족삼리(足三里)(St36)의 전침자극(電鍼刺戟)이 fMRI상 뇌활성(腦活性) 변화(變化)에 미치는 영향(影響)

김영일,김영화,임윤경,이현,이병렬,김연진,Kim, Young-il,Kim, Young-hwa,Lim, Yun-kyoung,Lee, Hyen,Lee, Byung-ryul,Kim, Yeon-jin 대한침구의학회 2003 대한침구의학회지 Vol.20 No.5

Objective: Recently. many studies have showed the evidences of the effect of the Electro-acupuncture treatment through scientific. Methods : One of these methods is functional MRI. We performed electro-acupuncture on Zusanli(St36) and observed the change of brain activation using fMRI. Zusanli(St36) is located on the lateral side of the lower leg. 3 cun(寸) inferior to the Patella of the lower border. Theoretically and clinically. this point has been considered very important for gynecological disorders. spleen and stomach disorders. and psychological disorders. To see the effects of electro-acupuncture stimulation on Zusanli(St36). the experiment was carried out on twelve healthy volunteers. using the gradient echo sequence with the 3.0T whole-body fMRI system(ISOL). After the needle insertion on right Zusanli(St36). 2 Hz of electric stimulation was given for 30 seconds. repeated five times. with 30 seconds' intervals. The Image analysis including motion correction. talairach transformation, and smoothing was done with SPM99. Results ad conclusion : The electro-acupuncture stimulation on Zusanli(St36) activates Brodmann Area 6, 13, 2, 19, 21, 22, 39, 40, 38, 3which indicates the pathways of the electro-acupuncture stimulation on Zusanli(St36) and the possibility of the relationship of the electro-acupuncture stimulation on Zusanli(St36) with autonomic nervous system, internal organic system.

태충(太衝)(Liv3)의 전침자극(電鍼刺戟)이 fMRI상 뇌활성(腦活性) 변화(變化)에 미치는 영향(影響)

하치홍,이현,임윤경,홍권의,이병렬,김연진,Ha, Chi-hong,Lee, Hyun,Lim, Yun-kyoung,Hong, Kwon-eui,Lee, Byung-ryul,Kim, Yeon-jin 대한침구의학회 2003 대한침구의학회지 Vol.20 No.5

Objective: Recently, many studies have showed the evidences of the effect of the acupuncture treatment through scientific methods. One of these methods is functional MRI. We performed electro-acupuncture on Liv3 and observed the change of brain activation using fMRI. Methods: To see the effect of electro-acupuncture stimulation on Liv3. the experiment was carried out on 12 healthy volunteers. using the gradient echo sequence with the 3.0T whole-body MRI system(ISOL). After the needle insertion on right Liv3. 2 Hz of electric stimulation was given for 30 seconds. repeated five times. with 30 seconds' intervals. The Image analysis including motion correction, talairach transformation. and smoothing was done with SPM99. Results : 1. Group averaged brain activation induced by bilateral electro-acupuncture stimulation on Liv3 activates Brodman Area 6, 13, 18, 19, 22, 31, 39, 44, 2. Group averaged brain deactivation induced by bilateral Electro-acupuncture stimulation on Liv3 activates Brodman Area 4, 6, 9, 19, 36, 37, 39. 3. Group averaged brain activation induced by unilateral(right side) electro-acupuncture stimulation on Liv3 activates Brodman Area 2, 3, 6, 9, 10, 22, 40, 42, 43. 4. Group averaged brain deactivation induced by unilateral(right side) electro-acupuncture stimulation on Liv3 activates Brodman Area 6, 18, 19, 28, 30, 31, 35, 37. 5. Brain region activated by motor stimulation activates Brodman Area 4, 6, 13, 19, 42.

음릉천(陰陵泉)(Sp9)의 전침자극(電鍼刺戟)이 functional MRI상 뇌활성(腦活性) 변화(變化)에 미치는 영향(影響)

김정호,이현,임윤경,홍권의,이병렬,김연진,Kim, Jeong-ho,Lee, Hyun,Lim, Yun-kyoung,Hong, Kwon-eui,Lee, Byung-ryul,Kim, Yeon-jin 대한침구의학회 2003 대한침구의학회지 Vol.20 No.4

Objective : The meridian theory in oriental medicine explains that Sp9(Yinlingquan) has been considered very important for gynecological disorders, spleen and stomach disorders, and water metabolic disorders. Functional MRI is the best method of showing the evidences of the effect of the Electro-acupuncture treatment through scientific methods. On this supposition, Electro-acupuncture stimulation on Sp9(Yinlingquan) was carried out on six healthy volunteers, using the gradient echo sequence with the 3.0T whole-body MRI system(ISOL). Methods : Electro-acupuncture stimulation on Sp9(Yinlingquan), the experiment was carried out on six healthy volunteers, using the gradient echo sequence with the 3.0T whole-body MRI system(ISOL). After the needle insertion on right Sp9(Yinlingquan), 2Hz of electric stimulation was given for 30 seconds, repeated five times, with 30 seconds' intervals. The Image analysis including motion correction, talairach transformation, and smoothing was done using SPM99. Results : The electro-acupuncture stimulation on Sp9(Yinlingquan) activates Brodmann Area 13, 19, 22, 39, 40, 47 which may be the central pathways of the electro-acupuncture stimulation on Sp9(Yinlingquan). We also hypothesize that those brain areas may be directly or indirectly related with the mechanism of the effect of electro-acupuncture stimulation on Sp9(Yinlingquan).

한중 여대생의 기초화장품 구매인식과 용기디자인 선호도 비교

임은진 ( Eunjin Im ),임윤경 ( Yun Kyoung Lim ),하준호 ( Junho Ha ) 대한미용학회(구 대한미용과학회) 2018 대한미용학회지 Vol.14 No.2

If customers in the past wanted a balance between price and brand of cosmetics, the contemporary customers take into account the functions and even exterior designs of a cosmetic item. The current study targeted Korean and Chinese female college students residing in Korea and did a comparative analysis of the students' cognizance on basic skin care product container design factors. To this end, a survey was carried out among the Korean and Chinese female college students of a college located in Chungcheong province for 3 weeks, starting from the 25th of October, 2017. The collected data were statistically treated through data coding and data cleaning before analysisusing SPSS v. 21.0 statistial package program. First, analysis of the preference for basic skin care products container shape, revealed that the rectangular shape(58.7%) showed the highest score for both type of the college students. Second, for mouth type of analysis, the 'tincture-mouthed'(32.4%) showed the highest score. For the Chinese college students, the preference was for tincture-mouthed type, while the Korean students preferred the tube-mouthed type. Third, analysis on 'the material of container' showed the highest score(M=3.58). The Chinese college students gave more importance on color, packaging design and the material than the Korean students. Results showed that the Korean students gave more importance on quality, price/quantity and brand when buying basic skin care products, and quality, price/quantity highly affected their re-purchasing. On the other hand, the Chinese students emphasized on quality, packaging design and brand when buying the basic skin products, and packing design had a large influence on their re-purchasing behavior. Furthermore, both the Korean and Chinese students laid stress on color, packing design and material and container designs but the ratio of Chinese was higher than that of the Koreans.

중증 전자간증 임산부의 제대동맥 이완기말 혈류 속도에 따른 제대혈 혈액소견 및 주산기 예후

오준환 ( Joon Hwan Oh ),임윤경 ( Yun Kyoung Lim ),이희종 ( Hee Jong Lee ),김행수 ( Haeng Soo Kim ),양정인 ( Jeong In Yang ),유희석 ( Hee Sug Ryu ),오기석 ( Kie Suk Oh ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.4

목적 : 중증 전자간증 환자를 대상으로 제대동맥 이완기말 혈류의 유무에 따른 제대혈 유핵 적혈구의 수와 주산기 예후를 비교하고자 하였다. 연구 방법 : 1999년 1월부터 2002년 9월까지 아주대학교 산부인과에 입원한 중증 전자간증 환자중 분만 72시간 전에 제대 동맥 이완기말 혈류속도를 측정한 49예를 대상으로 하여 이완기말 혈류 속도가 있었던 42예와 혈류 속도가 없는 7예 사이의 제대혈에서의 유핵 적혈구의 수와 태아의 주산기 예후를 비교하였다. Objective : To assess the umbilical nucleated red blood cell counts and perinatal outcomes according to umbilical artery Doppler end diastolic velocity in severe preeclampsia. Materials and Methods : A prospective case-control study comparing 42 severe pr

100 gm 경구 당부하검사 결과 하나만 비정상을 보인 임신의 양상

한기수(Ki Su Han),양성천(Seong Cheon Yang),김행수(Haeng Soo Kim),양정인(Jeong In Yang),이희종(Hee Jong Lee),임재현(Jae Hyun Lim),임윤경(Yun Kyoung Lim),오기석(Kie Suk Oh) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.10

N/A Objective : To evaluate the clinical outcomes of pregnancies showing one abnormal glucose tolerance test value. Method : We performed 50 gm glucose challenge test in 5,019 pregnant women at 24-28 weeks of gestation. In 1,170 women with plasma glucose levels over 130 mg/dL, 100 gm oral glucose tolerance tests (OGTTs) were performed at 28-32 weeks of gestation. In the 888 cases who were followed up, according to the National Diabetes Data Group (NDDG) criteria, 122 cases with one abnormal 100 gm OGTT value were divided into three groups (groups 1, 2, 3 : abnormal value after 1, 2, 3 hours, respectively). These were compared with 577 cases (control group) with normal 100 gm OGTT value, retrospectively. Result : The incidence of one abnormal glucose tolerance test value was 2.6%, and there were no cases where the fasting plasma glucose level only was elevated. The incidence (control, group 1, group 2, group 3 : 19.4%, 43.8%, 25.7%, 29.6%) of poor maternal outcomes which contain any one of preeclampsia, hydramnios, cesarean delivery for cephalopelvic disproportion or failure to progress or fetal distress was highest in group 1 (p=0.025). The incidence (15.8%, 43.1%, 14.3%, 21.1%) of poor perinatal outcomes which contain any one of fetal distress, Apgar score of 5 minute < 7, hypoglycemia, respiratory distress syndrome, small for gestational age, perinatal death was also highest in group 1 (p=0.009). Logistic regression analysis for poor maternal outcomes showed odds ratio of 2.83 (95% confidence interval 1.02-7.87) in group 1 and 2.08 (95% confidence interval 1.22-3.55) in group 3, and for poor perinatal outcomes odds ratio of 4.24 (95% confidence interval 1.02-17.52) in group 1 and 3.30 (95% confidence interval 1.45- 7.48) in group 3. Conclusion : Pregnancies complicated with one abnormal glucose tolerance test value, particularly the group showing abnormal glucose tolerance test value after 1 or 3 hour exhibited adverse maternal and perinatal outcomes.

ATP 에 의해 유도된 인간 난소 황체화 과립세포의 세포자멸사에 관한 연구

김미란(Mi Ran Kim),박동욱(Dong Wook Park),김영아(Young Ah Kim),조태섭(Tae Seop Cho),황경주(Kyung Joo Hwang),임윤경(Yun Kyoung Lim),민철기(Churl K . Min) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11

N/A Objective : To determine the effects of extracellular ATP on mitochondrial function and apoptosis during human luteinized granulosa cell cultures. Methods : The addition of various concentrations of ATP (0, 0.1, 0.25, 0.5, 0.75 mM) to luteinized granulosa cells obtained during In vitro fertilization ovum pickup procedures. After culture for 24 hours, purinoceptor activity and functional changes in mitochondria were measured by patch clamp, flow cytometry, and confocal microscopy. Results : Measurement by patch clamp of the granulosa cell membrane potential after ATP addition to cultured granulosa cells showed that both the inward and outward currents were expressed. After treatment of the granulosa cells with JC-1, measurement of the mitochondrial activity by confocal microscopy showed that the with increasing concentrations of ATP the relative ratio of undamaged mitochondria (red/green ratio) tended to decrease (P=0.027). After double staining of the cultured granulosa cells with Annexin V and Propidium Iodide, quantitative flow cytometry analysis showed that apoptosis increased with increasing concentrations of ATP (7.88%, 8.44%, 11.40%, 13.52%, 18.57%). Conclusion : The results of this study shows that apoptosis of granulosa cells increases with increasing extracellular ATP concentrations in cultured human luteinized granulosa cells. This is observed to be a consequence of cell membrane purinoceptor activity and functional changes in the mitochondria. It is therefore thought that remodelling processes of the ovarian tissue is regulated by neuroendocrine factors of the extracellular ATP.

복강경술을 이용한 난소 병변의 치료

임윤경,김영아,조미영,안상태,유희석,김미란,황경주 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.4

목적 : 난소 병변으로 복강경 수술을 받은 환자를 대상으로 복강경 수술의 장점, 단점, 적용범위 및 합병증 등에 대하여 알아보고자 하였다. 연구 방법 : 1994년 6월부터 2001년 9월까지 아주대학교 병원에서 난소 병변으로 진단되어 복강경 수술을 시행 받은 354명의 환자를 대상으로 후향적 고찰을 시행하였다. 결과 : 환자군의 나이 분포는 13세부터 77세였으며 평균나이는 30.9세였다. 병변의 크기는 7 cm 미만 (265예, 74.9%), 위치는 편측성 (313예, 88.4%)이 대부분이었다. 시행된 수술은 낭종제거술이 가장 많았고 (225 예, 63.6%), 난소난관절제술, 난소절제술, 나팔관절제술, 창문개구술, 조직검사의 순이었다. 수술시간은 최저 10분에서 최고 240분으로 평균 74.2분이었다. 수술 후 병리조직검사 결과에서, 편측성 난소 병변 중 조직검사를 시행한 군에서는 양성기형종이 가장 많았으며 (107/305, 35.1%), 자궁내막종, 낭선종 등의 순이었다. 경계성 종양을 포함한 악성종양은 4예에서 발견되었다 (4/305, 1.3%). 양측성 난소병변 중에는 자궁내막종이 대부분이었으며 (31/41예, 75.6%), 기형종, 낭선종, 섬유종 등의 순이었다. 수술 후 입원기간은 0일에서 19일까지로 평균 2.5일이었다. 대부분이 수술 후 합병증 없이 퇴원하였으며 (347예, 98.0%), 혈관손상으로 인한 혈관종 3예, 농양 형성 1예, 개복술로의 전환 3예가 있었다. 결론 : 복강경 수술은 난소 병변의 치료에 유용하며, 여러 가지 합병증은 적절한 환자군의 선택과 원칙에 따른 수술 및 숙련된 복강경 수술의사에 의해서 해결되어질 수 있는 문제들로 여겨진다. Objective : To assess the advantages, disadvantages, applicability, and complications of operative laparoscopy in ovarian pathologic lesions. Materials and Methods : A retrospective case series which compares 354 patients who had laparoscopic surgery at Ajou University Hospital from June, 1994 to September, 2001 for ovarian pathology. Results : The patient's ages ranged from 13 to 77 years, and their mean age was 30.9 years. Most of the lesions were less than 7 cm in size and unilateral. The operations performed were cystectomy in 225 cases (63.6%), salpingooophorectomy, oophorectomy, salpingectomy and fenestration or biopsy in order. Operative times were between 10 and 240 minutes (mean: 74.2 minutes). Pathologic examinations of unilateral ovarian tumors were performed in 305 cases. The most common pathology of unilateral ovarian tumor was teratoma (107/305, 35.1%), endometrioma and cystadenoma in order. Malignancies were found in 4 cases including borderline malignancy (1.3%). Pathologies of bilateral ovarian tumor were endometrioma (31/41, 75.6%), teratoma, and fibroma in order. Postoperative hospital stays were from 0 days to 19 days (mean: 2.5 days). There were 7 surgical complications including 3 vessel injury related hematomas, 1 abscess formation, and 3 exploratory laparotomy. Conclusions : We concluded that operative laparoscopy was useful in surgery of ovarian lesions, if there are carefully selected patients, standard procedures, and skilled laparoscopic surgeons.

Platinum sensitive 재발성 난소암에서 Carboplatin/Paclitaxel의 효과

장혜진,유희석,임윤경,문세희,장기홍,이정필 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4

목적 : 재발성 난소암에서 platinum 감수성을 기준으로 2차 항암요법으로 사용한 Carboplatin과 Paclitaxel의 효과를 알아보기 위하여 본 연구를 진행하였다. 연구방법 : 1998년 1월 1일부터 2003년 8월 31일까지 만 5년 8개월 간 아주대학교병원 산부인과에 재발성 난소암으로 입원한 환자 중에서 최초 수술로 난소암을 확진한 후 Cisplatin 또는 Carboplatin 등 platinum 제재가 포함된 항암치료를 받은 후 6개월 이후에 재발한 환자 29명을 대상으로 Carboplatin은 5 AUC를 그리고 Paclitaxel은 175 mg/m^(2)를 투여하였으며, 최소 3회에서 최고 16회까지 투여하였다. 치료효과의 판정은 CT, MRI, Ultrasonography등 영상진단상 암종괴의 크기가 완전히 소실되었을 경우를 완전반응(complete response)으로, 50%이상 감소되었을 경우를 부분반응(partial response)으로, 50% 미만으로 감소되었거나 20% 미만 증가하였을 경우를 불변(stable disease)으로, 그리고 20% 이상 증가되었을 경우를 진행(progressive disease)로 정의하였다. 결과 : 대상 환자에서 완전반응은 6명(21%), 부분반응은 11명(38%), 그리고 불변은 5명(17%)로 전체 반응율 (overall response rate)은 59% 그리고 임상적 유용성(clinical benefit=CR+PR+SD)은 76%이었다. 결론 : 재발성 난소암환자에서 기왕에 사용한 Platinum 제재에 민감한 환자에서는 Carboplatin과 Paclitaxel의 병행 투여가 효과적이었다. Objective : To ascertain the effect of Carboplatin and Paclitaxel combination as a second line regimen for recurrent ovarian carcinoma based on platinum sensitivity. Methods : From January 1st, 1998 through to August 31st, 2003, 29 patients were retrospectively reviewed who had previously underwent primary cytoreductive surgery and adjuvant chemotherapy with Cisplatin or Carboplatin for ovarian carcinoma, and who had later recurred during follow up. All 29 patients had recurred at least 6 months after therapy, and thereafter received second line chemotherapy consisting of Carboplatin (5 AUC) and Paclitaxel (175 mg/㎡) for a minimum of least 3 cycles and a maximum of 16 cycles. Treatment efficacy was assessed by imaging studies including Computerized tomography, Magnetic Resonance Imaging, or Ultrasonography. Complete response was determined as complete disappearance of tumor, partial response at least than 50% reduction in tumor volume, stable disease as less than 50% reduction or less than 20% increase in tumor volume, and progressive disease as more than 20% increase. Results : There was complete response in 6 (21%) patients, partial response in 11 (38%), stable disease in 5 (17%), showing an overall response rate of 59%. The clinical benefit (CR+PR+SD) was 76%. Conclusion : The combination of Carboplatin and Paclitaxel administration seems to be an effective mode of second line therapy in patients with recurrent ovarian carcinoma who had been sensitive to prior platinum based chemotherapy.

급성충수염의 임상적 고찰

백진기,임윤경,김성조,전경후 대한가정의학회 1996 Korean Journal of Family Medicine Vol.17 No.1