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주종일,최영석,이용갑,김탁현,김상용,Ju, Jong-Il,Choi, Young-Seok,Lee, Yong-Kab,Kim, Tak-Hyun,Kim, sangyong 한국유체기계학회 2003 한국유체기계학회 논문집 Vol.6 No.2
Numerical studies have been conducted to predict the solid-liquid separation efficiency of turbulent flow in a hydrocyclone using a commercial CFD code. To validate the CFD code, several preliminary numerical calculations are carried out to determine the influence of parameters such as grid systems, numerical schemes, and turbulence models. The numerical studies have been performed on the hydrocyclones with the different vortex finder geometries by changing the mass flow rate, and the results were compared with the experimental data. The results show that the CFD code can be used as a design tool to improve the performance of hydrocyclones.
주종일(Jong-Il Ju),최영석(Young-Seok Choi),이용갑(Yong-Kab Lee),김탁현(Tak-Hyun Kim),김상용(sangyong Kim) 한국유체기계학회 2002 유체기계 연구개발 발표회 논문집 Vol.- No.-
Numerical studies have been conducted on the turbulent flow in a hydrocyclone to predict the solid-liquid separation efficiency using commercial CFD code. To validate the CFD code, several preliminary numerical calculations are carried out to determine the influence of the parameters such as the grid systems, the numerical schemes and the turbulence models. The numerical studies have been performed on the hydrocyclones with the different vortex finder geometries by changing the mass flow rate and the results were compared with the experimental data. The results show that the CFD code can be used as a helpful tools to improve the performance of hydrocyclones.
뇌경색 환자의 안지오텐신 전환요소 유전자 다형성과 사상체질
배영춘,권덕윤,김경요,김일환,주종천,Bae, Young-Choon,Kweon, Deog-Yun,Kim, Kyung-Yo,Kim, Il-Hwan,Ju, Jong-Chun 사상체질의학회 2002 사상체질의학회지 Vol.14 No.1
The correlation between angiotensin converting enzyme (ACE) polymorphisms and cerebral infarction (CI) has been controversial. Such controversy may be due to different classifications of cerebrovascular diseases and ethnic differences. I studied the correlation between ACE genotypes and CI patients by case-control study in the Korean population. I also classified CI patients and control group into four types according to Sasang constitutional medicine. Furthermore I investigated the correlation among ACE genotypes, CI and Sasang constitutions. The frequencies of D allele were 0.32 in subjects with CI and 0.40 in the control group without CI (X2=0.128, p=0.720). In patients with CI, the frequency of Taeumins, one of four Sasang constitutional types, was significantly higher than that in controls (X2=15.425, p<0.00l). I did not find any correlation between ACE polymorphism and CI in Koreans. However, there were significant differences in allele frequencies between Koreans and Europeans, while similarities were shown to those of Japanese and Chinese populations.
최영석(Young-Seok Choi),주종일(Jong-Il Ju),주원구(Won-Gu Joo) 한국유체기계학회 2001 유체기계 연구개발 발표회 논문집 Vol.- No.-
A commercial CFD code is used to compute the 3-D viscous flow field within the inlet flow concentrator of the newly developed AHU(Air Handling Unit). To improve the performance of the AHU, the inlet air needs to be gradually accelerated to the fan's annular velocity without causing turbulence or flow separation. Three major geometric parameters were selected to specify the inlet shape of the AHU. Several numerical calculations are carried out to determine the influence of the geometric parameters on the performance of the AHU. The performance of the AHU could be measured by the inlet and outlet flow uniformity and the total pressure loss through the inlet flow concentrator. The optimized nondimensionalized velocity profile through the inlet flow concentrator were used for the design of the AHU with the various volume flow rates.
현준원,주종일 단국대학교 1999 論文集 Vol.34 No.-
We have studied annealing properties of Boron Nitride(BN) thin films. BN thin films were successfully grown on sillicon(100) substrate by rf magnetron sputter deposition. The effects of various annealing on BN thin films have been studied. The Fourier transform infrared absorption spectroscopy (FT-IR) of the depositied BN film (7000Å-1000℃-1-1hour) showed a strong absorption 1090 ㎝-1 clearly indication cubic structure. Surface roughness was observed by Atomic Force Microscope (AFM) and it shows that the roughness increase the phase of cBN. Using Dynamic ultra micro hardness tester, hardness of annealing BN thin film (7000Å-750℃-1-1hour) is about 4000 kgf/mm2 and it shows that it has the possibility of application as hard material. Therefore we conclude that the annealing temperature is related with formation of cBN phase.
마우스피부암 발생과정에 있어서 텔로머레이저 활성에 관한 연구
강호일,지승완,주종호,황명실,염영나,이국경,김옥희 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-
텔로머레이저는 진핵세포 염색체의 텔로미어를 합성하는 DNA 중합효소로서 정상세포에서는 발현되지 않지만 차부분의 악성종양에서 발현되고 있는 것으로 알려져 있다. 현재까지 형질변환 된 세표에서 무제한의 증식을 조절하는 효소로 알려져 있지만 텔로머레이저 활성화의 기전 및 조절인자들은 알려져 있지 않은 실정이다. 본 연구에서는 각기 다른 11전으로 발암촉진을 할 수 있는 4종류의 TPA,okadaic acid, anaralin 및 benzoyl perox겨e 발암촉진제를 사용하여 마우스 피부암을 운도한 후 이들 암 조직으로부터 텔로머레이저 활성을 측정함으로써 텔로머레이저f') 어떤 방식으로 재찰성화 되는가에 대한 단서를 추적하고 분자병리학적인 기법을 사용하여 조절기전을 찾고자 하였다. 븐 실험에서 사용 한 동물 발암모델은 다단계 발암과정을 비교적 용이하게 관찰할 수 있는 마우스 피부암 모델을 이웅하였다. 그 결과 TPA promotion 10주에서 22주까지 얻은 pap기oma 조직에서는 렐로머레이저 활성이 검출되었으며 TPA 대씬 benfoyl peroxide, okadaic acid, anthralin 으로 처리하여 얻은 papi13orna 조직(promotion 10주에서 22주까지)에서도 텔로머레이저 활성이 나타나는 것을 발견하였다. 그러나 TPA 를 포함하며 이들 발암축진제 등으로 처궈한 동일 주령의 papilloma 주위조직 및 acetone 만을 처리한 정상 피부조직아서늪 틸로머레아저 활성은 나타나지 않았다. 이상의 결과를 모두 종합하면 마우스 피부암 발생과정에사를 틸로머레이저 재활성화와 단백질 인산화와는 전혀 관련이 없는 것으로 추정되며 향후 텔로머레이저는 새로운 조기 암 진단지표로서 사용 가능성이 높다고 사료된다. Telomerase, a speciallzed RNA-directed BNA polymerase that extends telomeres of eukaryotic chromosomes, has acti)'ity in most malignant tumors and provides a mechanismfor the unlimited potential fo'S division of neoplastic celts. Although telornerase is known to hea regulated enzyme, the factors and mechanisms involved in telornerase regulation are not wellunderstood. In the present study, we compared the effect of 12-0-tetradecano?1-phorbol-13-acetate fTPA) and non-phorbol ester tumor promoters such as okadaic acid,anthralin and benzo!71 per()xide on the expression of telomerase in the mouse skincarcinogenesis system, a well characterized model for studying pre-malignant and malignantf-ogression. We found that most early papillomas harvested after 10 weeks of TPA promotionshowed telomerase activity- Other papillomas harvested after 10 weeks of okadaic acid,anthralin and benzoy3 peroxide promotion and after single treatment of DMBA only alsoshowed telomerase activity, 1-espec4ive3y. On the other hand, normal 3nd all skins surroundedby papiBlomas harvested after 10 11·eelts of these promo·ters has no telomerase activity. Takentogether these results, there .Bppears to be no clear association betwetn the level of telomeraseactivity and protein phosphor#lation in mouse skin papi31omas and telomerase may be useful asbio-markers in early detectiorl of tumors.