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- 저자 : 이준혁 ( Joon Hyoek Lee ) (검색결과 49 건)
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이준혁(Joon Hyoek Lee),고광철(Kwang Cheol Koh),백승운(Seung Woon Paik),심상군(Sang Goon Shim),류광현(Kwang Hyun Ryu),이풍렬(Poong Lyul Rhee),김재준(Jae Jun Kim),이종철(Jong Chul Rhee),최규완(Kyoo Wan Choi),이석호(Suk Ho Lee),이규택(K 대한내과학회 1999 대한내과학회지 Vol.56 No.1
Objectives : The purpose of present study is to investigate the influence of a spinal gamma-aminobutyric acid B (GABAB) receptor on a central regulation of blood pressure(BP) and heart rate(HR), and to define its mechanism in the spinal cord. Methods : In urethane-anesthetized, d-tubocurarine- paralyzed and artificially ventilated male Sprague-Dawley rats, intrathecal administration of drugs were carried out using injecton cannula(33-gauge stainless steel) through the guide cannula(PE 10) which was inserted intrathecally at lower thoracic level through the puncture of a atlantooccipital membrane. Results : Intrathecal injection of an GABAB receptor agonist baclofen(30, 60, 100 nmol) decreased both blood pressure and heart rate dose-dependently. Pretreatment with 8-bromo-cAMP(50 nmol), a cAMP analog or glipizide(50 nmol), a ATP-sensitive K+ channel blocker attenuated the depressor and bradycardic effects of baclofen (100 nmol) but not with 8-bromo-cGMP(50 nmol) a cGMP analog. Conclusions : The GABAB receptor in the spinal cord plays an inhibitory role in central cardiovascular regulation and that this depressor and bradycardic actions are mediated by the decrease of cAMP via the inhibition of adenylate cyclase and the opening of K+ channel.
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혈액투석 중인 만성 신부전 환자에서 G 형 간염 바이러스의 감염률 및 임상적 의의
이준혁 ( Joon Hyoek Lee ),고광철 ( Kwang Cheol Koh ),백승운 ( Seung Woon Paik ),이종철 ( Jong Chul Rhee ),최규완 ( Kyoo Wan Choi ),이윤하 ( Yun Ha Lee ),김윤구 ( Yun Gu Kim ),오하영 ( Ha Yung Oh ),이효석 ( Hyo-Suk Lee ),김정룡 ( C 대한소화기학회 1999 대한소화기학회지 Vol.33 No.1
Background/Aims: We aimed to elucidate the prevalence and risk factors of HGV infection in patients with chronic renal failure undergoing hemodialysis, and to define the potential etiologic-role of HGV in the development of chronic liver disease. Methods: One-hundred and seventy-eigh patients with chronic renal failure undergoing hemodialysis were included. After extraction of RNA from serum, reverse transcription polymerase chain reaction was performed using the primers from the NS5a region. The PCR products were analyzed by liquid hybridization. Results: The prevalence was 9.0% (16/178). The prevalence rates were not statistically different according to the presence (8.5%) or abscence (10.8%) of past history of blood transfusion, patient' s age or maintenance duration of hemodialysis (p>0.05). Anti-HBc-positive patients (12.4%, 16/129) showed significantly higher prevalence rate (p=0.01) of HGV infection than anti-HBc-negative patients (0%, 0/49). Twelve of the 14 HGV positive patients without co-infection showed persistently normal ALT level during a year of follow-up. Conclusions: The prevalence of HGV in patients with chronic renal failure undergoing hemodialysis is significantly higher than that of volunteer blood donors. HGV may share the route of transmission with adulthood HBV infection. The etiologic-role of HGV in the development of ch ronic liver disease may be considerably poor. (Kor J Gastroenterol 1999;33:78 - 89)
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이준혁(Joon Hyoek Lee),백승운(Seung Woon Paik),심상군(Sang Goon Shim),류광현(Kwang Hyun Ryu),이풍렬(Poong Lyul Rhee),김재준(Jae Jun Kim),이종철(Jong Chul Rhee),최규완(Kyoo Wan Choi),이석호(Suk Ho Lee),이규택(Kyu Taek Lee),이종균(Jong 대한내과학회 1999 대한내과학회지 Vol.57 No.1
Low-grade gastric MALT lymphoma arises from long-standing Helicobacter pylori(Hp) infection. High remission rates for these lymphoma have been observed after H. pylori eradication. There was debates on the optimal treatment of low-grade gastric MALT lymphoma. The purpose of this study is to investigate clinical and endoscopic characteristics of primary low-grade gastric MALT lymphoma and to assess short-term clinical outcome of various modalities of treatment. Methods : 30 patients(14 male, 16 female, mean age 44.9 years, range 26-76, mean follow-up 22.9 months) with primary low-grade gastric MALT lymphoma, diagnosed at the Samsung Medical Center from March 1995 to September 1998, were evaluated in a retrospective study. We evaluated patient's presenting symptoms, endoscopic finding, Hp status, staging by Musshoff system, and recurrence rate according to treatment mordalities. Results : The most common symptom is epigastric discomfort or pain(36.7%). Endoscopic appearances of gastric MALT lymphoma shows the wide variation from mucosal thickening to overt malignancy. The most common site of gastric MALT lymphoma is the gastric antrum and lower body(9 and 6 patients). Histologically, 70% were found to be Hp infected. Of 21 Hp(+) patients, 11 patients were clinical stage IE and received Hp eradication by PPI-based triple regimens. 81.8%(9/11) showed complete remission. Among 11 patients, 6 patients studied by PCR. After Hp eradication, 5 in 6 patients showed persistent IgH rearangement by PCR. The mean follow-up time is 22.8 months(range 3 to 36 months), One patient, who showed complete histologic regression during second endoscopy, relapsed MALT lymphoma after 6 months. The other one patient showed no change of lymphoma and underwent surgery. 12 patients underwent surgical treatment and showed no evidence of relapse. The mean follow-up time is 35.9 months. 2 patients received chemotherapy with CHOP regimen and showed complete remission. The mean follow-up time is 6.7 months. 2 patients received radiotherapy and showed no evidence of relapse. The mean follow-up time is 15 months. Conclusion ' Our study shows that complete remission rate after Hp eradication is as high as some studies recently reported. This suggest that Hp eradication may be considered as first-line therapy of low-grade gastric MALT lymphoma of stage IE.
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이석호(Suk Ho Lee),이풍렬(Poong Lyul Rhee),이준혁(Joon Hyoek Lee),이규택(Kyu Taek Lee),이종균(Jong Kyun Lee),심상군(Sang Gun Sim),이상구(Sang Ku Lee),김재준(Jae Jun Kim),고광철(Kwang Cheol Ko),백승운(Seung Woon Paik),이종철(Jong Chu 대한소화기학회 1999 대한소화기학회지 Vol.34 No.4
Intestinal capillariasis is caused by Capillaria philippinensis. Among them, only 4 species have been found in humans: Capillaria hepatica, C. aerophila (Eucoleus aerophilus), C. plica and C. philippinensis. Reports of human infections with C. hepatica, C. aerophila and C. plica are rare, but reports of C. philippinensis infections are increasing and spreading geographically. Human infestation by C. philippinensis is a rare parasitic disease. We experienced a case of intestinal capillariasis which was misdiagnosed for intestinal tuberculosis or Crohn's disease at first but correctly diagnosed later by detection of numerous eggs of C. philippinensis on the stool examination. The eggs were found in stool only after ingestion of prednisolone for treatment of misdiagnosed Crohn's disease. The 42 year-old patient had a journey to Saipan island in Pacific ocean 6 months ago and ate sliced raw eels. Abdominal pain, watery diarrhea were subsided after therapy of albendazole. (Kor J Gastroenterol 1999;34:542 - 546)
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간암의 술전 검사로서 CTAP , CTHA 및 Lipiodol CT 의 유용성
이석호 ( Suk Ho Lee ),이규택 ( Kyu Taek Lee ),김재준 ( Jae Jun Kim ),김승훈 ( Seung Hun Kim ),백승운 ( Seung Woon Paik ),이종균 ( Jong Kyun Lee ),이준혁 ( Joon Hyoek Lee ),고광철 ( Kwang Cheol Koh ),이풍렬 ( Poong Lyul Rhee ),이 대한소화기학회 1999 대한소화기학회지 Vol.32 No.6
Background/Aims: Computed tomography during arterial portography (CTAP), computed tomo-graphy during hepatic arteriography (CTHA) and Lipiodol CT are highly sensitive methods to detec intrahepatic tumor. Their sensitivity and accuracy are over 90% and 85%, respectively. We evaluated the usefulness of CTAP, CTHA and Lipiodol CT as a preoperative examination. Methods: For eighty two patients with hepatocellular carcinoma which were considered as the resectable on spiral CT and angiogram, CTAP and CTHA were performed. The additional nodules on CTAP and CTHA were confirmed by Lipiodol CT. Results: CTAP and CTHA could find additional nodules in 28% of the patients. The treatment plan was changed from surgical to nonsurgical method in 12% of the patients The larger tumor nodules were on the spiral CT, the more additional tumor nodules were found on CTAP and CTHA (p=0.03). The probability of finding additional nodules on CTAP and CTHA is no related with the counts of tumor nodules on the spiral CT (p=0.84). CTAP and CTHA could find additional nodules in 6 cases of 27 cases who underwent Lipiodol CT. The treatment plan was changed to nonsurgical treatment in 3 cases by the results of CTAP and CTHA. Conculusions: We concluded that CTAP, CTHA and Lipiodol CT are useful in avoiding unnecessory operation. (Kor J Gastroenterol 1998;32:740 - 748)
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사례보고 : 급성 신부전을 동반한 전격성 간염으로 발현하여 간이식을 시행한 A형간염 4예
오세훈 ( Se Hoon Oh ),이준혁 ( Joon Hyoek Lee ),황지원 ( Ji Won Hwang ),김혜영 ( Hye Young Kim ),이창훈 ( Chang Hoon Lee ),곽금연 ( Geum Youn Gwak ),최문석 ( Moon Seok Choi ),고광철 ( Kwang Chul Koh ),백승운 ( Seung Woon Paik ) 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.3
A형간염은 대부분의 경우 가벼운 임상경과를 거치게 되나 드물게 전격성 간염으로 발전하여 사망에 이르거나 간이식을 시행하게 된다. 저자들은 비교적 높은 연령의 환자에서 급성 신부전을 동반한 전격성 간염으로 발현되어 간이식까지 시행했던 A형간염 4예를 경험하였기에 보고하고자 한다. 본 증례들은 공통적으로 1) 30대 후반 이상의 상대적 고령에 발생, 2) 급성 신부전을 동반, 3) 간종대를 동반, 4) 조직 소견에서 아광범성 간괴사 소견의 특징을 보였다. Hepatitis A is generally known as a mild, self-limiting disease of the liver, but in rare instances it can progress to fulminant hepatitis, which may require liver transplantation for recovery. Such cases are known to be related to old age and underlying liver disease. We report four cases of hepatitis A in which patients presented with fulminant hepatitis and acute renal failure and underwent liver transplantation. The following common features were observed in our cases: (1) occurrence in relatively old age (≥39 years old), (2) association with acute renal failure, (3) presence of hepatomegaly, and (4) microscopic features of sub-massive hepatic necrosis. (Korean J Hepatol 2009;15:362-369)
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한국인 건강검진자에서 연령 특이적 A형간염바이러스 항체 혈청 양성률
송영봉 ( Young Bong Song ),이준혁 ( Joon Hyoek Lee ),최문석 ( Moon Seok Choi ),고광철 ( Kwang Cheol Koh ),백승운 ( Seung Woon Paik ),유병철 ( Byung Chul Yoo ),최윤호 ( Yoon Ho Choi ),손희정 ( Hee Jung Sohn ),이경한 ( Kyung Han 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.1
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