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      • 니페디핀이 암피실린의 흡수에 미치는 영향

        정현정,용철순,최윤수,오두만 영남대학교 약품개발연구소 1997 영남대학교 약품개발연구소 연구업적집 Vol.7 No.-

        Amino-β-lactam antibiotics are absorbed by the dipeptide transporter in the small intestine. These uptakes are coupled to a proton influx. The inward proton gradient is partly induced by the Na^(+)/H^(+) exchanger and cakium ion is involved in control of this antiport. Interaction between ampicillin which is one of the amino-β-lactam antibiotics and nifedipine which is one of calcium channel blocking agents was studied in rats in vivo and with rabbit jejunum mounted on the Sweetana/Grass diffusion cells in vitro. Bioavailability of ampicillin was increased significantly when nifedipine was co-administered orally in rats. There were no differences in the distribution phase and the elimination phase when ampicillin was given either alone or with nifedipine intravenously. Conditions for in vitro experiments were determined. The lift rate of O₂/CO₂ gas was controlled to 3 bubbles/sec and ampicillin was stable in the Kreb's buffer at pH6.0 Absorption of ampicillin was the greatest when the completely-stripped serosal membrane was used. Transport of ampicillin from mucosal to serosal side in the rabbit jejunum was enhanced by 32% in the presence of nifedipine (p=0.059). Above results suggest that nifedipine might increase the plasma level of ampicillin via the improved absorption in the intestine rather than the reduction in the elimination or/and alteration in the distribution.

      • 미생물 포괄 고정화방식을 이용한 수산물 가공공장 폐수처리

        정병철,장수현,김종배,김건배,최선남,이근우,정병곤 7개 국립대학교 환경연구논문집 공동발행 위원회 2005 공업기술연구 Vol.5 No.-

        Feasibility of simultaneous removal of organic and nitrogen is evaluated as applying microbial entrapping method to treat fish processing wastewater. Treatability test is conducted immobilizing activated sludge from municipal sewage treatment plant to gel matrix made of cellulose triacetate. Stable operation can be possible when applying organic and nitrogen loading rate increasingly to wastewater treatment system composed of anoxic and oxic tank. Organic loading rate and nitrogen loading rate are applied 0.65-1.72kg COD/㎥/d and 0.119-0.317kg T-N/㎥/d, respectively. In case of wastewater from fish processing plant used in this study, it is evaluated that 0.3kg T- N/㎥/d is upper limit of applicable space loading rate because effluent T-N concentration is exceed 60mg/L, legal effluent dishargeable limit of T-N concentration in Korea, when space loading rate is exceed 0.3kg T-N/㎥/d. It is evaluated that nitrification of system is performed efficiently regardless fo variation of applied loading rate because removal efficiency of NH_(4)^(+)-N is relatively constant when the applied NH_(4)^(+)-N loading rate is increased gradually, while decrease of T-N removal efficiency is apparent when the applied loading rate is increased gradually. Nitrate removal efficiency in this study is varied from 98.62% to 99.51% depending on applied loading rate, while nitrification efficiency of oxic reactor is varied from 94.0% to 96.9%. It is showed that COD removal efficiency is varied from 94.2% to 96.6% and T-N removal efficiency is varied from 73.4% to 83.4% depending on loading rate applied in this study.

      • 한국류 정석의 특성에 관한 연구

        정수현 명지대학교 예체능연구소 2000 藝體能論集 Vol.11 No.-

        "Korean-style Jeongsuk"ndicates the corner-fight patterns which appeared around the end of the twentieth century along with the Korean professional Baduk players’ outstanding achievements in the international Baduk contests. It is thought to be different from exisisting josekis(Japanese jeongsuks) In its feature as follows: 1) It is based on the real game paradigm, not theoretical paradigm. 2) It tends to transcend the idea of ‘form’ of stones, which has long been related to the thoughts that a nice shape can lead to a favorable result. 3) It sometimes avoids formality as a fighting pattern because of the flexible viewpoint of a jeongsuk. 4) Unlike the concept of a jeongsuk that means an equal division in part, it often has a relatinship with the opening as a whole. 5) It was made by re-examining the exisisting jeongsuks with a critical viewpoint, while the ordinary new patterns are derived from creative moves. 6) It pursues the most effective result in every move consisting of a jeongsuk. These characteristics reveal the strong point of Korean-style baduk, which seek for a new recognition from the practical point of view on the basis of a real game, and thus finds a new value of moves ignored in the past time due to theoretical prejudice.

      • 아마추어 기사의 직업관에 관한 문화기술적 연구

        정수현,김달수 명지대학교 예체능연구소 2003 藝體能論集 Vol.14 No.-

        The purpose of this study is to analyze amateur baduk players' viewpoint on their lives, especially in relation to their job, by means of participant-observation and in-depth interview. Amateur baduk players are engaged in a variety of baduk activities and have been causing some conflict with the group of professional players because of their ambiguous status. Understanding their way of living and thinking, therefore, will be able to help resolve some troubles aroused by the subtle relationship with an institutional baduk organization The result indicates that. 1) They devote themselves to the baduk-related jobs with a firm consciousness that baduk is of their calling, although they have no license as a professional expert on baduk. 2) They would not have a will to proceed to other realms because they recognize the lack of knowledge and experience about them, which was caused by their long-time absorbtion to baduk. 3) Their everyday life is characterized by low income, unrestricted freedom, and indulgence to drinking. Most of them tend to enjoy getting together for drinking after work and communicating with their colleagues. 4) They have an Utopian concept of baduk, being enthralled by the strong attraction of the game and making an extraordinary effort in the study of it. 5) They seem to keep a deep regret in their mind against their long-cherished dream of being a professional was frustrated. This is sometimes manifested in the movement of organizing an institution hostile to Hankook-Kiwon(Korean Baduk Association). Since this study relies mainly on the researchers' personal interpretations on several amateur players' discourse, it should be investigated in various ways, qualitative or quantitative.

      • 지식의 유형과 문제해결의 관계에 관한 분석

        정수현 명지대학교예술체육연구소 2006 예술체육논집 Vol.17 No.-

        Although the importance of fostering the ability of problem-solving has been emphasized in a variety of fields, it is hard to find an explicit direction to its method or the role of knowledge in solving problems. To find out the relationship between knowledge and problem-solving, this study focuses on analyzing the correlation between the two factors through the game of baduk regarded as a useful model of complex problem-solving. The research results are as follows: First, in the subjects' performance, there was a significant positive correlation among baduk strength, knowledge, and problem-solving. Second, in the relationship between the types of knowledge and problem-solving, conditional knowledge shows the highest relation, followed by procedural knowledge, while declarative is the lowest. Third, the types of knowledge reveals a meaningful correlation with the steps of exploring and implementing solutions in the sub-factors of problem-solving, but no significant relation with the steps of identifying and defining the problem. Among the three kinds of knowledge, conditional knowledge indicates a remarkably high relationship with exploration and implementation stages. Fourth, many low-level baduk players who are lacking in related knowledge had serious difficulty with problem-solving, even giving up their attempt, whereas professionals surprisingly made mistakes in solving not very difficult problems. These results imply that conditional knowledge plays an important role in ill-structured authentic problem-solving, and therefore students should be provided with the opportunities to learn conditional knowledge as well as declarative and procedural knowledge. Another implication is that it is necessary to induce problem-solvers to reflexively monitor their performance to lesson fallacy in the course of problem-solving.

      • 바둑기술의 문제해결적 접근

        정수현 명지대학교 예체능연구소 2002 藝體能論集 Vol.13 No.-

        Traditionally, the learning of baduk skills has been greatly depended upon the acquisition of the knowledge on fight patterns, problems of life and death, theoretical principles, and real game techniques. Baduk learners memorize these technical knowledge and accumulate them on their memory. In this case, however, baduk learners have great difficulty having access to baduk techniques because there are daunting amount of baduk knowledge to learn. In an attempt to avoid such difficulty, this study suggests that the problem-solving approach be needed for learning baduk, which is characterized by experiencing baduk skills on the basis of the principles required in each step of bad problem-solving. In this approach, one must start with the question of "at does the given situation require me to do?"and then decide his goal to carry out. The next step is the most important, for among many empty points, one should look for some possible means to accomplish his goal, which is followed by the stage of reasoning what is going on from them. Finally, one evaluates the good or bad of the results by comparing them with each other. Considering baduk moves from this viewpoint and teaching this method to learners are thought to lead them to a better understanding of baduk techniques and even the knowledge from the traditional teaming. For this reason, this approach needs to be studied actively and systematically in the future.

      • 후복막섬유증 5례의 임상적 고찰

        정충식,김수현,안병수,심대성,박도영,김철성,장대수 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.1

        Retroperitoneal fibrosis is a fibrotic process of the retroperitoneum that frequently produces ureteral obstruction. It can occur as an idiopathic disease or in association with various non-malignant and malignant condition. In the early phase of the retroperitoneal fibrosis ; symptoms originate from the disease process itself, while in the late state the clinical features represent the effect of obstructive uropathy and renal failure. Treatment consist of steroid therapy, urinary diversion and ureterolysis with jntraperitonealization or lateralization or wrapping with omentum. Herein we present 5 cases of retroperitoneal fibrosis.

      • 바둑의 이해와 대학 바둑판과 학생들의 의식 실태에 관한 연구

        정수현,박장근 명지대학교 예체능연구소 1998 藝體能論集 Vol.9 No.-

        The purpose of this study is to make a general survey of Baduk, which is believed to have been invented in ancient China about 2,000 B.C. and has long been one of the main hobbies for Koreans, arid to examine what the students of the Dep. of Baduk think about various problems related to their major. Since Baduk has been regarded as an amusement and studied mainly from the technical point of view, the Department, established for the first time in history at the end of 1996, has very little material for schooling. The result from the study is, accordingly, considered helpful to making people understand the wider aspects of Baduk and to deciding on a direction of the Department. A questionnaire is given to each of 33 students(freshmen and sophomores), which contains 29 questions about one's viewpoint of his major, the reason for choosing the Baduk Department, the degree of understanding Baduk, etc. The summary of the examination is as follows: 1. In spite of uncertainty to their future, almost all students take pride in majoring; in Baduk for they study a very specific and unique subject. 2. There is outstanding distinction between freshmen and sophomores in the respect of satisfaction for their major; freshmen have a consierably clear object in their major, while sophomores tend to have a vague idea what to do after finishing the whole course. This reveals that freshmen had more opportunities to contact information about the Dep. of Baduk than sophomeres. 3. Most students take interest in learning Baduk except some sophomores who are in the lower level in the skill of Baduk. It suggests that a new student should have a high-level strength in the art of Baduk for interesting and earnest learning, and that the school authorities should make an effort to inform the existence of the Department for the purpose of inducing excellent students to enter it.

      • KCI등재

        방사선사진에서의 골질과 임상적으로 평가한 골질 분류의 상관관계

        김현우,허경회,박관수,김정화,이원진,허민석,이삼선,최순철 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.37 No.1

        Purpose : To investigate the validity of digital image processing on panoramic radiographs in estimating bone quality before endosseous dental implant installation by correlating bone quality in radiographic images with clinical bone quality classification. Materials and Methods : An experienced surgeon assessed and classified bone quality for implant sites with tactile sensation at the time of implant placement. Including fractal dimension eighteen morphologic features of trabecular pattern were examined in each anatomical sites on panoramic radiographs. Finally bone quality of 67 implant sites were evaluated in 42 patients. Results : Pearson correlation analysis showed that three morphologic parameters had weak linear negative correlation with clinical bone quality classification showing correlation coefficients of -0.276, -0.280, and -0.289, respectively (p<0.05). And other three morphologic parameters had obvious linear negative correlation with clinical bone quality classification showing correlation coefficients of -0.346, -0.488, and -0.343 respectively (p<0.05). Fractal dimension also had a linear correlation with clinical bone quality classification with correlation coefficients -0.506 significantly (p<0.05). Conclusion : This study suggests that fractal and morphometric analysis using digital panoramic radiographs can be used to evaluate bone quality for implant recipient sites. (Korean J Oral Maxillofac Radiol 2006; 36 : 25-32)

      • KCI등재

        Bortezomib과 Dexamthasone으로 치료한 골수외 형질세포종 4예

        백종현,이은영,장리라,손창배,신은경,서정아,이지숙,이호섭,이상민,신성훈,김양수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

        Despite the use of aggressive local and systemic treatment including autologous stem cell transplantation in multiple myeloma, extramedullary recurrences are common and the prognosis of these patients is poor. Many novel drugs such as thalidomide, lenalidomide and bortezomib improve the response of treatment of multiple myeloma, but some reports failed to describe thalidomide has effect in extramedullary plasmacytoma. Recent data report on the successful treatment plasmacytomas with bortezomib in patients with advanced multiple myeloma. We treated 4 relapsed or refractory extramedullary plasmacytomas with bortezomib at our institution. We recognized all these extramedullary plasmacytomas decreased and showed more than partial response. This report lends support to the efficacy of bortezomib in the treatment of plasmacytoma and describes the safe use of bortezomib. Responses may, however, be of short duration. Therefore, despite our limited experience, we propose that bortezomib may be considered a therapeutic option for such patients who have risk of radiation therapy

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