FCT 5 : Fractional laser-assisted topical imiquimod 5% cream treatment for recalcitrant common warts in children

( Hyun Chang Ko ),( Jeong Min Kim ),( Hyun Ho Cho1 ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Conventional destructive modalities for warts like cryotherapy or laser ablation have some limitations that are excruciating pain during procedure, in especially pediatric patients. Imiquimod is a topical immune response modifier that was approved for treating genital and perianal warts. But, thick stratum corneum of common warts may act as a barrier against drug permeation via the skin. Objectives: To evaluate efficacy and safety of above treatment. Methods: Eleven pediatric patients (6 female and 5 male, mean age 12.5 years) were included in this study. The lesions were treated by fractional 2940 nm Er:YAG laser for achieving the penetration of stratum corneum with 1 or 2 weeks intervals. Then, imiquimod 5% cream was self-applied once daily for 5 days a week. Assessment of response and adverse effects was performed every 2 weeks until complete clearance or up to maximum of 48 weeks. Pain during procedure was checked by VAS (0-10). Results: 8 out of 11 (72.7%) patients experienced complete clearance of all warts lesions. Mean duration of total treatment was 29.7 (16-48) weeks. Mean number of fractional laser treatment was 17.5 (8-37) times. No significant adverse effect was observed. VAS score of the pain during fractional laser treatment was 2.4 (1-4), comparing with 6.2 (5-8) during cryotherapy. Conclusion: Fractional ErYAG laser-assisted topical 5% imiquimod cream is an effective and safe treatment option for recalcitrant common warts of the children do not tolerate pain well.

人蔘 Total Saponin, Protopanaxadiol 및 Protopanaxatriol의 消炎作用에 關한 硏究

조태순,이선미,정국현,이범구,이석용,박종대 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-In an attempt to elucidate the anti-inflammatory action of ginseng total saponin, protopanaxadiol and protopanaxatriol, the anti-inflammatory activity of three compounds was investigated under various acute and chronic inflammatory models. The blood vessel permeability was slightly inhibited by total saponin and protopanaxatriol treatments. Granuloma formation induced by 2% carrageenan was inhibited by total saponin and protopanaxatriol. The cotton-pellet granuloma formation was significantly inhibited by intraperitoneal injection of total saponin. Total saponin and protopanaxadiol inhibited leukocyte emigration and protein exudation in CMC-induced pouch but protopanaxatriol increased leukocyte emigration. The swelling of rat hind paw induced by 1% carrageenan was significantly inhibited by total saponin, protopanaxadiol and protopanaxatriol both single and 2 weeks treatments. Total saponin, protopanaxadiol and protopanaxatriol decreased the anti-inflammatory activity in adrenalectomized rat. Our results suggest that total saponin, protopanaxadiol and protopanaxatriol have potent anti-inflammatory activity, this may be mediated in part through stimulation of adrenal glands.

서울올림픽 이후의 體育施設 活用施設 活用方案 意識實態 調査硏究

趙庚旭,金昌範,金顯俊 忠北大學校 平生體育硏究所 1990 平生體育硏究所 論文集 Vol.4 No.-

The research material of this study is randomly chosen out of an area of large cities, small and medium cities, and towns. The object persons are totaled to 852; male 519 and female 333. 1. More than falf of the answers say that they are in good health condition. And they want take part in individual and easy sport games. And they cannot take part in sports or games because they have no spare time or facilities. So, to give many chances, we have to make some effective plan to prolong the spare time and we have to locate the sports facilities near the dwelling place. And we have to make a standard for the sports facilities according to the population and have to keep it. They usually use the public sports facilities. To popularized the socio-physical training, the public sports facilities take more important role than other elements. And to make the best use of the vacant space, the adminisrtative cooperation is needed. And we have to formulate thesystem which can prepare the nongovernmental organized sports facilities. 2. Most people want the entire opening of the Olypic facilities to the individual, and they show very positive attitude to the Olympic facilities and its environment. Also, they need a guide who can help their recreation. But almost answers(about 97%) do not know the way how to use the Olypic facilities. So anouncement using mass-media, guidebooks, and newsletters and many various and active information is required. We have very good sports facilities, but if we cannot run the facilities effectively, the rate of use is lowered. So we, who have few sports facilities, have to make a concrete plan to make the best use of the Olympic facilities. And now, we have to consider who, when, and how can use the Olympic facilities, according to the potentiality of each facilities, and make it can be used more easily than now to make the national spirit more sound and give more various chance of enjoying recreation. Also, we must consider the economical aspect in order to keep a ballance in management.

외상환자에서 전신성 염증 반응 증후군 (Systemic Inflammatory Response Syndrome)의 발생과 혈청 TNF-α와의 관계

김현,이강현,임종천,조준휘,오범진,황성오 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.4

Background and purpose: The systemic inflammatory response syndrome(SIRS), as defined recently by critical-care specialists, may result from various etiologies including infection, burn, or trauma. The purpose of this study was to determine whether TNF-αis associated with the development of systemic inflammatory response syndrome caused by multiple trauma. Methods: The study population consisted of 21 patients with multiple trauma presented emergency department within 2 hours after insult were enrolled in this study. Multiple blood samples were serially drawn to measure serum TNF-αlevel on admission, 12 hours, 24 hours, and every day until 5 days after injury. Serum TNF-αwas measured by ELISA ("Sandwich type"). Blood samples of fifteen volunteers were used as a reference value for serum TNF-α. Results: Serum TNF-αlevels of SIRS group were persistently elevated above reference value until 3 days after on admission. Peak serum TNF-αlevel at 12 hours after admission was higher in SIRS group than non-SIRS group(p<0.05). There was no significant correlation between injury severity score and TNF-αlevels on regression analysis, all patients with ISS higher than 16 had SIRS. No one had SIRS among patients with ISS less than 16. Conclusion: The result of this study suggests that persistent elevation of TNF-αand degree of injury severity are associated with the development of systemic inflammatory response syndrome in multiple trauma.

외상에 의한 영구치의 손상과 치아 고정술의 예후에 관한 연구

임현범,조용석,김경원 충북대학교 의과대학 충북대학교 의학연구소 1997 忠北醫大學術誌 Vol.7 No.1

경제 성장과 더불어 교통수단의 발달과 취미 활동에 대한 높은 관심과 함께 교통사고, 스포츠 등의 레저 활동, 폭력 등에 의하여 악안면부의 외상은 빈번하게 발생할 수 있다. 1996년 1월부터 1996년 12월까지 1년간 본과에 내원한 악안면부 외상 환자 중 상악골, 하악골, 관골 등의 악안면골 골절을 동반하지 않고 주로 치아 손상을 주소로 이에 대한 치아 고정술을 시행한 환자 43명에 대하여 의무 기록과 방사선 사진 등의 자료를 참고로 하여 영구치의 손상과 치아 고정술의 예후에 대하여 평가하여 다음과 같은 결론을 얻었기에 추후 영구치 손상 환자에 대한 치료술식과 예후 판정에 참고로 하고자 문헌 고찰과 함께 보고하는 바이다. 1. 치아 외상은 여자보다 남자에게서 더 많이 발생하였다. 2. 치아 외상을 받은 호발 연령은 10대와 20대였다 3. 치관 외상의 주된 원인은 낙상, 교통사고와 운동 순이었다. 4. 치아 외상시 가장 호발부위는 상악 전치부였다 5. 치아고정시 아치 바와 강선을 이용한 방법과 강선과 치과용 레진을 이용한 방법의 예후에는 큰 차이가 없었다. 6. 치아고정시 가장 큰 병발증은 치아 실활에 따른 신경치료, 치근 흡수, 발치였다. The injuries of the offal and maxillofacial region occrurred frequently because of the accidents, sports and violences. The authors experienced the injuries of the teeth that did not involve the bony fracture of the maxillofacial bones. We reviewed the 96 teeth of 43 patients that were fixed after replacement and/or replantation of luxated teeth during 1year(1996). We analysed and evaluated the treatment methods and the prognosis of the fixated teeth using the hospital records and radiographies. The results were as follows. 1. The occurrences of teeth injuries were more frequent in male than in female 2. The prevalent age groups were the second and third decades. 3. The major etiologies of teeth injuries were fall-down, traffic accidents and sports. 4. The prevalent teeth injured area were the upper anterior teeth area. 5. The prognosis of the teeth fixation methods between arch bar with wiring and wire with dental resin were not different significantly. 6. The major complications were the endodontic treatment due to discoloration and/or non-vitalization of teeth, root resorption and extraction of injured teeth.

Al-Cu-Mn 합금의 내열특성과 조직변화

章昌範,趙顯麒 경북대학교 산업기술연구소 1987 産業技術硏究誌 Vol.15 No.-

Experiments were carried out to improve the heat-resistance characteristic of Al-Cu-Mn alloy with ageing condition and casting condition. The results obtained were as follows : The alloys were rapidly solidified from the melt at cooling rates between 10^2 and 10^3K/sec using water cooling mold. Specimens which produced by rapid solidification method appeared better heat-resistance characteristic than commonly used mold casting method. By addition Mn element to Al-Cu binary alloys, age hardening was delayed and ageing hardenability was decreased because T phase exist as dispersed phase at solid solution treatment. T' phase revealed better heat-resistance at temperature than θ' phase by TEM observation.

악안면 골결손부의 이종골이식을 이용한 수복에 관한 연구

김경원,조용석,이경호,임현범 충북대학교 의과대학 충북대학교 의학연구소 1998 忠北醫大學術誌 Vol.8 No.2

연구목적 : 구강 및 악안면영역의 소수술시 발생할 수 있는 골결손부에 대하여 이종골을 이용한 골이식을 시행하고 치료결과 및 예후를 평가하고자 하였다. 재료 및 방법 : 1996년 1월부터 1996년 12월까지 내원한 환자중 골결손부에 대힌 골이식이 필요하였던 환자중 이식 후 추적 관찰이 가능하였던 36명에 대하여 의무 기록과 방사선 사진을 이용하여 분석하였다 결과 : 대상 환자중 10대와 20대(72.7%)가 가장 많았으며, 골이식이 필요하였던 질병으로는 낭종, 양성 종양, 매복치, 치근단 질환 등이었으며, 이식후 평균 7개월의 추적 관찰을 시행한 결과 36례중 6례(약17%)에서 술후 경미한 정도의 감염 소견이 있었으며 그 외는 특별한 합병증이 발견되지 않았다. 결론 : 구강 및 악안면영역의 비교적 작은 골결손부에 대하여 이종골이식을 선택적으로 시행할 수 있을 것으로 생각된다. Purpose : We evaluated the result and prognosis of the heterogenic bone graft for restoration of the bone defect in oral and maxillofacial region. Materials and Methods : We collected and analysed the patents who received the heteogenic bone graft from January 1996 to December 1996 in Chungbuk National University Hospital. Results : Prevalent age groups of heterogenic bone graft were 2nd and 3rd decades(72.2%), and cysts and benign tumors, impacted teeth, apical lesions were causative diseases of bone defects. The average period of follow-up was 7 months after operation. Major complications were postoperative infections(17%), but they were not severe. Conclusion : We recommend a heterogenic bone graft for restoration of the relatively small bone defect in oral and maxillofacial region selectively.

두가지 혈류 유발방법에 의한 새로운 심폐소생술(이중 혈류 유발 심폐소생술)장치의 개발

황성오,김현,조준휘,오범진,임종천,최경훈,윤정한,이승환,김영식,이강현,이윤선 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: There have been many efforts to augment blood flow during cardiopulmonary resuscitation. These efforts have focused on maximizing the effect of cardiac pump or thoracic pump alone. However, considering that the heart is the biggest blood reservoir and increase of intrathoracic pressure can generate blood flow, simultaneous exploitation of both mechanisms may have synergistic effect. We hypothesized that simultaneous chest constriction in addition to sternal compression by standard CPR may have additive hemodynamic effects by preventing deformation of the chest and increase of intrathoracic pressure. Methods and results: we built a new mechanical device to perform compression and thoracic constriction simultaneously. The device consists of two main elements. Piston in the center is to depress the sternum. Strap is to constrict the thorax circumferentially. Strap is attached to both sides of the piston. When the piston is pushed down, it depresses the sternum and pulls on the thoracic strap. To determine strap width to produce optimal hemodynamic effect, we measured hemodynamic parameters with variable widths of strap in two dogs after induction of ventricular fibrillation. Result of the experiment showed that 10cm wide strap was determined to be most effective. We also determined optimal depth of compression to produce maximal hemodynamic effect with animal experiments using two dogs. Animal experiments showed that the highest aortic pressure could be generated when the stemum was depressed to 5 cm. Cardiopulmonary resusciation using a new device could generate higher systolic aortic pressure, coronary perfusion pressure and end-tidal carbon dioxide tension in comparison with standard cardiopulmonary resuscitation in a pilot animal study using two dogs. Conclusion: New cardiopulmonary resuscitation method using a mechanical device designed by us could perform sternal compression and simultaneous thoracic constriction, and generate better hemodynamic effects than standard cardiopulmonary resuscitation in pilot animal experiments.

일차성 식도이완불능증의 풍선확장술후 치료효과의 객관적 평가지표

손영해,나호영,조성범,주영은,김현수,최성규,유종선,김세종 全南大醫大 2001 전남의대학술지 Vol.37 No.2

老齡者의 建康을 위한 生活習慣 實態調査

申東敏,長鳳愚,李揆文,金賢俊,金昌範,崔宗洙,崔鍾晥,李鍾珏,金圭碩,趙庚旭,金鍾聲,朴鍾振 平生體育硏究所 論文集 1987 平生體育硏究所 論文集 Vol.2 No.-

With a view to examining the habit and method in which old people maintain and improve their health, we consulted 551 men and 444 women who were over 65 years old, and concluded as follows: 1. Habit of eating It's been revealed that most of the old people keep a regular eating hour, control the quantity of meal or eat a little food, and prefer vegetables to meat. 2. Mental health Old people feel the necessity for mental health and most of them (about 80%) keep good mental health without becoming pessimistic. Their chief concenrs have turned out to be about their sons and daughters and their own health and finance. 3. Managing Good Health It has been revelaed that old people do not possess any special kind of secret to keep good health but taking plenty of rest, regular meal, and proper exercise, and many of them (about 60%) have been shown to eat invigorant food that they can easily get around their living area. 4. Physical Functions It has been revealed that many old people are conscious of some symptoms about their parts of body and about to percent of them suffers from neuralgia. Some measures like medical aid especially for old people need to be taken as soon as possible. As we have found that the health-keeping method of old people consists plenty of rest, proper exercise, and appropriate nutrition, we can conclude that the recreatonal and culture facilities and programs for keeping old people in good health should be developed. It is also necessary to study food that contribute to their health and develop ways to get rid of the stresses to which they are exposed in their daily life. Presides, it is natural that government found an administrative department to deal with these matters effectively.