새로운 Acetylcholinesterase inhibitors의 합성

최순규,김형민,조승환,최학기,박유미,이용균,정대일,김인식,한정태 동아대학교 부설 기초과학연구소 2004 基礎科學硏究論文集 Vol.21 No.1

노인성 치매의 일종인 alzheimer's disease의 효과적인 억제제를 합성하기 위해 우리는 분자 모델링에 의한 가장 적합한 물질인 m-[(N,N,N-trimethylammonio)phenyl]boronic acid를 합성하였다. 출발물질인 3-aminophenylboronic acid monohydrate의 경우 boronic acid의 작용기인 hydroxyl group을 protecting시킴으로써 반응의 안정성을 기하였다. Quarternary ammonium salt는 과량의 methyliodide와 염기 촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시켜 상당히 높은 수율을 얻을 수 있었다. 또한 과량의 methyliodide와 염기촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시킨 결과 boronic acid의 protection없이도 안정하게 반응이 진행되어짐을 확인할 수 있었다. In order to syntheisize a effective inhibotor for alzheimer's disease, we synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 which is designed by molecular modeling form. We protected the hydroxyl group of 3-aminophenylboronic acid monohydrate 1 with ethlyne glycol to remove the reactivity if hydroxyl group. To synthesize m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4, we reacted 3-aminophenylboronic acid monohydrate 1 with ezcess methyl iodide and potassium hydrogen carbonate as a base-catalyst in methanol. but On executed reaction without protection on hydroxyl group, we found out the result that the hydroxyl group of boronic acid group at 3-aminophenylboronic acid monohydrate 1 didn't react with excess methyliodide. Synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 is in progress about biological tests as a plausible acetylcholinesterase inhibitor.

임신중 우측난소의 자궁내막장종의 성장과 파열의 1례

이종학,홍순도,남상욱,최종호,허광현,박일영 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.2

계명의대 산부인과에서 35세된 경산부에서 임신과 동반된 우측 난소의 자궁내막낭종의 성장과 파열을 경험하였기에 이에 문헌고찰과 함께 보고하는 바이다 Pregnancy had long been considered to have beneficial effect on endometriosis. During the pregnancy, extrauterine endomertrial tissues did not growth or enlarged because of physiologic amenorrhea and producing hormonal effect. However, we experienced a patient who underwent emergency exploratory laparotmy at gestation week 34/4 for rupture of an ovarian endometriotic cyst. The patient had a Cesarean section delivery of a 1,960gm female baby, who died at 1st day of life.

最近 3年間 本敎室에서 經驗한 腫瘍 253例에 對한 臨床病理組織學的 考察

李揆鶴,高永春,李廷鎭,朴鍾雲,李鍾元,林鍾福,林春悅,朴順道 최신의학사 1964 最新醫學 Vol.7 No.4

민속놀이와 체육의 관계

이병익,이재학,박순진 龍仁大學校 武道硏究所 1999 武道硏究所誌 Vol.10 No.1

The purpose of this study is to serve as a basis for the spread and development of playing culture that is suitable for our bodies, by examining the relationship between folk play and physical eucation, by exploring the potentiality of folk play's development into one of the traditional physical eucation and by offering Korean physical eucation history a nwe domain to e studied in the future. To attempt a grafting between folk play and physical eucation, folk play is largely classified into two categories, entertainment and martial play, and the research domain of physical eucation history is divided into entertainment and martial arts. The entertainment is again divided into Taedong, group and individual play, and martial arts is classified into the traditional, training and tounarment ones. Studies on Taedong play is very poorly carried out in physical eucation history. This kind of play must be carefully studied, because it is one of the traditional physical activities to be appropriate for not only individual harmony in group life but also collective harmony and unity, which are one of the pysical activities targets the modem physical eucation intends to achieve and its restoration is urgently required, as one of practical physical eductio. The play is considered as a pure play that people amused Themselves kill time. The martial play contained the characteristics of play, in which people enjoyed pitting their strength against each other in a specific form. The entertainment, martial play, contention and exercise sometimes shared the same quality, according to the environmental factors of the times. The environmental factors of the times made the feature of entertainment or martial play be sometimes strong or ometimes weaker. The entertainment hadn't the form of play at first and passed through pitting against each other according to instinct, faih or ceremony. As days went by, that reached the stage of play with a stronger characteristics of amusement, and in turn, that play developed into a specific form of martial play. The characteristics of amusement still existed in that millitary play, The martial play also lost the firs feature of martial play by the environmental factor of the times, and converted into martial arts, which had a specific regulation and needed some instruments, techniques, knowledge or durability. When it come to the relationship between folk play and physical education, folk play can be, from a viewpoint of physical education, said to cultivate national spirits and offer an opportunity of unity through the traditional physical actitives, and those activites are based on the traditional view and thoughts of the body. The folk play was more than a general leisure activity, including the characteristics of both entertainment and martial play. The entertainment possessed the quality of pure play in a contention form, and the martial play developed into martial art of tounament or training type, losing the guailty of play gradually.

백서에서 신 허혈성 손상에 미치는 칼슘 길항제의 효과

문철웅,정종훈,박천국,이승일,배학연,장경식,김만우,정춘해,홍순표,이병래,김호중 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Renal ischemia is one of the most common causes of acute renal failure. Four factors related to the pathogenesis of acute renal failure are vasoconstriction, decreased glomerular filtration rate, tubular back leak of filtrate, and intratubular obstruction. The cellular response to renal ischemic insults include decreased content of adenosine trihosphate, lipid peroxidation induced membrane degradation, alteration in cellular pH, and calcium or phospholipase induced mitochondrial dysfunction. Much attention has been given to the role of increased cellular calcium as a pathogenetic contributor to cell injury during ischemia. Author studied the protective effects of calcium antagonists on cellular injury during renal ischemia in rat. To investigate the protective role of these agents, author measured the amount of malondialdehyde(MDA) and the enzyme activities of free radical scarvengers-superoxide dismutase(SOD), catalase and glutathione peroxidase from non-pretreated group and calcium antagonists pretreated groups in control, ischemia and reflow subgroups. The results were summerized as follows: 1) The amount of MDA in non-pretreated group was higher in the reflow compared with the control(<p<0.01). But, in all pretreated groups, there was no statistically difference in the amount of MDA. 2) The SOD activity in non-pretreated group was lower in both the ischemia and the reflow compared with the control (P<0.05). But, in both verapamil and trifluoperazine-pretreated groups, there was no statistically difference in the SOD activity. 3) Both catalase and glutathione peroxidase activities in non-pretreated group were lower in both the ischemia and the reflow compared with the control (P<0.05). But in all pretreated groups, there was no statically difference in both catalase and glutathione peroxidase activities. These results suggest that free radical mediated ischemic injury by renal artery clamp in rat can be protected by intraperitoneal pretreatment with calcium antagonists. As trifluoperazine has a protective effect in renal ischemia, the calcium activated calmodulin dependent enzyme may play a role in renal ischemic injury.

정신보건법의 주요 쟁점 조항에 대한 선진국과의 사례 비교

홍진표,황순찬,박수빈,서동우,정은기,김진학,박종익,안주연,김수정,장홍석 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.2

Objectives The Mental Health Act is an initiative aimed at changing and shaping mental health services and protecting human rights of persons with mental disorders. Since the Mental Health Act was legislated in 1995, four amendments have been made according to the issues that arose from public concerns. However, there are still many debates about the human rights protection of the mentally iII. This study aimed to provide information regarding major aspects of the Mental Health Act by comparing them among several developed countries. Methods Current Mental Health Acts of the state of Michigan in the United States, Scotland in England, the state of Victoria in Australia, and Japan were reviewed. Issues regarding the Korean Mental Health Act were collected from seminar materials, news media contents, and mental health professionals Results The definition of subjects in Korean Mental Health Act was more inclusive than other countries and was derived from a medical classification of mental illness. Family members or guardians were granted important responsibilities for deciding the involuntary admission of mentally ill patients in Korea and Japan. In Western countries, Mental Health Review Tribunals or courts have the primary responsibility for important decisions about mentally ill patients. The regulation of immediate dis- charge after request by voluntarily admitted patients was not enacted in all countries except Korea. The mandatory procedure for involuntary admission in Western countries includes an individual case review with personal interview by a Mental Health Review Tribunal or court. Conclusion The Korean Mental Health Act appears to meet the basic standards of Guidelines from international organizations. Our traditional culture and inherent health systems seem to influence the legal regulation of mental health service and might be related to the problems of human rights protection of mentally ill patients in Korea.

난황낭종 환자에서 보존적 수술 및 항암 화학요법 후 성공적인 자연임신

정은환, 홍승화, 박연진, 지일운, 김학순 충북대학교 의과대학 충북대학교 의학연구소 2012 忠北醫大學術誌 Vol.22 No.1

침윤성 난소암의 경우 생식력의 보존이 중요한 도전이라고 할 수 있다. 20대 중반의 여성에서 거대 한 난황낭종이 발견되어 생식력의 보존을 위해 보존적 수술과 복합항암화학요법을 시행한 후 임신 및 출산에 성공한 증례를 경험하였기에 문헌고찰과 함께 보고한다.

출생 후 요관방광이음술로 치료받은 딴곳요관낭종 태아

지일운, 홍승화, 박연진, 정은환, 김학순 충북대학교 의과대학 충북대학교 의학연구소 2011 忠北醫大學術誌 Vol.21 No.2

-본문참고-

자궁외임신 216례

남상욱,송재경,최종호,홍순도,이종학,허광현,박일영 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3

This study was undertaken to review the case series of 216 ectopic pregnancies admitted to the Department of Obstetrics and Gynecology, Pohang Sunrin Hospital from January, 1990 to December, 1991. The incidence of ectopic pregnancy was relatively high, being found to be 1 in 34.4 delivery cases. On the symptomatology, low abdominal pain was encountered in 96.8 percent, amenorrhea in 93.5 percent and vaginal bleeding in 16.2 percent in order. The fallopian tube was the most frequently, being found to be 98.6 percent, followed by the ovary with 0.9 percent and the cervix with 0.5 percent.

農村에 있어서의 母子保健實態 現況

李性寬,金斗熙,金希敎,洪淳鎬,芮旻海,鄭鍾學,申在鉉,朴在錫,申泰圭 慶北大學校 醫科大學 1972 慶北醫大誌 Vol.13 No.2