운동처방 유형이 중년여성의 혈중지질 및 체지방량에 미치는 영향

정혜윤,임달식,박후성,전용욱,김재호,노재성 朝鮮大學校 스포츠科學硏究所 2007 스포츠科學硏究 Vol.18 No.-

This study was to examine the effects of Aerobic exercise program of body fat and mood state for women with obesity, and to apply this exercise program to the treatment and the promotion of health maintenance of obese women as a nursing intervention. Date were analysed by SPSS Win 12.0 program. Descriptive statistics used on demographic data of the participants was analysed in real number and percentage, body fat and the difference in mood state before and after the walking exercise program were analysed using the paired t-test . The results of this study were as follows: With administration of this program, so, the Aerobic exercise program showed and effect of the decrease for women with obesity and it also had an effect on the decrease of percentage of body fat for them. According to the results of this study, the walking exercise program as a nursing intervention had an effect of the body fat for women with obesity. however, the program did not prove the statistical significance for the change of mood state. Aerobic exercise program showed that effect is though fat woman's sieve local rate, Decrease that T-C keeps in mind from exercise rakeful and great kindness change to 207.8±23.2 as statistical difference that appeared, and decreased from great kindness change to shame upper HDL-C's exercise ago but keep in mind as statistical appear, Is looked that decrease that change before LDL-C's exercise keeps in mind as statistical by 138.1±20.5 appears. When see on the basis of result of something wrong continuous and regular abortion small success exercise because have middle age woman's physical strength E according to exercise form health promotion plan though to effect by Iteulgeot is considered, and decrease to note sieving amount power of a number and sieve local amount and appeared that abortion small success exercise exerts more affirmative effect.

경부 림프절 및 비강의 양성 림프조직에서 Epstein-Barr Virus 유전자의 검출

고영혜,박찬금,이중달 한양대학교 의과대학 1995 한양의대 학술지 Vol.15 No.2

Recent studies have suggested that nasal NK/T cell lymphoma have strong association with Epstein-Barr virus(EBV). This study was performed to determine whether the association of EBV with NK/T cell lyphomas was ascribed to the immunophenotype and location or not. A sensitive in situ hybridization technique was used to detect EBV encoded RNA (EBER) in paraffin sections from 38 benign lymph nodes, 10 nasal mucosa and 12 adenoids and tonsils. Among 60 cases, 7(11.7%) were EBER-positive and their distribution was lymph node in 6 cases, adenoid in 1 case but none in the nasal cavity. Double in situ hybridization and immunhistochemistry revealed EBER-positive lymphocytes were B-lineage in 4 cases and T-lineage in 2 case. In one case, determination of lineage was failed. From these results, we concluded that high association between nasal NK/T cell lymphomas with EBV might not be simply ascribed to location or immunophenotype of the lymphoma.

首都圈 衛星都市의 住民福祉向上을 위한 市議會와 行政機關의 役割에 관한 硏究 : Centering Around Koyang-Shi Kyung Ki-Do Area. (京畿道 高揚市를 中心으로)

윤석달,박오화,함영훈,황정룡,허희영 한국항공대학교 1993 論文集 Vol.31 No.-

地方化時代의 到來로 高揚市는 많은 變化가 豫想되고 있다. 1980年부터 繼續的으로 論議되던 地方自治의 問題가 지금은 現實化되어 1991年 4月에는 基礎地方自治의 議會를 構成하고 6月에는 廣域自治團體의 議會를 構成하였고 머지않은 將來 에 地方自治團體의 長을 選出할 豫定이다. 앞으로 많은 施行錯誤가 있을 수 있겠으나 地方自治時代에 돌입한 것은 누구 도 否認 할 수 없는 사실이다. 1997年경의 住民構成은 1990年代初期의 高揚市에 居住하고 있던 原住民과 一山을 포함한 新高揚 開發地域에 90萬의 新 入住者로 구성될 것이며, 이러한 高揚市 住民構成의 變化는 地方自治에 커다란 衝擊要因으로 작용될 것이다. 新.原住民의 要求를 調和하는 問題는 여러 形態로 나타날 수 있으나 住民福祉라는 側面이 매우 강하게 대두될 것이다. 高揚市의 福祉活動은 生活保護者들을 위한 특수한 경우를 제외하고는 거의 전무한 상태이다. 地方自治制度가 어느정도 安定的인 국면으로 접어들면, 地域的 次元에서 市民 모두를 위한 福祉活動이 深度있게 展開되어야 할 것이다. 市行政機 關과 市議會는 兒童福祉, 婦女福祉, 老人福祉및 醫療福祉에 대한 現況울 把握하고 이에 대한 해결의 優先順位를 결정하 여 다가오는 人口의 增加에 따른 福祉需要를 충족시켜 나가야 할 것이다. 福祉需要에 대한 優先順位를 硏究者들이 제시하여 보면 託兒施設과 더불어 綜合病院施設을 擴充하여 市民들에게 奉仕 하는 태세를 體系化하여야 할 것이며 그밖에는 施設을 擴充하는 方式보다는 年齡과 性別 및 職業 등의 基準에 맞게 "프 로그램"을 積極的으로 開發하는 努力이 경주되어야 할 것이다. 그러으로써 量的인 意味에서 뿐만이 아니라 質的인 意味 에서 福祉活動을 展開할 수 있는 基盤을 造成할 수 있을 것이다. It is expected that Koyang City have lots of changes according to the emergence of Decentralization era. Nowdays local self-government has been realized since its disscussion in 1980. On april, 1991, the assembly of basic self-government was established, and the assembly of extensive self-government constructed on june, 1991. The chairman of local-government assembly is supposed to be elected in the new future. None can deny the beginning of local-government era inspite of potential trial and errors. Population structure in 1997 is expected to be composed of the existing civilians of Koyang City in early 1990's and about 0.90millions of new comers in new cities including llsan area, and he change of the city population will significant impacts on the self-government scheme of Koyang City. The problem to coordinate desires of existing civilians and that of new comers might be embodied in many kinds of aspects, but welfare-raising will be strengthed first of all. Existing welfare programme of Koyang City dosen't show any signigicant activities except the case of Green Card programme. It is desirable that whole-sideed welfare programme be perfomed by local levels in the stage of staionary self-government systems. Administrative institutions and assembly of city should survey and research the present situations of children welfare, female welfare, the old age welfare, and medical welfare, and decide their priorities to meet increasing desires coming from rapid increase of city-population. We, researchers, propose several outstanding problems by priority as follows; to expand medical institutions and public nursery schools accompanies by strenthening the attitude of government employees for public service, to develop various programmes in order to activate many exiting institutions more efficiently rather than to build new institutions needed, in consideration of ages, sex and occupations of their users. If these propositions accomplished the welfare programme will have cornerstone to enrich its activities as well as activities as well as enlarge it bounderies.

실험적 간암의 전암병변에 관한 면역 조직화학적 및 유세포 계측 연구 : C-ras, C-erb B2, Proliferating Cell Nuclear Antigen 및 C-myc의 변동 Expression of C-ras, C-erb B2, PCNA, and C-myc

이중달,김종만,고영혜,김재영 한양대학교 의과대학 1994 한양의대 학술지 Vol.14 No.1

To investigate the role of oncogenes in the hepatocarcinogenesis, author had undertaken an experimental study of hepatic carcinogenesis induced in 50 rats by feeding 2-acetylaminofluorene(2-AAF) in diet. The animals were sacrificed at 2, 4, 6, 8, 12, 16, 27, and 36 weeks after 2-AAF administration, and each liver was immunostained with monoclonal antibodies for c-ras, c-erb B2, and proliferating cell nuclear antigen(PCNA), and analysed by flow cytometry for c-myc oncoprotein. 1.The control livers were negative for expression of c-ras, c-erb B2, and c-myc oncoprotein, and positive for PCNA in 0.2% of hepatic cells. 2.The oval cells were markedly proliferated at 4 weeks after 2-AAF administration. They eventually became differentialted into bile ductular cells and small hepatocytes. 3.The oval cells and small hepatocytes showed high positive rate for PCNA with strong reaction for c=ras, c-erb B2, and c-myc oncoprotein whereas bile ductular cells failed to react for c-ras and c-erb B2. 4.Most hepatocytes in regenerative nodules lost the expression for c-myc, c-ras, and c-erb B2, although the oncoproteins persisted in some hepatocytes in the nodules. 5.Hepatocellular carcinoma of trabecular type and undifferentiated carcinoma were induced by 36 weeks after 2-AAF administration. The undifferentiated carcinoma cells expressed both PCNA and c-erb B2 oncoprotein rather strongly. Above results suggested that in the early phase of the experiment, c-ras, c-erb B2, and c-myc oncogenes were activated and stimulated to proliferation makes the oval cells to e transformed into malignant cells. However, the findings that most oval cells were differented into reversible cells in regenerating nodules suggested that overexpression of these oncogenes might not be sufficient to obtain irreversible phenotype of malignant cells. Also strong expression of oncoproteins and high PCNA positive rate in small hepatocytes and in a few cells of the hyperplastic nodules suggested that the pathway of the cancer might go through the development of oval cells to small hepatocytes to nodules and eventually to cancer. However, the results that most hepatocytes in the nodules lost oncoproteins and development of undifferentiated carcinoma in the absence of nodule formation suggested that the hepatocellular carcinoma arose from oval cells directly without a morphologic intermediate.

수학교육에서 평가결과에 기초한 개별화 학습과정의 위계도

변두원,정인철,박달원,노영순,김승동 한국수학교육학회 2004 수학교육 Vol.43 No.1

Comparing to the other subject, hierarchy among mathematical contents is strong from the perspective of knowledge order as grades go up. That is, the knowledge that students already have learned, are learning and will learn are closed related from grade to grade. We expect students to be proactive and creative in studying mathematics, which is the goal of 21th century, analyzing their knowledge structure based on the hierarchy of knowledge through assessment. Especially, using computer system, we provide students with substantial feedback for the assessment as well as objective validity is increased along with speedy and exact process in a bid to help students' mathematical understanding grow. This paper seeks to analyze the assessment data by applying knowledge spaces to computer system and develops efficient methods based on the analyzed results, to diagram each student's knowledge structure.

자궁원발성 비호지킨 악성림프종 -3예 보고-

박찬필,고영혜,이중달,박문일,김경태,조삼현 대한병리학회 1995 Journal of Pathology and Translational Medicine Vol.29 No.3

2-Acetylaminofluorene으로 유발된 실험적 간암의 세포 동태학적 연구

금주섭,고영혜,이중달 한양대학교 의과대학 1995 한양의대 학술지 Vol.15 No.2

Kinetics of hepatocytes in various precancerous and cancer iesions during hepatocarcinorenesis was evaluated in 38 Sprague-Dawley rats fed with 0.075% 2-acetylaminofluorene diet. The rats were sacrificed after 4, 7, 10 days. 2, 3, 4, 6, 8 weeks, and 3, 4, 5, 6, 7, 8 months of the experiment. The lesions were divided as altered cell lesions (clear cell focus, acidophilic cell focus, and basophilic cell focus). regenerating nodules. neoplastic nodules, and hepatocellular carcinomas. Cell kinetics was studied by intraperitoneal bromodexyuridine(BrdU) injection 2 hours before sacrifice. After detection of the BrdU-incorporated nuclei with monoclonal antibody kit, the BrdU labelling index(BLI) was measured as percentage of BrdU labelled cells among about 1000 cells. The liver cells in the altered cell lesions showed significantly increased BLI(clear cell 1.66: acidophilic 2.39: basophilic 2.41) in comparion with normal control(0. 18) or non-lesional hepatocytic lobules (0. 47), and lower BLI than hepatocellular carcinoma(8.61∼27.07) (P<0.05). Regenerating and neoplastic nodules did not differ in their BLI (1.54 and 1.70), and were significantly lower in their proliferating kinetics than acidophilic or basophilic cell foci (P<0.05). It was suggested from this study that the altered cell lesion should be true premalignant lesion, which was composed of at least initiated cells by the chemical carcinogen. The basophilic and acidophilic foci in altered cell lesions were suggestive of close correlation with the hepatocellular carcinoma in that they had greatest proliferative cell kinetics of all the lesions occurred before cancer developed.

가공 송전선의 부식진단시스템 개발

김성덕,심재명,정원일,장석구,이승호,김영달 大田産業大學校 2000 한밭대학교 논문집 Vol.17 No.1

A diagnosis method to inspect deterioration in overhead ACSR conductors is discussed in this paper. Corrosion would be occurred by various and complex factors such as atmospheric indices, installation environment and metallic configuration, but must of corrosions are mainly due to atmospheric corrosion, galvanic corrosion and crevice corrosion. Such corrosion in ACSR would lead to be zinc loss of galvanized steel strand and reduction of cross section area of aluminum strand and it may be mechanical strength of power conductor in service to reduce. Global corrosion can be treated as average corrosion occurring on the conductor and it would appear to any material variations by the elapsed years of the conductor in the atmosphere. Therefore, as estimating the loss rate of tensile strength of aged conductor corresponding to the elapsed years, it would be possible to quantify global corrosion indirectly to a prediction function. Through such results, loss degree for ACSR 97[mm2] is classified to 4 ranges. i.e., no loss, possible loss, partial loss and sever loss. Both local and global corrosion could not be detected by visual inspection, but we proposed a corrosion detector system using a solenoid eddy current sensor in order to inspect such corrosion for old conductor. Corrosion detecting system is constituted to a corrosion detector and a ground station controller. Corrosion detector consists of sensor coil and sensing head, signal processing unit, data communication system, motor driver and controller, u-processors and power supply. After considering operation and manipulation in the field, motor, battery and wheels were selected and designed in order to reduce the weight of corrosion detector. Programs for u-processors, measurement program operated in a PC were also developed. Before testing the corrosion detector in the field, several experiments were carried out in the laboratory for artificial corroded samples. Sensor performance, mechanical tests such running ability and weight, and RF data transmission as well as measurement program were examined. After testing a simple corrosion detector system in the laboratory, several filed tests were carried out in practice transmission lines installed in domestic area. Finally, the suggested corrosion detecting system shows an effectiveness to detect local corrosion in acted conductor in practice.

2-Acetylaminofluorene으로 유발된 실험적 간암의 TGF-a 및 EGF발혈에 관한 연구

박정희,고영혜,이중달 한양대학교 의과대학 1995 한양의대 학술지 Vol.15 No.2

Transforming growth factor-α(TgF-α) and epidermal growth factor (EGF) are growth factors acting on proliferation and differentiation of cells and expressed in various types of cancer. TGF-αmay be a physiological regulaor during liver development and liver regeneration in injured liver and known as increased in hepatocellular carcinoma. To investigate the role of TGF-αand EGF in hapatocarcinogenesis, author had undertaken an experimental study of hepatic carcinogenesis induced in 50 rats by feeding 2-acetylaminofluorene(2-AAF) in diet. The animals were sacrificed periodically after 2-AAF administration, and each liver was examined grossly and microscopically and immunostained with monoclonal antibody for TGF-αpolyclonal antibody for EGF. 1. At the third week of the experiment, the oval cells were markedly proli ferated and extended from the periphery to central areas of hepatic lobules. The altered hepatic foci, including acidophilic cell area on the fourth week and clear cell area on the second month were noted. At the third month, hype rplastic nodules developed. At the seventh month, one case of hepatocellular carcinoma and angiosarcoma were noted. At the eighth month, four cases of hepatocellular carcinoma of trabecular type were noted. Among these, three cases of squamous cell carcinoma on the neck skin occurred. 2. The control livers expressed only a few scattered hepatocytes positive for TGF-αin hepatic lobule. At the third week after 2-AAF administration, the hepatocytes exihibiting positive reaction were more widely distributed along the portal areas and around central veins. At the third month, several of the hyperplastic nodules showed strong to moderate positive reaction for TGF-α. The relationship between the TGF-αexpression and cytomorphologic changes in nodular hepatocytes was not present. All of the hepatocellular carcinoma cells and cells in the neighboring nodules at the seventh and eighth months expressed TGF-α. Oval cells were negative for TGF-αand bile ductular cells showed only focal positivity. 3. EGF was negative in cells of the centrol livers and most experimental livers. At the eighth month, one case of hepatocellular carcinoma and tree cases of squamous cell carconoma showed positive reaction for EGF. Above results suggest that TGF-α, may play a role in hepatocarcinogenesis by the mechanism that TGF-αacts as promotor for the transformation of initiated hepatocytes by 2-AAF in multistep of hepatocarcinogenesis.

사무직 근로자에서 직무스트레스 및 VDT작업과 목·어깨 근골격계 증상과의 관련성

이의철,김환철,정달영,김동현,임종한,박신구 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.3