사상공원 식생의 활력에 미치는 환경영향에 관한 연구

김형석,박승범,김석규 東亞大學校 建設技術硏究所 2001 硏究論文集 Vol.25 No.2

To object of this study was to analyze the effects of air pollution of industrial park to the environmental-ecology characterization in the Sa-Sang Park and the vicinity of South Gate in Mt. Geumjung. 6 transects(each size 400m2 were set up and surveyed each park. The relationships of the distribution of dominant groups for forest vegetation structure and the environmental condition between the Sa-Sang Park and the vicinity of South Gate San-Sung Amusement Park were analyzed by similarity index, frequencies of tree species, importance value, soil pH, SO2ㆍCOㆍNO2 and PM10 density of air and tree vitality. The results obtained were as follows, 1. For analysis of vegetation structure in the Sa-Sang Park, upperstory of forests was mostly consisted of Pinus thunbergii Parl and partly of Alnus japonica Steudel. In midstory, major components were Alnus japonica Steudel and partly of Pinus thunbergii Parl. In lower story Rhus sylvestris S. et Z, which was known to be resistant to air pollution, was found in large number. While the vicinity of South Gate in Mt. Geumjung has various species and stable forest vegetation, upperstory of forests was mostly consisted of Pinus rigida Mill and partly of Pinus densiflora S. et Z. Quercus serrata Thunb. Quercus mogolicα Fischer. Alnus hirsuta Rupr. In midstory, major components were Pinus rigida Mill and Alnus hirsuta Rupr. In lower story Rhododendron yedoense Maximowicz var. poukhanense(Le'v.) Nakai. and Rubus crataegifolius Bunge, Lespedeza bicolor Turcz. Similarity index in the Sa-Sang Park and the vicinity of South Gate in Mt. Geumjung was 42.31%. 2. Frequencies class of tree species were analyzed A(23.53%), B(17.65%),C(11.76%), D(5.88%), E(41.18%) in the Sa-Sang Park and A(29.41%), B(29.41%). C(23.53%), DC5.88%), E(11.77%) the vicinity of South Gate in Mt. Geumjung 3. Soil pH decreased to below pH 0.7 in the Sa~Sang Park as compared to pH 4.9in the vicinity of South Gate in Mt. Geumjung. In addition Water content decreased to below 7.7% in Sa~Sang Park as compared to 9.3% the vicilli앙 of South Gate in Mt. Geumjung. While SO2ㆍCO2 density of air and tree vitality were higher than those in the vicinity of South Gate in Mt. Geumjung. It is concluded that the Sa~Sang Park is only afraided to survive stronge tree species which resist to air pollution and decrease a function of city park in a few years that tree vitality of the Sa~Sang Park is higher than those in the vicinity of the South Gate in Mt. Geumjung. as a result environmental factorsCfor example SO2ㆍCOㆍNO2 and PM10 density of air, Water content, Soil pH and so on).

C-reactive protein accelerates DRP1-mediated mitochondrial fission by modulating ERK1/2-YAP signaling in cardiomyocytes

( Suyeon Jin ),( Chan Joo Lee ),( Gibbeum Lim ),( Sungha Park ),( Sang-hak Lee ),( Ji Hyung Chung ),( Jaewon Oh ),( Seok-min Kang ) 생화학분자생물학회 2023 BMB Reports Vol.56 No.12

C-reactive protein (CRP) is an inflammatory marker and risk factor for atherosclerosis and cardiovascular diseases. However, the mechanism through which CRP induces myocardial damage remains unclear. This study aimed to determine how CRP damages cardiomyocytes via the change of mitochondrial dynamics and whether survivin, an anti-apoptotic protein, exerts a cardioprotective effect in this process. We treated H9c2 cardiomyocytes with CRP and found increased intracellular ROS production and shortened mitochondrial length. CRP treatment phosphorylated ERK1/2 and promoted increased expression, phosphorylation, and translocation of DRP1, a mitochondrial fission-related protein, from the cytoplasm to the mitochondria. The expression of mitophagy proteins PINK1 and PARK2 was also increased by CRP. YAP, a transcriptional regulator of PINK1 and PARK2, was also increased by CRP. Knockdown of YAP prevented CRP-induced increases in DRP1, PINK1, and PARK2. Furthermore, CRP-induced changes in the expression of DRP1 and increases in YAP, PINK1, and PARK2 were inhibited by ERK1/2 inhibition, suggesting that ERK1/2 signaling is involved in CRP-induced mitochondrial fission. We treated H9c2 cardiomyocytes with a recombinant TAT-survivin protein before CRP treatment, which reduced CRP-induced ROS accumulation and reduced mitochondrial fission. CRP-induced activation of ERK1/2 and increases in the expression and activity of YAP and its downstream mitochondrial proteins were inhibited by TAT-survivin. This study shows that mitochondrial fission occurs during CRPinduced cardiomyocyte damage and that the ERK1/2-YAP axis is involved in this process, and identifies that survivin alters these mechanisms to prevent CRP-induced mitochondrial damage. [BMB Reports 2023; 56(12): 663-668]

복강내 Polyadenylic-Polyuridylic acid 투여에 의한 악성복수의 치료효과

박형석,진춘조 건국대학교 1994 學術誌 Vol.38 No.2

Intracavitary antitumor chemotherapeutic agents such as nitrogen mustard, 5-FU and bleomycin have been used for the treatment of malignant effusions to kill the tumor cells in the effusions. But because of many side effects such as anorexia, nausia, hepatic and renal dysfunction, other therapeutic agents have been tested. In this study, we have investigated the use of intraperitoneal infusion of polyadenylic-polyuridylic acid, a synthetic double stranded helical ribopolynucleotide complex, which stimulates both humoral and cell mediated immune response and enhances the NK cell activity in 17 patients of malignant ascites. Following results were obtained ; 1) The mean age of patients was 50.2 and male to female ratio was 1.4 : 1. Primary tumor site was stomach 15 cases, colon 1 case, primary unknown 1 case. The diagnostic methods of malignant ascites were peritoneoscopic biopsy 5 case, positive cancer cell in ascites 4 case, characteristics of ascites 8 cases, respectively. 2) Among the 17 cases who recieved infusion treatment, 14 cases were able to evaluate the response 8 cases (57.1%) were responded to treatment and 6 cases(42.9%) were not responded. The mean effect duration was 10.6 weeks. 3) There was no difference in clinical and laboratory finding between response group and non-response group. The response rate was higher in case of positive cancer cell in ascites and short interval from the diagnosis to development of ascites, although statistically non-significant. 4) There was no side effect except 1 case of febrile reaction. Laboratory finding of pre and post treatment was not changed. In conclusion, the peritoneal administration of polyadenylic-polyuridylic acid seems to be effective and safe method in the patients with malignant ascites.

SHS법에 의한 Fe함량에 따른 TiB₂특성 연구

박명균,이형복,박원석 明知大學校 産業技術硏究所 2000 産業技術硏究所論文集 Vol.19 No.-

Ti-2B-Fe system ceramics were synthesized from the mixture of metal titanium, boron and iron powder by SHS method. The powders and sintered body were not appeared the second phase. Grain growth of TiB₂increased with increasing the iron content but grain size were smaller than starting raw materials. The relative density of TiB₂-2wt% Fe composition sintered at 1900℃ for 60min by pressureless sintering were 85% and the sintered properties were the most excellent at 2wt% Fe content in TiB₂-Fe system.

Plasma arc light를 이용한 bracket 부착시의 전단결합강도와 파절양상의 유형

박영철,유형석,오영근,이승연 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.2

본 연구의 목적은 bracket 부착시 광조사시간을 획기적으로 감소시킬 수 있는 plasma arc licht의 임상적 유용성을 visible light 중합시의 전단결합강도와 접착파절양상과 비교해 봄으로써 평가해 보는데 있다. 사람의 상하악 소구치를 포매하여 만든 레진블럭시편에 광중합 접착제인 TransbondR를 사용하여 수종의 bracket을 각각의 조건에 따라 부착한 후 만능 물성시험기를 이용하여 전단결합강도를 측정하고, 접착파절양상을 stereoscope을 이용하여 관찰하여 다음과 같은 결과를 얻었다. 1.Plasma arc light를 이용한 수종의 bracket 접착시 metal bracket과 ceramic bracket의 전단결합강도는 임상적으로 사용하기에 충분한 값을 나타내었으며, resin bracket의 경우 다른 bracket에 비해 전단결합강도가 현저히 작은 값을 나타내었지만 임상적으로 사용이 가능한 값을 나타내었다. 2.Visible light를 이용한 metal bracket의 광중합시 광조사시 간에 따른 전단결합강도는 광조사 시 간에 따른 유의 한 차이를 보이지 않았으며, 임상적으로 사용하기에 충분한 강도를 나타내었다. 3.Plasma arc light를 이용한 수종의 bracket 접착시 접착제 잔류지수를 통해 접착파절양상을 관찰한 결과, metal bracket과 resin bracket의 경우 bracket기저면에 접착제가 반 이상 남아 있지 않은 경우가 많았으며, ceramic bracket의 경우 bracket기저면에 접착제가 반 이상 남아 있는 경우가 많았다. 4.Metal bracket의 부착시 plasma arc light를 2초간 광조사한 군과 visible light를 10초간 광조사한 군의 전단결합강도와 접착파절양상을 비교시 유의한 차이를 보이지 않았다. 6.Plasma arc light를 이용한 광중합시 광조사 거리에 따른 전단결합강도는 거리가 증가할수록 감소하였다. 이상의 실험 결과는 plasma arc light를 이용한 bracket의 접착시 전단결합강도 저하의 우려 없이 임상적으로 사용 가능함을 시사한다. The puruose of this study was to evaluate the clinical usefulness of plasma arc light which can reduce the curing time dramatically compared by shear bond strengths and failure patters of the brackens bonded with visible light in direct bracket bonding. Some kinds of brackets were bonded with the TransbondR to the human premolars which were embedded in the resin blocks according to the various conditions. After bonding, the shear bond strength was tested by Instron universal testing machine and in addition , the amount of residual adhesive remaining on the tooth after debonding was measured by the stereoscope and assessed with adhesive remnant index(ARI). The results were as follows : 1.When plasma arc light was used for bonding the brackets, the shear bond strength was clinically sufficient in both metal and ceramic brackets, but resin brackets showed significantly lower bond strength but which was clinically useful. 2.When metal brackets were bonded using visible light, there was no significant difference in shear bond strength due to the light-curing time and the bond strength was clinically sufficient. 3.When the adhesive failure patterns of brackets bonded with plasma arc light were observed by using the adhesive remnant index, the bond failure of the metal and resin bracket occurred more frequently at bracket-adhesive interface but the failure of the ceramic bracket occurred more frequently at enamel-adhesive interface. 4.There was no statistically significant difference of the shear bond strength and adhesive failure pattern between metal bracket bonded for 2 seconds by curing with plasma arc light and 10 seconds by curing with visible light. 6.When metal brackets were bonded using plasma arc light, the shear bond strength decreased as the distance from the light source increased. The above results suggest that plasma arc light can be clinically useful for bonding the brackets without fear of the decrease of the shear bond strength.

치과용 Titanium 합금의 부식거동

박익민,김형일,최석규 大韓齒科器材學會 1991 대한치과재료학회지 Vol.18 No.2

Ti and Ti alloys are used in the dental field because of its high strength-to-density ratio, good fracture properties, corrosion resistance, and excellent biocompatibility. Corrosion characteristics of the cast pure Ti, Ti-6Al-4V, Ti-5Al-2.5Sn, have been investigated in 1% NaCl solution (37℃) and 40% CaCl₂solution (room-temperature) by means of Potentiodynamic polarization method. Corrosion potentials and corrosion current density of Ti alloys were compared to the Co-Cr alloy. The results are as follows: 1. The corrosion resistance of Ti-5Al-2.5Sn alloy was higher than pure Ti, Ti-6Al-4V alloy, Co-Cr alloy in the 37℃, 1% NaCl solution. But in the 40% CaCl₂solution(room-temperature), the corrosion resistance decreases in the order of Ti-6Al-4V, pure Ti, Ti-5Al-2.5Sn alloy. 2. The corrosion product (Ti₂O₂Cl₄) was formed on the corroded surface of Ti alloys in the 1% NaCl and 40% CaCl₂solution.

생쥐 소장의 interstitial cells of Cajal에서 ATP-민감성 K^(+)통로를 통한 향도잡이 전류의 조절

박찬국,김만우,김형석,최석,전제열 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Objectives: This study was performed to investigate whether ATP-sensitive K^(+) channels exist in interstitial cells of Cajal (ICC) of mouse small intestine and the physiological role of ATP-sensitive K^(+) channels in gastrointestinal motility. Methods: ICC were isolated from mouse small intestine and cultured for 2 days. Electrical activities of ICC were recorded using the whole-cell patch-clamp technique at 30°C. Results: ICC displayed rhythmic slow waves and spontaneous inward currents (pacemaker currents). Pinacidil, an ATP-sensitive K^(+) channel opener, induced membrane hyperpolarization and decreased amplitude of slow waves in current clamping mode. Also, pinacidil inhibited amplitude and frequency of pacemaker currents and activated outward currents at a holding potential of -70 mV. Pinacidil effects on slow waves and pacemaker currents were blocked by glibenclamide, a specific blocker of ATP-sensitive K^(+) channel. Forskolin, an activator of adenylate cyclase, induced membrane hyperpolarization and inhibited pacemaker currents like as pinacidil and blocked by glibenclamide. Conclusions: These results suggest that ATP-sensitive K^(+) channels exist in ICC and may be play an important role in regulating gastrointestinal motility through the modulation of pacemaker activities of ICC.

페로브스카이트형 La_(1-x)Sr_xBO_(3±y) (B=Fe,Ni) 복합산화물의 생성 및 반응성

박일현,이형표,황호순,최원석 성균관대학교 기초과학연구소 1989 論文集 Vol.40 No.1

Nonstoichiometry, thermal stability and reactivity in static H2 atmosphere of perovskite-type La_(l-x)Sr_xBO_(3±y)(B=Fe, Ni) mixed oxides were investigated by means of temperature programmed reduction method and X-ray diffraction. Nonstoichiometry of these oxides was determined as following; LaFeO_3.05, La_0.9Sr_0.1FeO_3.0l, La_0.8Sr_0.22FeO_2.95, La_0.7Sr_0.3FeO_2.94, LaNiO_2.93, La_0.98Sr_0.02NiO_2.85, La_0.96Sr_0.04NiO_2.81. From the results of temperature programmed reduction, thermal stability of these perovskites relatively lowered than non-dopant according to the content (x values) of dopant(Sr^2+). According to the kinetic studies, it was revealed that the first and second step reductions in La_(1-x)Sr_xFeO_(3±y) (x=0.1, 0.2, 0.3) oxides and the first step reduction in LaFeO_3.05 oxide and La_(1-x)SrxNiO(3-y) (x=0, 0.02, 0.04) oxides were followed by Ginstling-Broushtein equation, indicating three dimensional diffusion of reactant. The third step reduction in La_(1-x)Sr_xFeO_(3±y) (x=0.1, 0.2, 0.3) oxides and the second step reduction in LaFeO_3.05 oxide were followed by contracting sphere model at reaction interface between reactant and product, and the second step reduction in La_(1-x)Sr_xNiO_(3-y) (x=0, 0.02, 0.04) oxides were fitted Avrami-Erofeev equation, indicating this step was controlled by formation and growth of reaction nuclei via the reaction interface.

상부 소화관 내시경으로 진단된 각종 위질환 10,770예에 대한 임상적 고찰

박형석,진춘조 건국대학교 1992 學術誌 Vol.36 No.2

A clinical analysis was carried out on 10770 cases who were examined by panendoscope in the department of internal medicine, Minjoong Hospital, Konkuk University from Jan. 1982 to Dec. 1990. The results obtained are as fellows; 1) Of the 10,770 cases, 5,419 cases were male, and 5351 were female. Their mean age was 39.7 years. 2) The most frequent endoscopic finding was gastritis(60.1%), followed by peptic ulcer disease(16.6%), gastric cancer(2.6%), gastric polyp(0.7%), duodenitis(0.6%), esophageal varix(0.4%) in order. 3) The mean age of gastric ulcer(45.7) was statistically higher than that of duodenal ulcer(37.5) (p <0.05). The ratio of male to female was 2.9 : 1 in gastric ulcer and 3.2 : 1 in duodenal ulcer respectively. 4) The male to female ratio of gastric caner was 1.8 : 1 and the mean age was 55.1 years. The most frequent type of advanced gastric cancer was type III (50.6%) according to Borrmann's classification. 5) In patients with upper gastrointestinal bleeding, the most frequent endoscopic finding was duodenal ulcer (32.5%), followed by gastric ulcer (22.2%), hemorrhagic gastritis(14.5%), gastric cancer(12.8%), esophageal varix(10.3%), and Marrory-Weiss syndrome(3.4%) in order. In summary, gastrointestinal endoscopic examination was very useful method in the diagnosis of upper gastrointestinal tract disease.

Bisphosphonates의 이독성에 관한 연구

박일석,김형종,임현준 대한이비인후과학회 1998 대한이비인후과학회지 두경부외과학 Vol.41 No.3