이면성 및 도플러 심초음파도를 이용하여 진단한 선천성 거대 좌회선지-좌심실 관동맥루

진승원,박준철,이영중,유병현,박현옥,김용주,윤호중,김재형,홍순조,최규보,권종범,원용순,박건 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

一酸化炭素中毒의 統計的 觀察

朴衡淳 최신의학사 1961 最新醫學 Vol.4 No.12

스파르가눔(sparganum) 표피의 미세구조

박원창,강신영,이순형 중앙대학교 의과대학 의과학연구소 1981 中央醫大誌 Vol.6 No.1

An electron microscopic study was performed in order to know the basic tegumental structure of sparganum, which was obtained from the subcutaneous tissue of naturally infected snakes (Matrix tigrina lateralis). Two anterior and middle portions of worm tissuses were cut, and prepared for transmission electron microscopy by conventional methods. Then the sections were examined by means of A.E.I. Corinth 500 electron microscope. General structure of the tegument of sparganum resembled that of the body wall of other cestodes on electron micrograph. The teguments both of the anterior and middle portion revealed such components, i. e., an outer vesicular layer with numerous microtriches, and inner fibrous layer. Below the fibrous layer, there were layers of muscle bundles, and tegumental cells. The surface of sparganum was covered by intermingling microtriches of two distinctly different types. But the characteristic elongated 'pyramid-shaped' microtriches were observed mainly on the surface of anterior portion, whereas those of slender cylindrical 'filamentous form' were distributed mainly on the surface of middle portion of the worm. The tegumental cells, which were often filled with many secretary granules, as well as the flame cell-like structures having characteristic cilia were found in the subtegumental tissue. And possible function of this larval tegument were discussed.

저혈당을 동반한 자가면역 인슐린 증후군 2예

박시형,이신원,정귀화,최창훈,이순희,한정훈,김정국,하승우,김보완 대한내분비학회 2001 Endocrinology and metabolism Vol.16 No.4-5

천연 생약복합추출물이 Streptozotocin 유발 당뇨성 흰쥐의 장기무게 및 혈당내성에 미치는 효과

박형래,조정순 명지대학교 자연과학연구소 2006 자연과학논문집 Vol.25 No.-

상엽, 지황, 산약, 구기자 및 황기 등 5가지 천연복합추출의 일반성분 분석의 결과 100g 당 325 kcal이었으며, 수분함량 7.4%, 조지발 0.3g, 탄수화물 66.1g, 회분 11.7g이었다. 무기질 중 칼슘은 1503.96 mg, 칼륨은 2510.27 mg, 철분 9.68 mg, 소디움 1.20 mg이었다. streptozotocin(STZ)으로 당뇨를 유발시킨 흰쥐에 5가지 천연복합추출물(BG515)를 12주간 경구 투여한 후 다음과 같은 결과를 얻었다. 체중변화에서 실험군 모두에서 정상군에 비하여 유의적으로 낮은 체중증가를 나타냈었으며 BG515-4군에서 가장 낮은 체중증가 경향을 나타내었다. 평균 1일 식이섭취량 비교에서 STZ-control군을 포함한 실험군 모두에서 정상군에 비하여 현저한 증가를 나타내었으며 STZ-control군 및 천연복합물질 BG-515 투여군 사이에는 유의적인 차이는 없었다. 평균 1일 음수량 비교에서 당뇨가 유발된 STZ-control군을 포함한 실험군 모두에서 정상군에 비하여 6배 정도의 높은 음수량을 나타내었다. 신장과 간, 폐 및 심장조직의 중량은 STZ-control군을 포함한 실험군 모두에서 실험 전 기간에 걸쳐 정상군에 비해 상대적 중량이 유의적으로 높게 나타났으며 췌장의 중량도 정상군에 비해 실험군 모두에서 유의적인 증가를 나타내었으며, 비장의 중량은 정상군을 포함한 모든 실험군에서 비슷한 경향을 나타내었다. 천연복합물질의 섭취가 당뇨쥐의 내당능에 미치는 영향을 관찰한 경과 정상군의 경우 15분 후에 혈당이 최고치에 달하였고 90분 후에는 다시 공복 시 혈당수분으로 회복되었고 STZ-control군에서는 혈당이 60분 후에 최고치에 이르렀고 120분 후에도 공복 시 혈당치보다 현저히 높은 수준에 머물렀다. BG515-1군, BG515-2군 및 BG515-4군에서는 30분대에 가장 높은 수준에 달하였으며 120분 후에는 현저하게 감소되어 거의 공복전의 수준에 도달하였고 BG515-2군에서 가장 좋은 내당능 효과를 보였다. This study was designed to investigate natural medicinal plants-extracts (BG515), which are multi extracts of Mori Folium, Rehmannia glutinosa Liboschitz, Dioscorea japonica, Lycii fructus, and Astragalus Radix on blood glucose level and lipid metabolism in streptozotocin induced diabetic rats. The contents of carbohydrate in the natural medicinal plants extracts was 66.1g, crude protein was 14.5g, crude fat was 0.3g, ash was 11.7g, moisture was 7.4% per 100g edible portion. The contents of calcium in BG515 was 1503.96 mg, phosphorus was 468.31 mg, iron was 9.6 mg, sodium was 1.20 mg, and potassium was 2510.27 mg per 100g. 35 Male Sprague-Dawley (SD) rats weighing 150-170g each (6 weeks old) were randomly divided into one control (Group A) and 4 STZ-induced diabetic groups and subjected to one of the following treatment for 12 weeks. Group A and B were fed on basal diets and Group C, D and E received same diets as group A and B but additionally supplemented 150 mg/kg, 300 mg/kg, and 600 mg/kg of BG515 orally for 12 weeks, respectively. Diabetes of Group B, C, D and E were induced by intravenous injection of 45 mg/kg body weight of STZ in sodium citrate buffer (pH 4.5) via tail vein, respectively. Diabetic rats including BG515 administered groups showed the lower weight gain compared to the normal rats. but weight loss in STZ-control group is much stronger than BG515 groups. There were significant increases of feed-and drinking water consumption in all STZ-treated diabetic rats including BG515 administered groups compared to normal group. Especially, drinking water consumption in STZ-groups is increased with six fold in compare with control group. In BG515 -2 groups, showed the best of glucose challenge in normal and diabetic rats fed experimental diets.

페로브스카이트형 La_(1-x)Sr_xBO_(3±y) (B=Fe,Ni) 복합산화물의 생성 및 반응성

박일현,이형표,황호순,최원석 성균관대학교 기초과학연구소 1989 論文集 Vol.40 No.1

Nonstoichiometry, thermal stability and reactivity in static H2 atmosphere of perovskite-type La_(l-x)Sr_xBO_(3±y)(B=Fe, Ni) mixed oxides were investigated by means of temperature programmed reduction method and X-ray diffraction. Nonstoichiometry of these oxides was determined as following; LaFeO_3.05, La_0.9Sr_0.1FeO_3.0l, La_0.8Sr_0.22FeO_2.95, La_0.7Sr_0.3FeO_2.94, LaNiO_2.93, La_0.98Sr_0.02NiO_2.85, La_0.96Sr_0.04NiO_2.81. From the results of temperature programmed reduction, thermal stability of these perovskites relatively lowered than non-dopant according to the content (x values) of dopant(Sr^2+). According to the kinetic studies, it was revealed that the first and second step reductions in La_(1-x)Sr_xFeO_(3±y) (x=0.1, 0.2, 0.3) oxides and the first step reduction in LaFeO_3.05 oxide and La_(1-x)SrxNiO(3-y) (x=0, 0.02, 0.04) oxides were followed by Ginstling-Broushtein equation, indicating three dimensional diffusion of reactant. The third step reduction in La_(1-x)Sr_xFeO_(3±y) (x=0.1, 0.2, 0.3) oxides and the second step reduction in LaFeO_3.05 oxide were followed by contracting sphere model at reaction interface between reactant and product, and the second step reduction in La_(1-x)Sr_xNiO_(3-y) (x=0, 0.02, 0.04) oxides were fitted Avrami-Erofeev equation, indicating this step was controlled by formation and growth of reaction nuclei via the reaction interface.

E. coli 과량발현을 통한 B형 간염 바이러스 preS1 유도체의 안정한 동위원소 N의 치환

박병관,김세하,한규훈,김선영,홍요정,이시형,한동설,김순종,박진구 木浦大學校基礎科學硏究所 1997 基礎科學硏究誌 Vol.15 No.-

We have used molecular biology technique to label the side chains and backbone of HBV preS1(1-56) with stable isotope (??) during E. coli over-expression and purified the protein to near homogeneity. The expression level of ?? labelled preS1(1-56) seems to be ∼15% of the total protein. to characterize the secondary structure of the labelled protein, circular dichroism was used. In different buffer conditions including pH 3.3 and pH 7.4 the protein seems to be devoid of any stable secondary structure probably suggesting that the N-terminal portion (preS1(1-56)) of HBV preS1 might be unstructured before binding to its target cells.

웨이블렛 변환을 이용한 수기문서저장 시스템에 관한 연구

박종현,박순영,고형대 목포대학교 정보산업연구소 2000 情報産業硏究誌 Vol.8 No.-

본 논문에서는 입력된 데이터로부터 공간-주파수(spatial-frequency) 영역에서의 분석에 용이한 웨이블렛 변환(wavelet transform)을 적용하여 특징벡터를 추출하고 이를 데이터베이스화한 수기문서 저장 시스템에 관한 연구를 제안하였다. 일반적으로 흘림체로 쓰여진 수기문자를 높은 정확도로 인식할 수 있는 기술을 개발하고 이를 대형 병원의 처방전달 시스템에 적용하여, 처방전을 데이터베이스에 자동 입력하고 빠르게 검색할 수 있도록 하여 효율적인 의료처방전달 시스템을 개발하는데 있다. 제안된 의료처방전달 시스템은 수기문서인식 시스템과 데이터베이스시스템으로 구성된다. 수기문자인식은 입력 문자영상에 고효율의 영상 압축기술인 웨이블렛 변환을 적용하여 압축한 문자영상에서 17종의 인식인자(factor)들을 추출한 후 이들의 특성을 분석하여 문자를 인식하였다. 실험 결과 웨이블렛 변환에 의한 공간-주파수의 분석에 의해 효율적으로 입력 데이터에 대하여 특징벡터를 추출할 수가 있었으며 시스템의 효율성을 분석할 수가 있었다.

제주도 마래사상충 자충의 정기출현성 분석을 위한 수학적 검토

박영일,강신영,이순형,심태섭 중앙대학교 의과대학 의과학연구소 1981 中央醫大誌 Vol.6 No.2

The different periodicity of microfilariae of Brugia malayi in the blood has been observed by many investigators in the various areas. This study was undertaken to determine the periodicity of microfilaria in Cheju area, where malayan filariasis is endemic, and to compare author's results with that of calculating result from the data reported by Kim(1971). In this study, 9 microfilaria positive cases in Cheju area were analysed. For the mathematical analysis of periodicity pattern in the microfilaria positive cases in Cheju area, the model of Aikat & Das (1976) was applied to the observed data. The periodicity of the present data was distinctly nocturnal pattern in which the peak hour of microfilaria density was 01:37 a. m. and periodicity index was calculated to be 90.13% by using above mathematical model, while the inland area of Korea, the peak hour was at 00:34 a. m. and periodicity index was calculated to be 128.86%. On the base of the above mathematical analysis, it was clearly shown that there was almost no difference in peak hour and periodicity index between the two areas. Also it is certain that the periodicity pattern of Brugia malayi in Korea is tangibly nocturnal and is closely similar to that in the Penang strain of Malaya and Kerala strain of India.