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- 저자 : Byung-Gyu Ahn (검색결과 145 건)
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박영규,안상로,민병무,박우찬 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2
We performed the surgery for correction of ocular torticollis in 20 patients with asymmetric gaze nystagmus. Modified kestenbaum procedure was performed for 30 degrees of ocular torticollis, 40% augmented modified Kestenbaum procedure for 45 degrees, and 60% augmented modified Kestenbaum procedure for 60 degrees. At the final follow up visit (averaging 9.9 months), 12 patients showed complete corrections of previous head turn, five patients showed a small residual head turn of less than 10 degrees, and three patients show residual head turn of 15 degrees to the same side of the preoperative head turn. The success rate was 85%. After the first operation three patients were received the addiitonal operation due to residual head turn, but the results were satisfactory. Three were few significant complications and no overcorrected cases. Among the 14 patients who were able to measure the visual acuity, seven patients showed no internal change in visual acuity and the other seven patients showed increased visual acuity over one Snellen line. From above results, we obtained good results with modified Kestenbaum procedure and augmented modified Kestenbaum for correction of ocular torticollis with asymmetric gaze nystagmus.
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할로아세틸시코닌 유도체의 합성 및 항암성 평가 : Synthesis and Evaluation of Antitumor Activity
鄭相國,金光洙,송규용,조훈,안병준 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-
The secondary hydroxy group at side chain of shikonin structure was selectively acylated with various haloacetic acids in presence of dicyclohexylcarbodiimide and 4-dimethylaminopyridine to produce haloacetylshikonin derivatives. The cytotoxicity of monohaloacetylshikonin derivatives against L1210 cells increased in the following order: monochloroacetylshikonin (ED_50, 0.142 ㎍/㎖) nonobromoacetylshikonin (ED_50, 0.158㎍/㎖)>monoiodoacetylshikonin (ED_50, 0.173 ㎍/㎖). Introduction of larger halogen atoms decreased the cytotoxic activity, presumably due to steric hinderance. The cytotoxicity of chloroacetylshikonin derivatives was dependent on the number of chlorine atom, thus increasing in the following order : trichloroacetylshikonin (0.032 ㎍/㎖)>dichloroacetylshikonin (0.059 ㎍/㎖)> monochloroacetylshikonin (ED_50, 0.142 ㎍/㎖). Thus, the electron-withdrawing effect seems to be important for the cytotoxicity of chloracetylshikonin derivatives. Consistent with the above, dichloracetylshikonin (T/C, 182%) and trifluoroacetylshikonin (195%) showed higher T/C values than monochloroacetyl-(T/C, 122%), monobromoacetyl-(T/C, 154%) and monoiodoacetylshikonin (T/C, 117%) derivatives. Haloacetylshikonin derivatives showing lower cytotoxic activities against L1210 cells exhibited lower T/C values. It seems that there is a relationship between the cytotoxicity of haloacetylshikonin and their antitumor activity.
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Effective Estimation Method of Routing Congestion at Floorplan Stage for 3D ICs
Byung-Gyu Ahn,Jaehwan Kim,Wenrui Li,Jong-Wha Chong 대한전자공학회 2011 Journal of semiconductor technology and science Vol.11 No.4
Higher integrated density in 3D ICs also brings the difficulties of routing, which can cause the routing failure or re-design from beginning. Hence, precise congestion estimation at the early physical design stage such as floorplan is beneficial to reduce the total design time cost. In this paper, an effective estimation method of routing congestion is proposed for 3D ICs at floorplan stage. This method uses synthesized virtual signal nets, power/ground network and clock network to achieve the estimation. During the synthesis, the TSV location is also under consideration. The experiments indicate that our proposed method had small difference with the estimation result got at the post-placement stage. Furthermore, the comparison of congestion maps obtained with our method and global router demonstrates that our estimation method is able to predict the congestion hot spots accurately.
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Effective Estimation Method of Routing Congestion at Floorplan Stage for 3D ICs
Ahn, Byung-Gyu,Kim, Jae-Hwan,Li, Wenrui,Chong, Jong-Wha The Institute of Electronics and Information Engin 2011 Journal of semiconductor technology and science Vol.11 No.4
Higher integrated density in 3D ICs also brings the difficulties of routing, which can cause the routing failure or re-design from beginning. Hence, precise congestion estimation at the early physical design stage such as floorplan is beneficial to reduce the total design time cost. In this paper, an effective estimation method of routing congestion is proposed for 3D ICs at floorplan stage. This method uses synthesized virtual signal nets, power/ground network and clock network to achieve the estimation. During the synthesis, the TSV location is also under consideration. The experiments indicate that our proposed method had small difference with the estimation result got at the post-placement stage. Furthermore, the comparison of congestion maps obtained with our method and global router demonstrates that our estimation method is able to predict the congestion hot spots accurately.
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Kim, Byung Gyu,Ko, Young-Guk,Hong, Sung-Jin,Ahn, Chul-Min,Kim, Jung-Sun,Kim, Byeong-Keuk,Choi, Donghoon,Jang, Yangsoo,Hong, Myeong-Ki,Lee, Seung Hyun,Lee, Sak,Chang, Byung-Chul Elsevier 2018 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.255 No.-
<P><B>Abstract</B></P> <P><B>Aims</B></P> <P>Peripheral artery disease (PAD) is frequently present in patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis. This study assessed the impact of PAD on clinical outcome after TAVI.</P> <P><B>Methods</B></P> <P>A total of 115 patients who underwent TAVI were evaluated retrospectively. Patients were divided into PAD and non-PAD groups, with PAD defined as stenosis≥50% in lower extremity arteries. Immediate and late clinical outcomes were compared between the two groups.</P> <P><B>Results</B></P> <P>PAD was present in 31.3% (36/115) of the patients undergoing TAVI. Compared to the non-PAD group, the PAD group had higher Society of Thoracic Surgeons' (STS) risk scores (8.83%±6.20% vs 6.23%±4.15%, p=0.039) and more frequent diagnoses of diabetes (52.8% vs 30.4%, p=0.021) and multi-vessel coronary artery disease (55.6% vs 29.1%, p=0.007). The PAD group also had higher incidence of major vascular complication (11.1% vs 1.3%, p=0.033), 30-day mortality (13.9% vs 1.3%, p<0.001), and subsequent 1-year (30.6% vs 3.8%, p<0.001) and 2-year (47.2% vs. 10.1%, p<0.001) all-cause mortality. PAD was identified as an independent predictor of increased 1-year mortality (hazard ratio [HR] 8.65; 95% confidence interval [CI], 1.05–71.14, p=0.045) after TAVI along with high STS score (HR 11.18, 95% CI 1.36–92.04, p=0.025).</P> <P><B>Conclusions</B></P> <P>Presence of PAD was significantly associated with increased rates of major vascular complications as well as immediate and late mortality in patients undergoing TAVI. Assessment of PAD before TAVI is essential to choose an access strategy and to predict clinical results.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Peripheral Artery Disease is common in transcatheter aortic valve implant patients. </LI> <LI> PAD was associated with major vascular complications in TAVI patients (p=0.033). </LI> <LI> PAD was associated with immediate and late mortality in TAVI patients (p<0.001). </LI> <LI> PAD was an independent predictor of 1-year mortality after TAVI (p=0.025). </LI> <LI> Assessment of PAD before TAVI is essential to determine procedure and clinical outcome. </LI> </UL> </P>
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개구리 정맥동(Sinus Venosus)의 전기적 성질에 관한 연구
안병규,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1983 中央醫大誌 Vol.8 No.1
The frog sinus venosus were studied with conventional glass microelectrode technique in order to elucidate the underlying mechanism of spontaneous pacemaker activity. The analyses were focussed on the ionic nature of pacemaker current by changing the concentrations of extracellular K^+ and/Na^+, or by using blockers of K- and Ca-current and chronotropic transmitters. 1. The action potential sinus venosus has some characteristic feature of maximal diastolic potential ranged from -65 to -75mV, resting potential from -45 to -50 mV and overshoot voltage about +20mV, respectively. Duration of the action potential taken from rapid upstroke to maximal diastolic potential was about 600 msec. Usual discharge rate was 30~35/min at room temperature(18~20℃). 2. In Ringer solution containing 50% Na(substituted by equimolar Tris) reduction of extracellular sodium concentrations diminished the amplitude and frequency of the action potential. And 0 and 11 mm Na hyperpolarize the restal membrane potential greatly. It suggest the resting Na Conductance is significantly high in sinus venosus. 3. Caesium(10mM), K-current blocker decreased pacemaker depolarization. Manganese(2mM) known to be Ca-current antagonist, blocked spontaneous activity completely. 4. Adrenaline and acetylcholine showed positive and negative chronotropic effect. It is concluded that K-, Na- and Ca-current components are involved in the genesis of spontaneous activity of the frog sinus venosus like other cardiac pacemaker tissues.
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Ahn, Joong Gyu,Choie, Mok Kyun,Choi, Byung Chull CATHOLIC MEDICAL CENTER 1993 Bulletin of the Clinical Research Institute Vol.21 No.1
The bone responses, on the osserointegrated implants with different surface characteristics such as, Bonfit^?? (titantum plasma sprayed hollow-screw type), Integral^?? (hydroxylapatite-coated cylinder type), Steri-Oss^?? (hydroxylapatite-coated screw type), and Steri-Oss^?? (uncoated smooth surfaced screw type) in the mandible of dogs. In 3 adult flogs (20-25 kg B.W.), 4 kinds of implants were placed in the edentulous sites previously extracted four months ago. The animals were sacrificed at r, 8, and 12 weeks. The specimens were prepared by using Villaneuva staining and undecalcified ground sectioning and evaluated under a light microscope. The obtained results were as follows; 1. After 4 and 8 weeks, titanium plasma sprayed or hydroxylapatite-coated implants had less fibrous tissue contact and more bone formation than uncoated implants. Hydroxylapatite-coated implants were most favorable in the degree of osseointegration. 2. Bone tissue were substituted for fibrous tissue adjacent to the surface of the implants and the implants were surrounded with compact lamellar bone after 12 weeks. 3. Bone contact with the surface of the: implants was more intimate and bone remodelling was faster in the cortical bone than in the medullary bone. 4. Bone ingrowth into the porous surfaced implants was faster than the smooth surfaced implants. The results from this study demonstrate that the hydroxylapatite coating provides an osteophilic surface for bone deposition and the porous surface allows more rapid bone ingrowth, but there are no significant differences depending on surface characteristics with time.
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Byung Gyu Kim,Sung-Jin Hong,Byeong-Keuk Kim,Yong-Joon Lee,Seung-Jun Lee,Chul-Min Ahn,Dong-Ho Shin,Jung-Sun Kim,Young-Guk Ko,Donghoon Choi,Myeong-Ki Hong,Yangsoo Jang 대한심장학회 2023 Korean Circulation Journal Vol.53 No.12
Background and Objectives: We evaluated the effect of diabetes on the relationship between body mass index (BMI) and clinical outcomes in patients following percutaneous coronary intervention (PCI) with drug-eluting stent implantation. Methods: A total of 6,688 patients who underwent PCI were selected from five different registries led by Korean Multicenter Angioplasty Team. They were categorized according to their BMI into the following groups: underweight (<18.5 kg/m2), normal weight (18.5–24.9 kg/m2), overweight to obese (≥25.0 kg/m2). Major adverse cardiac and cerebrovascular events (MACCE), defined as a composite of death, nonfatal myocardial infarction, stroke, and target-vessel revascularization, were compared according to the BMI categories (underweight, normal and overweight to obese group) and diabetic status. All subjects completed 1-year follow-up. Results: Among the 6,688 patients, 2,561 (38%) had diabetes. The underweight group compared to normal weight group had higher 1-year MACCE rate in both non-diabetic (adjusted hazard ratio [HR], 2.24; 95% confidence interval [CI], 1.04–4.84; p=0.039) and diabetic patients (adjusted HR, 2.86; 95% CI, 1.61–5.07; p<0.001). The overweight to obese group had a lower MACCE rate than the normal weight group in diabetic patients (adjusted HR, 0.67 [0.49–0.93]) but not in non-diabetic patients (adjusted HR, 1.06 [0.77–1.46]), with a significant interaction (p-interaction=0.025). Conclusions: Between the underweight and normal weight groups, the association between the BMI and clinical outcomes was consistent regardless of the presence of diabetes. However, better outcomes in overweight to obese over normal weight were observed only in diabetic patients. These results suggest that the association between BMI and clinical outcomes may differ according to the diabetic status.
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