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그레이브스병 환자에서 알레르기 지표와 갑상선자극호르몬 수용체 항체의 관련성
김효정 ( Hyo Jeong Kim ),이병훈 ( Byoung Hoon Lee ),이재형 ( Jae Hyung Lee ),전재석 ( Jae Seok Jeon ),김상훈 ( Sang Hoon Kim ),안영민 ( Young Min Ahn ),채정돈 ( Jung Don Chae ) 대한천식알레르기학회 2010 천식 및 알레르기 Vol.30 No.3
Background: IgE might play a role in the pathogenesis of Graves` disease in Japanese population. Objective: We designed this study to evaluate the possible relationship between atopic parameters and the level of TSH receptor antibody in Graves` disease. Method: In 406 patients with Graves` disease, we measured total IgE, eosinophil count and specific IgE against Dermatophagoides farinae (D. farinae), as well as TSH receptor antibody (TRAb, thyrotropin-binding inhibitory immunoglobulin [TBII]). We collected histories of common allergic diseases by a questionnaire and performed skin tests with 8 common aeroallergens. Result: TBII was higher in patients who had treatment history or clinical symptoms of asthma within 12 months and also higher in smokers. TBII was positively related to total IgE. Duration of treatment was significantly lower and total IgE was significantly higher in TBII ≥15 IU/L group than those of TBII <15 IU/L group. TBII was significantly higher in group of specific IgE against D. farinae ≥0.7 kU/L. Total IgE level was higher in whom need medication for maintaining euthyroid state than that of remission state patients. Conclusion: TBII was significantly related to atopic markers including total IgE, specific IgE against D. farinae and history of asthma, suggesting that there is a close link between autoimmune thyroid disease and allergic immune response. (Korean J Asthma Allergy Clin Immunol 2010;30:195-201)
흰 쥐의 감염된 전층피부 결손에서 Iodine의 드레싱 방법에 따른 창상치유 효과의 비교
이종훈,김요한,민경희,홍성희,이원미,채정돈,전진현,Lee, Jong-Hoon,Kim, Yo-Han,Min, Kyung-Hee,Hong, Sung-Hee,Lee, Won-Mi,Chae, Jeong-Don,Jun, Jin-Hyun 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.3
Purpose: Iodine has been used for the prevention or management of wound infection as a topical agent. Although iodine was widely used mainly by Betadine$^{(R)}$ and cadexomer iodine, there was no comparative study on the efficacies of dressing methods of iodine. And also it's wound healing effect was not yet clear. The purpose of this study is to compare antibacterial effects and wound healing effects associated with various dressing methods of iodine on infected full thickness skin defect in the mouse. Methods: One full thickness skin defects in the mice (n=60) were developed on the back and left open for twenty-four hours. Sixty mice were divided into four groups : group S (dressing with Betadine$^{(R)}$ soaking, n=15), group T (dressing with Betadine$^{(R)}$ topping, n=15), group I (dressing with Iodosorb$^{(R)}$, n=15), group G (control group, dressing with dry gauze, n=15). The size of the wound defects and the grades of wound healing were evaluated in 4, 7, 10 days, and antibacterial effect was evaluated with restricted zone in Mueller Hinton agar by disk diffusion method. Results: After the wound was left open for twenty-four hours, many Staphylococcus aureus were cultured. The wound defect size was decreased in order of Betadine$^{(R)}$ soaking, Iodosorb$^{(R)}$, Betadine$^{(R)}$ topping and gauze dressing group in all days, but difference among experimental groups was not statistically significant. The grade score of wound healing was increased in order of Betadine$^{(R)}$ soaking, Iodosorb$^{(R)}$, Betadine$^{(R)}$ topping and gauze dressing group, and the difference was statistically significant. Antibacterial effect for S. aureus was increased in order of Iodosorb$^{(R)}$, Betadine$^{(R)}$ soaking, Betadine$^{(R)}$ topping and gauze dressing group, and the difference was statistically significant. Conclusion: Selection of the effective dressing method of iodine for infected wounds remains a controversial decision. According to this study, Iodosorb$^{(R)}$ may be most effective method for antibacterial effect and Betadine$^{(R)}$ soaking may be most effective method for infected wound healing. However, further study is necessary to evaluate the clinical efficacy of dressing methods of iodine and to search for the mechanisms that explain their effects.
흰 쥐의 감염된 전층피부결손에 대한 항균연고들의 항균효과 및 창상치유 효과의 비교
전소연,이종훈,민경희,홍성희,이원미,채정돈,전진현,Jeon, So-Yeon,Lee, Jong-Hoon,Min, Kyung-Hee,Hong, Sung-Hee,Lee, Won-Mi,Chae, Jeong-Don,Jun, Jin-Hyun 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.2
Purpose: Many topical agents had been used for contaminated wound treatment. Although antimicrobial ointments were widely used as topical agents, their comparative antibacterial and wound healing effects were largely unreported. The purpose of this study was to compare antibacterial effects and wound healing effects of common topical ointments on infected full thickness skin defect in the mouse. Methods: One full thickness skin defects in the mice (n=60) were developed on the back and left open for twenty-four hours. Sixty mice were divided into four groups: group B (dressing with Bactroban$^{(R)}$, n=15), group I (dressing with Iodosorb$^{(R)}$, n=15), group T (dressing with Terramycin$^{(R)}$, n=15), group G (control group, dressing with dry gauze, n=15). The size of wound defects and the grades of wound healing were evaluated at 4, 7, 10 days, and antibacterial effect was evaluated with restricted zone in Mueller Hinton agar by disk diffusion method. After the wound was left open for twenty-four hours, many Staphylococcus aureus was cultured. The wound defect size was decreased in order of Bactroban$^{(R)}$ (B), Iodosorb$^{(R)}$ (I), Terramycin$^{(R)}$ and gauze dressing group in all days, but difference among experimental groups was not statistically significant. The grade score of wound healing was increased in order of Bactroban$^{(R)}$, Iodosorb$^{(R)}$, Terramycin$^{(R)}$ and gauze dressing group, and the difference was statistically significant. Antibacterial effect for was increased in order of Bactroban$^{(R)}$, Iodosorb$^{(R)}$, Terramycin$^{(R)}$ and gauze dressing group, and the difference was statistically significant. Conclusion: Topical antimicrobial ointments application was effective against wound infections by S. aureus. Bactroban$^{(R)}$ may be an optimal topical treatment for infected wounds according to this study. However, further study is necessary to evaluate the clinical efficacy of antimicrobial ointments and to search for the mechanisms that explain their effects.
Yersinia enterocolitica의 급성 충수염에서 원인균으로서 가능성
손태준(Tae Joon Son),김동희(Dong Hee Kim),조윤주(Yun Ju Jo),채정돈(Jeong Don Chae),홍부환(Boo Hwan Hong),강재희(Jae Hee Kang),이태석(Tae Seok Lee),한준길(Jun Gil Han) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.4
Purpose: With increasing frequency, Yersinia enterocolitica is being recognized as an important bacterial cause of acute gastrointestinal infection with abdominal pain. In addition, the association of Y. enterocolitica infections with acute appendicitis has been suggested. This study was undertaken to ascertain whether Y. enterocolitica is a possible infectious agent in acute appendicitis. Methods: Between December 2007 and April 2008, 162 patients who underwent appendectomy for presumed appendicitis, enrolled in this prospective study. After surgical excision of appendix, a portion of each specimen was cultured for Y. enterocolitica with highly selective media (Cefsulodin-Irgasan-Novobiocin agar). Results: Pathologically, 150 of the patients had appendicitis and 12 patients had normal appendices. Only one of the 150 patients (0.7%) with appendicitis was found to be culture positive for Y. enterocolitica, while it was not detected from normal appendices. Conclusion: The authors were unable to implicate Y. enterocolitica as a major pathogen in acute appendicitis within the Seoul area. However, we thought there to be more need for investigation for association of Y. enterocolitica with acute appendicitis over a broader area and season.
결핵성 흉막염 치료 후 잔류된 만성 흉막삼출에서 발생한 가성유미흉
박은경 ( Eun Kyoung Park ),정숙희 ( Sook Hee Chung ),배준호 ( June Ho Bae ),류상열 ( Sang Ryol Ryu ),이재형 ( Jae Hyung Lee ),김상훈 ( Sang Hoon Kim ),조영욱 ( Young Uk Cho ),채정돈 ( Jeong Don Chae ),이병훈 ( Byoung Hoon Lee ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.5
A pseudochylothorax, a chyliform pleural effusion, is a rare disease of pleural effusion that contains cholesterol crystals or high lipid content that is not the result of a disrupted thoracic duct. Most of the cases were found in patients with long-standing pleural effusion due to chronic inflammatory disease, such as old tuberculous pleurisy or chronic rheumatoid pleurisy. We experienced a case of pseudochylothorax in a 74-year-old man, who was being treated for pulmonary tuberculosis and pleurisy 10 years ago. The diagnosis was confirmed on pathological study of the pleural effusion, which contained cholesterol crystals having a diagnostic rhomboid appearance.
급성 우하복부 통증으로 내원한 성인 환자에서 Yersinia 감염에 대한 연구
정준영 ( Jun Young Jung ),박영숙 ( Young Sook Park ),백대현 ( Dae Hyun Baek ),최정호 ( Jeoung Ho Choi ),조윤주 ( Yun Ju Jo ),김성환 ( Seong Hwan Kim ),손병관 ( Byoung Kwan Son ),채정돈 ( Jeong Don Chae ),김동희 ( Dong Hee Kim ) 대한소화기학회 2011 대한소화기학회지 Vol.57 No.1
Background/Aims: Clinical manifestations of intestinal yersiniosis include enterocolitis, mesenteric adenitis, and terminal ileitis presenting with fever, right lower quadrant pain, and leukocytosis. According to a previous Korean study in 1997, Yersinia was revealed in two among 15 adult patients with mesenteric adenitis (13%). However, recent reports on the prevalence of Yersinia infection in adult patients are few. The aim of this study was to investigate the prevalence of Yersinia infection in adult patients with acute right lower quadrant pain. Methods: Adult patients (>18 years) who visited Eulji medical center, due to acute right lower quadrant pain were enrolled prospectively from December 2007 to July 2009. Abdominal CT, stool culture, serologic test for Yersinia, and Widal test were performed. Results: Among 115 patients, 5 patients were excluded due to positive Widal test or salmonella culture. In 110 patients, abdominal CT showed right colitis in 20 (18.2%), terminal ileitis in 16 (14.5%), mesenteric adenitis in 13 (11.8%), acute appendicitis in 10 (9.1%), acute diverticulitis in 7 (6.4%), non specific mucosal edema in 36 (32.7%) and no specific lesion in 8 (7.3%). Two (1.8%) of the 110 patients had antibodies to Yersinia. One patient showed acute enteritis and the other patient was diagnosed with acute appendicitis and underwent appendectomy. No Yersinia species were grown on stool or tissue culture. Conclusions: Nowadays, among adult Korean patients presenting with acute right lower quadrant pain, there have been few incidences of Yersinia infection. (Korean J Gastroenterol 2011;57:14-18)