벤처캐피탈의 투자처기업에 대한 회계적 평가 : Focus on the Business invested by Venture Capital

허익구,배주한 진주산업대학교 1997 論文集 Vol.36 No.-

The objective of this study is to examine measures of new performance measurement. And to investigate accounting strategy and the possibility for the development of venture capital, and to submit the problem of that. The assignment which has, in advance, to be done for the development of venture capital as follows; 1) The way how will it, the method estimating venture business's development possibility, be effectively accumulated and managed. 2) The application of its investment method so far accumulated to other business through new business development. 3) The obligation of audition by auditor to venture business.

화의절차와 정리위원의 회계적 판단에 관한 고찰

허익구,배주한 진주산업대학교 1998 論文集 Vol.37 No.-

The bankruptcy of a company causes other companies to be bankrupted since a company has linked with other companies and financial institutes as a dependent relationship. This crisis is considered as a social problem. What is worse, this serious economic situation makes many sound companies to be bankrupted. There is a measure to protect those companies from bankrupting thorough by the Bankruptcy Law, The Composition Law, The Liquidation Law. However, to resolve the problem between debtor and creditor is complicated procedures due to the confusion of interpretation of those laws. THus, mangers have difficult to deal with liquidation, composition procedures, bankruptcy procedures before resolving those legal problems. Thus, the purpose of this paper is as follows: First, providing deep understanding to the managers through the investigation about composition procedures. Second, providing a guideline to make managers to deal with composition procedures efficiently. Finally, providing some important factors which should be considered when they deal with financial aspects as accountants.

內膜1號丸 子宮內膜症 白鼠의 治療效果에 對한 硏究

권은정,배한익,이태균 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

Endometriosis is characterized by ectopic growth of tissue resembling endometriosis in various extrauterine locations. So we surgically implanted endometrial tissue to serosal wall of small intestine in rats. After that we administrated Naemak-1-ho-hwan for 10, 20, 40, 60, 80, 100 days. The results were as follows: 1. After 4weeks we could observe tissue resembling endometrium in serosal wall of small intestine. Endometrial tissue which was located serosal wall of intestine had the function of growing, secreting and bleeding. 2. The size of the endometrial tissue in the Naemak-1-ho-hwan administrated group was significantly reduced when we compared with water administrated group (control group) . Further more, as the time goes on, the effect of Naemak-1-ho-hwan much better. 3. In case of infected group, we could find abscess and fibriotic change, also like that case Naemak-1-ho-hwan was not effect. 4. There was no difference between Naemak-1-ho-hwan administrated group and control group in the shape of primordial follicle, primary follicle, maturing primary follicle and ovary size. So these results suggest that Naemak-1-ho-hwan will be effect for the patient who suffer from slight endometriosis.

Anti-inflammatory and Anti-oxidant Effects of PHBV/Collagen (PHCP) on Lipopolysaccharide-Induced Skin Inflammation

Jin-Yi Han3*, Xu Zi Guang, Jyung-Sik Kwak, Ki-Wan Oh, Han-Ik Bae 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.1

The anti-inflammatory effect of PHBV/Collagen (PHCP) was examined in a mouse model of lipopolysaccharide (LPS)-induced skin inflammation. Vascular permeability on the back skin was measured by the local accumulation of Evan’s blue dye after subcutaneous injection of LPS (30 μg site-1). Dye leakage in the skin showed a significant increase at 2 h after injection of LPS. This LPS-induced dye leakage was also completely inhibited by HO-1 inhibitor, ZnPP, and antioxidants, including methyl gallate, trolox, and mannitol. To study the possible mechanisms underlying the in vivo anti-inflammatory effect of PHCP against LPS-induced inflammation, we also examined the effects of PHCP on malondialdehyde (MDA) and glutathione levels in skin tissues and found that pretreatment with PHCP resulted in inhibited MDA elevation and a remarkable reduction of glutathione level. In addition, similar results were obtained after pretreatment with antioxidants, including trolox and mannitol, and HO-1 inhibitor, ZnPP. Histopathologically, an influx of neutrophils into the skin dermis was detected between 24 h and 72 h after LPS injection (30, 100 μg site-1), compared to control animals after injection of saline. This increase was greater in mice treated with 100 μg of LPS than in those treated with 30 μg of LPS and was significantly suppressed by pretreatment with PHCP, antioxidants, and HO-1 inhibitor. These results collectively suggest that PHCP has an anti-inflammatory effect against LPS-induced inflammation model in vivo and may be a good candidate for the skin tissue engineering biomedical application primarily through manipulation of the redox state.

세포브러쉬와 면봉도말법에 의한 부인과 세포학적 검사의 효율비교

김정란,김성숙,배한익,김용탁,심재철,임문환,윤혜원,이상식 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

A study was undertaken to evaluate the efficiency of the sytobrush compared with the cotton swab for obtaining cells from the uterine cervix. In 300 patients, the cytobrush technique was employed and in control 300 patients was smeared by the cotton swab. In 12 out of 300 patients(4%) endocervical cells were found on the cotton swab technique. A total of 252 out of 300 cytobrush sampler specimen(84%) contained endocervical cells. With the X²method for statistical comparison, the difference in endocervical cell yield between the cotton swab and the cytobrush sampler was significantly different(p<0.01). This was particularly true in older patients. We conclude from study that the cytobrush sampler is of value for obtaining as adequate cervical cytologic specimen.

소아 여성 요도탈출증

이경섭,최병기,배한익 東國大學校 1993 東國論叢 Vol.32 No.-

Urethral prolapse in female patients is a characterized by the protrusion of the urethral mucosa through the external urethral meatus. It is a rare pathological condition that generally occurs in prepubertal black girls and in postmenopausal white women. We experienced a case of urethral prolapse in a 12-year-old girl at Pohang hospital of Dongguk University. The clinical characteristics and treatment of the urethral prolapse are discussed with references.

초산 중독에 의한 범발성 혈관내 응고증: 1증례 보고

곽은경,김동자,박지영,배한익,채종민,곽정식,박태인 大韓法醫學會 1998 대한법의학회지 Vol.22 No.2

Strong corrosive acid is accidentally ingested by children or by psychiatric patients for the purpose of suicidal attempt. Late complications include chemical burn to pharyunx, perforation and stricture of upper gastrointestinal tract, respiratory insufficiencyand renal failure caused by hemoglobinuria following hemolysis. Acetic acid is difficult to ingestion large volume in a time because it is a strong irritant, provocating painful pharynx, and its autopsy case is rare. We report an autopsy case of acetic acid intoxication with acute disseminated intravascular coagulation (DIC) in several hours. We present pathogenesis of acetic acid intoxication and the associated forensic problems. A comatous 39-year-old female was admitted to emergency room 6 hours after she swallowed 90 gm of acetic acid. She was treated with gastric lavage but she was expired 9 hours after swallowing acetic acid. She was consulted to Department of Forensic Medicine of Kyungpook National University School of Medicine. She was grossly icteric and livor mortis was generally dark red. External wounds were 10 hemorrhagic lesions with 5 x 3.7cm and 3 x 2.8cm on the left arm and hand dorsum and facial abrasions. Internal gross examination revealed several purpural lesions in the gastric serosal surface and greater omentum. Microscopically, the stomach showed diffuse mucosal coagulation necrosis and intravascular hyalinized or fibrinoid thrombi in submucosal blood vessels. Liver showed necrosis of periportal area (zone I) and intracellular cholestasis around the central vein. Sections from renal tissue frequently show hemoglobin casts in the tubules and RBCs in the Bowman's capsules. Acetic acid of a remnant bottle, sampled blood and bloody necrotic tissues in the stomach were toxicologically examined in National Science Laboratory. The purity of ingested acetic acid is 98%, the concentration of acetic acid ion in blood is 734ppm and the content in gastric juice is 0.09%. In patients after acetic acid ingestion, DIC is most probably caused by procoagulants, produced by extensive acid-induced necrosis of the upper gastrointestinal tract. In this case, several purpural lesions were revealed on the arm, around facial abrasion and intravenous injection sites of the wrists. These are important to differentiate with contusion because she was battered before acetic acid ingestion. Purpurae in DIC are poorly demarcated, dark purple elevations with spreading margin but subcutaneous hemorrhage in contusion is grayish black or dark red with well demarcation (Table 2). But careful examination should be considered because traumatic hemorrhage is also exaggerated and mixed in DIC. (The Korean Journal of Legal Medicine)

정상심장을 가진 영아에서 발생한 대동맥판막의 심내막염 1례

이동석,김두권,최성민,배한임 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

감염성 심내막염은 심장내의 판막이나 심내막을 침범하는 염증성 질환으로 주로 선천성 심질환을 가진 환아에서 호발한다. 최근 진단술의 발전과 고위험군의 증가로 그 빈도가 점차 늘어나고 있다. 특히, 신생아나 영아에서 발생율이 증가하는 것은 혈관내 유치삽관의 빈도가 늘어나고 침습적인 진단 방법이 증가와 관련이 깊은 것으로 생각된다. 최근 저자들은 특별한 심질환이나 혈관내 유치삽관의 과거력이 없는 3개월 된 영아에서 대동맥 판막에 발생한 감염성 심내막염 1례를 경험하였기에 문헌 고찰과 보고하는 바이다. Infective endocarditis is one of the most dreaded complications of structural heart disease.Although mortality rate are declining, mortality and morbidity are high. Children with underlying cardiovascular disease develop infective endocarditis more commonly, but in recent years incidence is increasing in neonates and infants without structural heart disease. The main risk factors are indwelling catheters and invasive procedures. We report a case of infective endocarditis on left coronary cusp of aortic valve in a 3-Month-old girl with

자궁내막증 백서모형에서 Danazol과 Decapeptyl의 치료효과에 관한 연구

황선보,이민석,심재현,김동훈,배한익 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

본 연구의 목적은 장간막에 자궁내막 조직을 자가이식하여 수술적으로 유도된 자궁내막증 백서모형에서 자궁내막증의 치료를 위해 danazol과 decapetyl의 치료효과를 평가하는 것이다. 백서(n=48)들은 무작위적으로 정상대조군(n=12)과 수술적으로 유도된 자궁내막증군(n=36)으로 구분하였다. 후자는 비치료군과, danazol 치료군과 decapeptyl 치료군으로 세분하였다(각 군의 n=12). Danazol(8mg/일)은 수술후 4째주부터 구강을 통해 투여되었다. Decapeptyl(0.2mg/2주)은 근주하였다. 처음투약후 10일, 20일, 40일, 60일째에 각군의 2마리의 쥐를 희생시켰다. 저자들은 자궁내막증 이식체와 난소의 크기를 측정하여 다음의 결론를 얻었다. 1. 자궁내막증 이식체의 크기는 비치료군에 비해(3.91±1.08mm) danazol 치료군과 decapeptyl치료군에서 (각각2.28±0.17mm 과 2.78±0.97mm), 현저히 감소되었다(p<0.01). 2. danazol과 decapeptyl 두 치료군에서 장기치료가 단기치료보다 자궁내막증 이식체의 크기를 감소시키는데 더 효과적이었다(p<0.01). 3. 난소의 크기는 정상대조군과, 비치료군과 decapeptyl 치료군에서 유의하게 차이를 보이지 않은데 반해(각각 4.46±0.85mm, 4.77±0.82mm과 4.97±0.92mm), danazol 치료군에서는 유의하게 감소하였다(3.97±0.63mm) (p<0.63mm). 백서모형에서 수술적으로 이식된 자궁내막조직의 성장과 발달은 자궁내막증의 병인 이해와 신약개발에 유용한 연구모델을 제공할 수 있을 것 이다. The purpose of this study was to surgically induce endometriosis in the rat by autotransplanting endometrial tissue to the mesentery and to evaluate the efficacy of danazol and decapeptyl for the treatment of endometriosis. Rats(n=48) were randomly assigned to normal control group(n=12) and surgically induced endometriosis group(n=36). The latter was further divided into the untreated, danazol treated and decapeptyl treated groups (n=12 for each group). Danazol(8mg/day) was orally administrated from 4weeks after operation. Decapeptyl(O.2ml/2weeks) was injected intramuscularly. Two rats of each group are sacrificed on the 10th, 20th, 40th, 60th, 80th and lOOth day after the first drug administration. We measured sizes of endometriotic implants and ovaries. The results were as follows; 1. The sizes of endometriotic implants were significantly decreased(P<O.Ol) in the danazol and decapeptyl treated groups (2.28±O.71mm and 2.78±O.89mm, respectively) compared with untreated group(3.91±l.08mm). 2. Long term treatment was more effective than short term treatment in decreasing the size of endometriotic implants in both danazol and decapeptyl treated groups(P<O.Ol). 3. The size of ovaries was not significantly different among the normal control, untreated and decapeptyl treated groups(4.65±O.83mm, 4.77±O.82mm and 4.97±O.92mm, respectively) but was significantly decreased(P<O.Ol) in the danazol treated group(3.97±O.63mm). The successful growth and development of surgically transplanted endometrial tissue in the rat may offer an useful research model that can be used to understand pathogenesis of endometriosis and to explore new drug therapies.

The Status of Pathology Specimen Bank in Other Countries

Bae, Han Ik,Yoon, Ghil Suk 대한병리학회 2005 Journal of Pathology and Translational Medicine Vol.39 No.6

Pathology specimen has been collected for purposes of education and research, particularly with respect to basic, developmental and translational studies in many areas of cancer research including molecular biology, immunology, and genetics. Even though no policy or ethical guideline drafted to regulate research tissue bank in Korea, advanced countries has been concerned ethical issues in the collections, storages, specimen transports and informatics for pathology specimen bank. Informed consent and confidentiality for protection of personal data records, which can be directly or indirectly associated with linked data from the donors' point of view, are the key to banking all over the world. The institutional review board (IRB) is important to ensure the scientific and ethical quality of pathologic specimen research. Increasing molecular genetic testing is also resulting in an increased demand of quality control for high quality nucleic acids. Most recently, the use of stored human tissue for education and research has become an object of increased ethical concern in Korea. Korean Association of Pathologists (KAP) has in urgent need of the policies and a standardized operating procedure, regulating a good collection practice of pathology specimen bank.