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서울 소재 7개 종합병원 암환자들의 보완대체요법 이용양상
이은일,신유철,이주현,김순덕,김해준,조무성 대한보건협회 2002 대한보건연구 Vol.28 No.3
Objective of this study was to determine the prevalence and kinds of complementary and alternative medicine (CAM) used in cancer patients. Questionnaire survey was done by trained interviewers for use of CAM, demographic information, type of cancer and cancer stage for 512 cancer patients in 7 general hospitals in Seoul. Among the cancer patients, the total number of inpatients was 315 and outpatients 197. The results were as follows. Among cancer patients, 55.5% of them used CAM. The patients who were 30's and 40's showed high rate of CAM use(59.2%, 64,7%). Stomach cancer patients showed highest rate of CAM use(75.6%) among cancer patients. Liver cancer and breast cancer patients also showed high rate of CAM use(71.1%, 60.3%). The patients received chemotherapy showed higher rate of CAM use(60.6%) than the patients not received chemotherapy(43.7%). By multiple logistic regression, stomach cancer, liver cancer, and chemotheray were statistically significant variables for use of CAM. Among cancer patients, the use of herbs was highest(86.0%), followed by diet(46.5%) and chinese medicine(14.1%). Elm tree was the most frequently used(49.6%), however, total usage of mushrooms such as Sang-Whang, Young-Gee, Agaricus, Wooon-Gee were 57%. The number of CAM items used by cancer patients were limited and it is necessary for scientific data to prove the their effect.
Joohyun Ryu,Se Ryeon Lee,Sung Goo Park,강성현,김형준,박병철 생화학분자생물학회 2010 Experimental and molecular medicine Vol.42 No.9
Successful hematopoietic stem cell transplantation (HSCT) involves the restoration of hematopoietic function after engraftment, arising from the differentiation and proliferation of hematopoietic stem cells. Several factors could influence the course of allogeneic-HSCT (allo-HSCT). Therefore, knowledge of serum proteome changes during the allo-HSCT period might increase the efficacy of diagnosis and disease prevention efforts. This study conducted proteomic analyses to find proteins that were significantly altered in response to allo-HSCT. Sera from five representative patients who underwent allo-HSCT were analyzed by 2-dimensional gel electrophoresis and liquid chromatography tandem mass spectrometry, and were measured on a weekly basis before and after allo-HSCT in additional 78 patients. Fourteen protein spots showing changes in expression were further examined, and most proteins were identified as acute phase proteins (APPs). Studies of 78 additional patients confirmed that C-reactive protein (CRP) and haptoglobin undergo expression changes during allo-HSCT and thus may have the potential to serve as representative markers of clinical events after allo-HSCT. Maximal CRP level affected the development of major transplant-related complications (MTCs) and other problems such as fever of unknown origin. Particularly, an increase in CRP level 21days after allo-HSCT was found to be an independent risk factor for MTC. Maximal haptoglobin and haptoglobin level 14 days after allo-HSCT were predictive of relapses in underlying hematologic disease. Our results indicated that CRP and haptoglobin were significantly expressed during allo-HSCT, and suggest that their level can be monitored after allo-HSCT to assess the risks of early transplant-related complications and relapse.
( Sung Hee Lim ),( Jong-mu Sun ),( Joohyun Hong ),( Dongryul Oh ),( Yong Chan Ahn ),( Man Ki Chung ),( Han-sin Jeong ),( Young-ik Son ),( Myung-ju Ahn ),( Chung-hwan Baek ),( Keunchil Park ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.0
Background/Aims: Clinical trials have not consistently supported the use of induction chemotherapy (IC) for locally advanced head and neck squamous cell cancer. Hypopharynx and base of tongue (BOT) cancer has shown relatively poor survival. We investigated the role of IC in improving outcome over current chemoradiotherapy (CRT) in patients with hypopharynx and BOT cancer. Methods: Treatment-naïve patients with stage III/IV (M0) hypopharynx or BOT cancer were randomly assigned to receive CRT alone (CRT arm: cisplatin 100 mg/m<sup>2</sup> on D1 3-weekly, two times plus radiotherapy 68.4 Gy/30 fractions on weekdays) versus two 21-day cycles of IC with TPF (docetaxel & cisplatin 75 mg/m<sup>2</sup> on D1, and fluorouracil 75 mg/m<sup>2</sup> on D1-4) followed by the same CRT regimen (IC arm). The primary endpoint was progression-free survival (PFS). Results: This study closed early after enrollment of 36 patients (19 in the CRT arm, 17 in the IC arm). After a median follow-up of 47.2 months, there was no significant difference in PFS: the median PFS was 26.8 months for the CRT arm and was not reached for the IC arm (p = 0.13). However, the survival curves were widely separated with a plateau after 3 years, suggesting a potential survival benefit from IC: 3-year PFS rates were 45% and 68%, and 3-year overall survival rates were 56% and 86%, in the CRT and IC arms, respectively. Conclusions: This study failed to demonstrate that induction TPF chemotherapy improves survival in patients with BOT and hypopharynx cancer. However, it suggested a favorable outcome with IC to this population.
Pharmacological Interventions on Surgical Intensive Care Units Initiated by Pharmacists
Joohyun Lee,Eun-young Lee,여윤정,Yang-soon Oh,Sung-Soo Hong,이재명 대한외상중환자외과학회 2021 Journal of Acute Care Surgery Vol.11 No.1
Purpose: The severity of a patient’s medical condition, changing pharmacodynamics andpharmacokinetics, and variability in medication highlight the importance of pharmacologicalintervention by intensive care unit (ICU) specialized pharmacists. Methods: Retrospective observations of ICU interventions (omission, changes in medicine, sideeffects, changes in administration route and dosage, redundancy, and nutritional care) performedbetween April 2017 and March 2018, determined by an interdisciplinary team (including aspecialized ICU pharmacist and a surgical intensivist) on their surgical ICU round, were analyzed. Medicinal prescriptions were screened weekly during the surgical ICU round, and interventions weremade if any corrections were necessary. Two days later another team including a surgical intensivist,a pharmacist, and a nutritionist evaluated the patients’ nutritional status (performed weekly). Results: In the 23-bed ICU, the average number of patients whose prescriptions were examinedwas 22.38 per surgical round. There were 382 interventions made over 1 year, which was 9.68interventions per day. The interventions were for nutritional care (161 cases, 42.2%), followedby changes in administration route and dosage (94 cases, 24.6%), omission (59 cases, 15.5%),redundancy (40 cases, 10.4%), changes in medicine (15 cases, 3.9%), and side effects (13 cases, 3.4%). Conclusion: The conditions of patients admitted to ICU are typically unstable. Pharmacologicalinterventions suggested by a specialized pharmacist may help control the changing medicalcondition of patients in ICU. A higher participation of pharmacists specialized in working in aninterdisciplinary ICU team-based system could lead to safer treatments.