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혈중 Mg2+ 농도 및 유출에 미치는 Ethanol의 영향과 Melatonin의 억제효과 : Protective Effect of Melatonin
조성건,강형섭,김진상 한국수의공중보건학회 2001 예방수의학회지 Vol.25 No.2
Alcohol abuse is associated with a change in cellular electrolyte homeostasis. We investigated the changes in plasma and extracellular Mg2+ content and the protective effect of melatonin against changes in Mg2+ content in ethanol treated rats. The acute administration of ethanol to anesthetized rats resulted in an increase in plasma Mg2+ levels. As expected, the acute administration of ethanol mobilized a considerable amount of Mg2+ from perfused rat livers and hearts,indicating that organs have a major pool of Mg2+ which can be induced by ethanol. These acute ethanol-induced Mg2+release from perfused livers and hearts were inhibited by melationin. Also, acute ethanol administration in vivo produced an increase in urinary volume and urinary Mg2+ extrusion, and a decrease in plasma Mg2+ content in a dose-dependent fashion. Chronic ethanol feeding to rats for 4wk resulted in a decrease in plasma Mg2+ content and liver/body weight ratio. The heart/body weight ratio and the body weight gain, however, did not differ significantly between control and ethanol groups. This ethanol-induced decrease in Mg2+ content was reversed by combination-fed of melatonin or MgCl2. These results suggest that alcohol ingestion is associated with abnormalities in circulating or cellular Mg2+ concentration and that melatonin supplementation might attenuate ethanol-induced Mg2+ extrusion.
이항형 모형을 이용한 응용 소프트웨어 의 신뢰성 평가에 관한 연구
조성건,이상철 한국산업경영시스템학회 1992 한국산업경영시스템학회지 Vol.15 No.25
Computer software users develop and utilize their application software by themselves since Processing methods are different by quantity and qualify of the information The developed model needs input data and error numbers generated during the testing phases. However. total error numbers of the existing model and each error time was needed as data for developing the new model. But, maximum likelihood estimation must be used to exponential model of binomial-type and estimating of parameters by using the searched data. Parameter estimation can be done with trial and error or simulation.
조성건,이주학,한상웅,김호중 대한의학회 2013 Journal of Korean medical science Vol.28 No.2
Although renal calcium crystal deposits (nephrocalcinosis) may occur in acute phosphate poisoning as well as type 1 renal tubular acidosis (RTA), hyperphosphatemic hypocalcemia is common in the former while normocalcemic hypokalemia is typical in the latter. Here, as a unique coexistence of these two seperated clinical entities, we report a 30-yr-old woman presenting with carpal spasm related to hypocalcemia (ionized calcium of 1.90 mM/L) due to acute phosphate poisoning after oral sodium phosphate bowel preparation, which resolved rapidly after calcium gluconate intravenously. Subsequently, type 1 RTA due to Sjögren’s syndrome was unveiled by sustained hypokalemia (3.3 to 3.4 mEq/L), persistent alkaline urine pH ( > 6.0) despite metabolic acidosis, and medullary nephrocalcinosis. Through this case report, the differential points of nephrocalcinosis and electrolyte imbalances between them are discussed, and focused more on diagnostic tests and managements of type 1 RTA.
강형석,조성건,이동규,김병규 항공우주시스템공학회 2017 항공우주시스템공학회지 Vol.11 No.6
본 연구에서는 외골격 크기를 변화하여 효과적으로 구동력을 조절하고 우수한 장애물 통과능력을 가진 구형로봇을 구현하였다. 호버만구를 외골격으로 채택하고 슬라이더-크랭크 구조의 확대·수축 메커니즘을 설계하여 무선으로 로봇의 크기변화와 이동제어가 가능하도록 제어시스템을 구축하였다. 로봇의효율적인 구동에 필요한 주요 변수를 확인하기 위하여 오일러-라그랑주 운동방정식을 세워 해석하였고, 이를 바탕으로 DC 모터를 선정하였다. 로봇의 성능을 평가하기 위해 Prototype 의 기초 구동실험을 진행함과 동시에 유한요소 해석을 통해 구조적 안정성을 보완한 최종 모델을 제작하였다. 결과적으로, 외경 기준 최대 650 mm 에서 최소 520 mm 까지 수축/팽창이 가능한 로봇이 0.85 m/s로 주행이 가능한것을 확인하였다. We propose a variable frame structure connected with telescopic mast-shaped shaft for a robot displaying outstanding ability to cross obstacles, and for effective traction control. The wireless control system was built to extend and contract a deployable mechanism, which is shaped into a hoberman sphere assembled with frame structures. In order to develop important parameters for efficient locomotion, we derived an Euler– Lagrange equation for the spherical robot. According to the equation, the DC motor was selected. A prototype mechanism was tested and a Finite-Element Analysis (FEA) was conducted in parallel. Using these data, we constructed a deployable spherical robot with structural stability. The deployable robot moved at a speed of 0.85 m/s from 520 mm to 650 mm.