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Interferon-γ Inhibits in vitro Mobilization of Eosinophils by Interleukin-5
Park, Choon-Sik,Choi, Eun Nam,Kim, Jung Sun,Choi, Yun Sung,Rhim, Tai Youn,Chang, Hun Soo,Chung, Il Yup S. Karger AG 2005 International archives of allergy and immunology Vol.136 No.3
<P><I>Background:</I> Th2 cytokines play pivotal roles in allergic inflammation, including eosinophilia, and their actions are antagonized by Th1 cytokines, conferring them therapeutic potential. <I>Methods:</I> In this study, we examined the ability of a number of cytokines to suppress the activation of eosinophils that function as effector cells for allergic airway diseases. <I>Results:</I> Interleukin (IL)-5, IL-6, and tumor necrosis factor (TNF) induced an eosinophil shape change, whereas interferon (IFN)-γ significantly inhibited the shape change. Other cytokines, including IL-1β, IL-4, IL-10 and IL-13, had little or only slightly enhancing or reducing effects on the shape change. We further analyzed the IFN-γ effect, showing that pretreatment with IFN-γ strongly suppressed IL-5-induced eosinophil shape change, and cycloheximide (CHX) abrogated the suppression by IFN-γ, suggesting that new protein synthesis is required for the inhibitory effect by this cytokine. In agreement with these results, IFN-γ blocked the eosinophil migration and ERK phophorylation induced by IL-5, and the addition of CHX restored eosinophil chemotaxis. <I>Conclusions:</I> Collectively, IFN-γ may attenuate eosinophilic inflammation by directly negating eosinophil mobilization.</P><P>Copyright © 2005 S. Karger AG, Basel</P>
Indomethacin으로 유발된 흰쥐의 위장장애에 ChondroT가 미치는 영향
김주일 ( Joo-il Kim ),김선길 ( Sun-gil Kim ),김지훈 ( Ji-hoon Kim ),윤찬석 ( Chan-suk Yoon ),최지민 ( Ji-min Choi ),최찬헌 ( Chan-hun Choi ),김선종 ( Seon-jong Kim ) 한방재활의학과학회 2020 한방재활의학과학회지 Vol.30 No.3
Objectives The aim of this study was to investigate the inhibitory effect of ChondroT in indomethacin-induced gastric mucosal injury rat model. Methods Sprague-Dawley rats were randomly assigned to intact, control Joins, Celebrex, ChondroT50 and ChondroT200. Indomethacin (25 mg/kg) was used to induce damage to the gastric mucosal injury. ChondroT was administered by orally to inhibit the indomethacin-induced gastric mucosal injury. At the end of the experiment, pH level in stomach, stomach contents volume, tumor necrosis factor-α (TNF- α) level, interleukin-1β (IL-1β) level, prostaglandin E2 (PGE2) level, myeloperoxidase (MPO) activity, erythrocytes, and thrombocytes were measured. Ophthalmologic and histopathological examination was also analyzed. Results pH level in stomach and Stomach contents volume had no difference between Control, PC-Joins, PC-Cele, ChondroT50 and ChondroT200 group. TNF-α level was decreased in PC-Joins, PC-Cele, ChondroT50 and ChondroT200 group and there were no significant difference. IL-1β level was decreased in PC-Joins group and ChondroT200 group compared to control group. PGE2 level had no significant difference between Control, PC-Joins, PC-Cele, ChondroT50 and ChondroT200 group. MPO level and complete blood count level were decreased in PC-Joins, PC-Cele, ChondroT50 and ChondroT200. Symptom score of ophthalmologic examination was decreased in ChondroT50 and ChondroT200 group compared to control group. Conclusion Based on these results, It could be suggested that ChondroT was effective in reducing damage to the gastric mucosal injury. And further study is needed to conduct a rigorous clinical research. (J Korean Med Rehabil 2020;30(3):57-69)
Jisoo Kim,Joo Yun Kim,Ji-Woong Jeong,Il dong Choi,Soo-Dong Park,Jung Lyoul Lee,Jae-Hun Sim 한국자원식물학회 2020 한국자원식물학회지 Vol.33 No.6
Lilium lancifolium (LL) is widely cultivated in East Asia and used to attenuate airway diseases. Our current study aimed to investigate the therapeutic effect of LL on pain level and inflammatory response in a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis (OA). We first examined the effect of LL on inflammatory cytokines and inflammatory mediators in IL-1β-treated HTB-94 cells. The LL extract was found to significantly inhibit the levels of Interleukin-6 (IL-6), Interleukin-8 (IL-8), and prostaglandin-E2 (PGE-2) in Interleukin-1 β (IL-1β)-stimulated HTB-94 cells in a dose-dependent manner. Moreover, chronic oral administration of LL effectively restored the weight-bearing distribution in the rat model of MIA-induced OA. In addition, administration of LL inhibited inflammatory cytokines and inflammatory mediators, such as C-reactive protein (CRP), IL-6, leukotriene B4 (LTB-4), PGE-2, and matrix metalloproteinase-9 (MMP-9). Our findings collectively suggested LL as one of the potential therapeutic agents for OA, owing to its properties of reducing pain and inflammatory responses.
스폰서십(sponsorship)을 통한 스포츠문화 소비자의 브랜드이미지(brand image)에 대한 연구
성낙훈,최일도 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1
The purposes of this study were to promote sports in non-popular field by using sports as non-verbal communication in the process of brand marketing and to prepare the basis on sponsor's persuasion and sponsorship construction with industry and brand marketing activity. For this study, 120 customers were surveyed in 2003. For data analyses, frequency analysis and t-test were used. Most respondents in this study showed interests to non-popular sports. This study also found that respondents showed better impression on industry or brand supporting non-popular sports than those supporting popular sports.
한국판 임상가용 아동 및 청소년을 위한 외상후 스트레스장애 척도의 신뢰도 및 타당도 연구
구정일,김태형,은헌정,최말례,이선미,조수진,송옥선,김형욱 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6
Objectives : This present study was conducted to explore the reliability and the validity of Clinician Administered PTSD Scale for Children and Adolescents Korean version (CAPS-CA) Mcthods : The Subjects were children and adolescents (8-13yrs) from different places: a certain elementary school, three orphanages, a general hospital, and two neuropsychiathc local clinics. Only subjects who experienced a catastrophic traumatic event were tested by CAPS-CA, CDI, RCMAS, and TSC. Rcsults : The range of correlations between item-criterion were .67-.84. The coefficients of internal consistency were .87. and test-retest reliability was .90, were all the coefficients in the proper range. Inter-correlations of CAPS-CA, CDI, RCMAS, and TSC scale showed significant correlation. TSC showed the highest correlation coefficient. CAPS-CA can be a useful clinician-administered diagnostic instrument for children and adolescents PTSD symptoms. Conclusion : The reliability and the validity of CAPS-CA were confirmed. CAPS-CA could be applied for diagnostic purposes of PTSD in children and adolescents.
Kim, Seung-Hun,Park, Hee-Ju,Lee, Chang-Min,Choi, Il-Whan,Moon, Dong-Oh,Roh, Hwan-Jung,Lee, Hern-Ku,Park, Yeong-Min Elsevier 2006 FEBS letters Vol.580 No.7
<P><B>Abstract</B></P><P>Epigallocatechin-3-gallate (EGCG), a major form of tea catechin, has anti-allergic properties. To elucidate the anti-allergic mechanisms of EGCG, we investigated its regulation of matrix metalloproteinase (MMP-9) expression in toluene diisocyanate (TDI)-inhalation lung tissues as well as TNF-α and Th2 cytokine (IL-5) production in BAL fluid. Compared with untreated asthmatic mice those administrated with EGCG had significantly reduced asthmatic reaction. Also, increased reactive oxygen species (ROS) generation by TDI inhalation was diminished by administration of EGCG in BAL fluid. These results suggest that EGCG regulates inflammatory cell migration possibly by suppressing MMP-9 production and ROS generation, and indicate that EGCG may be useful as an adjuvant therapy for bronchial asthma.</P>
김명석,최상돈,조상규,김정호,전헌무,김호일 慶北大學校 師範大學 科學敎育硏究所 1998 科學敎育硏究誌 Vol.22 No.-
We review the contextuality of measured values in quantum mechanics from point of view of a conventional interpretation of quantum mechanics. We will, in particular, concentrate on Bell-KS theorem which, seemingly, disproved the existence of a hidden-variable interpretation of quantum mechanics. We introduce ways to accommodate the contextuality so that Bell-Ks theorem no longer holds and therefore the existence of a hidden-variable interpretation becomes possible.
초음파 트랜스듀서용 PZT-고분자 1-3-0형 복합압전체의 유전 및 압전특성
양윤석,최헌일,사공건 東亞論叢 1999 東亞論叢 Vol.36 No.-
In this study, piezoelectric composites with 1-3-0 connectivity have been studied. A piezoelectric ceramic PZT prepared by the Wet-Dry Combination method is used as a filler phase in mixture of the third filler phase and Eccogel polymer matrix. The density and stiffness of 1-3-0 type composites were decreased with increasing the third phase.