본사 - 공동운영기관의 새해 설계

이화미,나선정,정석순,박순양,이성조,이은숙,오카타리나 새가정사 1976 새가정 Vol.- No.-

사내커뮤니케이션과 보상이 내부공중의 임파워먼트와 조직애착심에 미치는 영향력 연구

이화미 한국방송학회 2008 한국방송학회 학술대회 논문집 Vol.- No.-

이축 휨 모멘트를 받는 철근콘크리트 단주의 신뢰성 해석 ( Reliability Analysis of RC Short Column Subjected to Biaxial Bending )

이화미,신영수,김요숙 대한건축학회 2002 大韓建築學會論文集 : 構造系 Vol.18 No.11

사내커뮤니케이션과 보상이 내부공중의 임파워먼트와 조직애착심에 미치는 영향력 연구

이화미 한국언론학회 2008 한국언론학회 학술대회 발표논문집 Vol.2008 No.-

Multiresidue Analysis of Pesticides in Agricultural Products by a Liquid Chromatography/Tandem Mass Spectrometry Based Method

이화미,박성수,임무송,이현숙,박형준,황혜신,박승영,조대현 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.5

A sensitive and specific liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed for the determination of 56 residual pesticides from commercial crops. For a validation of the method, the recoveries, linearities, limits of detection (LOD), and limits of quantitation (LOQ) of the 56 pesticides were investigated. The linearities, LOD, and mean recoveries of the pesticides ranged 0.9686-0.9999, 0.00-11.54 μg/kg, and 65-82%,respectively. This method was evaluated by its application to monitor 345 agricultural products collected from 9provinces in Korea 2011. Fifteen pesticides were detected from 39 samples and 2 or more residual pesticides were found in 7 samples. However, none of the compounds were observed above the corresponding maximum residue level. The results reflect that the detected pesticide residues were in a safe range and that residual pesticides in the agricultural products in Korea were properly controlled.

사각근간 상완신경총 차단 시 간헐적 투여와 지속적 투여에 따른 술 후 진통의 비교

이화미,최우종,최규택 대한마취통증의학회 2010 Anesthesia and pain medicine Vol.5 No.2

Background:Interscalene brachial plexus block (IBPB) is an effective method of postoperative analgesia after shoulder surgery. This study evaluates the effects and complications of IBPB with two different infusion methods (using intermittent bolus infusion versus automated continuous infusion). Methods:Thirty six patients who were scheduled for shoulder surgery were randomly assigned into two groups (the continuous vs. intermittent groups).All the patients received preoperative IBPB using 15 ml of 0.25% ropivacaine followed by insertion of a 20 gauge catheter.This catheter was connected to a patient controlled analgesia (PCA) pump after the operation.The intermittent group (n = 18) received IBPB with 0.2% ropivacaine 100 ml (bolus 15 ml, lock time 4 h) without basal infusion.The continuous group (n = 18) received IBPB with 0.2% ropivacaine 100 ml (basal rate 4 ml/h) without bolus injection.All the patients were given meperidine 25 mg when the postoperative visual analogue score (VAS) >40 mm. The VAS, heart rate, noninvasive blood pressure, respiratory rate, consumption of meperidine and complications were measured during the 64 h following surgery at intervals of 8 h. Received: December 30, 2009. Revised: 1st, January 13, 2010; 2nd, January 29, 2010. Accepted: February 28, 2010. Corresponding author: Kyu Taek Choi, M.D., Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan, College of Medicine, 388-1, Pungnap-dong, Songpa-gu, Seoul 138-736, Korea. Tel: 82-2-3010-3857, Fax: 82-2-470-1363, E-mail: qtek@amc.seoul.kr Results:The VAS was higher in the intermittent group than that in the continuous group at 24 h after surgery (P < 0.01).However, there was no significant difference for the VAS between the groups for the other assessment periods.There was no significant difference for the amount of meperidine consumed and the incidence of complications between the groups. Conclusions:Intermittent IBPB’s analgesic effects and complications for treating pain after shoulder surgery are similar to those of continuous IBPB. Therefore, intermittent IBPB could be used for the management of pain after shoulder surgery.

LC-MS/MS를 이용한 한국에서 유통되는 농산물의 잔류 농약 평가

이화미(Hwa-Mi Lee),허수정(Soo Jung Hu),이현숙(Hyun-Sook Lee),박승영(Seung Young Park),김남선(Nam-Sun Kim),신용우(Yong Woo Shin),최근화(Keun Hwa Choi),김성일(Sung Il Kim),남슬이(Seul Yi Nam),조대현(Dae Hyun Cho) 한국식품과학회 2013 한국식품과학회지 Vol.45 No.4

본 연구에서 한국 유통 농산물 17품목(쌀, 사과, 배, 오렌지, 복숭아, 딸기, 바나나, 파인애플, 포도, 키위, 수박, 토마토, 오이, 호박, 참외, 깻잎, 상추 등)을 대상으로 다성분 분석농약 60종을 분석하기 위하여 대상농산물의 대분류별로 곡류에서는 현미, 두류는 메주콩, 과실류에서는 감귤, 채소류는 고추, 서류에서는 감자,버섯류에서는 느타리버섯을 선정하여 회수율 실험을 수행하였다. 60% 이상의 낮은 회수율을 나타내는 성분 중 fluquinconazole, methomyl은 4가지 이상의 농산물에서 공통적으로 낮은 회수율을 나타내었다. fluquinconazole은 식품에 적용하는 식품공전 4.1.3.22의 개별 시험법을 이용한 전처리 과정을 통해 과일류, 과채류, 콩류에서 개선된 회수율 결과를 얻을 수 있을 것으로 예상되며 methomyl 은 고추, 대두, 버섯 등 식품에 적용하는 식품공전 4.1.3.15의 개별 시험법을 통해 개선된 회수율 결과를 얻을 수 있을 것으로 예상된다. 버섯, 고추에서 공통적으로 60% 미만의 낮은 회수율을 나타내었던 butocarboxim은 현재 식품공전상 개별 시험법이 존재하지 않는 항목이므로 이에 대한 개별시험법을 개발하여 다종농약다성분 시험법을 보완할 필요가 있다고 사료된다. 한국 유통 농산물 17품목(쌀, 사과, 배, 오렌지, 복숭아, 딸기, 바나나, 파인애플, 포도, 키위, 수박, 토마토, 오이, 호박, 깻잎, 상추)을 대상으로 다성분 분석농약 60종을 분석하여 농약 잔류실태를 조사하였다. 조사대상 농산물 358건 중 대부분의 농산물인 291건(81.3%)의 농산물은 농약이 검출되지 않았으며, 67건(18.7%)의 농산물에서 농약이 검출되었으나, 잔류허용기준 미만으로 검출되었다. 쌀 등 17품목에의 다소비 농산물의 농약 잔류실태를 조사한 결과 농약의 잔류량은 잔류허용기준 미만으로 ADI 대비 EDI는 0.000009%에서 0.0861%로 위해도가 아주 낮은 것으로 조사되었으며 비교적 안전한 수준으로 농산물에 대한 농약관리가 이루어지는 것으로 판단되었다. Pesticide residues in agricultural products in Korea were evaluated to create a data base to inform food policy. Pesticide residues were investigated in 17 commodities collected from 9 provinces in 2012. Our analytical method of multiresidue analysis, involved the analysis of individual recovery, linearity, limit of detection, and limit of quantitation of 60 pesticides in six matrices. The pesticides, including acetamiprid and forchlorofenuron, were evaluated in 358 agricultural samples by liquid chromatography/tandem mass spectrometry. Twenty three pesticides were detected from 67 samples. The results showed that the ratio of estimated daily intake to acceptable daily intake was 0.00009-0.0861% by the intake assessment, which means that residual pesticides in agricultural products in Korea are properly controlled.

건강기능식품 중 잔류용매 분석법 개발 및 모니터링

이화미(Hwa-Mi Lee),신지은(Ji-Eun Shin),장영미(Young-Mi Jang),김희연(Hee-Yun Kim),김미혜(Meehye Kim) 한국식품과학회 2010 한국식품과학회지 Vol.42 No.4

Residual solvents in foods are defined as organic volatile chemicals used or produced in manufacturing of extracts or additives, or functional foods. The solvents are not completely eliminated by practical manufacturing techniques and they also may become contaminated by solvents from packing, transportation or storage in warehouses. Because residual solvents have no nutritional value but may be hazardous to human health, there is a need to remove them from the final products or reduce their amounts to below acceptable levels. The purpose of this study was to develop and evaluate an analytical method for the screening of residual solvents in health functional foods. Furthermore, the aim of this study was to constitute a reasonable management system based on the current state of the market and case studies of foreign countries. Eleven volatile solvents such as MeOH, EtOH, trichloroethylene and hexane were separated depending on their column properties, temp. and time using Gas Chromatography (GC). After determining the GC conditions, a sample preparation method using HSS (Head Space Sampling) was developed. From the results, a method for analyzing residual solvents in health functional foods was developed considering matrix effect and interference from the sample obtained from the solution of solvents-free health functional foods spiked with 11 standards solutions. Validation test using the developed GC/HSS/MS (Mass Spectrometry) method was followed by tests for precision, accuracy, recovery, linearity and adequate sensitivity. Finally, examination of 104 samples grouped in suits was performed by the developed HSS/GC/MS for screening the solvents. The 11 solvents were isolated from health functional foods based on vapor pressure difference, and followed by separation within 15 minutes in a single run. The limt of detection (LOD), limit of quantification (LOQ), recovery and coefficient of variation (C.V.) of these compounds determined by the HSS/GC/MS were found to be 0.1 pg/㎖, 0.1-125 pg/ g, 51.0-104.6%, and less than 15%, respectively. Using the developed HSS/GC/MS method, residual solvent from 16 out of 104 health functional products were detected as a EtOH. This method therefore seems to be a valuable extension of analytical method for the identification of residual solvents in health functional food.

Arrhythmogenic potential develops rapidly at graft reperfusion before the start of hypotension during living-donor liver transplantation

황규삼,이화미,박수경,문영진,김정원,김선기,상보현,서동균,유병우 대한마취통증의학회 2016 Korean Journal of Anesthesiology Vol.69 No.1

Background: Detailed profiles of acute hypothermia and electrocardiographic (ECG) manifestations of arrhythmogenicity were examined to analyze acute hypothermia and ventricular arrhythmogenic potential immediately after portal vein unclamping (PVU) in living-donor liver transplantation (LT). Methods: We retrospectively analyzed electronically archived medical records (n = 148) of beat-to-beat ECG, arterial pressure waveforms, and blood temperature (BT) from Swan-Ganz catheters in patients undergoing living-donor LT. The ECG data analyzed were selected from the start of BT drop to the initiation of systolic hypotension after PVU. Results: On reperfusion, acute hypothermia of < 34oC, < 33oC and < 32oC developed in 75.0%, 37.2% and 11.5% of patients, respectively. BT decreased from 35.0oC ± 0.8oC to 33.3oC ± 1.0oC (range 35.8oC–30.5oC). The median time to nadir of BT was 10 s after PVU. Difference in BT (ΔBT) was weakly correlated with graft-recipient weight ratio (GRWR; r = 0.22, P = 0.008). Compared to baseline, arrhythmogenicity indices such as corrected QT (QTc), Tp-e (T wave peak to end) interval, and Tp-e/QTc ratio were prolonged (P < 0.001 each). ST height decreased and T amplitude increased (P < 0.001 each). However, no correlation was found between ΔBT and arrhythmogenic indices. Conclusions: In living-donor LT, regardless of extent of BT drop, ventricular arrhythmogenic potential developed immediately after PVU prior to occurrence of systolic hypotension.

소아 간이식 동안 수액 반응성 예측인자: 수축기와 이완기 시간 변이도와 맥압 변이도의 비교

문영진,이화미,김정원,정형주,이수호,허인영,황규삼 대한마취통증의학회 2015 Anesthesia and pain medicine Vol.10 No.3

Background: In pediatric patients, dynamic preload indices to predict fluid responsiveness remain controversial. Because each beat of blood pressure (BP) — waveform — contains evidence of a systolic and diastolic time interval (STI, DTI), we compared pulse pressure variation (PPV) with respiratory STI and DTI variation (STV, DTV) as predictors of fluid responsiveness during pediatric liver transplantation. Methods: A total of 61 datasets from 16 pediatric liver transplant patients (age range one month to seven years), before and after an inferior vena cava clamp was applied, were retrospectively evaluated from electronically archived BP and central venous pressure (CVP) waveforms. STI and DTI were separated by a beat-to-beat blood pressure waveform. STV, DTV and PPV were calculated by averaging three consecutive respiratory cycles. Averaged CVP was used as a static preload index. A PPV threshold of ≥16%, a known cutoff value in pediatric surgery, was used to discriminate fluid responsiveness in the receiver operating characteristic (ROC) curve analysis. Results: PPV showed correlations with STV and DTV (r = 0.65 and 0.57, P < 0.001, respectively), but not with CVP (r = −0.30, P = 0.079). The area under the ROC curves (AUC) of STV, DTV and CVP were 0.834, 0.872, and 0.613, respectively. Cut-off values of STV and DTV were 7.7% (sensitivity/specificity, 0.80/0.83) and 7.7% (sensitivity/specificity, 0.70/0.88), respectively. Conclusions: This study demonstrates that STV and DTV from a BP waveform showed the potential to predict fluid responsiveness as a surrogate of PPV during pediatric surgery.