폐경기후 골다공증의 약물요법

노흥규,송치운,이진홍,안미애,송민호 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Postmenopausal osteoporosis is an enormous public health problem. Estrogens, and various drugs were developed and used for prevention and treatment of postmenopausal bone loss. In this study, We evaluated the effects of cycloprogynova, cyclofenil and ipriflavone on postmenopausal bone loss. Fourty post menopausal women were divided into 3 groups by treatment modalities Cyclofenil group (groupl), Cycloprogynova group(group 2) and Ipriflavone group(group 3). Basal bone mineral densities in all subjects were determined by DEXA(Dual Energy X-ray Absorptiometry) and those were compared with bone mineral densities after medication. The durations of medication in all groups were showed no statistical difference, group 1 11.4 ± 3.4 months, group 2 10.6 ± 3.9 months, group 3 12.9 ± 3.4 months. The patients of group 2 showed significant increase in bone mineral densities and the patients of group 1 and group 3 revealed no significant bone loss on paired T-test. Comparing with rates of bone loss in normal Korean postmenopausal women, the rates of bone loss in all subjects were effectively retarded. The significant bone loss (above longterm intertest coeffcient of variation) was noted in 8 patients out of 23 subjects in group 1, in 9 patietns out of 11 subjects in group 2 and in 2 patients out of 6 subjects in group 3. In conclusion, estrogen/progesteron(Cycloprogynova) replacemnt therapy showed most prominent bone preserving effect and Cyclofenil and Ipriflavone also effectively delays shorterm bone loss in postmenopausal women.

산후 갑상선염의 경과에 관한 임상적 고찰

노흥규,송치운,송민호 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

Postpartum thyroiditis is a disease with transient changes of thyroid function as hyperthyroidism, hypothyroidism and normal recovery 2-4 months after delivery. It occurs in 7-9% of postpartum women, is needed careful differential diagnosis from Graves' disease or Hashimoto's thyroiditis because of quite different clinical course. In order to establish the points for differentiation, we evaluated 30 cases of postpartum thyroiditis patients with the following results. 1. 14 patients were diagnosed as hyperthyroidism 4.4±1.6 months after delivery with mild degree of thyrotoxic symptoms. The anti-thyroglobulin antibody and anti-microsomal antibody were positive but thyrotropin receptor antibody were negative. 2. 16 cases were diagnosed as hypothyroidism with enlarged goiter 6.1±0.9 months after delivery and the ATA and AMA were positive both but TBII was negative in all cases. 3. The thyroid function of 71.4% of hyperthyroid patients became hypothyroidism in 1-3 months and recovered to normal in 1-3.5 months thereafter. In 68.8% of hypothyroid patients became euthyroidism within 1-8 months and 21.4% 1(3 cases) of the patients remained as hypothroidism untill 12 months' observation. In conclusion, the thyroid function changes as hyperthyroidism, hypothyroidism and euthyroidism stepwise in most cases of pospartum thyroiditis and serum TBII is negative, which are the most important features in differentiating from other autoimmune thyroid disease.

부신 결핵에 의한 Addison씨병 1예

송치운,구본정,안봉수,전준식,안미애,이진홍,송민호,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Addison's disease is a rare primary adrenal insufficient disorder resulting from chronic deficiency of adrenal cortical hormones. Clinical manefestations are generalized weakenss, weight loss, hyperpigmentation (especially sun exposed area and mucous membrane), hypotension, hyponatremia, hyperkalemia, gastrointestinal symptoms (involving anorexia, nausea, vomiting, abdominal pain). A 34-year-old woman has experienced slowly progressive generalized weakenss and skin pigmentation, anorexia, nausea, vomiting with ascites and diffuse abdominal pain. On the time of admission, her main clinical manifestations were anorexia, nausea, vomiting, fatigue, generalized weakness, amenorrhea, hair loss, diffuse abdominal pain revealed as Addison's disease due to bilateral adrenal tuberculosis. Her adrenal insufficient symptoms were recovered with the replacement of adrenocortical hormones and antituberculous medications. After treatment, Her skin pigmentation was decreased and menstruation was reappeared. Here we experienced one cases of Addison's disease with tuberculous peritonitis.

호안 설치지점에 따른 해빈변형 해석

咸契運,徐在天,申炯宇 慶尙大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.14 No.-

When seawall was constructed on the beach, erosion in front of seawall was especially displayed, the erosion of foreshore and scouring of the sand at the toe of its foundation. In this study, authors will compare theoretical formulas with empirical formulas and detected difference between theoretical formulas and empirical formulas.

혈액투석중인 만성신부전 환자에서 골대사 지표로써의 Osteocalcin치

송치운,이진홍,안미애,윤환중,윤상임,성기양,이강현,송민호,이강욱,신영태,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Background : Serum osteocalcin is synthesized by osteoblast and has been shown to be sensitive indicator of bone turnover inpatients with various metabolic bone disease. In renal osteodystrophy, serum osteocalcin is elevated due to decreased renal clearance and elevated level of PTH. This study was done to evaluate the usefulness of serum osteocalcin as a marker of bone metabolism and the correlation with other biochemical markers of bone metabolism. Methods : We measured serum osteocalcin, calcium, phosphorus, ALP(alkaline phosphatase) and PTH(parathyroid hormone) in 37 patients with end stage renal disease on hemodialysis. Osteocalcin was determined by radioimmunoassay and PTH was determined by radioimmunometric assay. Results : 1) The mean level of serum osteocalcin in ESRD patients was 233.8± 218.2ng/ml which was significantly higher than that of controls(p<0.0001). 2) The mean level of serum PTH in ESRD patients was 40.5± 43.8pg/ml was significantly higher than that of controls(p<0.005). 3) There was a significant positive correlation between the level of serum PTH, ALP and the level of serum osteocalcin in ESRD patients. 4) By using multiple regression, PTH is most reliable factor that affect to elevated level of serum osteocalcin ( beta coefficient = 0.687, Sig T<0.05). Conclusion : Serum osteocalcin as a marker of bone metabolism in ESRD patients is more useful than other biochemical marker such as serum calcium, phosphorus, ALP and PTH is a most reliable factor that affect to elevated level of serum osteocalin.

전남 동부지역의 해수욕장 저질특성에 관한 분석

咸契運,申炯雨,徐在天 경상대학교 생산기술연구소 2001 工學硏究院論文集 Vol.1 No.-

The grain distribution of beaches are measured by classification of sediments by grain diameter and this range is 2㎛ -200㎜. In this study it was used regions of Man Soung Ri beach and Nam Youl Ri beach and Bal Po beach in the Eastern Jeonnam. In this region Man Soung Ri beach was divided five sector, Nam Youl Ri beach was divided four sector, and Bal Po was divided four section. This paper was analyzed each beach are ever sector beach grain distribution and shore line in and out grain size distribution.

당뇨병환자에서 게이트심장혈액풀신티그라피를 이용한 심기능 평가

윤상임,송치운,이진홍,안미애,성기양,송민호,이강욱,신영태,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Major cardiovascular complications of diabetes are coronary atherosclerosis, diabetic dilated cardiomyopathy, autonomic neuropathy and those are major causes of morbidity and mortality in diabetic patients. Gated blood pool heart scan is noninvasive and useful method for evaluation of functional status of heart in diabetics. We evaluated 52 patients with diabetes and divided 3 groups. Group 1 were 11 patients without proteinuria or with proteinuria less than 550mng during 24 hours. Group 2 were 9 patients with proteinuria more than 550mg during 24 hours and group 3 were 32 patients with endstage renal diasese due to diabetes. We performed 99mTc-HSA cardiac gated blood pool scan and used left ventricular ejection fraction(LVEF), peak ejection rate(PEF) to indices of LV systolic function and peak filling rate(PER) to index of LV diastolic function. The results were follows : 1) LVEF, PER were significantly lower in diabetics with ESRD than diabetics without ESRD, but there were no significant difference between normal controls and diabetics without ESRD 2) PFR was significantly lower in diabetics than normal controls, but there were no significant differences in diabetics with or without nephropathy. 3) There were negative correlation between PER, PFR and duration of diabetes. On the basis of results, PFR is a LV functional index of GBPS which can disclose early change of LV dysfunction in patients with diabetes.

철광석 Brand 별 수소환원 반응속도

김영홍,이광학,김영진,서도수,이재운,김흥식 울산대학교 1999 공학연구논문집 Vol.30 No.2

반응온도가 증가할수록 Brand별 철광석의 환원율은 증가하였으며 일정반응온도에서 원광석형태인 Romeral 보다 펠렛형태인 CVRD,IOC 및 ALG 시편의 환원율이 더 높음을 알수 있었고 펠레시편 중 IOC가 타 시편에 비해 환원율이 가장 큼을 알 수 있었다. 수소가스에 의한 원광석 및 펠렛시편의 환원반응에서 전반응속도는 계면화학반응에 의해 율속됨을 알 수 있었으며, 활성화에너지값은 Romeral, CVRD, IOC 및 ALG의 경우 각각 약 4.8, 7.7, 4.5 및 5.3kcal/mol이었다. 이들 활성화에너지값으로부터 수소가스에 의한 환원반응은 펠렛형인 IOC가 가장 우수함을 알 수 있었다. In order to get an fundamental data to select a suitable ore brand for hydrogen reduction, the reaction kinetics of hydrogen for ore brands was investigated. Four kinds of ore brands such as Romeral ore, CVRD, IOC,ALG pellet were selected for this experiment. It was observed that the reduction ratio of pellets was higher than ore and IOC pellet showed the highest in comparing with other pellets. The kinetics data was fitted to [1-(1-R)1/3] = kt for surface reaction control. The activation energy for the reduction of Romeral, CVRD, IOC and ALG were 4.8, 7.7, 4.5 and 5.3 kcal/mol respectively. It was shown that the overall reduction rate was controlled by surface reaction. And also, we can get result that IOC was the most suitable ore for the reduction with hydrogen gas among the specimens

Effects of Naringin in Animal Models of Parkinsonʼs Disease

Heung Deok Kim,Min Tae Jeon,Un Ju Jung,Sang Ryong Kim 한국식품영양과학회 2015 한국식품영양과학회 학술대회발표집 Vol.2015 No.8

Distribution of Uniform Reliability over AADTs Estimated for a New Highway Route

Heung-Un Oh 대한토목학회 2003 KSCE journal of civil engineering Vol.7 No.5