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진행성 위암과 동반된 후복막 섬유화증 7예의 임상적 고찰
장재영,천영국,최우봉,김진오,조주영,이준성,이문성,심찬섭 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1
Background/Aims: Retroperitoneal fibrosis is a fibrosing disease process which frequently develops ureteral obstruction. Malignant retroperitoneal fibrosis has been reported that various types of cancer including cancer of the breast, stomach, prostate, lung, cervix, uteri, colon, pancreas, ovary, and even Hodgkin's disease. While the pathogenesis remains obscure, small foci of metastatic neoplasm in the retroperitoneal space can elicit a desmoplastic reaction in secondary form to malignancy. Methods: Recently we experienced 7 cases of retroperitoneal fibrosis with advanced gastric cancer. So, we report 7 cases of retroperitoneal fibrosis with clinical and radiologic characteristics. Results: The most common signs and symptoms were related irreversible renal dysfunction. The urologic finding noted medial deviation of the involved ureters and hydronephrosis Conclusions: Clinical manifestations are abdominal pain, back pain, hydronephrosis, and uremia. When sudden back pain and hydronephrosis develop in advanced malignancy, physicians should be considerd for retroperitoneal fibrosis.
Spontaneous Action Potential from Threadlike Structures on the Surfaces of Abdominal Organs
Cheon-Joo Choi,정종현,소광섭,류연희,류판동,박상현 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.58 No.4
A threadlike structure in the abdominal cavity closely resembled the primo vascular system (Bonghan system), which was proposed to be the anatomical reality of acupuncture meridians. The threadlike structure consisted of thread parts and nodes. The membrane potential of cells from the thread parts and the nodes was measured to investigate the electrophysiological characteristics of the cells and to verify the existence of excitable cells. To this end, an intracellular recording technique was applied to measure the action potentials. We examined approximately one hundred threadlike structures in order to measure the spontaneous action potentials. Interestingly, we succeeded in three cases, two of which were from thread parts and one from a node. Moreover, the shapes of the action potentials were very unique. Although the shapes of these three cases differed from one another, the full widths at half maximum (FWHMs) of the action potentials were tens of milliseconds for all three. The FWHMs were significantly different from those of a neuron, a skeletal muscle cell, and a cardiac muscle cell. This result suggests that these action potentials were measured from smooth muscle cells, secreting cells, or immune cells.
Hyung-Joo Choi,Hyojun Park,Bo-Wi Cheon,Kyunghoon Cho,Hakjae Lee,Yong Hyun Chung,염연수,Sei Hwan You,Hyun Joon Choi,민철희 대한방사선방어학회 2024 방사선방어학회지 Vol.49 No.1
Background: The gamma emission tomography (GET) device has been reported a reliable technique to inspect partial defects within spent nuclear fuel (SNF) of pin-by-pin level. However, the existing GET devices have low accuracy owing to the high attenuation and scatter probability for SNF inspection condition. The purpose of this study is to design and optimize a Yonsei single-photon emission computed tomography version 2 (YSECT.v.2) for fast inspection of SNF in water storage by acquisition of high-quality tomographic images. Materials and Methods: Using Geant4 (Geant4 Collaboration) and DETECT-2000 (Glenn F. Knoll et al.) Monte Carlo simulation, the geometrical structure of the proposed device was determined and its performance was evaluated for the 137Cs source in water. In a Geant4-based assessment, proposed device was compared with the International Atomic Energy Agency (IAEA)-authenticated device for the quality of tomographic images obtained for 12 fuel sources in a 14 × 14 Westinghouse-type fuel assembly. Results and Discussion: According to the results, the length, slit width, and septal width of the collimator were determined to be 65, 2.1, and 1.5 mm, respectively, and the material and length of the trapezoidal-shaped scintillator were determined to be gadolinium aluminum gallium garnet and 45 mm, respectively. Based on the results of performance comparison between the YSECT.v.2 and IAEA’s device, the proposed device showed 200 times higher performance in gamma-detection sensitivity and similar source discrimination probability. Conclusion: In this study, we optimally designed the GET device for improving the SNF inspection accuracy and evaluated its performance. Our results show that the YSECT.v.2 device could be employed for SNF inspection.
OB-15 : Clinical characteristics of pregnancies complicated by congenital myotonic dystrophy
( Cheon Ga Yee ),( Na Ri Shin ),( Suk Joo Choi ),( Soo Young Oh ),( Cheong Rae Roh ),( Jong Hwa Kim ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: The objective of this study was to investigate the clinical characteristics of pregnancies complicated by congenital myotonic dystrophy diagnosed in our institution. 방법: We retrospectively reviewed cases with congenital myotonic dystrophy of mothers and newborns admitted NICU and diagnosed after birth between July 2004 and May 2014 (6 inborn and 5 outborn babies). Clinical features including maternal history of infertility and prenatal ultrasonographic findings were reviewed from medical record available. The results from myotonic dystrophy protein kinase (DMPK) gene mutation test with the number of CTG repeat expansion from mothers and neonates were also assessed. 결과: All mothers were not aware of their own myotonic dystrophy traits before their pregnancies. History of infertility followed by assisted reproductive technology accounted for 57.1% (4/7). Median maternal age was 32 years old (range, 29-40). Median gestational age at delivery and neonatal birth weight were 35+6 week (range, 29+1-38+5) and 2850gm (range, 1380-3600) respectively. Most distinctive prenatal ultrasonographic finding was severe polyhydramnios (66.7%, 4/6) with median AFI of 43 (range, 37-66). In 37.5% (3/8) cases, decreased fetal movement was evident in prenatal ultrasound exam. Median hospital stay in NICU was 37 day (range, 5-397) and there was one infant death, which was complicated with hydrops. One-minute Apgar score <4 was 44.4% (4 /9) and five-minute Apgar score <7 was 66.7% (6/9). Median number of CTG repeat of mothers and neonates were 400 (range, 166-1000) and 1300 (range, 700-2700), respectively. 결론: Our data suggests that severe polyhydramnios with decreased fetal movement in pregnant women especially with a history of infertility requires a differential diagnosis of congenital myotonic dystrophy.
Choi, Suck-Chei,Lee, Eun-Kyung,Lee, Sung-Ga,Chae, Soo-Cheon,Lee, Myeung-Su,Seo, Geom-Seog,Kim, Sang-Wook,Yeom, Joo-Jin,Jun, Chang-Duk The Korean Association of Immunobiologists 2005 Immune Network Vol.5 No.4
Background: We examined global gene expression profiles of peripheral blood mononuclear cells (PBMCs) in patients with ulcerative colitis (DC), and tested whether the identified genes with the altered expression might be associated with susceptibility to UC. Methods: PBMCs from 8 UC and 8 normal healthy (NH) volunteers were collected, and total RNAs were subjected to the human 8.0K cDNA chip for the micro array analysis. Real time-PCR (RT-PCR) was performed to verify the results of micro array. One hundred forty UC patients and 300 NH controls were recruited for single nucleotide polymorphism (SNP) analysis. Results: Twenty-five immune function-related genes with over 2-fold expression were identified. Of these genes, two chemokines, namely, CXCL1 and CCL20, were selected because of their potential importance in the evocation of host innate and adaptive immunity. Four SNPs were identified in the promoter and coding regions of CXCL1, while there was no significant difference between all patients with UC and controls in their polymorphisms, except minor association at g.57A>G (rs2071425, p=0.02). On the other hand, among three novel and one known SNPs identified in the promoter region of CCL20, g. -1,706 G>A (p=0.000000055), g. -1,458 G>A (p=0.0048), and g. -962C>A (p=0.0006) were found to be significantly associated with the susceptibility of Uc. Conclusion: Altered gene expression in mononuclear cells may contribute to IBD pathogenesis. Although the findings need to be confirmed in other populations with larger numbers of patients, the current results demonstrated that polymorphisms in the promoter region of CCL20 are positively associated with the development of Uc.