Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats

장성백,김동주,김성연,박창희,정지훈,구효정,이재휘 대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.1

The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and SLS micelles improved the in situ permeability of b-lap in all intestinal segments tested although the mixed micellar formulation was more effective in increasing the intestinal absorption of b-lap. The permeability of b-lap was greatest in the large intestinal segments. Compared with SLS micelles, the effective permeability coefficient values measured with mixed micelles were 5- to 23-fold higher depending on the intestinal segment. Our data suggest that b-lap should be delivered to the large intestine using a mixed micellar system for improved absorption.

우측 이하선에서 발생한 다형선종유래 암종

장성백,김도형,이성탁,권대근,최소영,신홍인 대한구강악안면병리학회 2017 대한구강악안면병리학회지 Vol.41 No.4

Carcinoma ex pleomorphic adenoma (Ca ex PA) is an uncommon malignant tumor. It is an aggressive salivary carcinoma, arising from a primary or recurrent benign pleomorphic adenoma (PA). The most common clinical presentation of Ca ex PA is a firm mass in the parotid gland. Here we report a case of Ca ex PA, arising from a recurrent benign PA in the right parotid gland, in a 70-year old female patient. The lesion was first diagnosed as a PA and a superficial parotidectomy was performed. Re-operation was performed for recurrent PA. The second recurrence was diagnosed as Ca ex PA.

Pilomatricoma of the Inferolateral Area of the Parotid Gland

장성백,신홍인,김진욱,최소영 대한구강악안면병리학회 2017 대한구강악안면병리학회지 Vol.41 No.1

Pilomatricoma is the second most common benign dermal-subcutaneous tumor of the head and neck region, after epidermoid cyst, originating from the outer sheath cells of the hair follicle. It can be easily treated with surgical excision. However, it is a relatively unknown skin lesion to maxillofacial surgeons. Therefore, we report a case of pilomatricoma occuring inferolateral area of the parotid gland in a 54-year-old man; with a review of the relevant literature.

참쑥의 정유 성분 ( 5 )

장성백(Sung Baek Jang),장승엽(Seung Yeup Chang),인문교(Mun Kyo Inn),정진현(Jin Hyun Jeong),육창수(Chang Soo Yook) 경희대학교 동서약학연구소 2000 경희약대 논문집 Vol.28 No.-

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2022년 총량관리사업장 대기오염물질 배출량 및 저감량 분석

백원석,이명훈,성기욱,장성신,유승도 한국대기환경학회 2023 한국대기환경학회 학술대회논문집 Vol.2023 No.10

특발성 재발성 십이지장 및 공장염 1예

장성열 ( Sung Yeol Jang ),김정희 ( Jung Hee Kim ),하승혜 ( Sung Hae Ha ),황정아 ( Jeong Ah Hwang ),박상종 ( Sang Jong Park ),백소야 ( So Ya Paik ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.3

There are various etiologies of duodenojejunitis such as Henoch-Schonlein purpura (H-S purpura), vasculitis, Crohn`s disease, celiac sprue, ischemia, lymphoma, Zollinger-Ellison syndrome, bacteria or parasite infection, radiation, drug induced jejunitis, eosinophilic jejunitis, and toxins. A 31-year-old man presented with left upper quadrant pain. He did not have febrile sense, hematochezia, melena, diarrhea, arthralgia and hematuria. He had neither drug history nor traveling history. Esophagogastroduo-denoscopy showed diffuse mucosal erythema and segmental hemorrhagic erosions on the distal area to the descending portion of the duodenum and proximal jejunum, which were commonly observed in the gastrointestinal involvement of H-S purpura. However, he showed no skin lesions, joint and urologic problems until the discharge. Autoimmune markers such as antinuclear antibody and antineutrophil cytoplasmic antibody were negative. Celiac and mesenteric angiogram showed no vascular abnormality. After the administration of oral prednisolone 40 mg daily for therapeutic trial, abdominal pain and endoscopic lesions were improved. He experienced relapses of same episode without skin lesions 16 times during follow-up of 8 years, which were also treated with prednisolone. The abdominal computed tomography during the follow-up also showed no significant finding. We report a case of primary recurrent duodenojejunitis similar to the gastrointestinal involvement of H-S purpura without purpura.

증례 : 소화기 ; 생검으로 진단된 간의 혈관근지방종 1예

장성일 ( Sung Ill Jang ),박형순 ( Hyung Soon Park ),유정환 ( Jung Whan Yu ),배성창 ( Sung Chang Bae ),정재준 ( Jae Jun Chung ),백용한 ( Yong Han Paik ),김자경 ( Ja Kyung Kim ) 대한내과학회 2010 대한내과학회지 Vol.79 No.3

저자들은 건강검진상 우연히 발견된 간내종물에 대해 생검을 시행하여 간의 혈관근지방종으로 진단된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Angiomyolipoma occurs most commonly in the kidneys; the liver is the second most frequent site of involvement. Hepatic angiomyolipoma is a rare, benign, mesenchymal neoplasm, composed mainly of blood vessels, smooth muscle cells, fat, and myelocomponents. Radiologic findings are non-specific because the various elements of these neoplasms vary in their proportion and distribution within the tumor. Thus, data obtained by imaging technologies such as computed tomography, ultrasonography, or magnetic resonance imaging tend to be merely suggestive; definitive diagnosis usually requires histologic confirmation. We report here a case of angiomyolipoma in an incidental tumor of the liver of a 53-year-old female. Tissue was removed from the tumor by ultrasonography-guided gun biopsy and subjected to immunohistochemical analysis. Data showed that tumor cells were positive for HMB-45 and SMA, but negative for cytokeratin, anti-hepatocyte antigen, and α-fetoprotein. The patient did not receive any treatment and is being followed up. (Korean J Med 79:295-300, 2010)

간암으로 오인된 Castleman 병: 증례 보고 및 문헌 고찰

장성열 ( Sung Yeol Jang ),김보현 ( Bo Hyun Kim ),김정희 ( Jung Hee Kim ),하승혜 ( Sung Hae Ha ),황정아 ( Jeong Ah Hwang ),연재우 ( Jae Woo Yeon ),김기호 ( Ki Ho Kim ),백소야 ( So Ya Paik ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.1

Castleman`s disease is a rare disease characterized by lymph node hyperplasia. Although Castleman`s disease can occur wherever lymphoid tissue is found, it rarely appears in the abdominal cavity, and is especially rare adjacent to the liver. Here, we report a rare case of Castleman`s disease in the portal area that mimicked a hepatocellular carcinoma (HCC) in a chronic hepatitis B patient. A 40 year-old woman with chronic hepatitis B presented with right upper quadrant discomfort. Computed tomography and magnetic resonance imaging results showed a 2.2 cm-sized, exophytic hypervascular mass in the portal area. HCC was suspected. However, histologic examination revealed Castleman`s disease. We suggest that Castleman`s disease should be included as a rare differential diagnosis of a hypervascular mass in the portal area, even in patients with chronic hepatitis B. (Korean J Gastroenterol 2012;59:53-57)

3차원 영상 데이터를 활용한 콩 생육 측정 방법 평가

권동원,장성율,반호영,박혁진,상완규,백재경,서명철,조정일,조재일 경상국립대학교 농업생명과학연구원 2023 농업생명과학연구 Vol.57 No.1

Recently, 3D (3-Dimentional) image data utilization technology has been attracting attention, and studies are being made to measurethe growth of crops using equipment such as laser scanners and depth cameras. If 3D image data is used to measure the growth characteristicsof crops, it has the advantage of using structure and shape information that cannot be measured in planar data. In this study, the growth characteristics of soybeans were estimated using 3D image data. Soybeans were measured at beginning bloom (R1), beginning pod (R3),and beginning seed (R5) by using a depth camera. The x, y coordinate position of the main stem was specified using the centroidof the object projected on the plane for estimating the plant height and showed a high determination coefficient. In the case of plantheight estimation, as the structure and shape of stems and leaves developed, the method using the distance between the top points ofan object from the ground in 3D image had a large error between the actual measurement and the estimated value. For estimating theleaf area, object surface points with 3D position values were divided according to height, and the area of each height section was calculated. The estimated value was overestimated because the calculated area in each height section increased due to the increased number ofpoints in the 3D data merging. For more precise growth investigation using 3D images in the future, it is thought that data pre-processingand analysis method development taking into account the characteristics of unique growth variables of crops are required. 최근 3차원 영상 데이터 활용 기술이 주목받으며 레이저 스캐너, 깊이 카메라와 같은 장비를 활용하여 작물의 생육을 측정하려는 연구가 시도되고있다. 작물의 생육 특성을 측정할 때 3차원 영상 데이터를 활용한다면 평면 데이터에서 측정하지 못한 구조와 형태 정보를 이용할 수 있는 장점이있다. 본 연구에서는 콩의 생육 특성을 3차원 영상 데이터를 활용하여 추정하였다. 깊이 카메라를 이용하여 콩의 개화시(R1), 착협기(R3), 종실비대기(R5)에 촬영하고 3차원 데이터로 개체의 초장과 엽면적을 추정하고 실측 값과 비교하였다. 초장 추정을 위해 평면에 투영된 개체의 무게 중심을 이용하여원줄기의 x, y 좌표 위치를 지정하였는데 눈으로 보고 지정한 원줄기의 위치와 무게 중심 점의 x, y 좌표 위치는 높은 결정 계수를 보였다. 초장추정의 경우 콩의 구조와 형태가 발달함에 따라 3차원 영상에서 지면으로부터 개체 상단 지점 간 거리를 이용하는 방법은 실측과 추정 값간오차가 컸다. 엽면적 추정을 위해서 3차원 위치 값을 갖는 개체 표면 점들을 높이에 따라 분할하고 각 높이 구간의 면적을 계산하였다. 3차원데이터 병합 과정에서 늘어난 점 개수로 인해 각 높이 구간에서 계산된 면적이 증가하였기 때문에 추정 값은 과대평가되었다. 향후 3차원 영상을이용한 보다 정밀한 생육 조사를 위해서는 작물 고유의 생육변수 특성을 고려한 데이터 전처리 과정과 분석 방법 개발이 필요할 것으로 사료된다

담낭염 및 담관염을 동반한 노인 환자에서 우연히 발견된 섬모상간전장낭 1례

황정아,하승혜,장성열,박주상,백현욱,김기호,백소야 대한노인병학회 2011 Annals of geriatric medicine and research Vol.15 No.4

Ciliated hepatic foregut cyst(CHFC) is a rare disease that originates from the tracheobronchial tree of the foregut. Most patients with CHFC, which is believed to be a non-malignant neoplasm, are clinically asymptomatic. However, there have been some case reports that identify it as changing to malignant in the last decade of the condition. Surgical excision is, therefore, preferred to observation as the treatment of CHFC. However, surgical excision of CHFC in asymptomatic elderly patients is controversial. We experienced a rare case of a 73-year-old female patient who was accidentally diagnosed with CHFC while being diagnosed for cholecystitis and cholangitis. The patient simultaneously underwent laparoscopic cholecystectomy and resection of CHFC, which was finally diagnosed as benign. We report asymptomatic CHFC in elderly patient, focusing our discussion on whether surgical excision of CHFC is necessary for asymptomatic elderly patients. Accor- ding to a review of case reports, surgical excision of CHFC is not necessary for asymptomatic elderly patients.