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Hollow Microtube Resonators via Silicon Self-Assembly toward Subattogram Mass Sensing Applications
Kim, Joohyun,Song, Jungki,Kim, Kwangseok,Kim, Seokbeom,Song, Jihwan,Kim, Namsu,Khan, M. Faheem,Zhang, Linan,Sader, John E.,Park, Keunhan,Kim, Dongchoul,Thundat, Thomas,Lee, Jungchul American Chemical Society 2016 Nano letters Vol.16 No.3
<P>Fluidic resonators with integrated microchannels (hollow resonators) are attractive for mass, density, and volume measurements of single micro/nanoparticles and cells, yet their widespread use is limited by the complexity of their fabrication. Here we report a simple and cost-effective approach for fabricating hollow microtube resonators. A prestructured silicon wafer is annealed at high temperature under a controlled atmosphere to form self-assembled buried cavities. The interiors of these cavities are oxidized to produce thin oxide tubes, following which the surrounding silicon material is selectively etched away to suspend the oxide tubes. This simple three-step process easily produces hollow microtube resonators. We report another innovation in the capping glass wafer where we integrate fluidic access channels and getter materials along with residual gas suction channels. Combined together, only five photolithographic steps and one bonding step are required to fabricate vacuum-packaged hollow microtube resonators that exhibit quality factors as high as similar to 13 000. We take one step further to explore additionally attractive features including the ability to tune the device responsivity, changing the resonator material, and scaling down the, resonator size. The resonator wall thickness of similar to 120 nm and the channel hydraulic diameter of similar to 60 nm are demonstrated solely by conventional microfabrication approaches. The unique characteristics of this new fabrication process facilitate the widespread use of hollow microtube resonators, their translation between diverse research fields, and the production of commercially viable devices.</P>
김영란법 제정을 통해 본 언론관계의 PR 윤리 및 준법성에 대한 PR 실무자 인식 연구 -실제적인 윤리적 갈등 상황과 향후 변화 전망을 중심으로
허주현 ( Joohyun Heo ),김수연 ( Soo Yeon Kim ) 한국PR학회 2015 PR연구 Vol.19 No.4
On March 2015, the Anti-corruption Kim Young-ran Law was passed, and the scope of the law``s subjects included journalists. This offered a critical opportunity to investigate ethical issues in media relations from the public relations industry``s perspectives. This study explored public relations practitioners`` perceptions of ethical conflict and predictions of change after the law is executed. In conducting in-depth interviews with 13 public relations practitioners, media reports for strings attached, costly fam tours for journalists, and various services for journalists were found to be significant ethical issues for media relations. Public relations practitioners believed that abstract ethical codes and ethical education are not helpful for resolving ethical issues. Some expected that the law would change public relations practitioners`` attitudes, publicize existing unethical practices, reorganize ethical guidelines, and promote practical changes in public relations ethics. However, others were concerned that new methods to avoid this law``s influence would arise and that the law would not be effective. Finally, this study discusses how the public relations industry can cope with the societal and legal changes and practice public relations ethics in the real world.
Backki Kim,Dong-Gwan Kim,Gileung Lee,Jeonghwan Seo,Ik-Young Choi,Beom-Soon Choi,Tae-Jin Yang,Kwang soo Kim,Joohyun Lee,Joong Hyoun Chin,Hee-Jong Koh 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
Tongil (IR667-98-1-2) rice, developed in 1972, is a high-yielding rice variety derived from a three-way cross between indica and japonica. Tongil contributed to staple food self-sufficiency of Korea, an achievement that was termed the ‘Korean Green Revolution’. In this study, we analyzed the nucleotide-level genome structure of Tongil rice and compared it to those of the parental varieties. A total of 17.3 billion Illumina Hiseq reads, 47× genome coverage, were generated from Tongil rice. Three parental accessions, two indica and one japonica types, of Tongil rice were also sequenced for approximately 30x genome coverage. A total of 2,149,991 SNPs were detected between Tongil and Nipponbare; the average SNP frequency of Tongil was 5.77 per kb. Genome composition based on the SNP data by comparing with the three parental genome sequences on sliding window of Nipponbare genome sequence revealed that 91.8% of the Tongil genome originated from the indica parents and 7.9% from the japonica parent, different from the theoretical expectation in a three-way cross, i.e., 75% indica and 25% japonica parental origins on average. Copy number of SSR motifs, ORF gene distribution throughout the whole genome, gene ontology (GO) annotation, yield-related QTLs or gene locations, and polymorphic transposon insertions were also comparatively analyzed between Tongil and parents using sequence-based tools. The results indicated that each genetic factor was transferred from parents into Tongil in proportion to the whole-genome composition. The Tongil rice is the first successful superior cultivar derived from indica × japonica hybridization in Korea. Defining of genome structure demonstrates that the Tongil genome is composed mostly of the indica genome with a small proportion of japonica genome introgression. This work was supported by a grant from the Next-Generation BioGreen 21 Program (Plant Molecular Breeding Center No. PJ008125), Rural Development Administration, Republic of Korea.
[PE-0079] Multi-trait GWAS of grain shape study with advanced breed lines of Korean rice
Muhyun Kim(Muhyun Kim),Tae-Ho Ham(Tae-Ho Ham),ByeongYong Jeong(ByeongYong Jeong),MiYoung Park(MiYoung Park),Yeong Shin(Yeong Shin),Yeonju Kim(Yeonju Kim),Min Young Song(Min Young Song),Joohyun Lee(Joo 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
김관일(Kwan -Il Kim),서경석(Kyung-Suk Suh),김주현(Joohyun Kim),신우영(Woo Young Shin),이남준(Nam-Joon Yi),장진영(Jin-Young Jang),김선회(Sun-Whe Kim),김세형(Se Hyung Kim),이건욱(Kuhn Uk Lee) 한국간담췌외과학회 2008 한국간담췌외과학회지 Vol.12 No.2
Purpose: The incidence and risk of malignancy are elevated in solid organ transplant recipients compared to persons in the general population. Epidemiological data reveal that the length of exposure to immunosuppressive therapy and the intensity of therapy are clearly related to the post-transplant risk of malignancy. The purpose of this study was to investigate the course of incidental intraductal papillary mucinous neoplasms (IPMN) of the pancreas after liver transplantation. Methods: We retrospectively reviewed the medical records of 17 patients with IPMNs of the pancreas who underwent liver transplantation between January 2000 and December 2006. The mean follow-up duration was 29.6 ± 22.8 months. Results: The mean patient age was 55.2 ± 7.2 years, and the male to female ratio was 14:3. All patients had branch duct type IPMNs. The lesions were located principally in the head (64.7%) and body (52.9%) of the pancreas. The mean tumor size was 13.0 ± 6.2 mm. There were no newly developed symptoms associated with these lesions, and none of the lesions enlarged during the follow-up period. No patients underwent surgical resection of their lesions. Conclusion: The course of each of the incidental small IPMNs of the pancreas was uneventful for more than 2 years after liver transplantation. Therefore, patients with incidental small IPMNs of the pancreas are not immediate candidates for surgical pancreas resection. However, a longterm follow-up study with a larger sample size will be required to establish treatment guidelines in immunosuppressed patients.
Jung Kyeongmin,Yoon Joohyun,Ahn Yeeun,Kim Soyeon,Shim Injeong,Ko Hyunwoong,Jung Sang-Hyuk,Kim Jaeyoung,Kim Hyejin,Lee Dong June,Cha Soojin,Lee Hyewon,Kim Beomsu,Cho Min Young,Cho Hyunbin,Kim Dan Say,K 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Irritability is a heritable core mental trait associated with several psychiatric illnesses. However, the genomic basis of irritability is unclear. Therefore, this study aimed to 1) identify the genetic variants associated with irritability and investigate the associated biological pathways, genes, and tissues as well as single-nucleotide polymorphism (SNP)-based heritability; 2) explore the relationships between irritability and various traits, including psychiatric disorders; and 3) identify additional and shared genetic variants for irritability and psychiatric disorders. We conducted a genome-wide association study (GWAS) using 379,506 European samples (105,975 cases and 273,531 controls) from the UK Biobank. We utilized various post-GWAS analyses, including linkage disequilibrium score regression, the bivariate causal mixture model (MiXeR), and conditional and conjunctional false discovery rate approaches. This GWAS identified 15 independent loci associated with irritability; the total SNP heritability estimate was 4.19%. Genetic correlations with psychiatric disorders were most pronounced for major depressive disorder (MDD) and bipolar II disorder (BD II). MiXeR analysis revealed polygenic overlap with schizophrenia (SCZ), bipolar I disorder (BD I), and MDD. Conditional false discovery rate analyses identified additional loci associated with SCZ (number [n] of additional SNPs = 105), BD I (n = 54), MDD (n = 107), and irritability (n = 157). Conjunctional false discovery rate analyses identified 85, 41, and 198 shared loci between irritability and SCZ, BD I, and MDD, respectively. Multiple genetic loci were associated with irritability and three main psychiatric disorders. Given that irritability is a cross-disorder trait, these findings may help to elucidate the genomics of psychiatric disorders.
Joohyun Kim,Chang-Ju Kim,Il-Gyu Ko,Sun Hyung Joo,Hyung Joon Ahn 대한외과학회 2012 Annals of Surgical Treatment and Research(ASRT) Vol.82 No.4
Purpose: Small-for-size syndrome (SFSS) is a major problem in liver surgery, and splenectomy has been used to prevent SFSS. However, it is unknown whether splenectomy has the same effect on liver regeneration in both standard and marginal hepatectomy. The aim of this study is to see a difference in effect of splenectomy on liver regeneration according to the amount of liver resection. Methods: Thirty male Sprague-Dawley rats (220 to 260 g) were divided into the following five groups: control (n = 6), 70% hepatectomy (n = 6), 70% hepatectomy with splenectomy (n = 6), 90% hepatectomy (n = 6), and 90% hepatectomy with splenectomy (n = 6). The animals were euthanized 24 hours after surgery and liver specimens were obtained. To assess liver regeneration, we performed immunohistochemistry of liver tissue using 5-bromo-2-deoxyuridine (BrdU) labeling and Western blot analysis of hepatic growth factor (HGF) and transforming growth factor-β (TGF-β) in the liver tissue. Results: The splenectomized subgroup had a higher BrdU-positive cell count in the 90% hepatectomy group, but not in the 70% hepatectomy group (P < 0.001). Splenectomy significantly decreased TGF-β expression (P = 0.005) and increased the HGF to TGF-β ratio (P = 0.002) in the 90% hepatectomy group, but not in the 70% hepatectomy group. Conclusion: The positive effect of splenectomy on liver regeneration was greater in the group with the larger liver resection. This phenomenon may be related to the relative balance between HGF and TGF-β in the liver.