Journal of biochemistry and molecular biology Vol.28 No.3

Famesyl protein transferase involved in the first step of post-translational modification of $p21^{ras}$ proteins transfers the famesyl moiety from famesyl pyrophosphate to a cysteine residue in $p21^{ras}$ proteins. The enzyme was first purified 30,000-fold from bovine testis by use of 30~50% ammonium sulfate fractionation, DEAE-Sephacel ion exchange chromatography, Sephacryl S-300 gel filtration chromatography, Sephacryl S-200 gel filtration chromatography, and hexapeptide (Lys-Lys-Cys-Val-Ile-Met) affinity chromatography. The molecular weight of the purified enzyme was estimated to be ~100 kDa by gel filtration and SDS-polyacrylamide gels showed two closely spaced bands of ~50 kDa protein. These indicate that the enzyme consists of two nonidentical subunits, a and 13, which have slightly different molecular weights. The enzyme was inhibited by hexapeptide (Lys-Lys-Cys-Val-Ile-Met), which acted as an alternative substrate that competed for famesylation. Kinetic analysis by measuring initial velocities showed that famesyl protein transferase is a very slow enzyme. EDTA-treated famesyl protein transferase showed little activity with $Mg^{2+}$ or $Zn^{2+}$ alone, but required both $Mg^{2+}$ and $Zn^{2+}$ for the catalytic activity.

North Korea’s Transport Policies: Current Status and Problems

Ryo Hinata-Yamaguchi(히나타-야마구치 료) 동아시아국제정치학회 2016 국제정치연구 Vol.19 No.2

열악한 정치경제 관리로 인해 북한의 교통 부문은 심각한 순환적, 네거티브섬적, 경로의존적 문제들을 겪고 있다. 이 문제들은 북한의 발전을 훼손 할 뿐만 아니라, 교통 부문을 둘러싼 구조, 과정 및 상황의 극복을 불가능하게 했다. 북한 교통 분야에서의 문제점들을 구성적으로 이해하기 위해서는 정치경제, 사회경제, 사회정치, 그리고 안보적 관점에서 포괄적으로 분석하는 것이 중요하다. 그러므로 이 논문에서는 북한의 국내 장거리 대중교통에 초점을 맞추어 북한의 대중교통 시설과 운영에서의 주요 문제의 보편적, 상호 연관성을 분석한다. 이 연구는 북한 정권이 일으킨 문제들의 심각성을 밝히며 북한 문제와 한반도의 미래에 중요한 질문들을 제기한다. Due to poor political-economic management, the transport sector in North Korea suffers from grave problems that are cyclic, negative-sum, path-dependent in nature. The constellation of problems not only undermine the Stalinist state’s development, but the problems in the structure, processes, and circumstances surrounding North Korea’s transport sector have gone beyond the threshold of no return with very little remedies available. To comprehensively conceptualize the troubled state of North Korea’s transport sector and their operations, one needs to examine the topic from the political-economic, socio-economic, socio-political, and security viewpoints. Focusing on long-distance public transport, this study aims to conceptualize the pervasive, inter-relating nature of the key problems in North Korea’s transport infrastructure and its operations. The study will reveal not only the extent of the problems caused by the North Korean regime, but also raise important questions to deal with the North Korean issue and the future of the Korean peninsula.

Giant Superior Mesenteric Artery Aneurysm Treated by Endovascular Treatment in a Very Elderly Female

Ryo Okubo,Shinsuke Kikuchi,Norifumi Otani,Masahiro Tsutsui,Hiroyuki Kamiya 대한혈관외과학회 2023 Vascular Specialist International Vol.39 No.2

Superior mesenteric artery (SMA) aneurysms (SMAAs) are rare and account for approximately 7% of all visceral artery aneurysms. If the anatomical complexity permits and the patency of organ perfusion is allowed, then an endovascular approach is the first choice for minimally invasive procedures. We report the case of a 92-year-old female with a giant SMAA and challenging anatomy, including a short proximal sealing zone from the origin of the SMA and a short distal sealing zone from the hepatic artery bifurcation. In view of her advanced age, she was treated endovascularly with covered stents. Reintervention was required to correct a postoperative endoleak; however, a favorable outcome was achieved with endovascular therapy.