치면열구전색제의 열구 침투에 primer의 효과

정혜선,최병재,최형준,이제호 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.2

본 연구의 목적은 치면열구전색제 수복시에 상아질 접착제의 primer 도포의 치면열구전색제 열구 침투도 향상 효과를 확인하는 것으로 발거된 영구 구치상에서 통상적으로 치면열구 전색제를 도포한 대조군과 Scotchbond™ Multi-Purpose system과 ?? 2 system의 primer 도포 후에 치면열구전색제를 도포한 실험군들의 열구 기저부까지 전색제 침투 성공률을 비교하여 다음과 같은 결론을 얻었다. 1. Scotchbond™ Multi-Purpose system과 All-Bond 2 system의 primer를 사용한 군의 열구 기저부까지 치면열구전색제 침투 성공률은 primer를 사용하지 않은 대조군보다 높았으나 통계학적으로 유의성 있는 차이는 없었다(p>0.05) 2. 열구 깊이와 폭 및 '깊이/폭' 값은 열구 기저부까지 전색제 침투성공율에 대하여 통계학적으로 유의성 있는 효과를 나타내었다.(p<0.05) 3. 열구 기저부까지 전색제 침투 성공률은 열구 깊이가 25㎛ 증가할 때마다 약 0.9배로 감소하였고, 열구 입구의 폭이 25㎛ 증가할 때마다 약 1.1배로 증가하였으며, 열구의 '깊이/폭' 비율이 1 증가할 때마다 약 0.6배로 감소하였다. The objective of this study is to confirm the effect of dentine bonding primer application on penetration of sealant. Extracted permanent molars were used to compare penetration success rate of control group (sealant application only) and experimental groups (sealant application after applying the primers of Scotchbond™ Multi-Purpose system and All-Bond 2 system). The following results were obtained: 1. The experimental groups using the primers showed increased sealant penetration success rate to the base of fissure when compared to control group but there was no statistically significant differences(p>0.05). 2. The depth, width and 'depth/width' value of fissure had statistically significant effect on sealant penetration success rate(p<0.05). 3. The penetration success rate decreased about 0.9 times as the depth of fissure increased every 25㎛, and increased about 1.1 times as the width of the fissure orifice increased every 25㎛, and decreased about 0.6 times as the 'depth/width' value increased every 1. From the above results, it can be concluded that fissure morphology had a great effect on sealant penetration and for better penetration, use of dentine bonding primer can be helpful but it needs more study in clinical bases.

변위된 미맹출 상악 견치의 교정 치험례 : CASE REPORT

임혜정,최남기,김선미,양규호 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.3

상악 견치는 가장 긴 치근을 가지며 저작기능과 함께 하악의 측방운동을 유도하고 심미적으로도 치열궁의 구각부위에 위치하여 교합관계의 조화와 대칭을 유지하는 등의 중요한 기능을 수행한다. 상악 견치는 발육기간이 가장 길며 형성되어 맹출하기까지 복잡한 경로를 갖기 때문에 다른 치아보다 매복의 빈도가 높다. 이러한 매복치를 치료하기 위해 임상의는 관찰을 하거나 외과적 노출과 교정적 견인, 자가치아이식, 발치 등 다양한 치료방법을 고려할 수 있다. 외과적 노출과 교정치료는 견치를 교합선상에 배치할 수 있기 때문에 가장 이상적인 접근으로 생각할 수 있다. 본 증례 보고는 구개측으로 매복된 상악 견치를 외과적 노출과 교정적 치아이동을 통해 기능적, 심미적으로 양호한 결과를 얻었다. The maxillary canine is especially important as it has the longest root, provides guidance for lateral movement of the mandible and masticatory function and is a key in esthetics due to its position. Maxillary canine has the longest time to develop and a complex route from the place of formation to the site of eruption, and so it is prone to impaction more than other teeth. The clinician should consider the various treatment options : (a) No treatment and observation, (b) surgical exposure and orthodontic traction (c) autotransplantation (d) extraction. Surgical exposure of the canine and orthodontic treatment to bring the tooth into the line of occlusion is considered the most desirable approach. This case presents the results of treatment for impacted maxillary canine by surgical exposure and orthodontic tooth movement.

상악 전치부에 발생한 여러 유형의 치아 외상 : CASE REPORT

임혜정,최남기,양규호,김선미 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.1

외상으로 인해 완전 탈구와 함입성 및 정출성 탈구가 병합되어 나타나는 경우는 드물다. 2003년 7월에 10세 2개월의 여아가 상악우측 측절치의 완전탈구와 상악우측 중절치의 함입성 탈구, 상악 좌측 중절치의 정출성 탈구로 전남대학교병원 소아치과에 내원하였다. 내원 당일 외상치아를 외과적으로 재위치시켰으며 레진 강선 고정을 시행하였다. 외상 2주 후 완전탈구된 상악우측 측절치는 근관치료를 시행하였다. 외상 3개월 후 방사선사진 상에 상악 좌우측 중절치의 치근 외흡수가 관찰되었으며 수산화칼슘을 이용한 근관치료를 시행한 후 치근 외흡수가 정지되었다. 1년 4개월 동안의 관찰기간 동안 병적인 변화없이 양호한 결과를 보였으며 추후 장기적인 추적관찰이 필요하리라 사료된다. It is rare that the complete avulsion, intrusive luxation, and extrusive luxation occurred by trauma at the same time. In July, 2003, 10-year and 2 month-old-girl was referred to Department of Pediatric dentistry, Chonnam National University Hospital due to complete avulsion of upper right lateral incisor, intrusive luxation of upper right cental incisor and extrusive luxation of upper left central incisor. Traumatized teeth were surgically repositioned and fixated with resin-wire splint at the same day. Endodontic treatment of avulsed tooth was performed 2 weeks after trauma. A radiograph was taken 3 months after trauma, which demonstrated root resorption of both upper central incisors. External root resorption was arrested by the root canal therapy with calcium hydroxide. It showed good results for 1 year and 4 month but further follow-up is needed to check root resorption and ankylosis.

地衣類의 脂質과 蛋白質 含量

徐信惠,李鴻善,崔璟姬,崔正渼 효성여자대학교 가정대학 학도호국단 1984 家政大論集 Vol.3 No.-

地衣類의 영양학적 가치를 조사하기 위하여 地衣類(지붕, 바위, 나무)와 석이의 總脂質 含量, 脂質 분포, 脂肪酸 조성, 蛋白質 含量을 측정하였다. 그 결과 총지질 함량은 100g당 석이는 3.47g, 바위에 地衣類는 3.40g, 지붕의 地衣類는 3.17g, 나무의 地衣類는 2.73g 이었고 TLC法에 의한 脂質의 분포는 석이와 地衣類 모두 cholesterol ester와 phospholipid 등이 있었고 나무 地衣類에는 TG 및 cholesterol의 흔적을 보였다. 지방산 조성은 대부분 C_12~C_18 fatty acid였고 그 중 C_18 : 1 C_18 : 2인 것이 50% 정도로 높게 나타났다. 나무의 地衣類에는 C_18 이상의 fatty acid도 상당량 분포되어 있었으며 C_20.4 fatty acid는 18.9%였다. 단백질 함량은 석이 6.60g, 地衣類는 8.22g이었다. To investigate the nutritional value of lichens, contents of total lipid, compositions of fatty acids, distributions of lipids and contents of total proteins in lichens (on the rock, roof and tree) and sogi were examined. The results were summarized as follow. The contents of total lipid in sogi, rock, roof, and tree lichens were 3.47±0.05%, 3.40±0.09%, 3.17±0.02%, 2.73±0.04% respectively. Lipids in all them were cholestrol ester and phospholidpid, and TG and cholesterol were existed only the lichen on the tree. Fatty acids were composed of that of carbon number 12-18; C_18:1 and C_18:2 were about 50%, Contents of total protein in sogi and lichen (roof) were 6.60% and 8.22% respectively.

과학 포트폴리오 체제의 적용이 초등학생의 사회심리학적 교실 환경에 미치는 효과

조선형,김찬종,김범기,김철영,김혜정 한국교원대학교 과학교육연구소 2001 청람과학교육연구논총 Vol.11 No.1

The purpose of the research is to investigate the effects of a portfolio system on students' socio-psychological classroom environments in elementary science class. Two schools were selected from a metropolitan area, a city, and one school from a rural area in central Korea. Two fifth-grade classes were sampled from each school selected, and one class is assigned to experimental group and the other to control group, respectively. The total number of participants of the study is 399. Portfolio system was administered to experimental group, and conventional teaching to control group for two and half month. WIHIC, an inventory to measure socio-psychological classroom environment, was administered as a pre-and post-test. Experimental group gained statistically higher scores on WIHIC after administering portfolio system. They showed more positive perceptions on sub-areas of WIHIC such as teacher support, task orientation, and equity. There is interaction between region and group: the effects of the portfolio system is highest in rural area, lowest in metropolitan area, and the city in between. Portfolio system have positive effects on students' socio-psychological classroom environments. Enhanced socio-psychological classroom environments is expected to contribute to positive self-concept, higher science achievements, and self-directed learning.

Inhibitory Effect of Clavicepitaceae on Serotonin Release out of Human Platelets and Human Platelet Aggregation

박화진,--,--,--,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1

We have investigated the effects of hypha-water extracts (HWE), fruit body-water extracts (FWE) and cordycepin from Cordyceps militaris on serotonin release out of human platelets and human platelet aggregation. HWE and FWE inhibited the release of [^(3)H]-serotonin from human platelet stimulated by thrombin (2 U/ml) or collagen (20 ㎍/ml) in a dose-dependent manner. Furthermore, cordycepin, a major component of Cordyceps militaris, inhibited the human platelet aggregation induced by collagen (10 ㎍/ml) in a dose-dependent manner. These results suggest that cordycepin containing in HWE and FWE may inhibit the serotonin release by suppressing the collagen-induced human platelet aggregation. Accordingly, our data demonstrate that HWE and FWE containing much cordycepin might have antithrombotic and antimigrainous functions.

Inhibitory Effect of Cordycepin on Human Platelet Aggregation

박화진,--,--,--,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1

Cordycepin separated from Cordyceps militaris is a major physiologic active component in Cordyceps militaris. The platelet aggregation is stimulated by Ca^(2+), which is either mobilized from intracellular endoplasmic reticulum or transported from extracellular space. cGMP antagonizes the actions of Ca^(2+). Based on these facts, we have investigated the effects of cordycepin on the mobilization of Ca^(2+) and the production of cGMP on collagen (10 ㎍/ml)-induced human platelet aggregation. Cordycepin potently stimulated the human platelet aggregation induced by collagen (10 ㎍/ml) in a dose-dependent manner. Cordycepin (500 μM) inhibited also the collagen-induced human platelet aggregation in the presence both 1 mM and 2 mM of CaCl_(2). These are in accord with the results that cordycepin inhibited the Ca^(2+)-influx on collagen-induced human platelet aggregation. These results suggest that cordycepin decrease the intracellular Ca^(2+) concentration to inhibit collagen-induced human platelet aggregation. Besides, cordycepin increased the level of cGMP on collagen-induced human platelet aggregation. This result is related with the decrease of intracellular Ca^(2+) concentration, because cGMP inhibits the mobilization of Ca^(2+). In addition, cordycepin inhibited the human platelet aggregation induced by LY-83583, inhibitor of guanylate cyclase. This result suggested that cordycepin inhibit the platelet aggregation by stimulating the activity of guanylate cyclase. In conclusion, we demonstrated that cordycepin might have the antiplatelet function by inhibiting Ca^(2+)-mobilization via the stimulation of the production of cGMP.

유치열의 이중치 및 결손치의 발생빈도와 영구치열과의 상호관계

양규호,임혜정,최남기,김선미 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.3

CT-26 선암을 접종한 마우스에서 Iodine-131-Iodomisonidazole 의 생체분포 및 종양저산소증의 영상화

Yang, David J,Kim, E Edmund,김혜원,김창근,윤권하,김현정,정선관,노병석,Lee, Hyun-Chul 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.3

urpose: Misonidazole is a radiosensitizer that binds in hypoxic cells. The purpose of this study was to find out the feasibility of I-131-Iodomisonidazole (IMISO) for imaging of tumor hypoxia. Materials and Methods: Tosyl precursor was dissolved in acetonitrile and I-131-NaI was added to synthesize IMISO. Balb/c mice inoculated with CT-26 adenocarcinoma were injected with IMISO. Mice were sacrificed at 1,2,4,24 hr and % of injected dose per gram of tissue (%ID/g) was determined. For scintigraphy and MRI, mouse bearing CT-26 adenocarcinoma was administered with IMISO and imaging was performed 4 hr after. Then, mouse body was fixed and microtomized slice was placed on radiographic film for autoradiography. Results: %ID/g of tumor was 1.64 (1h), 0.98 (2h), 0.85 (4h) and 0.20 (24h), respectively. At 24h, %ID/g of tumor was higher than that of all other tissues except thyroid. Tumor to muscle ratio increased with time and tumor to blood ratio also increased with time and reached 1.53 at 24 hr. On autoradiogram, tumor was well visualized as an increased activity in central hypoxic area of the tumor which corresponds to the area of high signal intensity on T2-weighted MR image. On scintigraphy, tumor uptake was visualized. Conclusion: This results suggest that IMISO may have a potential for tumor hypoxia imaging in mouse model. However, further study is needed to improve it's localization in tumor tissue and to achieve acceptable images of tumor hypoxia.

홍삼류의 섭취가 비만과 혈중 지질의 상호관계에 미치는 영향

박화진,이정희,이소진,함혜선,조현정,임창률,유영빈,박기현 대한의생명과학회 2000 Journal of biomedical laboratory sciences Vol.6 No.4

비만은 동맥경화의 위험인자로서 혈중에 triglyceride의 농도를 종가시키고, 상대적으로 HDL-Cholesterol의 농도를 감소시킴과 동시에 수축기 혈압을 상승시킨다. 본 연구에서 홍삼제품류를 4년 또는 5년 동안 복용해 온 건강한 사람 (ginseng군)과 홍삼제품을 복용하지 않은 건강한 사람 (control군)을 대상으로 하여 신체 계측치로부터 비만지수를 구하고 이것과 혈중의 triglyceride (TG)농도, TG/HDL-Cholesterol ratio 및 수축기 혈압과의 상호관계를 연구한 바, ginseng군에서는 대조군에 비해 혈중의 TG 농도가 일정하게 유지되었고, TG/HDL-Cholesterol ratio 및 수축기 혈압도 일정하게 유지되었다. 이러한 현상은 ginseng군에서 기호품으로 alcohol을 섭취하거나, 흡연을 한 경우에도 상관없이 일정하게 유지 되었다. 이 결과는 홍삼제품류를 장기 복용하면 비만의 저하 및 고혈압 또는 동맥경화의 위험인자가 억제될 수 있고, 결론적으로 비만, 고혈압 및 동맥경화를 예방할 수 있을 것으로 추정한다. Obesity is the risk fcactor of atherosclerosis and not only increases triglyceride concentration in blood but also decreases relatively the ratio of TG to HDL-Cholesterol in blood. In case of obesity, systolic blood pressure is also increased in responding the increase of TG in blood. Index of obesity in red ginseng-taking group (ginseng group) was lower as compared with non-red ginseng-taking group (control group). The TG concentration, the ratio of triglyceride to HDL-cholesterol in blood and systolic blood pressure were decreased in the subjects of ginseng group compared with that in control group. It is inferred that long-term intake of ginseng products may help to prevent the risk of atherosclerosis and obesity.