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한국 정상인에서 연령에 따른 뇌혈류분포와 혈류예비능의 변화 : Tc-99m HMPAO SPECT 에 의한 연구
문대혁,이희경,송호천,이재태,범희승,손혜경,정환정,민정준,김지열 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.3
Purpose: The aim of this study was to evaluate the normal values of regional cerebral blood flow (rCBF) and cerebrovascular reserve (CVR) in normal children to aged volunteers using Tc-99m HMPAO. Materials and Methods: Thirty four right-handed normal volunteers (20 males, 14 females, mean age 40.3±24.9 years, range 4 to 82 years) were underwent rest/acetazolamide (ACZ) brain SPECT using Tc-99m HMPAO and the sequential injection and subtraction method. rCBF was estimated on the basis of a semiquantitative approach by means of right/left ratio, region/cerebellum and region to whole brain ratios in frontal, parietal, temporal, and occipital lobes, basal ganglia, thalami, and cerebellum. CVR was measured by means of % perfusion increase calculated as % mean count change compared to rest rCBF in each regions. Results: Mean values of right to left ratios range from 1.004 to 1.018. rCBF was highest in cerebellum and lowest in basal ganglia and thalami. Frontal and temporal rCBF decreased while occipital and thalami rCBF increased according to age. No sexual difference of rCBF was noted. Mean CVR was 29.9±12.9%. Mean CVR significantly increased to late teens, and declined thereafter. After 6th decade, CVR in both frontal lobes, left parietal lobe and right basal ganglia decreased significantly with advancing age. There was no sexual difference of CVR. Conclusion: Quantitative assessment of CVR was possible by ACZ Tc-99m HMPAO brain SPECT. It revealed that rCBF and CVR changed according to age in normal Korean volunteers. There was no sexual difference.
정응기,이기환,원용재,박향미,전남수,최준호,구연충,한창덕,은무영,김태산,남민희 Plant molecular biology and biotechnology research 2005 Plant molecular biology and biotechnology research Vol.2005 No.
This study was conducted to investigated the major characteristics of genetically modified rice of "Milyang 204" originated from Dongjinbyeo compared to a non-transgenic rice varieties Dongjinbyeo and Junambyeo. Basta resistant transgenic rice lines carrying bar gene produced by the Yeongnam Agricultural Research Institute were evaluated for their agronomic characters. The transgenic Japonica rice of "Milyang 204" showed inferior phenotypic traits compared to a non-transgenic rice variety Dongjinbyeo and Junambyeo. On the basis of UPOV (Union Internationale Pour la Protaection des Obtentions Vegetables) and NSMO(National Seed Management Office) the transgenic "Milyang 204" showed difference in some traits out of some agronomic traits, such as leaf color, angle of flag leaf, number of spikelets, culm length, white core and white belly compared to the nontransgenic varieties rice.
정응기,이기환,원용재,박향미,전남수,최준호,구연충,한창덕,은무영,김태산,남민희,Jeong Eung-Gi,Yi Gi-Hwan,Won Yong-Jea,Park Hyang-Mi,Cheon Nam-Soo,Choi Jun-Ho,Ku Yeon-Chung,Han Chang-Deok,Eun Mu-Yeong,Kim Tae-Sas,Nam Min-Hee 한국식물생명공학회 2005 식물생명공학회지 Vol.32 No.2
밀양 204호는 작물과학원 영남농업연구소 생명공학연구팀이 직파적응 제초제저항성 벼 품종을 육성할 목적으로 '98년 bar 유전자를 동진벼에 아그로박테리움법으로 형질 전환하여 제초제저항성 벼를 양성하였다. '98/'99년 동계에 단간 내도복 양질인 주남벼를 인공교배하여 약배양 등 육종프로그램에 적용하여 우량계통을 선발하고 밀양 204호로 계통명을 부여하였다. GM 벼와 Non-GM 벼의 농업적 특성을 UPOV 및 국립종자관리소의 품종등록 기준에 따른 농업적특성 중 차이가 있었던 것은 엽색도, 지엽의 형태, 간장, 수당립수 등 이었다. This study was conducted to investigated the major characteristics of genetically modified rice of 'Milyang 204' originated from Dongjinbyeo compared to a non-transgenic rice varieties Dongjinbyeo and Jun-ambyeo. Basta resistant transgenic rice lines carrying bar gene produced by the Yeongnam Agricultural Research Institute were evaluated for their agronomic characters. The transgenic Japonica rice of 'Milyang 204' showed inferior phenotypic traits compared to a non-transgenic rice variety Dongjinbyeo and Junambyeo. On the basis of UPOV (Union Internationale Pour la Protaection des Obtentions Vegetables) and NSMO(National Seed Management Office) the transgenic 'Milyang 204' showed difference in some traits out of some agronomic traits, such as leaf color, angle of flag leaf, number of spikelets, culm length, white core and white belly compared to the non-transgenic varieties rice.
Jun, Je-Cheon,Kim, Jin Hee,Park, Young Jae,Kang, Hee Woong,Chung, Jae Seung,Chung, Ee-Yung The Malacological Society of Korea 2012 The Korean Journal of Malacology Vol.28 No.2
The morphology and taxonomic values of the sperm in male Chlamys (Swiftopecten) swiftii were investigated by transmission electron microscope observations. The morphologies and ultrastructures of the sperm nucleus and the acrosome of this species are the vase type and long cone shape, respectively. Spermatozoa are approximately $45-50{\mu}m$ long including a sperm nucleus (approximately $2.60{\mu}m$ long), an acrosome (about $0.63{\mu}m$ long), and a tail flagellum (approximately $44-47{\mu}m$ in long). The axoneme of the sperm tail shows a 9+2 structure. In this study, the right and left basal rings in the acrosomal vesicle of this species show electron opaque part (region), and also the anterior apex part of the acrosomal vesicle shows electron opaque part (region). These characteristics of the acrosomal vesicle were found in Pectinidae and other several families in subclass Pteriomorphia. The number of mitochondria in the midpiece of the sperm of this species are four, as one of common characteristics appear in most species in Pectinidae in subclass Pteriomorphia. In addition, the satellite fibres are found near the distal centriole of this species, as have been reported in other species of Pectinidae in subclass Pteriomorphia. Accordingly, structutral characteristics which are found in the acrosomal vesicle, four mitochondria in the sperm midpiece and the appearance of the satellite fibers near the distal centriole of C. (S.) swiftii in Pectinidae (subclass Pteriomorphia), can be employed for phylogenetic and taxonomic analyses as taxonomic key or a significant tool.
( Jun Kong Cheon ),( Cheon Hee Park ),( Kan Taeck Hwang ),( Bo Yoon Choi ) 대한마취과학회 2011 Korean Journal of Anesthesiology Vol.60 No.4
Background: We wanted to determine the postoperative analgesic effi cacy of preincisional caudal epidural block versus instillation (splash block) following inguinal herniorrhaphy in children. Methods: Thirty children (age range: 1-7 years) who were scheduled to undergo inguinal herniorrhaphy were divided into 2 groups: the caudal block group and the splash block group with 15 children in each group. Tracheal intubation was performed. Fifteen children received caudal block with 1.0 ml/kg of 0.25% ropivacaine (Group 1). Caudal block was performed using the loss of resistance method via the sacral hiatus. Fifteen children in Group 2 received local instillation (splash block) in the surgical site with up to 0.4 ml/kg of 0.25% ropivacaine. The patients were observed for 90 minutes in the postanesthesia care unit and then they were transferred to the ward. The pain scores were taken 4 times. We assessed pain using the Faces pain scores. Results: There were no significant differences between the groups regarding the pain scores at 10, 30 and 60 minutes upon entering the postanesthesia care unit. The pain scores of Group 1 were slightly lower at the last evaluation point when compared to that of Group 2. One patient in Group 1 required supplemental postoperative intravenous (IV) tramadol, while all the other patients in both groups did not require supplemental IV tramadol. The intraoperative requirement for sevoflurane was decreased in Group 1 as compared to that of Group 2. There were no major complications related to either type of block. Conclusions: We conclude that a splash block can have a similar analgesic effect as that of a caudal block for the postoperative herniorrhaphy pain of children. (Korean J Anesthesiol 2011; 60: 255-259)
Mutations in gyrA and gyrB among Drug Resistant Mycobacterium Tuberculosis in Korea
( Hee Joo Lee ),( Hwi-Jun Kim ),( Ryeun Heo ),( Cheon-Tae Kim ),( Hee-Jin Kim ),( Jeong-hui Gwon ),( Gicheon Bae ),( Sumi Kang ),( Soul-hee Kim ),( Seungmo Kim ),( Eunseon Kim ),( Arim Song ),( Dea-Se 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Purpose In 2020 KATRD, we analyzed 65 isolates to see how gyrA and gyrB are associated with 7H9 broth microdilution method (BMD) and Lowenstein-Jensen (L-J) drug susceptibility test (DST) because fluoroquinolones (FLQ) have been recognized as important anti-TB agents. In this study, the aim is to evaluate the correlation between gyrA and gyrB mutations and resistance to FLQ with BMD and L-J DST as a follow up of the previous study. Method Since 2020, we have analyzed 304 INH or RIF mono resistant cases by molecular DST using sequencing for gyrA and gyrB genes of FLQ. MICs were measured by BMD for moxifloxacin (MFX, 0.0625~8.0 μg/mL) and levofloxacin (LFX, 0.0625~8.0 μg/ mL). In L-J DST, concentration of MFX was 1.0 μg/mL, 2.0 μg/mL and LFX was 2.0 μg/mL. Results In gyrA and gyrB sequencing, 270 strains (88.81%) were wild type (WT), 34 strains (11.18%) were mutant type (MT). Among 29 gyrA MT strains, 13 isolates (44.82%) had mutation at D94G, 7 isolates (24.14%) at A90V and 5 isolates (17.24%) at D94A. Among 5 gyrB MT strains, 2 isolates (40%) had D500N mutation. In L-J DST, 100% of gyrA MT strains were resistant to MFX. On the other hand gyrB MT strains, 60% to MFX and 40% to LFX were resistant. In BMD, 93.10% of gyrA MT strains ranged 0.5 ~ 4.0 μg/mL and 60% of gyrB MT strains ranged 0.5 ~ 4.0 μg/mL to MFX. Meanwhile 96.55% of gyrA MT strains ranged 1.0 ~ 8.0 μg/mL and 80% of gyrB MT strains ranged 1.0 ~ 8.0 μg/mL to LFX. Conclusions Most of the mutant isolates had mutations in gyrA and most of mutant type (38.23%) was gyrA_D94G (GAC/GGC). In this study we observed gyrA genes were associated with higher MICs based on 7H9 and L-J DST than gyrB genes. # No.2021R1F1A1061358
Jun Hyeon Cho,Jong Hee Lee,Ji Yun Lee,Young Bo Son,Soo Kwon Park,Sang Yeol Kim,Choon Woo Lee,Un Sang Yeo,Dong Soo Park,You Cheon Song,Min Hee Nam 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Geneally, rice seeds regardless indica or japonica are showing low germination ratio or completely lost germination ability together with lost of good eating quality under high temperature and humidity conditions. Thus, this study was designed to evaluate a longevity for conservation of good eating quality during long term storage in rice. For the longevity evaluation, germination ability was studied after 5 days of high temperature and humidity stress (50℃/RH 95%). Dharial, originated from Bangladesh and showing weedy type with red pericarp, was selected as a good donor for longevity genes. A mutant was developed from Dharial through EMS mutagenesis and two populations of Dharial/4*Ilmibyeo and Dharial/4*Gopumbyeo were also developed for genetic study. In the 2-DE analysis followed by MALDI-TOF MS with wild and mutant lines, several candidate genes were identified. In the longevity test of two populations, a few lines showing good germination ability after high temperature and humidity stress were selected and subjected to confirm the relationships between longevity and conservation of good eating quality under long term storage.
( Seong Hee Kang ),( Minjong Lee ),( Moon Young Kim ),( Seul Ki Han ),( Jun Hyeok Lee ),( Baek Gyu Jun ),( Tae Suk Kim ),( Dae Hee Choi ),( Ki Tae Suk ),( Young Don Kim ),( Gab Jin Cheon ),( Dong Joon 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: This study investigated the effect of non-selective ß-blockers (NSBB) in real-life situations and whether low-dose NSBB is beneficial compared to maximally tolerated doses. Methods: Study participant of 890 were divided into two groups: primary prophylaxis (PP) and secondary prophylaxis (SP); 595 in the PP group (NSBB = 370, non-NSBB = 225) and 291 in the SP group (NSBB = 217, non-NSBB = 74). The NSBB group was sub-divided into 2 groups: low-dose (≤ 80 mg) and high-dose (>80 mg). Hepatic venous pressure gradient (HVPG) measurement was performed before NSBB treatment in the majority of patients (n=803). Results: In the PP group, 272 patients received NSBB only, while 98 patients received NSBB plus endoscopic band ligation (EBL) (low-dose NSBB, n=170; high-dose NSBB, n=200). The NSBB group showed similar survival rates to the non-NSBB group. However, NSBB was partially effective for patients who had clinically significant portal hypertension (CSPH, HVPG ≥10 mmHg: hazard ratio [HR], 0.63; P=0.02) or CTP class B/C (HR, 0.59; P=0.01). The low-dose NSBB had significant reductions in the risk of mortality compared with the non-NSBB (HVPG ≥10 mmHg: HR, 0.55; P=0.02 and CTP class B/C: HR, 0.52; P=0.01), but effect size was weaker in the high-dose NSBB. In the SP group, 217 received NSBB plus EBL (low-dose NSBB, n=87; high-dose NSBB, n=130). NSBB prolonged survival regardless of the severity of portal hypertension (adjusted HR, 0.56; P<0.001). The low-dose NSBB had a greater benefit with a 58% risk reduction in mortality compared to a 39% risk reduction in mortality in the high-dose NSBB. Conclusions: NSBB therapy was partially associated with longer survival in patients of the PP group with CSPH. In the SP group, NSBB therapy improved survival, and relatively low-dose NSBB had a greater benefit than standard-titrated high-dose NSBB.