Cholelithiasis complicated with biliary sludge and urolithiasis in a dog

Seung-gon Lee,Dong-gun Kim,Joon-seok Lee,Ho-hyun Kwak,Hyun-sook Nam,Heung-myong Woo*, In-Chul Park**, Changbaig Hyun1,In-chul Park,Chang-baig Hyun 한국임상수의학회 2006 한국임상수의학회지 Vol.23 No.3

A 10-year-old intact female Miniature Schnauzer dog was referred with the primary complaint of persistentanorexia, remittent fever, vomiting and abdominal pain. Hemogram suggested a chronic inflammatory disease. Serumbiochemistry showed moderate hepatobiliary cellular damage with severe cholestasis. Abdominal radiography andultrasonography revealed hepatomegaly, choleliths and sludges in gall bladder and small stones in urinary bladder. Basedcholecystectomy and cystectomy, choleliths and uroliths were removed from gall bladder and urinary bladder,respectively. The clinical condition was dramatically improved after surgery.

全北地方의 藥用作物 재배 및 生産現況

郭晙洙,金昌洙,宋英恩,金柱,朴珍華,韓宗鉉,宋昊俊 圓光大學校 韓醫學硏究所 1997 원광한의학 Vol.7 No.1

본격적인 지방화 시대를 맞이하면서 지역특화작물의 개발과 농가소득증대를 위한 새로운 기술개발이 절실한 이때 주요 소득원작물의 하나인 약용작물의 재배 및 생산현황을 파악하여 지역특성에 맞는 새로운 작목개발 및 정책 입안 자료로 활용하고자 조사분석한 결과는 다음과 같다. 1. 생산량을 기준으로한 전북지방의 주요 약용작물을 특화계수 분석결과 총 31개작목 중 독활, 백지, 양유, 오미자, 지황 등은 핵심품목으로 길경, 두층, 방풍, 작약, 천마 등은 주산품목으로 조사되었으며 강활 등 21개 작목은 비특화 작물로 분석되었다. 재배면적을 기준으로 한결과는 독활, 백지, 양유, 지황 등이 핵심품목으로 길경, 두층, 목단, 방풍, 백출, 오미자, 의이인, 작약 등은 주산품목으로 강활 등 19개 품목은 비특화 작물로 분석되었다. 2. 주요 약용작물 재배 계획면적 조사에서는 당귀, 두층, 오미자, 독활, 천궁 등이 계획 대비 실제 재배면적의 차이가 큰 작목으로서 이들은 일반적으로 상품가격의 영향을 많이 받는 것으로 분석되었다. 3. '96 재배면적 조사 결과 전북지방의 주요 약용작물 재배 계획 면적은 총 1,692.7ha였으며 이중 독활이 426ha로 가장 많았고, 길경(283ha), 양유(179ha), 작약(165ha), 두층(154ha), 당귀(113ha), 오미자 의이인, 지황, 산수유, 천궁, 방풍 등의 순이었으며 기타작목으로 백지, 황기, 백하수오 등 28작목이 조사되었다. With the beginning of the new localization era, epoch-making techniques in local agriculture are needed to improve farm income and devlop a locally specialized crops. On the basis of these trends in local agriculture, the status quo of production in medicinal plants which are one of the major income crops were surveyed and analyzed the data for developing a new crops and drafting a policy. The major results are as follows; 1. The results analyzed by Location Quotient of production rate in Chonbuk were classified three catagories. 5 items including Aralia continentalis K_ITAGAWA among 31 items were so rted out as a core crops, another 5 items including Platycodon grandiflotum(J_ACQ.) A.DC. were as a main crops and other 21 items were as a non-specialized crops. Analyzed by cultivation area, 4 items were sorted out as a core crops, another 8 items were as a main crops and the other 19 items were as a non-specialized crops. 2. In comparison with the gap between intended cultivation area and real cultivation area, 5 items including Eucommia ulmoides OLIVER were showed more larger than the others. The above mentioned items were assumed to be more influenced by the price. 3. Farmer's intended cultivation areas of the major medidinal plants in 1996 were surveyed totals of 1.692 ha in Chonbuk. Among them, Aralia corolata was surveyed as the top totals of 426 ha. in area.

全北地方의 藥用 資源植物 分布

郭晙洙,金昌洙,宋英恩,金柱,朴珍華,韓宗鉉,宋昊俊 圓光大學校 韓醫學硏究所 1997 원광한의학 Vol.7 No.1

국민 소득이 늘어나고 건강에 대한 관심이 높아지면서 한약재에 대한 수요가 증가하게 되고 WTO체제의 출범과 함께 선진각국의 유전자원 확보전이 치열해지면서 국내에서도 약용자원식물의 분포상황 및 이들 유전자원 식물의 보전이 중요한 과제로 대두되고 있다. 따라서 전북지방의 약초자원식물의 분포상황 및 이들 유전자원식물의 보전이 중요한 과제로 대두되고 있다. 따라서 전북지방의 약초자원식물의 분포현황을 조사하여 그에 대한 보전대책 수립 및 연구의 기초자료를 얻고자 수행한 본연구의 주요결과는 다음과 같다. 1. 전북지방에 분포하는 약용 자원식물의 목록을 작성한 결과 총 40목 129과에 걸쳐 762종류의 식물이 정리되었다. 2. 이들 분포식물중 항암효과가 보고된 약용식물은 36과 74종류였다. 3. 지역적으로는 덕유산지역에 가장 다양한 식물이 반포하고 다음으로는 남원, 변산반도, 모악산, 무주군, 완주고산, 내장산, 장안산, 선운산, 비안도, 적상산 등의 순으로 나타났다. 4. 식물군별로는 쌍자엽식물강의 이판화군과 합판화군이 가장 다양하였고, 각 목별 과(科) 수는 통화식물목이 10개 과로서 가장 많았으며, 각 목별 종류 수에 있어서는 장미목이 99종으로 가장 많았고, 초롱꽃목(77종), 통화식물목(67종), 백합목(53종), 미나리아재비목(43종), 산형화목(39종) 등이 비교적 많은 종들을 포함하는 것으로 분석되었다. 5. 각 과별 종수 분석에서는 국화과가 70종으로 가장 많았고, 장미과(46종), 콩과(40종), 백합과(40종)등으로 나타나 이들 4개과의 합계 종수가 196종류로서 전체의 25.72%를 차지하였다. 그 다음으로 산형과(27종), 미나리아재비과(26종), 꿀풀과(25종), 벼과(22종), 마디풀과(19종), 현삼과(15종), 석죽과(12종), 제비꽃과(11종), 난초과(11종) 등이 비교적 많은 종수를 가지는 과(科)들이었다. With the improving of the people's standard of life and the heightening of the concerns of health, the demands of medicinal plants are more rapidly increase. Also, with the inauguration of World Trade Organization, and acceleration of openness in domestic markets, the procurement competitions of gene pools in medicinal plants are more intense among the countries. With these trends of the world, an acute subjects are coming up for us such as distribution status quo and preservation of medicinal plants in domestic area. Therefore this paper surveyed the distribution status quo of medicinal plants in Chonbuk province, arranged the catalogue and analyzed the data by plants and regions. The major results are as follows; 1. The total amounts of 762 species, 129 families, 40 orders of medicinal plants distributed in Chonbuk province. 2. The number of medicinal plants which are assumed to contain antineoplastic agents totals 36 families and 74 species. 3. In distribution of medicinal plants by region, the most diverse flora showed in Mt. Dukyoo followed by circumferences of Namwon, Byun-san, Mt. Moak, Muju, Dosan, Mt. Naejang, Mt. Jangan, Mt. Seon-woon, Beeando island and Mt. Juksang etc. in Chonbuk province.

겸상적혈구 혈증에 의한 동통성 발작 1례

김효철,배택환,정윤석,김현수,조준필,김준식,곽연식 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

The sickle cell disease are a group of hemoglobin disorders characterized by red cells that undergo sickle shape transformation when they are deoxygenated. Sickle cell disease is transmit-ted as an autosomal recessive trait. This unusual property, due to the polymerization of sickle hemoglobin results in anemia and vasoocclusive complication. 1) The most clinically significant of these disease are sickle cell anemia, sickle cell hemoglobin C disease, and sickle cell beta thalassemia. Symptoms of pallor, fever, abdominal and joint pain, enlargement of the liver and spleen, swelling of hands and feet first appear near the latter part of the first year of life. Intravascular sickling affects all organs. For clinical and therapeutic purposes, exacerbations may be classified as vasoocclusive or pain, aplastic, hemolytic or sequestration crisis. we experienced a 22 year old female patient who suffered severe multiple joint pain and back pain thought to be caused by vasoocclussive phenomena.

The practice patterns of second trimester fetal ultrasonography: A questionnaire survey and an analysis of checklists

( Hyun Soo Park ),( Won Joon Seong ),( Joon Seok Hong ),( Hyun Joo Seol ),( Han Sung Hwang ),( Kunwoo Kim ),( Hyun Sun Ko ),( Dong Wook Kwak ),( Soo Young Oh ),( Moon Young Kim ),( Sa Jin Kim ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.6

Objective To analyze practice patterns and checklists of second trimester ultrasonography, and to investigate management plans when soft markers are detected among Korean Society of Ultrasound in Obstetrics and Gynecology (KSUOG) members. Methods An internet-based self-administered questionnaire survey was designed. KSUOG members were invited to the survey. Checklists of the second trimester ultrasonography were also requested. In the questionnaire survey, general practice patterns of the second trimester ultrasonography and management schemes of soft markers were asked. In the checklists analysis, the number of items were counted and also compared with those recommended by other medical societies. Results A total of 101 members responded. Eighty-seven percent routinely recommended second trimester fetal anatomic surveillance. Most (91.1%) performed it between 20+0 and 23+6 weeks of gestation. Written informed consents were given by 15.8% of respondents. Nearly 60% recommended genetic counseling when multiple soft markers and/or advanced maternal age were found. Similar tendencies were found in the managements of individual soft markers. However, practice patterns were very diverse and sometimes conflicting. Forty-eight checklists were analyzed in context with the number and content of the items. The median item number was 46.5 (range, 17 to 109). Of 49 items of checklists recommended by International Society of Ultrasound in Obstetrics and Gynecology and/or American Congress of Obstetricians and Gynecologists, 14 items (28.6%) were found in less than 50% of the checklists analyzed in this study. Conclusion Although general practice patterns were similar among KSUOG members, some of which were conflicting, and there is a need for standardization of the practice patterns and checklists of second trimester ultrasonography, which also have very wide range of spectrum.

Phase III Clinical Trial (RERISE study) Results of Efficacy and Safety of Radotinib Compared with Imatinib in Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia

Kwak, Jae-Yong,Kim, Sung-Hyun,Oh, Suk Joong,Zang, Dae Young,Kim, Hawk,Kim, Jeong-A,Do, Young Rok,Kim, Hyeoung Joon,Park, Joon Seong,Choi, Chul Won,Lee, Won Sik,Mun, Yeung-Chul,Kong, Jee Hyun,Chung, Jo American Association for Cancer Research 2017 Clinical Cancer Research Vol.23 No.23

<P><B>Purpose:</B> Radotinib is a second-generation BCR-ABL1 tyrosine kinase inhibitor (TKI) approved in Korea for chronic phase chronic myeloid leukemia (CML-CP) in patients newly diagnosed or with insufficient response to other TKIs. This study was conducted to evaluate the efficacy and safety of radotinib as first-line therapy for CML-CP.</P><P><B>Experimental Design:</B> This multinational, open-label study assigned patients (1:1:1) to one of two twice-daily radotinib doses, or imatinib daily. The primary endpoint was major molecular response (MMR) by 12 months.</P><P><B>Results:</B> Two hundred forty-one patients were randomized to receive radotinib 300 mg (<I>n</I> = 79) or 400 mg twice-daily (<I>n</I> = 81), or imatinib 400 mg daily (<I>n</I> = 81). MMR rates by 12 months were higher in patients receiving radotinib 300 mg (52%) or radotinib 400 mg twice-daily (46%) versus imatinib (30%; <I>P</I> = 0.0044 and <I>P</I> = 0.0342, respectively). Complete cytogenetic response (CCyR) rates by 12 months were higher for radotinib 300 mg (91%) versus imatinib (77%; <I>P</I> = 0.0120). Early molecular response at 3 months occurred in 86% and 87% of patients receiving radotinib 300 mg and radotinib 400 mg, respectively, and 71% of those receiving imatinib. By 12 months, no patients had progression to accelerated phase or blast crisis. Most adverse events were manageable with dose reduction.</P><P><B>Conclusions:</B> Radotinib demonstrated superiority over imatinib in CCyR and MMR in patients newly diagnosed with Philadelphia chromosome–positive CML-CP. This trial was registered at www.clinicaltrials.gov as NCT01511289. <I>Clin Cancer Res; 23(23); 7180–8. ©2017 AACR</I>.</P>

아데포비어 단독요법에 반응을 보인 라미부딘 내성 HBeAg 양성 만성 B형간염 환자에서 아데포비어 중단 후 임상경과

정현욱 ( Hyun Wook Jung ),최문석 ( Moon Seok Choi ),김갑현 ( Kap Hyun Kim ),박성현 ( Sung Hyun Park ),곽금연 ( Keum Yeon Kwak ),이준혁 ( Joon Hyoek Lee ),고광철 ( Kwang Cheol Koh ),백승운 ( Seung Woon Paik ),유병철 ( Byung Chul 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.1

Variations in the trophic niche overlap between native and invasive fishes under environmental change in the southern coast of Jeju

Jung Hyun Kwak,Jung Nyun Kim,Joon Chul Ko,Hyun Je Park,Chang-Keun Kang 한국수산과학회 양식분과 2022 한국수산과학회 양식분과 학술대회 Vol.2022 No.10

Seasonal variation trophic overlap between native and invasive fishes revealed by carbon and nitrogen stable isotopes

Jung Hyun Kwak,Jung Hwa Choi,Joon Chul Ko,Hyun Je Park,Chang-Keun Kang 한국수산과학회 양식분과 2022 한국수산과학회 양식분과 학술대회 Vol.2022 No.5

응급의료센터로 내원한 급성 A형 간염 환자의 임상적 고찰

곽영호,신중호,정성구,이중의,서길준,윤여규,이창현 대한응급의학회 2002 대한응급의학회지 Vol.13 No.3

Purpose: We conducted this study to evaluate the clinical manifestations of acute hepatities A in an emergency center. Methods: All hepatitis A patients who visited the emergency center of Seoul National University Hospital from October 1999 to March 2002 were analyzed using a retrospective medical record review. Variables included in the data analysis were age, sex, clinical symptoms and signs, and laboratory findings on initial presentation and their peak values. Results: A total of 31 patients showed positive for the anti-HAV lgM antibody, and 29 patients had apparent hepatitis A. The number of hepatitis A cases per month in 1999, 2000, 2001, and 2002 were 1.33, 0.25, 0.92, and 4.3, respectively. Among the 29 patients, 15 were brought to the emergency center and constituted the study group. The mean age were 22.3 years old. The most common symptoms were nausea and vomiting (100%), followed by fever (86.7%), anorexia (66.7%). Common signs were jaundice (53.3%) and hepatomegaly (46.7%). Seven patients admitted via the outpatient department were older and had a longer duration of symptoms from onset to diagnosis than the study group. The mean values of the initial laboratory tests were serum aspartate aminotransferase (AST) of 3,044 IU/L, alanine aminotransferase (ALT) of 3,521 IU/L, and a total bilirubin of 4.15 mg/dL. The peak mean values of those variables were 4,067 IU/L, 4,662 IU/L, and 7.35 mg/dL, respectively. All patients recovered without complications. Conclusion: Patients with hepatitis A showed benign clinical features. This study revealed a trend of increasing incidence of hepatitis A in adults and suggested the possibility of an outbreak. Further effort to prevent the propagation of the disease is warranted.