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플라즈마 표면처리에 의한 Silk/PLA 바이오복합재료의 계면접착
추보영,권미연,이승구,조동환,박원호,한성옥,Chu, Bo Young,Kwon, Mi Yeon,Lee, Seung Goo,Cho, Donghwan,Park, Won Ho,Han, Seong Ok 한국접착및계면학회 2004 접착 및 계면 Vol.5 No.4
견섬유와 폴리라틱산(PLA) 사이의 계면접착 특성을 향상시키기 위하여 천연섬유 표면을 아르곤과 에틸렌 플라즈마로 각각 처리하였다. 플라즈마 표면처리 후, 견섬유의 표면 모폴로지와 접착이 크게 변화하였다. 다음의 여러 플라즈마 처리조건이 본 연구에 사용되었다: 10, 25, 50 그리고 150 W의 전력, 1, 3, 5, 7 그리고 10분의 처리시간 및 10과 50 sccm의 가스흐름속도, 플라즈마 처리된 Silk/PLA 바이오복합재료의 계면전단강도는 단섬유 micro-droplet debonding 시험방법으로 측정하였다. 결과는 Silk/PLA 바이오복합재료의 계면접착을 향상시키기 위한 최적의 플라즈마 처리 조건을 제공하여 주었다.
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가토 모델에서 복강경 수술 시 전기방사 나노섬유 유착방지제의 효과 및 안전성
이영우(Young Woo Lee),추보영(Boyoung Chu),이윤기(Yun Gee Lee),김남현(Nam Hyun Kim),김준호(Jun Ho Kim),김광일(Kwang Il Kim),권성원(Sung Won Kwon) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.2
Purpose: Most recently developed anti-adhesive membranes are not suitable for laparoscopic surgery due to weak mechanical properties or adhesive characteristics. To overcome these problems, we prepared electrospun bioabsorbable nanofibrous poly (lactic-co-glycolic acid)-based membranes as an adhesion barrier. We evaluated the efficacy and safety of this material for laparoscopic surgery in a rabbit model. Methods: A standardized laparoscopic surgical trauma was made on the rabbit’s uterine horn and adjacent abdominal wall to induce adhesion formation. The injured uterus was covered by a nanofibrous barrier or it was left untreated (the negative control group) (each group: n=14). To evaluate acute toxicity of this material, blood sampling was made 3 and 7 days after laparoscopic surgery to check liver and renal function. Three weeks after laparoscopy, a second look laparoscopy was performed and the adhesions were scored according to Blauer"s scoring system. Tissue between abdominal wall and uterus was obtained to examine microscopically. Liver, kidney and uterus were harvested to examine chronic toxicity. Results: 36.4% of the nanofiber treatment group and 70% of the untreated control group showed severe adhesions (grade>3) after laparoscopic surgery but failed to get a statistical significance (P=0.198). Acute and chronic toxicity induced by this material were not noted in the blood and tissue exam. Conclusion: This study showed that nanofiber barrier seems to be a novel resorbable biomaterial for the reduction of postoperative adhesions. Easy placement and handling of this material make these membranes potentially successful candidates for laparoscopic surgery. But further study is needed to get a statistical significance.
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백서 맹장/복벽 찰과상 모델에서 점도별 HA/CMC 유착 방지 용액의 유효성 및 안정성 평가
이윤기(Yun Gee Lee),추보영(Boyoung Chu),김남현(Nam Hyun Kim),김준호(Jun Ho Kim),이영우(Young Woo Lee),김광일(Kwang Il Kim),권성원(Sung Won Kwon) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.6
Purpose: Guardix-sol™ is solution type of anti-adhesion barrier, and it is composed of a mixture of hyaluronate (HA) and carboxymethylcellulose (CMC). The anti-adhesive effect was proved through several clinical trials with using this material, but the most efficient viscosity for this solution has not been shown by the previous research. The objective of this study was to evaluate the efficacy and safety of HA/CMC mixture solutions, with varying viscosities, in a rat model. Methods: Three different viscosities (low=LV, mid=MV and high=HV) of the HA/CMC mixture solutions were prepared to evaluate their potential as a tissue adhesion barrier. The viscosity was measured by a Brookfield viscometer. To evaluate the anti-adhesion effect, a cecal-abdominal wall abrasion model was adopted. The denuded cecum was coated by a HA/CMC mixture of different viscosity or it was left uncoated (the negative control group) and then the denuded cecum was apposed to the abdominal wall (each group: n=10). All the rats underwent a second celiotomy after 14 days to evaluate the extent of their abdominal adhesions and tissue reactions (inflammatory response, granulation tissue formation and toxicity in organs). Results: The viscosities of the HA/CMC mixture solutions were 248.±24.4 cps in the LV, 1,353.8±4.4 cps in the MV and 3,556.7±38.8 cps in the HV. The grade of adhesion and the adhesion area were significantly lower in the all HA/CMC mixture solution groups compared to the control regardless of their viscosity. The inflammatory responses were not remarkable at the application site and the major solid organs did not show histological change in the experimental groups. Conclusion: The difference of viscosity of HA/CMC mixture solutions did not affect the efficacy of the adhesion barrier. All the HA/CMC mixture solutions with varying viscosities showed a low inflammatory response and non-toxicity.
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백서 모델에서 갑상선 절제술 후 Poloxamer/Alginate/CaCl₂ 유착방지제의 효과
김준호,이진호,이윤기,추보영,김남현,권성원,이영우,김광일 한국생체재료학회 2008 생체재료학회지 Vol.12 No.1
This study was conducted to compare the effectiveness of Poloxamer/alginate/CaCl₂ for reducing adhesion after thyroidectomy in a rat model. Tissue adhesion is one of the major causes of well known postsurgical complications, including patient's pain, functional obstruction and difficult preoperative surgery. Several adhesion barriers have been developed in the form of solution or membrane in an attempt to solve the postsurgical problems. However both types of tissue barriers have some limitations in their practical applications. In order to overcome these problems, a temperature- sensitive Poloxamer/alginate/CaCl₂ was prepared as an adhesion barrier. The sol-gel transition behavior was measured using a viscometer. And in vitro gel stability test was performed. The anti-adhesion effect was evaluated using a thyroidectomy model. Two week after surgery, the level of adhesion was graded from zero to two using a wholenumber system. And also toxicity, inflammation and the adhesion prevention effect were evaluated. The LCST (lower critical solution temperature) of the Poloxamer/Alginate/CaCl₂ was 25℃. The gel stability of Poloxamer was improved by adding cross-linked sodium Alginate/CaCl₂. The adhesion grade was significantly lower in the experimental group than in the control. From the results, Poloxamer/alginate/CaCl₂ is an excellent candidate material having highly effective anti-adhesion, low inflammatory response, and non-toxicity for clinical applications as a tissue adhesion barrier gel.
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