Variation in clinical usefulness of biomarkers of acute kidney injury in young children undergoing cardiac surgery

Baek, Hee Sun,Lee, Youngok,Jang, Hea Min,Cho, Joonyong,Hyun, Myung Chul,Kim, Yeo Hyang,Hwang, Su-Kyeong,Cho, Min Hyun The Korean Pediatric Society 2020 Clinical and Experimental Pediatrics (CEP) Vol.63 No.4

Background: Acute kidney injury (AKI) is one of the most significant postoperative complications of pediatric cardiac surgery. Because serum creatinine has limitations as a diagnostic marker of AKI, new biomarkers including neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and interleukin-18 (IL-18) are being evaluated to overcome these limitations and detect AKI at an early stage after cardiac surgery. Purpose: This study aimed to investigate the clinical usefulness of these biomarkers in young children. Methods: Thirty patients with congenital heart diseases who underwent cardiac surgery using cardiopulmonary bypass (CPB) were selected, and their urine and blood samples were collected at baseline and 6, 24, and 48 hours after surgery. Serum creatinine and blood urea nitrogen levels as well as NGAL, KIM-1, and IL-18 levels in urine samples were measured, and clinical parameters were evaluated. Results: Of the 30 patients, 12 developed AKI within 48 hours after cardiac surgery. In the AKI group, 8 of 12 (66.6%) met AKI criteria after 24 hours, and urine KIM-1/creatinine (Cr) level (with adjustment of urine creatinine) peaked at 24 hours with significant difference from baseline level. Additionally, urine KIM-1/Cr level in the AKI group was significantly higher than in the non-AKI group at 6 hours. However, urine NGAL/Cr and IL-18/Cr levels showed no specific trend with time for 48 hours after cardiac surgery. Conclusion: It is suggested that urine KIM-1/Cr concentration could be considered a good biomarker for early AKI prediction after open cardiac surgery using CPB in young children with congenital heart diseases.

주물공장 근로자에서 발생한 국한성 석면폐증 1예

김태우,고동희,김민기,유승원,류향우,한정희,정순희 大韓産業醫學會 2009 대한직업환경의학회지 Vol.21 No.2

배경: 주물공장 근로자에서 발생한 석면폐증의 작업 관련성을 평가하고 그 증례를 보고하고자 한다. 증례: 30년간 주물공장에서 근무한 환자로 인후통, 기침, 노란 가래가 있어 검사한 결과 결핵이 의심되어 치료 하였으며, 치료 중 석면폐증으로 진단되었다. 작업 관련성 평가를 위해 실시한 폐 조직의 조직학적 검사에서 1 cm^(2)당 3개의 석면소체가 발견되었고, 투과전자현미경으로 분석한 석면 함유량은 23.26x10^(6) fibers/g이었다. 결론: 작업환경조사, 폐 조직의 석면 분석 등을 통해 작업 관련성이 높다고 판단하였다. Background: Foundry workers are known to be exposed to silica and have an increased risk of Silicosis. There are also reports that state these foundry workers were associated with asbestos-related change in the X-ray results of the lungs. This report discusses a case of localized asbestosis developed in a foundry worker who worked in 12 Korean foundries. Case report: A 49-year-o1d man who worked at molding and melting for 30 years, Presented with sore throat, cough and yellow sputum for 1 month. From physical and clinical examination, Pulmonary tuberculosis was highly suspicious; therefore, he was medicated for 6 months. After tuberculosis medication, the radiological finding was reactivation of tuberculosis, and an asbestos body was detected at a trans-bronchial lung biopsy. During an operation, operators found multiple palpable masses and bullae 10calized in the right upper lobe (RUL) and performed right upper lobectomy and right middle lobe wedge resection. Using hematoxylin-eosin stain and iron stain, we could detect asbestos bodies by light microscopy. We analyzed the asbestos fiber burden in dry lung tissue by transmission electron microscopy with energy dispersive X-ray spectrometer (TEM-EDX). The fiber type was chrysotile and the fiber burden was 23.26 x 10^(6) fiber/g dry lung. Discussion: This case study of a foundry worker with localized asbestosis is uncommon in Korea. We found an occupational relationship between the foundry worker and localized asbestosis through various investigative techniques such as measurements taken at his working environment, clinical, radiological and pathological examination of the foundry worker and mineralogical examination of the asbestos fiber.

Original Article : Geographic difference of epidemiological features of HCV infection in Korea

( Kyung Ah Kim ),( Sook Hyang Jeong ),( Eun Sun Jang ),( Young Seok Kim3 ),( Youn Jae Lee ),( Eun Uk Jung ),( In Hee Kim ),( Sung Bum Cho ),( Mee Kyung Kee ),( Chun Kang ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.4

Background/Aims: The prevalence of hepatitis C virus (HCV) infection in Korea exhibits significant geographic variation, with it being higher in Busan and Jeonam than in other areas. The reason for this intranational geographic difference was investigated in this study by conducting a comparative analysis of the risk factors related to HCV infection among three geographic areas: the capital (Seoul), Busan, and the province of Jeolla. Methods: In total, 990 patients with chronic HCV infection were prospectively enrolled at 5 university hospitals located in Seoul (n=374), Busan (n=264), and Jeolla (n=352). A standardized questionnaire survey on the risk factors for HCV infection was administered to these three groups of patients, and a comparative analysis of the findings was performed. Results: The analysis revealed significant regional differences in exposure to the risk factors of HCV infection. By comparison with patients in Seoul as a control group in the multivariate analysis, patients in Busan had significantly more experience of invasive medical procedures, acupuncture, cosmetic procedures, and multiple sex partners. In contrast, patients in Jeolla were significantly older, and they had a higher prevalence of hepatocellular carcinoma, a lower prevalence of multiple sex partners, and had experienced fewer invasive procedures. Conclusions: There was a significant geographic difference in the exposure to potential risk factors of HCV infection between patients from the three studied regions. This may explain the regional variation of the prevalence of HCV infection in Korea, and should be taken into account when planning strategies for the prevention and management of HCV infection. (Clin Mol Hepatol 2014;20:361-367)

척수 경막외 혈관 기형에 의한 재발성 척수병증

오동호,김희태,박운규,이영주,김승현,김주한,김명호,박문향 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5

Purs Lane의 유용성분과 아질산염 소거능 검색

김향숙,변복수,최주희,박지영 충북대학교 교육생활연구소 2001 생활과학연구논총 Vol.4 No.-

This study was carried out to examine the useful components of Purs Lane and their nitrite scavenging effect. Leaves and stems were separated and analyzed fo general chemical composition, amino acid composition, and dietary fiber contents. Anti-oxidant nutrient such as total vitamin C, total phenol ice, and vitamin E contents were also analyzed. Nitrite scavenging effects of methanol extract and aqeous extract were examined.

녹차분말 첨가량에 따른 절편과 설기떡의 기호도 및 품질 특성

김향희,박금순 동아시아식생활학회 1998 동아시아식생활학회지 Vol.8 No.4

This study was conducted to aerermine the sensory evaluation and the texture characteristics after making greentea Sulgidduk and Julpyun added to greentea powder in according to concentration which has nutritive value and medical effect of white Sulgidduk and Julpyun traditional dduk. Greentea Julpyun was better evaluated than Sulgidduk in color, flavor, hardness, chewiness and overall quality as the result of the sensory evaluation. In the whole sensory Julpyun was highly evaluated at the 3% of concentration of greentea powder but Sulgidduk was highly evaluated at 7% as the concentration of the greentea powder was getting stronger and stronger. In case of texture analysis hardness, cohesiveness, gumminess and chewiness of greentea Julpyun were getting lower by increase ofconcentration of greentea powder. The hardness, springiness, gumminess and chewiness of greentea Sulgidduk were lower by increase of concentration of greentea too. As the result of the measurement with texture analyser, Sulgidduk was lower than greentea Julpyun in the hardness, springiness, cohesiveness, gumminess and chewiness. As the result of the values of Hunter color system the lightness and redness of greentea Julpyun were the lowest when nothing was added. The lightness and redness of greentea Sulgidduk were the highest in nothing added group. The yellowness was the highest at 3% of added greentea amount. The results of correlation between the sensory properties and texture properties of greentea Julpyun showed that flavor described the lightness of measurement through texture and negative correlation, yellowness described positive correlation.

정부교체기의 학교체육진흥을 위한 문제와 방향

김대광,황향희 江原大學校附設體育科學硏究所 2002 江原大學校附設體育科學硏究所論文集 Vol.- No.25

This study has the purpose of presenting the direction for the promotion of school physical education by analyzing the change and problems of school physical education in the past through administrative approach of physical education at present when government is to be changed in two months for the importance and developmental necessity of school physical education, and the conclusion is presented as the follows as the proposal through general analysis as the abobe. 1. Central organization of government shall be set up in order to control elite physical education, school physical education and sport for all professionally and generally and at the same time I think it is necessary to establish tentatively named "Operational and strategic committee for National physical education" under the rule of prime minister for the reformation of structural contradiction and problems of Korean physical education. 2. It is judged that school physical education shall be managed either by the ministry of education and human resources or by the minister of culture and tourism for complete transfer of the function they have. 3. Medium and long term development plan shall be made with government, school physical education teachers and the professional sports personnels participating. 4. It will be possible for us to establish professional physical education school such as the golf elementary school, jubo middle school, and Taekondo high school from elementary to high school. 5. It is necessary to include the concrete contents on school physical education in the promotion act of national physical education through amending and complementing current act extensively. 6. It is recommended that diverse and professional opinions shall be received from various fields of the sports for the execution and evaluation when establishing or deciding the policy of school physical education.

운동선수들의 정신력에 관한 연구

김윤래,황향희 강원대학교 체육과학연구소 2001 江原大學校附設體育科學硏究所論文集 Vol.- No.24

The purpose of this study is to investigate the difference in mental toughness between the athletes of team sport and the athletes of individual sport Subjects for this research were totally 319 consisting of 171 athletes of team sport and 148 athletes of individual sport in high school male athletes. The mental toughness were measured by mental toughness inventory witch was developed by Loehr(1982). The results were the followings. The self-confidence, motivation and positive energy were not significant difference between the athletes of team sport and the athletes of individual sport. The athletes of team sport showed more significant the level of attention control and attitude control than athletes of individual sport. The athletes of individual sport showed more significant the level visualization and imagery control, anxiety control and motivation than athletes of them sport.

도라지가 난소를 절제한 흰쥐의 혈 중 지질 함량 변화에 미치는 영향

김미향,김원희,박미라,한희선,배송자 신라대학교 자연과학연구소 2003 自然科學論文集 Vol.11 No.-

This study was designed to observe the effects of the feeding Platycodon grandiflorum A.DC(PG) extract on the improvement of the lipids on serum in ovariectomized rats. To investigate the effects of ethanol extract, Sprague-Dawley female rats were randomly assigned to groups as follows: Sham, OVX-control and ovariectomized rats supplemented with PG at 50㎎/㎏ bw/day. Body weight gain was not significantly different in groups. The levels of total cholestcrol was higher in ovaiectornized control rats than Sham-operated rats, but supplementation of PG ethanol extracts at 50mg/kg bw/day decreased the level of cholesterol in surum. These results might be expected that ethanol extract of PG is believed to be possible protective effects for the fatty serum increasing serum lipid.

볼링에 대한 참가여부와 몰입도가 생활만족과 정신건강에 미치는 영향

김윤래,황향희 江原大學校 附設 體育科學硏究所 1998 江原大學校附設體育科學硏究所論文集 Vol.- No.22

The following study is to clarify the effects on the life satisfaction and the mental health of the participation or non-participation in bowling and the flow degree on it. and the purpose is to present the necessary theoretical foundations to activate bowling with the base on the actual data of social psychological value. The study targeted for the 126 housewife participants and 143 non-participants. a total of 269 people. We researched the flow degree in bowling base on the flow experience questionnaire of Omodei & Wearing(1990). the life satisfaction based on Life Satisfaction Index which Medley developed (1976) and the mental health based on Symptom, Check List-go Revision of Derogatis et al(1973) On the case of the participation or non-participation. the life satisfaction of the participants was higher than the non-participants as the result. There was no significant difference in the interpersonal sensitivity, hostility, phobic anxiety and psychiticism on the case of mental health However. the participants showed lower respond(it means they are healthful) than the non-participants significantly on the somatization. obsessive-compulsive, depression. anxiety and paranoid ideation. It was found that th higher flow degree. the superior life satisfaction and mental healthe in the bowling participant groups.