특정 온도에서의 Q.C.M을 이용한 유기가스 반응 특성

김경환,진철남,최용성,박재철,권영수 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

Stearic acid was deposited on surface of 9[MHz], AT-cut quartz crystal microbalance as gas sensing material using Langmuir-Blodgett(LB) technique. We measured gas response between deposited LB films and organic gas for special temperature(0, 25, 50, 80℃). The resonant frequency changed due to absorbance of organic gas such as methanol, ethanol, propanol and butanol gas at special temperature. As a result, the resonant frequency responded to organic gas at 0, 25 [℃]. but, the resonant frequency almost not responded to organic gas at 50, 80[℃].

건축계획심의제도의 개선방안에 관한 연구

김재철,박철민 제주대학교 공과대학 첨단기술연구소 2003 尖端技術硏究所論文集 Vol.14 No.1

The primary purpose of this thesis lies in the institutional examination of the contents related with Building Deliberation Commission by using the literature inquiry. The second purpose is a help to improvement of discussion of the administrative structure and improvement of the beauties of city through the systematic analysis of building deliberation system. The extent of space is selected according to the case of building planning deliberation of Jeju city as the axis of Free International City, the center of administration, education, and culture. The period of time of examination is from January, 2002 to December, 2002. The subject of study is apartment which is deeply related with our lives by analyzing 2,231 discussion cases.

제주시 건축계획심의제도 운영에 관한 관련그룹간 인식차이에 관한 연구

김재철,박철민 제주대학교 공과대학 첨단기술연구소 2003 尖端技術硏究所論文集 Vol.14 No.2

The architecture deliberation committee has played various important roles as the final check point for the overall urban management in Jeju-City. Although nobody can argue that the committee is useless, participants' assessments on the results of the introduction and operation of the architecture deliberation committee are diversified. Architects' complaints on its operational system have never been reduced and the deliberation system has been reviscd several times but partially in oder to accomodate the complaints. However, the regulators have paid little attention to the causes of the discord among the reviewers and the reviewees. There have been only some piecemeal and intermittent discussions on the causes. This paper tries to document, using an organized survey, the endless discords between the participating parties in the architectural review process and to analyze the causes of the discords. This survey results indicate that both architects as reviewees and architectural review committee members as reviewers recognize the necessity of architectural review in principle.

폐쇄성 수면 무호흡증 환자에 있어서 하악 재위치 장치 장착과 체위에 따른 상기도 구조와 근활성도의 변화에 관한 EMG 및 두부방사선학적 연구

박영철,배응권,이정권,이종석,김태관 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.4

폐쇄성 수면 무호흡증(obstructive sleep apnea, 이하 OSA로 표시)은 수면 도중 계속 반복 되어 일어나는 상기도 폐쇄로 인하여 무호흡증을 나타내는 장애(disorder)이다. 근래의 연구에 의하면 상기도 구조의 해부학적 요인뿐 아니라 생리적 요인도 무호흡 발생에 기여한다고 하였으며 또한 이설근이 상기도 유지에 중요한 역할을 한다고 하였다. OSA의 치료를 위해 다양한 술식이 시행되었으며 하악 재위치 장치를 통한 치료 역시 양호한 결과를 나타낸다고 하였다. 그러나 하악 재위치 장치 장착에 따른 구조적 생리적 작용기전에 대한 연구는 미비한 상태이다. 이에 본 저자는 연세대학교 치과대학병원 교정과에 내원한 OSA 환자 26명(남 17명, 여 9명)과 일반 정상 성인 20명(남 10명 여 10명)을 대상으로 앙와위에서 장치 장착 전후의 두부방사선사진을 채득하여 장치에 따른 상기도의 구조 변화를 연구하고 두군 사이의 장치 장착에 따른 효과를 비교하였으며, 또한 OSA 환자 14명(남자 10명 여 4명)을 대상으로 체위 변화와 장치장착에 따른 이설근 근전도 변화를 연구하여 다음과 같은 결론을 얻었다. 1. 상기도 구조에 대한 두부계측학적 측정치 중 연구개의 길이, 연구개 최대 두께와 SPAS, MAS, VAL, H-H1. MP-H에서 정상군과 OSA군 사이의 통계적 유의차를 보였으며, IAS와 EAS는 두 군간에 통계적 유의차를 보이지 않았다. 2. 정상군과 OSA군 모두에서 장치 장착에 따라 후두개가 전방 이동하면서 후두개 수준(epiglottis level)의 기도 폭경은 증가하였고 연구개의 최대 두께가 변하였으며 설골은 전방 이동하였으나 두 군 모두 IAS에서는 다양한 반응을 나타내었다. 장치 장착에 따른 상기도 구조에 대한 효과는 두 군 사이에 서로 차이을 나타내었다. 3. 체위 변화에 따라 앙와위에서 이설근 근전도가 증가하는 경향을 나타내었으나 통계적 유의차는 없었으며, 직립위와 앙와위 모두에서 하악 재위치 장치 장착시에 통계적으로 유의하게 이설근 근전도가 증가하였다. 하악 재위치 장치는 상기도의 해부학적 구조뿐 아니라 상기도 영향을 미치는 것으로 생각되며 장치에 대한 반응은 정상군과 OSA군 사이에 차이를 나타내었고, 두 군은 상기도 생리에 있어서도 서로 다르다고 사료된다. Obstructive sleep apnea (OSA)is a disorder characterized by repetitive episode of upper airway collapse during sleep. Recent studies showed that not only the anatomic factors but the physiologic factors of the upper airway also have effects on the occurrence of apnea and that the genioglossus muscle also plays in important role in the maintenance of the upper airway. A variety of therapies were performed to treat OSA, and among them the use of mandibular repositioning appliances showed reasonable results. But there is still a lack of research on the structural and physiological mechanism upon the use of mandibular repositioning appliances. The author selected 26(male 17, female 9) OSA patients that came to the Yonsei University Dental Hospital, Department of Orthodontics, and 20 normal adults (male 10, female 10) and took cephalometric radiographs of them in a supine position before and after the palcement of the mandibular repositioning appliance to see the structural changes of the upper airway and compare the therapeutic effects between the two groups. We also studied the waking genioglossus muscle activity in OSA patients and investigated the difference in the electromyogram of the genioglosssus muscle upon the change in body posture and the use of mandibular repositioning appliance. Following results were obtained. 1. Among the cephalometric measurements of the upper airway structure, the length of the soft palate, maximum thickness of the soft palate and SPAS, MAS, VAL, H-HI, MP-H showed statistically significant differences between the normal and OSA groups, but the IAS and EAS showed no statistically significant differences between the two groups. 2. In both the normal and OSA groups, as the epiglottis moved forward on wearing the mandibular repositioning appliance, the epiglottis level of the upper airway increased and the maximum thickness of the soft palate changed and the hyoid bone also moved forward, but the IAS in both groups showed various results and the effect of the mandibular repositioning appliance on the structure of the upper airway was different in the two groups. 3. Upon changing the position, the electromyogram of the genioglossus muscle showed a increasing tendency but there was no statistically significant differences, and when the mandibular repositioning appliance were worn there was a statistically significant increase in the electromyogram of the genioglossus muscle in both the upright and supine positions. The mandibular repositioning appliances not only have an effect on the anatomical structure of the upper airway but also on the physiology of the upper airway. There are different responses to the use of mandibular repositioning appliance between the normal and OSA groups therefore it could be considered to have the different physiology of the upper airway between the two groups.

Complex法에 의한 配水管網의 最適管徑 決定에 관한 硏究

安松燁,金洙源,蘇在喆 圓光大學校 1986 論文集 Vol.20 No.2

Box-complex 알고리즘을 적용하여 배수관망의 관 포설경비를 목적함수로, 유속과 관경을 제약조건으로 고려하여 관경을 최적화 하였으며, 본 연구에 적용된 알고리즘의 적용가능성, 안정성 및 효율성등을 분석하여 다음과 같은 결과를 얻었다. 1. Box-Complex 알고리즘은 배수관망의 설계에 매우 적합한 최적화 기법이다. 2. 지반고가 일정한 배수관망의 관경을 최적화하여 최적관경을 얻었으므로 지반고가 일정하지 않은 배수관망이나 대형의 관망 최적화에도 용이하게 적용할 수 있을 것이다. 3. 도송배수관로와 배수관망을 연결하여 최적관경을 구하면 배수관망 자체만의 최적화에서 구한 관경보다 경제적인 관경을 얻을 수 있다고 사료된다. 4. 본 연구에서 적용한 알고리즘은 초기치를 달리하여도 목적함수값이 변하지 않고 짧은 시간내에 일정한 값에 수렴하므로 적용성이 있고 효율적이며 안정성이 있는 알고리즘으로 사료된다. This study deals with the optimization of pipe diameter applying the Box-Complex algorithm and considering the velocity of flow and pipe diameter as constraints with the pipe paving cost of water pipe networks as their objective function. Then this study obtains the results as follows, analyzing the applicational possibility, stability and efficiency of algorithm which are applied to this study. 1. A Box-Complex algorithm is a very suitable optimization technique for the optimal design of the water pipe networks. 2. The optimal pipe diameter will be applied easily for the optimization of the large scale water pipe networks or the water pipe networks that the ground height inclines because the optimal pipe diameter is attained through the optimization of pipe diameter of water pipe networks that the ground height is horizontal. 3. If the optimal pipe diameter is attained through the linking of a water pipe channel with pipe networks, then it will be more economical pipe diameter than the one which is attained from the optimization of pipe networks itself. 4. The algorithm applied to this study is applicable, efficient and stable algorithm because it converges to a constant value within a shore time and does not change its objective function value through the initial value of the design valuables is different.

Effect of subcutaneous drain on wound dehiscence and infection in midline laparotomy for gynecological disease (KGOG 4001)

( Chel Hun Choi ),( Nam Kyeong Kim ),( Kidong Kim ),( Yong Jae Lee ),( Keun Ho Lee ),( Jong-min Lee ),( Kwang Beom Lee ),( Dong Hoon Suh ),( Sunghoon Kim ),( Min Kyu Kim ),( Seok Ju Seong ),( Myong Ch 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Objective: To identify the effect of subcutaneous (SQ) drain on wound dehiscence and infection in patients who underwent midline laparotomy for gynecological disease. Methods: Patients planned to undergo midline laparotomy for gynecologic disease, BMI< 35, age >18 years and ECOG performance status 0-2 were 1:1 randomized to case (with SQ drain) vs. control (without SQ drain) at 9 institutes in Korea, from February 2021 to December 2021. We compared the incidence of wound dehiscence at 4 weeks post-surgery and cumulative incidence of wound dehiscence and infection up to 4 weeks post-surgery between case and control group. Results: Of the 174 randomized patients (case 84, control 90), 12 patients were dropped due to follow-up loss (case 5, control 7) and 162 patients (intention-to-treat [ITT] cohort: case 79, control 83) were included. Fourteen patients (case 10, control 4) did not follow assigned intervention depending on the operator’s decision because the SQ layer was either too thick or too thin, and were excluded from per-protocol [PP] analysis (case 69, control 79). In ITT cohort, the frequency of cancer surgery (63/79 [79.7%] vs. 64/83 [77.1%]; p=0.683) and surgery time (mean ± standard deviation = 227.7±133.9 minutes vs. 226.7±118.2 minutes; p=0.960) were comparable in the case and control group. Mean wound length was also similar in both groups (case vs. control; 24.2 cm vs. 24.3 cm; p=0.933). There were no significant differences in the incidence of wound dehiscence at 4 weeks post-surgery (1/79 [1.3%] vs. 2/83 [2.4%]; p>0.999), the cumulative incidence of wound dehiscence (7/79 [8.9%] vs. 5/83 [6.0%]; p=0.491), and the cumulative incidence of wound infection (1/79 [1.3%] vs. 0/83 [0.0%]; p=0.488) between case and control group. PP analysis showed similar result to ITT analysis. Conclusion: SQ drain insertion did not decrease wound dehiscence and infection in patients who underwent midline laparotomy for gynecological disease.

Middle temporal vein access for transvenous embolization of Cavernous sinus dural arteriovenous fistula: A case report and review of literature

Kim Su-Chel,Kim Jae-Hyun,Kim Chang-Hyun,Lee Chang-Young 대한뇌혈관외과학회 2022 Journal of Cerebrovascular and Endovascular Neuros Vol.24 No.1

Transvenous endovascular treatment is the first choice for treating most cavernous sinus dural arteriovenous fistulas (CDAVFs). Among several available venous routes, the inferior petrosal sinus is the most commonly used. We report a case of CDAVF treated with endovascular treatment via the middle temporal vein (MTV). A 65-year-old man presented with unilateral chemosis and exophthalmos for approximately two months. Digital subtraction angiography showed a right CDAVF with predominant venous drainage toward the right superior ophthalmic vein. The superior ophthalmic vein primarily drained into the dilated MTV. Both sides of the inferior petrosal sinus were occluded; therefore, transvenous embolization was performed via the MTV route. The fistula was completely obliterated. The patient’s symptoms improved and the postoperative course was uneventful. The transfemoral approach via the MTV to treat CDAVF provides a crucial alternative when other venous routes are difficult or impossible to navigate with a catheter.

CDK7 is a reliable prognostic factor and novel therapeutic target in epithelial ovarian cancer

Kim, Jihye,Cho, Young-Jae,Ryu, Ji-Yoon,Hwang, Ilseon,Han, Hee Dong,Ahn, Hyung Jun,Kim, Woo Young,Cho, Hanbyoul,Chung, Joon-Yong,Hewitt, Stephen M.,Kim, Jae-Hoon,Kim, Byoung-Gie,Bae, Duk-Soo,Choi, Chel Elsevier 2020 Gynecologic oncology Vol.156 No.1

<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>Cyclin-dependent kinase 7 (CDK7) engages tumor growth by acting as a direct link between the regulation of transcription and the cell cycle. Here, we investigated the clinical significance of CDK7 expression and its potential as a therapeutic target in epithelial ovarian cancer (EOC).</P> <P><B>Methods</B></P> <P>CDK7 expression was examined in 436 ovarian tissues including normal to metastatic ovarian tumors using immunohistochemistry, and its clinical implications were analyzed. Furthermore, we performed <I>in vitro</I> and <I>in vivo</I> experiments using CDK7 siRNA or a covalent CDK7 inhibitor (THZ1) to elucidate the effect of CDK7 inhibition on tumorigenesis in EOC cells.</P> <P><B>Results</B></P> <P>The patient incidence of high CDK7 expression (CDK7<SUP>High</SUP>) gradually increased from normal ovarian epithelium to EOC (<I>P</I> < 0.001). Moreover, CDK7<SUP>High</SUP> was associated with an advanced stage and high-grade histology (<I>P</I> = 0.035 and <I>P</I> = 0.011, respectively) in EOC patients and had an independent prognostic significance in EOC recurrence (<I>P</I> = 0.034). CDK7 inhibition with siRNA or THZ1 decreased cell proliferation and migration, and increased apoptosis in EOC cells, and this anti-cancer mechanism is caused by G0/G1 cell cycle arrest. In <I>in vivo</I> therapeutic experiments using cell-line xenograft and PDX models, CDK7 inhibition significantly decreased the tumor weight, which was mediated by cell proliferation and apoptosis.</P> <P><B>Conclusion</B></P> <P>Mechanistic interrogation of CDK7 revealed that it is significantly associated with an aggressive phenotype of EOC, and it has independent prognostic power for EOC recurrence. Furthermore, CDK7 may be a potential therapeutic target for patients with EOC, whether platinum sensitive or resistant.</P> <P><B>Highlights</B></P> <P> <UL> <LI> CDK7 inhibition has an anti-cancer effect on platinum-sensitive EOC. </LI> <LI> CDK7 inhibition could induce responsiveness to platinum chemotherapy in platinum-resistant EOC. </LI> <LI> CDK7 overexpression had independent negative prognostic value for disease recurrence of EOC. </LI> <LI> CDK7 might play a critical role in EOC tumorigenesis, and it also serves as a possible therapeutic target in EOC. </LI> </UL> </P>

Clinical significance of galectin-7 in epithelial ovarian cancer.

Kim, Ha-Jeong,Jeon, Hye-Kyung,Lee, Jae-Kwan,Sung, Chang Ohk,Do, In-Gu,Choi, Chel Hun,Kim, Tae-Joong,Kim, Byoung-Gie,Bae, Duk-Soo,Lee, Jeong-Won Potamitis Press 2013 Anticancer research Vol.33 No.4

<P>Galectin-7 (GAL-7) has been highlighted as an important marker in many types of cancers by either inhibiting or promoting tumor growth. In this novel study, we assessed the association of GAL-7 with clinicopathological variables and survival outcomes in epithelial ovarian cancer (EOC) and investigated the role of GAL-7 in proliferation of ovarian cancer cell lines.</P>

Safe criteria for less radical trachelectomy in patients with early-stage cervical cancer: a multicenter clinicopathologic study.

Kim, Hee Seung,Choi, Chel Hun,Lim, Myong-Chul,Chang, Suk-Joon,Kim, Yong Beom,Kim, Min A,Kim, Tae-Jin,Park, Sang-Yoon,Kim, Byoung-Gie,Song, Yong Sang,Bae, Duk-Soo,Kim, Jae Weon Raven Press 2012 Annals of Surgical Oncology Vol.19 No.6

<P>To determine the safe criteria for less radical trachelectomy to treat patients with early-stage cervical cancer.</P>