성인에서 Haemophilus influenzae 감염증의 임상양상과 미생물학적 특성

이종섭,황병연,정희진,김우주,박승철,이도현,이창규,신종희,황규잠,이영희 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.2

목적 : H. influenzae는 성인에서 흔히 호흡기 감염을 일으키는 균주로, 최근 ampicillin 내성 β-lactamase 생성 균주들이 지속적인 증가를 보이고 있어, 이에 국내 성인에서 H. influenzae에 의한 감염의 임상양상과 분리된 균주들의 미생물학적 특성을 조사하고자 하였다. 방법 : 1998년 3월부터 1999년 9월까지 고려대 구로병원에 내원한 환자중에서 H. influenzae가 분리된 68명을 대상으로 임상양상을 조사하고 항균제 감수성 검사를 시행하였다. 분리된 33주에 대해서 혈청형, 생물형, 세포외막 단백분석을 시행하였고, β-lactamase 생성여부에 따른 감염 환자군간 임상상 및 예후의 차이를 비교하였다. 결과 : 환자의 평균연령은 68세였고, 지역사회 획득감염이 전체의 85%를 차지하였다. 폐렴과 기관지염과 같은 하기도 감염이 전체환자의 75%를 차지하였고 분리 검체 역시 객담이 84%로 가장 많았다. 환자의 71%가 기저질환을 가지고 있었으며, 그 중에 만성 폐쇄성 폐질환, 심혈관 질환, 악성종양, 당뇨병이 대부분이었다. 혈청형으로는 nontypeable 형이 68%로 가장 많았고 b형은 한 예도 없었다. β-lactamase 생성율은 63.2%였고, β-lactamase 양성균주의 항균제 내성율이 음성균주에 비하여 높았으나 β-lactamase 생성 여부에 관계없이 cefotaxime, azithromycin, ciprofloxacin에 대하여 100%의 감수성을 나타내었고 cefaclor, cefuroxime에 대해서는 10% 이하의 낮은 내성율을 보여 이들 항균제들이 치료에 효과적일 것으로 사료된다. 세포외막 단백분석에서는 C형과 D형이 전체의 64%로 가장 많았으며, 혈청형과의 유의한 연관성은 보이지 않았다. 결론 : 성인에서 H. influenzae는 주로 만성 기저질환자에서 급성 호흡기감염 또는 만성 폐쇄성 폐질환의 급성 악화를 유발한다. 기존의 보고에 비해 β-lactamase 양성율이 증가하였고, 이에 따른 항균제 내성율도 증가하여 항균제의 선택에 유의하여야 할 것으로 생각된다. 세포외막 단백분석상 특정한 유형의 균주에 의해 감염이 집중적으로 발생하고 있어 향후 역학 조사의 도구로 이용할 수 있겠다. Purpose : H. influenzae is one of the common causative microorganisms of respiratory tract infections in adults. Recently. β-lactamase producing, ampicillin-resistant H. infiuenzae has become worldwide problem as well as in Korea. We studied to investigate the clinical features and microbiologic characteristics of H. infiuenzae infections in adults. Materials & Methods : From March 1998 to September 1999, 68 patients were enrolled in this study. Clinical features of H. infiuenzae infections were investigated, 68 isolates were subjected to the β-lactamase test, and 33 isolates were used for serotyping. biotyping, antibiotic susceptibility and outer membrane protein (OMP) analysis. Results : Mean age of study patients was 68 years-old and the acquisition rate in community was 85%. Pneumonia and bronchitis were the most common type of infection such as 80%, sputum was the most common clinical specimen for H. mQuenzae isolation. 70% of patients had chronic underlying diseases. Non-typeable strains were 68% and β-lactamase producing rate was 63%. There was no difference in the clinical features and prognosis of H. influenzae infection between the β-lactamase positivie and -negative groups. The susceptibility of cefotaxime, azithromycin, and ciprofloxacin was 100% and that of cefaclor, cefuroxime was under 10% in spite of β-lactamase positivity. In OMP analysis, C and D types were dominant (64%). Conclusion : H. influenzae caused acute respiratory infections in adults with chronic underlying disorders. This study shows higher β-lactamase producing rate and antibiotic-resistance rate than that were reported previously. OMP analysis shows that two major types of strains cause clinical infections intensively.

무전해도금법에 의한 Co-Mi-P 및 Co-Zn-P 합금도금층의 자기적성질에 미치는 합금성분 및 도금조건의 영향

이종섭,박병옥,윤병하 경북대학교 산업기술연구소 1991 産業技術硏究誌 Vol.19 No.-

Magnetic properties of Co-Ni-P film deposited from the electroless plating bath with pyrophosphate as a complexing agent were investigated. Deposition rate of Co-Ni-P alloy was faster than that of Co-Zn-P alloy. For Co-Ni-P deposits, the coercive force of deposits with thickness of 0.2㎛ was maximum with 910 Oe at 0.1 molar ratio of nickel to cobalt in the bath, and orientation of (100) plane of α-Co was disappeared due to adding nickel in the deposits. For Co-Zn-P deposits, the coercive force of deposits with thickness of 0.2㎛ was maximum with 750 Oe at 0.1 molar ratio of zinc to cobalt in the bath, and orientation of (100) plane of α-Co was weakened due to adding zinc in the deposits. Under the condition of vertical magnetic field, saturation magnetization of 0.1 molar ratio of nickel and zinc to cobalt in the bath was decreased, but that 0.4 molar ration of nickel and zinc to cobalt in the bath was not decreased. Orientation of α-Co was changed from (100) plane to (002) plane due to increasing external magnetic field.

문화학습을 통한 영어능력향상 방안 : 정의적 의사소통능력을 중심으로

박병주,김재명,조홍섭 忠州大學校 2003 한국교통대학교 논문집 Vol.38 No.1

This paper aims to explore the relationship between English literature and language teaching. It is often said that teaching English literature does not have a great influence on improving English skills. It is mainly because teachers concentrate on analysing literary works in terms of literary theory and translating English text into Korean. According to recent research, literature is suitable for student-centered education. It is also suitable for a whole language approach, by which four language skills can be developed at the same time. Given that the affective side of language learning contributes in a significant way to enriching learners' language learning, we would like to propose the need for integrating a humanistic approach in this paper. This paper shows that teaching literature based ON AFFECTIVE SIDE OF LEARNER is characterized by cooperative and interactional activities in their relation to such factors as self-esteem, autonomy, and motivation. This paper suggests a paradigmatic shift from traditional approach to affective approach through English literature which emphasizes process, self-esteem, social skills, cooperative learning, dynamic curriculum, intrinsic motivation, meaning based activities. It is important to select a suitable text for increasing a learner's spontaneous pleasure in reading. Literary works written by major authors but not difficult for language learners are recommended in that they satisfy the need of both the course and the learners.

리튬이온이차전지 정극용 LiNixMn₂-xO₄의 합성과 전기화학적 특성에 관한 연구

김병습,손영국 부산대학교 생산기술연구소 2000 生産技術硏究所論文集 Vol.58 No.-

LiNixMn2-xO4, (0≤x≤0.5)를 저온합성이 가능한 sol-gel법을 이용하여 합성하였다. 합성된 분말은 x선회절분석을 통하여 cubic spinel 구조임을 확인했고, Ni의 치환량이 증가함에 따라 격자상수는 감소했다. 순환전압전류 및 충방전 시험을 통하여 전기화학적 특성을 측정해본 결과 LiMn2O4에 비해 Ni의 치환량이 증가함에 따라 4V피크는 점차 사라졌지만, 3V피크에서의 방전용량과 싸이클 특성은 모두 우수한 특성을 나타내었다. LiNixMn2-xO4 (0≤x ≤0.5) cathode materials were synthesized at low temperature using sol-gel process. X-ray diffraction studies showed that the powders have cubic spinel structure and its lattice constants decreased as doped Ni contents increased. The electrochemical properties of the spinel LiNixMn2-xO4cathode materials were evaluated by cyclic voltammetry and charge discharge test. As doped Ni contents increased, 4V peak disappeared but capacity and cycling properties at 3V peak were improved than LiMn2O4.

잿빛곰팡이병균(Botrytis cinerea) 방제 살균제의 약효 및 저항성 연구를 위한 검정 방법의 비교

김병섭 강릉대학교 동해안지역연구소 2000 東海岸硏究 Vol.11 No.2

Five fungicides with different action mechanism and nine isolates of Botrytis cinerea were used for comparisons of test methods for activity evaluation and resistance research of fungicides. Test method compared by this experiment were mycelial growth inhibition (Test 1), spore germination inhibition (Test 2), protective (Test 3) and curative (Test 4) effect by the cucumber cotyledon and peter disk method, cucumber fruites (Test 5) and leaves of kidney bean (Test 6) treated with various fungicides, and seedling test (Test 7), respectively. All methods except Test 4 with insignificant correlation had a good botryticide screening ability with significant correlation. The fungal responses (sensitive or resistant) on fungicides with different mode of action were agreed with results of all test method. However, the in vivo test methods (Test 3, 5, 6, and 7) using plants appeared to be more effective as a botryticide screening system than an in vitro such as Test 1.

참전군인 복지정책 개선에 관한 실증적 연구 : 지원대상, 지원체계, 재정, 지원사업을 중심으로

윤병섭,이홍재 慶熙大學校 社會科學硏究院 行政硏究所 2001 行政問題硏究 Vol.8 No.1

參戰軍人 福祉政策에 관한 理論的 考察

尹昞燮 慶熙大學校 社會科學硏究院 行政硏究所 1999 行政問題硏究 Vol.6 No.1

산전초음파에서 발견된 기형의 계통별 진단 임신 주수의 차이

이병관,김선미,홍준석,심순섭,박중심,전종관,윤보현,신희철 대한산부인과초음파학회 2003 대한산부인과초음파학회지 Vol.5 No.2

딸기 시들음병균에 대한 Trichoderma 속 균의 길항작용에 관한 연구 : Ⅲ. Chitinase and β-1,3-glucanase Activity Ⅲ. Chitinase와 β-1,3-glucanase 활성

문병주,정후섭,조종택 東亞大學校生命資源科學大學附設 農業資源硏究所 1994 農業生命資援硏究 Vol.3 No.1

T. harzianum은 합성 배지에 유일한 탄소원으로서 chitin, laminarin, 본 병균의 세포벽, 밑기울 분말, clover잎 분말, maltose를 단독으로 첨가하여 생육시키면 chitinase와 β-1, 3-glucanase를 생성하였으나, chitinase 활성은 세포벽 첨가구에서 가장 높았고 다음은 chitin이었으며 maltose와 밑기울에서도 높은 활성을 보였으나 clover에서는 극히 낮았다. β-1, 3-glucanase 활성은 maltose에서 가장 높았고 다음은 laminarin이었으며 그 이외에는 극히 낮았다. 양 효소의 활성은 pH 3.5와 5.5가 pH 7.5에 비하여 높았으며, T. harzianum과 본 병균을 혼합하면 단독배양에 비하여 높았다. T. viride도 유일한 탄소원으로서 chitin 또는 laminarin을 첨가하면 각각 chitinase와 β-1,3-glucanase를 생성하였으나, chitinase 활성은 T. harzianum에 비하여 현저하게 낮았고 β-1,3-glucanase의 활성은 비슷하였다. Chitinase production by Trichoderma harzianum was highest in the culture with cell walls of the pathogen or chitin, moderately high with maltose or wheat bran, and very poor with clover leaf power. Relatively large amount of β-1,3-glucanase was excreted by T. harzianum when maltose or laminarin was used as a sole carbon source for the culture of the fungus, whereas cell walls, wheat bran and clover leaf powder had little effect on the enzyme production. For both of the enzymes, the enzyme activities were higher at pH 3.5-5.5 than at pH 7.5, and higher enzyme activities were detected in the dual culture of T. harzianum and Fusarium oxysporum f. sp. fragariae than in the culture of T. harzianum alone. The activity of chitinase by T. viride was significantly lower than by T. harzianum, and the activity of β-1,3-glucanase was similar between the two antagonisitcs, although T. viride produced chitinase and β-1,3-glucanase when chitin or laminarin was added as a sole carbon source.

조직특성과 대인관계 특성이 직무만족에 미치는 영향에 관한 연구 : 여성금융기관 종업원을 중심으로 focused on Female Employees in the Financial Institution

천명섭,최병우 한국생산성학회 2003 生産性論集 Vol.17 No.3

Reviewing the literature of human resources management, we found researchers have explored different impact factors of organizational characteristics, interpersonal characteristics, levels of perceived activities on job satisfaction. In this paper, we add a new factor that includes interactive effects of organizational characteristics and interpersonal characteristics on job satisfaction. Utilizing structural equation modeling, we test our proposed model among female employees in the financial institution. The Structural Equation Modeling approach has been employed to investigate the cross influences among the four categories. The proposed model produces the best fit. The organizational characteristics category is the most important effect among categories of the proposed model of job satisfaction. Additionally, the theoretical and managerial implications are discussed.