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조경상,김성윤,임점희,정기화,이청주,Jo, Gyeong-Sang,Kim, Seong-Yun,Im, Jeom-Hui,Jeong, Gi-Hwa,Lee, Cheong-Ju The Korean Society for Integrative Biology 1997 Korean journal of biological sciences Vol.1 No.3
Male accessory glands and ejaculatory duct of Drosophila melanogaster are reproductive organs which synthesize secretory seminal proteins. Several products of these organs involved in egg laying, receptivity, and sperm stability or storage were isolated from their lumens. Despite their secretory process play an important role, exocytosis pathway in these organs is not well known. In the present study, we characterized secretory protein profiles and determined their secretory mechanisms. Eight accessory gland secretory proteins and two ejaculatory duct secretory proteins were detected in their lumens. All these proteins were constitutively synthesized in these organs and secreted to their lumens. Secretion of newly synthesized proteins initiated at about 1 h after synthesis, and reached the peak at 4 h after synthesis. It seems that secretion of the proteins may occur via constitutive exocytosis pathway.
1989년 가을 전남지역에서 발생한 쭈쭈가무시병 25예의 임상적 고찰
조경상,이승일,김종두,박찬국,문철웅,홍순표 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.15 No.1
We observed 25 cases of tsutsugamushi disease occuring in the Chulanam-do area from October to November 1989, which were diagnosed clinically and serologically by indirect immunofluorescent antibody test. In korea, there has been an increasing concern as a possible cause of unknown febrile disease, since tsutsugmushi disease were first reported in 1986. The clinical illness was characterized by fever, skin rash, eschar and lymphadenopathy. On laboratory findings, antibody titer to three strains of R. tsutsugamushi ranged negative to 1 : 2560. All of the patients showed milder clinical courses than those reported till now in Korea, and showed good response to antibiotic therapy with doxycycline or chloramphenicol.
Effects of sarah/nebula knockdown on Ab42-induced phenotypes during Drosophila development
조경상,방세민,이수진,정해민,홍윤기,이장호,황수진,서윤석,이경호 한국유전학회 2016 Genes & Genomics Vol.38 No.5
The Down syndrome critical region 1 (DSCR1), a Down syndrome-associated protein, is an endogenous inhibitor of the Ca2?-dependent phosphatase calcineurin. It has been also suggested to be associated with Alzheimer’s disease (AD) but the role of DSCR1 in the pathogenesis of AD still remains controversial. In this paper, we investigated the effects of knockdown of sarah (sra), a Drosophila DSCR1 ortholog, on the Ab42-induced developmental phenotypes of Drosophila. Knockdown of sra showed detrimental effects on the rough eye phenotype and survival of Ab42-expressing flies without altering the Ab42 accumulation. Furthermore, the knockdown of sra increased glial cell numbers in the larval brains and its susceptibility to oxidative stress. Overexpression of an active form of calcineurin produced similar results to sra knockdown as they both exacerbated the Ab42-induced rough eye phenotype. However, sra knockdown did not alter apoptosis or c-Jun N-terminal kinase activation in Ab42-expressing flies. In conclusion, our results suggest that sra does play an important role in Ab42-induced developmental defects in Drosophila without affecting its stress responses.
조경상,김준기,유시영,홍윤기,고형종,정종경 한국유전학회 2007 Genes & Genomics Vol.29 No.2
Mating increases protein synthesis in the Drosophila male accesory glands. To elucidate the ting-induced phosphorylation of acesory gland proteins was examined. Mating prominently stimulates the phosphorylation of two proteins (Mr 20,000 and 30,000), which are inferred to be Drosophila eIF-4E binding protein (d4E-BP) and ribosomal protein S6. The stimulated phosphorylation corresponded with protein synthesis, and was inhibited by rapamycin and wortincreased phosphorylation of d4E-BP and S6, the dissociation of d4E-BP from eIF-4E, and S6 kinase activity. Colectively, these findings sugest that d4E-BP and S6 mediate the stimulation of protein synthesis by mating in Drosophila.
Terpenes from Forests and Human Health
조경상,임영란,이경호,이재석,이장호,이임순 한국독성학회 2017 Toxicological Research Vol.33 No.2
Forest bathing has beneficial effects on human health via showering of forest aerosols as well as physical relaxation. Terpenes that consist of multiple isoprene units are the largest class of organic compounds produced by various plants, and one of the major components of forest aerosols. Traditionally, terpene-containing plant oil has been used to treat various diseases without knowing the exact functions or the mechanisms of action of the individual bioactive compounds. This review categorizes various terpenes easily obtained from forests according to their anti-inflammatory, anti-tumorigenic, or neuroprotective activities. Moreover, potential action mechanisms of the individual terpenes and their effects on such processes, which are described in various in vivo and in vitro systems, are discussed. In conclusion, the studies that show the biological effectiveness of terpenes support the benefits of forest bathing and propose a potential use of terpenes as chemotherapeutic agents for treating various human diseases.