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만성간질환을 가진 환자에서 중합효소연쇄반응법 ( Polymerase Chain Reaction : PCR ) 을 이용한 HBV DNA 의 검출
한기수(Ki Su Han),이효랑(Hyo Rang Lee),박중원(Joong Won Park),유병철(Byung Chul Yoo),박실무(Sill Moo Park) 대한내과학회 1996 대한내과학회지 Vol.51 No.3
N/A Objectives: The detection of serum HBV DNA is important for the assessment of the disease activity and for the evaluation of the infectivity in chronic HBV infection. The goal of this study is to determine the detection rate of serum HBV DNA in Korean patients with chronic liver diseases by the PCR Southern blot analysis and to compare it with profiles of HBV serolosic markers. Methods: Serum samples from 306 Korean adults with chronic liver diseases(186 HBsAg(+ ) patients and 120 HRsAg( - ) patients)were tested for type B viral hepatits markers by RIA and HBV DNA by Polymerase Chain Reaction(PCR) Results : 1) In HBsAg(+ ) patients the detection rate of HBV DNA was 89.6%(164/186), Among these patients, in 96.1% of HBsAg(+), HBeAg(+)patients, 73.8% of HRsAg(+), anti-HBe (+)patiens, and 94.4% of HBsAg(+), HReAg( - ), anti- HBe( - )patients, HBV DNA was detected in their serum. 2) In HBsAg( - ) patients the detection rate of HBV DNA was 21,6%(26/120). Among these patients, 52.2% of anti-HBc(+), anti-HBs( - )patients, 13.0% of anti-HBc(+), anti-HBs(+)patients had HBV DNA in their serum. None of the HBsAg( - ), anti-HBc ( - ), anti-HBs( + ) patients had HBV DNA in their serum. Conclusion - HBV DNA was detected not only in HBsAg(+)patients but also in a significant portion(21.6%) Of HBSAg( - )patients, especially in anti-HBc(+)patients. Therefore hepatitis B virus may be related to HBsAg( - ) chronic liver diseases in Korea. Among anti-HBs(+)patients HBV DNA was detected in 13.0%, so that they may have some live virus even though they have obtained immunity against the virus. In 73.8% of HBsAg(+ ), anti-HBe(+ )patients, HBV DNA was deteced.
100 gm 경구 당부하검사 결과 하나만 비정상을 보인 임신의 양상
한기수(Ki Su Han),양성천(Seong Cheon Yang),김행수(Haeng Soo Kim),양정인(Jeong In Yang),이희종(Hee Jong Lee),임재현(Jae Hyun Lim),임윤경(Yun Kyoung Lim),오기석(Kie Suk Oh) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.10
N/A Objective : To evaluate the clinical outcomes of pregnancies showing one abnormal glucose tolerance test value. Method : We performed 50 gm glucose challenge test in 5,019 pregnant women at 24-28 weeks of gestation. In 1,170 women with plasma glucose levels over 130 mg/dL, 100 gm oral glucose tolerance tests (OGTTs) were performed at 28-32 weeks of gestation. In the 888 cases who were followed up, according to the National Diabetes Data Group (NDDG) criteria, 122 cases with one abnormal 100 gm OGTT value were divided into three groups (groups 1, 2, 3 : abnormal value after 1, 2, 3 hours, respectively). These were compared with 577 cases (control group) with normal 100 gm OGTT value, retrospectively. Result : The incidence of one abnormal glucose tolerance test value was 2.6%, and there were no cases where the fasting plasma glucose level only was elevated. The incidence (control, group 1, group 2, group 3 : 19.4%, 43.8%, 25.7%, 29.6%) of poor maternal outcomes which contain any one of preeclampsia, hydramnios, cesarean delivery for cephalopelvic disproportion or failure to progress or fetal distress was highest in group 1 (p=0.025). The incidence (15.8%, 43.1%, 14.3%, 21.1%) of poor perinatal outcomes which contain any one of fetal distress, Apgar score of 5 minute < 7, hypoglycemia, respiratory distress syndrome, small for gestational age, perinatal death was also highest in group 1 (p=0.009). Logistic regression analysis for poor maternal outcomes showed odds ratio of 2.83 (95% confidence interval 1.02-7.87) in group 1 and 2.08 (95% confidence interval 1.22-3.55) in group 3, and for poor perinatal outcomes odds ratio of 4.24 (95% confidence interval 1.02-17.52) in group 1 and 3.30 (95% confidence interval 1.45- 7.48) in group 3. Conclusion : Pregnancies complicated with one abnormal glucose tolerance test value, particularly the group showing abnormal glucose tolerance test value after 1 or 3 hour exhibited adverse maternal and perinatal outcomes.
황계호(Gye-Ho Hwang),변경범(Kyung-Beom Byun),임영태(Young-Tae Lim),한기수(Ki-Su Hab),한윤구(Yun-Goo Han),김순기(Soon-Ki Kim),이봉섭(Bong-Seob Lee) 한국조명·전기설비학회 2021 한국조명·전기설비학회 학술대회논문집 Vol.2021 No.11
As for the research direction of existing household electric range, research on efficiency increase and electricity consumption through resonant circuit configuration was conducted. In recent years, the research direction of household electric range is being actively researched to apply the user’s convenience. Therefore, this paper confirms the applicability of a circuit configuration with a remote(Wifi) control function added for user convenience for eco-friendly household electric ranges. In the future, the disabled and the elderly plan to test whether the proposed device can be controlled remotely.
임신성 내당능장애 및 임신성 당뇨를 동반한 임신의 양상 및 주산기 예후
이원종(Won Jong Lee),안성희(Seong Hee Ahn),김행수(Haeng Soo Kim),양정인(Jeong In Yang),김윤석(Yoon Seok Kim),오준환(Joon Hwan Oh),한기수(Ki Su Han),오기석(Kie Suk Oh) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.6
N/A Objective : To evaluate the clinical manifestations and perinatal outcomes of pregnancies complicated with gestational impaired glucose tolerance (GIGT) and gestational diabetes mellitus (GDM). Methods : We performed 50gm oral glucose tolerance test (OGTT) for GIGT and GDM screening in 4,367 pregnant women at 24-28 weeks of gestation. In 1,010 women with plasma glucose level over 130mg/dl, 753 women underwent 100gm OGTTs at 28-32 weeks of gestation. According to the NDDG criteria, 113 cases with GIGT (single positive level of OGTT ; group 2), 125 cases with GDM (group 3), and 515 cases with control (group 1) were identified among the 753 cases. Retrospective review of outcome of these patients was performed. ANOVA and chi-square test were used to determine the statistical significance. Results : The incidence of GIGT and GDM was 2.7%, 3.0%. The prepregnant body mass index (21.4±3.0kg/m2, 21.3±2.8kg/m2, 23.2±4.1kg/m2), overweight of BMI over 26 (7.4%, 4.4%, 14.4%) and obesity of BMI over 30 (1.2%, 0.0%, 8.0%) was significantly higher in group 3 than group 1 (p<0.05). We defined poor maternal outcome as those suffering from any one of birth canal injury, hydramnios or oligohydramnios, preeclampsia, cesarean delivery due to cephalopelvic disproportion, dystocia, fetal distress. Group 3 showed most highest poor maternal outcome (22.3%, 28.3%, 39.2%, p<0.05). And we defined poor neonatal outcome as those suffering from any one of hyperbilirubinemia, hypoglycemia, congenital anomaly, admission to neonatal intensive care unit due to respiratory distress syndrome. Group 2 and group 3 showed poor neonatal outcome than group 1 (6.2%, 13.3%, 21.6%, p<0.05). Conclusion : Pregnancies complicated with GDM showed poor maternal and neonatal outcome, and GIGT experienced no adverse maternal outcomes but showed poor neonatal outcomes compared to normal pregnancy, and showed less correlation with obesity than GDM. Further study of pathophysiology and proper management of GIGT will be mandatory.
이희종(Hee Jong Lee),이준서(June Seo Lee),김행수(Haeng Soo Kim),양정인(Jeong In Yang),오준환(Jun Hwan Oh),한기수(Ki Su Han),오기석(Kie Suk Oh) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.3
N/A Objective : To evaluate the perinatal outcomes of twin pregnancies with birth weight discordancy and to determine factors affecting on the outcomes. Methods : We studied 367 pairs of twin delivered after 28 weeks of gestation at the Ajou University Hospital between June 1994 and June 2000. Twins were stratified into three groups according to the percent difference of birth weight. Birth weight difference less than 15%(concordant) was classified into control group(268 pairs), between 15% and 25% into group 1(72 pairs), and more than 25% into group 2(27 pairs). Perinatal outcomes of each group were assessed retrospectively. Results : In smaller twins, mean birth weight(control vs group 1 vs. group 2 : 2274.3±424.9 gm vs. 2012.9±303.2 gm vs. 1635.2±440.8 gm, p<0.05), duration of neonatal intensive care unit admission(7.6±11.5 days vs. 11.6±10.8 days vs. 18.6±14.4 days, p<0.05), and the frequency of neonatal jaundice(8.6% vs. 12.5% vs. 29.6%, p<0.05), the frequency of small for gestational age infant(8.2% vs. 40.3% vs. 74.1%, p<0.05), and perinatal mortality(2.6% vs. 2.8% vs. 11.1%, p<0.05) in group 2 showed statistically significant difference from control group. No difference was found in larger twins. In multiple logistic regression analysis, independent prognostic factors of discordant twin were gestational age and birth weight. Conclusion : In twin pregnancies with birth weight discordancy, larger twins showed no difference in perinatal outcomes but smaller twins with birth weight discordancy more than 25% showed significantly higher perinatal mortality and morbidity. However independent prognostic factor was not discordancy itself but gestational age and birth weight.
유병철,장세경,박실무,홍석호,한기수,손승우,정우식 대한내과학회 1993 대한내과학회지 Vol.45 No.6
Pyoderma gangrenosum is an uncommon, chronic, painful, ulcerating skin disease originally described by Brusting and colleagues in 1930. The lesions have a distinctive clinical appearance of necrotic ulceration with a mucopurulent base and a violaceous underminded border surrounded by a peripheral zone of erythema. Pyoderma gangrenosum typically occurs most frequent- Iy on the lower Iimbs, and there is often a history of preceding minor trauma. Many adult patients have associated systemic abnormalities: arthritis, inflammatory bowel disease, and monoclonal gammapathy being the most common. Recently, we experienced a case of 18-year old woman with pyoderma gangrenosum associated with ulcerative colitis. Treatment with corticosteroids, sulfasalazine improved the symptoms of ulcerative colitis and the skin lesions. The case is presented with the review of literatures.