CNKI에서 중국의 사상체질의학(四象體質醫學) 철학 연구 현황과 특징

배영춘,Bae, Young-Chun 사상체질의학회 2019 사상체질의학회지 Vol.31 No.1

The purpose of this study is to understand how Sasang Constitutional Medicine has been understood in China. Methods I searched for topics in Chinese such as Sasang medicine (四象醫學), Sasang constitution (四象體質), Chao medicine (朝醫), philosophy (哲學), principles (原理), the school of Confucianism (儒家), Confucianism (儒學) and ideology (思想) in CNKI database on January 15, 2019. The selected studies were summarized as three sections; the basic principles of Sasang Constitutional Medicine, influences of Confucianism and comparison with other medicines. Results In China, the principles of Sasang Constitutional Medicine is explained using the concepts such as Heaven-Human-Nature-Order, the Great Ultimate (Taiji), Two Modes (Liang-Yi), Sasang, heart, sorrow-anger-joy-pleasure, nature-emotions (Xingqing), and viscera-bowels (Zang-Fu). Sasang Constitutional Medicine is considered to has been influenced by Confucianism. The form of Sasang Constitutional Medicine was affected by the Book of Changes (Zhouyi), and the contents were impacted by the Great Learning (Daxue), the Doctrine of the Mean (Zhongyong), the Mencius (Mengzi) and the Analects (Lunyu). Sasang Constitutional Medicine have distinctive characteristics in comparison with other medicines, such as inherent determinations of constitution, organs difference by constitution the actions of nature, emotions and desire, recognition of humans as social beings, and the signification of heart as a presiding center. Conclusion In China, the philosophy of Sasang Constitutional Medicine has been studied with basis of four-element structure; activity, mind, body and matter. Also, it has been researched in medical aspects of human trying to control the nature and emotions to be physically, mentally and socially healthy.

뇌경색 환자의 안지오텐신 전환요소 유전자 다형성과 사상체질

배영춘,권덕윤,김경요,김일환,주종천,Bae, Young-Choon,Kweon, Deog-Yun,Kim, Kyung-Yo,Kim, Il-Hwan,Ju, Jong-Chun 사상체질의학회 2002 사상체질의학회지 Vol.14 No.1

The correlation between angiotensin converting enzyme (ACE) polymorphisms and cerebral infarction (CI) has been controversial. Such controversy may be due to different classifications of cerebrovascular diseases and ethnic differences. I studied the correlation between ACE genotypes and CI patients by case-control study in the Korean population. I also classified CI patients and control group into four types according to Sasang constitutional medicine. Furthermore I investigated the correlation among ACE genotypes, CI and Sasang constitutions. The frequencies of D allele were 0.32 in subjects with CI and 0.40 in the control group without CI (X2=0.128, p=0.720). In patients with CI, the frequency of Taeumins, one of four Sasang constitutional types, was significantly higher than that in controls (X2=15.425, p<0.00l). I did not find any correlation between ACE polymorphism and CI in Koreans. However, there were significant differences in allele frequencies between Koreans and Europeans, while similarities were shown to those of Japanese and Chinese populations.

소양인 연속성 딸꾹질 환자의 치험례

배영춘,이상민,유관석,주종천,백동기,Bae, Young-Chun,Lee, Sang-Min,Yoo, Gwan-Seok,Joo, Jong-Cheon,Baek, Dong-Gi 사상체질의학회 2004 사상체질의학회지 Vol.16 No.2

1. Objectives Hiccup is one of common symptoms clinically and caused by various etiologies. Persistent hiccup is defined as hiccup lasting more than 48 hours. We have tried researching effect of herbal medicines(Dokhwaljihwang-tang, Yangkyuksanhwa-tang). 2. Methods To heal the persistent hiccup, we used Dokhwaljihwang-tang and Yangkyuksanhwa-tang. 3. Results A Soyangin patient diagnosed to have persistent hiccup was, treated with Soyangin herbal medicines (Dokhwaljihwang-tang and Yangkyuksanhwa-tang), and change of his symptom & general condition was managed. 4. Conclusions The constitutional treatment with Soyangin herbal medicines(Dokhwaljihwang-tang, Yangkyuksanhwa-tang) may have an effect on management of persistent hiccup. Further study on management of this disease is needed.

Dipeptidyl peptidase 4 (DPP4)/CD26 : Biological Functions, Disease Association, and Therapeutics

윤현이(Hyunyee Yoon),송문정(Moon Jung Song) 고려대학교 생명자원연구소 2021 생명자원연구 Vol.29 No.-

Dipeptidyl peptidase 4 (DPP4), 또는 CD26 단백질은 세포막 바깥쪽 도메인에 단백질의 2번 위치에 존재하는 프롤린이나 알라닌 잔기를 절단하는 dipeptidyl peptidase 효소활성을 갖는 다기능 당단백질이다. 세포내 중요한 신호전달 인자로 작용하는 다양한 생리활성 물질들이 DPP4의 기질이기 때문에, DPP4는 당대사 조절, 항염증반응 및 심혈관대사 작용에 중요한 역할을 한다고 알려져 있다. 흥미롭게도 고병원성 사람코로나바이러스인 MERS-CoV의 세포수용체로서 DPP4의 역할도 보고되었다. DPP4는 관련된 많은 질환에서 중요한 약물 표적으로 여겨져 왔기 때문에, 본 논문에서는 DPP4의 생물학적 기능, 질병연관성, 치료제 등에 관한 내용을 살펴보고자 한다. Dipeptidyl peptidase 4 (DPP4; also known as CD26) is a multifunctional glycoprotein containing an ecto-domain with didpetidyl peptidase enzymatic activity that cleave the proteins containing a position 2 proline or alanine. Since there are a variety of bioactive DPP4 substrates acting as important signaling messengers, DPP4/CD26 is shown to play key roles in transducing the glucoregulatory, anti-inflammatory, and cardiometablolic actions. Moreover, DPP4 can function through protein-protein interactions to exert its biological functions, regardless of its enzymatic activity. Interestingly, DPP4 was identified as a host receptor for middle east respiratory syndrome coronavirus (MERS-CoV), a highly pathogenic human coronavirus. Since DPP4 has been a critical therapeutic target for many related diseases, in this review, we will discuss the current understanding of DPP4/CD26 regarding its biological functions, disease association, and therapeutic approaches.

청심연자탕(淸心蓮子湯)이 심전도(心電圖) 변화(變化)에 미치는 영향(影響)에 관한 연구(硏究)

배영춘,이상민,김경요,김형순,Bae, Young-Chun,Lee, Sang-Min,Kim, Kyung-Yo,Kim, Hyoung-Soon 사상체질의학회 2003 사상체질의학회지 Vol.15 No.3

The purpose of this study is to examine the effects of Sasang constitutional herbal extracts, Cheongsimyeonjatang(CYT) on ECG(electrocardiogram). For this purpose, Ten hospitalized Taeumin patients were selected and changes of the ECG was investigated. The researcher also measured and observed ECG changes before and after CYT medication. The following is the summarized results of study. 1. The RV5+SV1 voltage was decreased in LVH patients. 2. The S-T voltage was decrease in the previous S-T elevated patients. 3. The heart rate was increased in the patients of lower heart rate than normal. 4. There was no remarkable change after medication on T-inversion and bundle branch block. From the above results, it is concluded that Cheongsimyeonjatang(CYT) have influenced on ECG.

전라북도 월경통 지원사업의 한방치료 결과 및 만족도 보고

배영춘,주종천 대한한의학회 2019 대한한의학회지 Vol.40 No.1

Objectives: The purpose of this study was to report the result and the satisfaction of Korean medicine treatment for patients with dysmenorrhea who participated in support program of Jeollabuk-do. Methods: The subjects of this study were 33 volunteers, suffering from primary dysmenorrhea. As the ‘Dysmenorrhea Treatment Project’, we conducted a dysmenorrhea program at 22 Korean medicine clinic and 1 Korean medicine hospital in Jeollabuk-do. From May to December 2018, we conducted the program and assessed the effect and satisfaction twice after first two menstrual cycles after Korean medicine treatment through questionnaire. They were treated by Korean medicine treatment such as herbal medicine, acupuncture, moxibustion, heat therapy, physical therapy and others in 2017. The results were measured by the visual analogue scale (VAS) and multidimensional verbal rating scale (MVRS) of overall pain. The disturbance in school activity for menstrual period and satisfaction of Korean medicine treatment were investigated by continuous rating scales. Results: The VAS score of overall pain was decreased significantly. Also the amount of the analgesic taken for menstrual period and the degree of disturbance in school activity were decreased significantly. Besides, the satisfaction of Korean medicine treatment was increased. Conclusions: This study might suggest that the Korean medicine treatment on dysmenorrhea is effective.

중증근무력증이 한의학적 치료로 개선된 임상 1례

배영춘,박수정 대한한방내과학회 2019 大韓韓方內科學會誌 Vol.40 No.1

Objective: The purpose of this study was to report on the alleviation of symptoms of a myasthenia gravis (MG) patient after Korean medicine treatment. Methods: A 39 year-old male patient who suffered from MG was examined. The patient was treated with herbal medicine, acupuncture, and pharmacopuncture. The Myasthenia Gravis Composite (MGC) scale and Myasthenia Gravis Activities of Daily Living (MG-ADL) profile were used to assess the change of MG symptoms after Korean medicine treatment. Results: The MGC and MG-ADL scores indicated significant improvement after 14 days of treatment. In addition, the degrees of fatigue, dyspepsia, vomiting, sweating, and dizziness were decreased. Conclusion: This study may suggest that Korean medicine treatment could be effective in treating the symptoms of MG.

말의 활액 및 혈청 분석을 통한 관절질환의 생화학적 예측 인자

배종환,김갑수,유영춘,이회영,이경복 한국임상수의학회 2001 한국임상수의학회지 Vol.18 No.3

The joint disease including osteoarthris (OA) and rheumatoid arthritis (RA) are common in the horse. Many studies have been performed to develop biochemical markers reflecting the abnormalities of cartilage and synovial membrane. However, no specific, sensitive and clinically well established assay systems have been yet available to characterize the severity of joint diseases. Indeed, radiography is still doctor's best choice of assessing joint damage in OA/RA. This review focuses on biochemical molecules such as proteoglycan, collagen, matrix metalloproteinases (MMPs), lectin and cytokine to assess their potential value for not only predicting stage of joint disease but also monitoring treatment efficacy.

Curdlan Sulfation 유도체의 항 응고 및 항 바이러스 활성

배종환(Jong Hwan Bae),유영춘(Yung Choon Yoo),이종교(Lee Chong Kyo),곽상태(Sang Tae Kwak),서은영(Eun Young Seo),문은호(Eunho Moon),이민재(Min-Jae Lee),이경복(Kyung Bok Lee) 한국실험동물학회 2001 Laboratory Animal Research Vol.17 No.2

경주마 관절질환의 조기 진단을 위한 생화학적 연구

배종환(Jong Hwan Bae),유영춘(Yung Choon Yoo),홍장희(Jang Hee Hong),문은호(Eunho L. Moon),송경식(Kyung Sik Song),이경복(Kyung Bok Lee) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.1

A modification of a colorimetric assay was used to determine the concentration of total and individual sulfated-glycosaminoglycan (GAG) in equine synovial fluid and serum with joint disease. For the identification of enzymatic active products of the equine synovial fluid, strong anion exchange-high performance liquid chromatography (SAX-HPLC) was performed. By the action of chondroitin ABC lyase, three unsaturated disaccharides, 2-acetamide-2-deoxy-3-O-(β-D-gluco-4-enepyranosyluronic acid)-D-galactose (△Di-COS), 2-acetamide-2- deoxy-3-O-(β-D-gluco-4-enepyranosyluronic acid)-6-O-sulfo-D-galactose (△Di-C6S), and 2-acetamide-2-deoxy-3-O-(β-D-gluco-4-enepyranosyluronic acid)-4-O-sulfo-D-galactose (△Di-C4S), were produced from the equine synovial fluid. Total GAG concentration of the equine synovial fluid was 0.82± 0.24 ㎎/㎖ (mean±SD) in normal horses, but it was decreased in horses with joint disease (0.17±0.12 ㎎/㎖). The concentration of keratan sulfate (KS), chondroitin sulfate (CS), and hyaluronic acid (HA) were decreased in horses with joint disease. The concentration of serum HA of normal horses was 77.00±66.14 ㎍/㎖, but it was markedly increased in joint diseases (168.50±147.50 ㎍/㎖), There appears to be some correlation between joint inflammation and serum HA levels as determined by experimental studies of animals. Irrespective of the explanation, it is clear that measurement of the level of serum HA may provide a useful marker for monitoring the onset and progression of a number of important diseases and disorders in equine.