혈액관류 요법과 함께 L-카르니틴을 투여한 valproic acid 중독 환자 1례

정진희,김기범,안기옥,어은경,Jung Jin Hee,Kim Gi Beom,Ahn Ki Ok,Eo Eun Kyung 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.2

Valproic acid (VPA) is used in the management of a variety of conditions including simple and complex absence seizure disorder. bipolar disorder, and migraine prophylaxis. Clinical manifestation of VPA overdose vary in severity from mild confusion and lethargy to severe coma and death. The treatment of VPA toxicity is mainly supportive. There is no specific antidote, nor are there specific guidelines for the management of VPA intoxication. Anecdotal reports describe the efficacy of naloxone and L-carnitine, but the data are insufficient to make strong conclusions. Various techniques of extracoporeal therapy for the management of VPA toxicity have been described, but none has prevailed as standard therapy. We report a patient with VPA overdose who was successfully treated with hemoperfusion with activated charcoal and L-carnitine. VPA levels of the patient was more than 1,000 ${\mu}g$/ml and was normalized after 3 times hemoperfusion. The patient was injected with L-carnitine by maximum 600 mg/kg/day for 5days without complications.

Pimozide와 Haloperidol 과량 복용 후 반복적으로 발생한 심실 빈맥 1례

정진희,장혜영,어은경,Jung, Jin-Hee,Jang, Hye-Young,Eo, Eun-Kyung 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.1

Pimozide and haloperidol are typical antipsychotics. They share a similarity in pharmacotherapeutic and adverse effect profiles. Cardiovascular effects may be seen as alterations in heart rate, blood pressure, and cardiac conduction. Conduction disturbances may occur ranging from asymptomatic prolongation of the QT interval to fatal ventricular arrhythmia. So in the case of anti psychotics overdose, the patient must be carefully monitored by continuous electrocardiography (ECG). We experienced a 34-year-old woman of schizophrenia with recurrent ventricular tachycardia after pimozide and haloperidol overdose. Initially she was slightly drowsy, however her ECG showed normal sinus rhythm. After 6 hours on emergency department entrance, her ECG monitoring showed ventricular tachycardia and we successfully defibrillated. There were five times events of ventricular arrhythmia during the in-hospital stay. She was discharged 5 days later without any other complications.

의료보장 형태가 혈액투석 서비스 제공에 미치는 영향에 대한 다수준 분석

정진희,권순만,김경훈,이선경,김동숙,Jung, Jin-Hee,Kwon, Soon-Man,Kim, Kyoung-Hoon,Lee, Seon-Kyoung,Kim, Dong-Sook 대한예방의학회 2010 예방의학회지 Vol.43 No.3

Objectives: This study aims to compare quality indicators for the hemodialysis services between patients with health insurance and those with medical aid. Methods: This study used data from sampled hospitals that provided a hemodialysis service. A total of 2287 patients were selected, and the information for hemodialysis service has been granted from medical record reviews. A multi-level regression analysis was used to examine the differences in process and outcome indicators for hemodialysis between patients with health insurance and those with medical aid. Process indicators were defined as: frequency of hemodialysis, hemodialysis time, erythropoietin (EPO) use, measurement of hemodialysis dose at least once a month, measurement of phosphate at least once every three months, and measurement of albumin at least once every three months. Outcome indicators were defined as: hemodialysis adequacy, anemia management, blood pressure management, and calcium, phosphate and nutrition management. The total scores for outcome indicators ranged from 0 (worst) to 4 (best). Results: There was a significant difference in the measurement of hemodialysis dose at least once a month between patients with health insurance and those with medical aid (OR 0.66, 95% CI = 0.43 - 0.99). However, frequency of hemodialysis, hemodialysis time, EPO use, measurement of phosphate at least once every three months, measurement of albumin at least once every three months, hemodialysis adequacy management, Hb${\geq}$11 g/dL, blood pressure within the range of 100-140 /60-90 mmHg, calcium x phosphate${\leq}$55 $g^2/dL^2$ and albumin${\geq}$4 g/dL were not significantly different between the groups. Conclusions: There were no significant differences in outcome indicators for hemodialysis between the groups. Further studies are warranted into the mechanism that results in no differences in the outcome indicators for hemodialysis.

이질형 바이오 데이터베이스 통합을 위한 게이트웨이 시스템

정진희,정민아,Jung, Jin-Hee,Jung, Min-A 한국정보통신학회 2005 한국정보통신학회논문지 Vol.9 No.8

이질적인 생물 데이터베이스의 통합은 데이터간의 연계 분석의 필요성이 높아짐에 따라 중요한 문제로 대두되고 있다. 그러나 이러한 데이터베이스들은 초기에 이질적 환경에서 각기 다른 목적에 의해 생성되므로 포맷, 설계자가 불일치하는 등 여러 가지 문제점으로 인해 통합하는데 어려움이 따른다. 그러므로 이질적인 데이터베이스의 통합을 위해서는 초기단계의 설계가 무엇보다도 중요하다. 본 논문에서는 대표적인 핵산 데이터베이스인 Genbank와 단백질 데이터베이스인 Swiss-Prot을 통합하기 위해 ER 모델을 사용하여 개념적 모델을 보인 후, 이를 합병하여 통합모델을 제시한다. 또한, 핵산-단백질 자료로 연계되는 정보를 통합 서비스할 수 있는 시스템 구조를 제안한다. 제안된 바이오 게이트웨이 시스템은 개념적 설계 단계에서 가장 원자적인 단위로 분할하여 모델링 함으로써 정교한 질의 처리가 가능하고, 사용자가 상세 조건을 알고 있을 경우에 기존의 검색시스템과 달리 여러 번의 검색 과정을 거치지 않고, 단시간에 원하는 결과를 얻을 수 있다는 장점을 지닌다. The Integration of biological databases is critically important because of the interconnectedness of biological research. But it's not easy to integrate these databases for the different formats and designers in heterogeneous environments. So initial design is indispensable to integrate heterogeneous databases. In this paper, after we performed conceptual modeling on a popular nucleotide database, GenBank and a protein database, Swiss-Prot and integrated them by considering cross-reference. we also propose the integration system architecture called Bio-Gateway System, which can help users query closely linked information between two biological databases within one system differently from existing systems as well as query easily on condition that user knows fine condition for less effort.

응집제 자동주입장치를 이용한 소화슬러지의 탈수효율 향상

정진희 ( Jin-hee Jung ),김진영 ( Jin-young Kim ),윤태경 ( Tae-kyung Yoon ),김정권 ( Jung-kwon Kim ),허승녕 ( Seung-nyung Huh ),정병길 ( Byung-gil Jung ) 한국환경기술학회 2013 한국환경기술학회지 Vol.14 No.6

본 연구는 하수처리장에서 발생되는 소화슬러지의 탈수성 향상을 위한 응집제 자동주입시스템과 기존 시스템의 탈수케이크 함수율 및 응집제 주입량에 미치는 영향을 비교·평가하는데 그 목적이 있다. 고분자 응집제 주입율은 기존 시스템에서 운영하고 있는 유입슬러지량 대비 고분자 응집제주입율인 14%를 기준으로 9%까지 점차적으로 낮추어 가면서 실험을 실시하였다. 실험결과 하수슬러지 탈수시 응집제 자동주입시스템이 기존시스템에 비해 함수율 및 약품주입량을 효과적으로 저감시킬 뿐만 아니라 중앙제어실을 통한 실시간 모니터링이 가능하므로 인력감축 유도 및 공정자동화에도 기여할 수 있을 것으로 판단된다. The purpose of this research was to evaluate the effects on enhanced sewage digested sludge dewatering and compare polymer dosage reduction between an automatic coagulant feeding system and a conventional system. The polymer dosage rate per sludge quantity was adjusted from 9% to 14% based on coagulant dosage of the conventional system. The results of this study indicate that the automatic coagulant feeding system not only could be effectively reduced the moisture contents and polymer dosage in the sewage sludge dewatering but also made the workforce reduction and automatic dewatering by real-time monitoring at central control room of sewage treatment plant more than a conventional system.

공업지역에서 Eco-water의 생산을 위한 Birm + 막공정(UF) 적용시 수질특성 및 UF membrane 오염 특성 파악

정진희 ( Jin Hee Jung ),이준희 ( Jun Hee Lee ),최영익 ( Young Ik Choi ) 한국수처리학회 2016 한국수처리학회지 Vol.24 No.4

This study aimed to secure a supply of reclaimed wastewater using the Birm filter to eliminate the manganese during the pretreatment stage. Another purpose was to analyze the characteristics of the UF membrane fouling. In this study, there were no investigations on the residual chlorine level, the chloride criterion, and the ABS criterion. Owing to these missing criteria, the quality of the reclaimed wastewater was found to be substandard when compared to the required quality standards for reclaimed water. However, it complied with the SS, BOD, turbidity, and chromaticity standards and was therefore still suitable for landscaping, cleaning that does not involve human contact and industrial applications. The water treatment facilities in industrial areas did not seem to need the Birm filter, since the removal of Mn ions in the wastewater was not effective enough. However, when manganese removal is required, injection of calcium permanganate or chlorine can remove the oxidation. The study of the UF membrane fouling involved SEM and EDX analyses, which indicated that carbon and oxygen ions accounted for 47% of the overall composition, but there was no trace of inorganic matter. Furthermore, the difference in the recovery rate of the fouled membrane between acidic and alkali cleaning was more than 78%. In conclusion, the results indicated that organic matter contributes to membrane fouling whereas inorganic matter has no effect.

MEPC. 227(64) 수질기준에 의한 SBR 및 MBR 복합공정 적용 가능성 평가

정진희 ( Jin Hee Jung ),이승철 ( Seung Chul Lee ),이슬기 ( Seul Kee Lee ),한영립 ( Young Rip Han ),윤영내 ( Young Nea Youn ),최영익 ( Young Ik Choi ) 한국환경과학회 2015 한국환경과학회지 Vol.24 No.12

The objective of this study was to make a SBR+MBR complex process to evaluate the possible use of the advanced water treatment system for ships (SBR+MBR complex process) in accordance with the amendments MAPOL 73/78 that went into effect. The conditions 1 and 2 did not show the quick reduction in anaerobic condition while in the precipitation and stirring stages of the SBR treatment which was determined to be ineffective denitrification, same as with the ORP. Removal of organic matters such as BOD5 and CODCr in the SBR treatment was observed to happen smoothly and going through the MBR treatment as well would provide a stable water quality. However, the results were not satisfactory in accordance with BOD5 25 mg/L and CODCr 125 mg/L. Thus, the operating conditions improvement is deemed necessary. Likewise for the nutrients (T-N and T-P), the nitrification in bioreactor, denitrification and phosphorus absorption in aerobic tank due to phosphorus release in anaerobic tank had not been proceeded effectively. It was concluded that the improved operating conditions and structural changes would provide more effective treatments since the removal rates of T-N and T-P were less than 70% and 80%, respectively, which were standards specified by the MEPC. 227(64).

연구논문 : SBR 및 MBR 공정을 이용한 분뇨폐수에서의 질소제거 특성

정진희 ( Jin Hee Jung ),윤영내 ( Young Nae Yoon ),이슬기 ( Seul Kee Lee ),한영립 ( Young Rip Han ),이승철 ( Seung Chul Lee ),최영익 ( Young Ik Choi ) 한국환경과학회 2015 한국환경과학회지 Vol.24 No.11

There are two treatment processes that are currently applied to ships are the biological treatment process using the activated sludge and the electrochemical treatment. However, neither of them are able to remove both nitrogen and phosphorus due to their limited ability to remove organic matters, which are main causes of the red tide. This study was conducted to identify the characteristics of nitrogen removal factors from manure wastewater by replacing the final settling tank in SBR (Sequencing Batch Reactor) process and applying immersion type hollow fiber membrane. SBR process is known to have an advantage of the least land requirement in special environment such as in ship and the immersion type hollow fiber membrane is more stable in water quality change. As the result, the average in the cases of DO (Dissolved Oxygen) is 2.9(0. 6∼3.9) mg/L which was determined to be the denitrifying microorganism activity in anaerobic conditions. The average in the cases of ORP (Oxidation Reduction Potential) is 98.4∼237.3 mV which was determined to be the termination of nitrification since the inflection point was formed on the ORP curve due to decrease in the stirring treatment after the aeration, same as in the cases of DO. Little or no variation in the pH was determined to have positive effect on the nitrification. T-N (Total Nitrigen) removal efficiencies of the finally treated water were 71.4%, 72.3% and 66.5% in relatively average figures, thus was not a distinct prominence. In being applied in ships in the future, the operating conditions and structure improvements are deemed necessary since the MEPC (Marine Environment Protection Committee). 227(64) ship sewage nitrogen is less than the standard of 20 Qi/Qe mg/L or the removal rate of 70%.

공업지역 하수처리장 하수방류수 재이용을 위한 (Birm + UF막) 공정 적용 시 금속물질 및 유기물질 제거에 관한 연구

정진희 ( Jin-hee Jung ),최영익 ( Young-ik Choi ) 한국환경기술학회 2016 한국환경기술학회지 Vol.17 No.5

본 연구에서는 고탁도시 막차압 상승을 방지하기 위해 (Birm Filter + UF막)을 적용해 금속이온 (Mn 및 Fe) 및 유기물질의 제거특성을 파악하고자 하였으며, 막오염의 주원인 물질인 금속이온 제거 (Mn 및 Fe)를 통해 막오염을 저감하고자 하였다. Birm filter + UF막의 연계처리 공정 적용 시 48.4% 및 49.7%로 역세 시간에 따른 제거효율 변화는 UF막 제거효율에 큰 영향을 미치지 않는 것으로 나타났으며 (Birm filter + UF막) 전처리 공정으로서 우수한 편은 아니지만 긍정적인 역할을 할 것으로 판단된다. 유기물질인 BOD₅의 경우 평균 58.9% 제거효율을 나타내었으며, COD_Mn의 경우 평균 60.6% 제거되었다. TOC의 경우 평균 21.2%의 제거효율을 나타내었다. (Birm filter + UF막)의 연계처리 공정으로는 TOC를 효과적으로 제거하기 어려운 것으로 나타나 추가공정으로 RO막 등 기타 추가 공정이 필요할 것으로 판단되며, 본 연구에 사용되어진 원수는 분해성 유기물 보다는 난분해성 유기물의 직접적인 유입이 많고 그 밖에 상당량 미생물에 의한 생물학적 분해가 낮다는 것을 알 수 있었으며 그밖에 산화성 무기물이 상당량 포함되어 있다는 것을 알 수 있었다. The purpose of this research was to identify the removal characteristics of metal ions (Mn and Fe) and organic matters by applying a combined Birm filter and UF membrane process. Additionally, the objective of using the particular media was to prevent an increase in transmembrane pressure under high turbidity conditions and to reduce the membrane fouling by removing the primary cause of membrane fouling, namely, the metals Mn and Fe ions. After applying the treatment processes Birm filter and UF membrane, the changes in the removal efficiency for Mn and Fe ions according to the backwash time was 48% and 49.7%, indicating there was little efficiency of the membrane. Therefore, the linked process was considered to play a positive role, although it was found not superior to the Birm filter - UF membrane pre- treatment process. As regards the organic matter BOD₅, As regards the organic matter BOD₅, showing the an average removal efficiency of 58.9%. Concerning COD_Mn showing the an average removal efficiency of 60.6%. As to TOC, showing an average removal efficiency of 21.2%. The results have indicated that the linked treatment process of the Birm filter-UF membrane could not effectively remove TOC; therefore, an additional process would be necessary, such as employing an RO membrane. The results have indicated that the linked treatment process of the Birm filter-UF membrane could not effectively remove TOC; therefore, an additional process would be necessary, such as employing an RO membrane. In addition, it was found that the raw water used for the present research showed a number of direct influxes containing more non-biodegradable than biodegradable organic matters. Moreover, this water showed low biodegradation by a substantial amount of microorganisms and contained a large amount of oxidative inorganic matters.

유아교육용 웹 콘텐츠 접근성 향상을 위한 인터페이스 연구

정진희(Jinhee Jung) 한국멀티미디어학회 2007 한국멀티미디어학회 학술발표논문집 Vol.2007 No.1

현재 웹 접근성에 대한 지침, 규칙 제정과 관련된 연구들은 주로 장애인ㆍ노인 등 소외계층을 주된 대상으로 진행되어져 왔고, 현재의 유아 대상 웹 콘텐츠의 경우 콘텐츠 저작자의 임의적인 설계에 의해 제작되고 있는 실정이다. 이에 웹 콘텐츠를 처음 접하는 유아를 위한 특화된 설계 기준이 마련되어야 할 필요성이 있다. 접근성이 향상될 경우 유아가 보다 편안하게 학습을 할 수 있게 되고, 그로 인해 학습효과 증진의 목적을 달성할 수 있다고 본다. 본 논문에서는, 유아교육용 웹 콘텐츠를 구성하고 있는 인터페이스 요소와 관련된 선행 연구회 평가항목 및 한국에서 제정한 웹 접근성과 관련된 지침을 통해, 유아교육용 웹 콘텐츠의 접근성 향상을 위한 인터페이스 가이드라인을 제시하는데 목표를 두고 있다.