소장교액을 동반한 식도열공 탈장

이진원(Jin Won Lee),김해성(Hae Sung Kim),류병윤(Byoung Yoon Ryu),김홍기(Hong Ki Kim),한상진(Sang Jin Han) 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.78 No.3

Paraesophageal hernias are usually classified into three distinct types: type Ⅰ, sliding hernias; type Ⅱ, paraesophageal hernias; type Ⅲ, a combination of type Ⅰ and Ⅱ. Herniation of other abdominal organs can be classified as type Ⅳ, and is a rare situation at the esophageal hiatus. We report herein a 73-year-old female patient who presented with epigastric pain and diagnosed as type Ⅳ paraesophageal hernia. Initial evaluation was focused on myocardial ischemia. There was no evidence of myocardial ischemia in the coronary angiography, but follow-up chest X-ray revealed air-fluid levels in the left mediastinum suggested hiatal hernia. On computed tomography, herniation and strangulation of proximal jejunum into the hemithorax via left diaphragmatic defect was found. After reduction of small bowel and resection of strangulated segment, the defect was closed. Fluid collection in the hernia sac was detected at postoperative day nine, but she was discharged without complication.

개방형 하드웨어 플랫폼 기반의 확장 용이한 스마트 홈 IoT 시스템

이진해,박광일,신종하,유성은,Lee, Jin-hae,Park, Gwang-il,Shin, Jong-ha,Yoo, Seong-eun 대한임베디드공학회 2016 대한임베디드공학회논문지 Vol.11 No.6

Recently, many changes have been made to people's life patterns as the technological advances in the ICT industry. The fusion of smart phones and various IT technologies has brought people convenience and welfare. A typical example of such fusion is the smart home. However, the existing smart home systems are difficult to be changed or extended. So we design a new smart home system with extensibility that can easily adopt legacy appliances and be scaled up. Among a variety of smart home features, this paper deals with IoT Devices that are responsible for controlling power or transmitting and receiving sensing values, IoT Gateway that connects users and consumer electronics via Internet, and Smart Home Manager that monitors and controls these components in the proposed smart home system.

각막반사와 사진을 이용한 새로운 사시각 측정법

이진아 ( Jin A Lee ),이해영 ( Hae Young Lee ) 대한안과학회 2002 대한안과학회지 Vol.43 No.10

Thioacetamide 유발 급성 간 손상에 대한 모과의 효과

이진아(Jin A Lee),신미래(Mi-Rae Shin),이지혜(Ji Hye Lee),박해진(Hae-Jin Park),노성수(Seong-Soo Roh) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.4

본 실험에서는 thioacetamide(TAA)로 유발한 간 손상 rats에 대한 모과 추출물의 간 보호 효과를 확인하기 위하여 SD rat에게 3일간 TAA 복강투여 및 모과 추출물을 경구 투여하였고, 실험 종료 후 혈액 채취 및 간조직을 적출하였다. 혈액을 이용하여 간 손상 지표, 암모니아 및 MPO의 수치를 확인하였는데, Control군보다 모과 투여군에서 GOT, GPT, 암모니아 및 MPO의 수치가 유의하게 감소하였고, 특히 암모니아는 CF200군에서 Normal군과 비슷한 수치를 나타내었다. 간조직 western blotting을 통해 NADPH oxidase와 염증성 단백질의 발현을 확인한 결과, 모과 투여군에서 NOX2, p47<SUP>phox</SUP>와 같은 NADPH oxidase의 발현이 감소하였고, 염증 전사인자 NF-κB, IκBɑ와 전염증성 단백질 iNOS, COX-2 및 염증성 사이토카인 TNF-ɑ, IL-1β의 발현이 유의하게 감소하였다. 또한, H&E staining을 통해 염증 및 간세포의 침윤을 확인한 결과, 모과 투여군에서 세포의 침윤 정도가 크게 감소하여 간 손상이 뛰어나게 완화된 것을 확인하였다. 이상의 결과를 종합해보면 모과 추출물은 혈액 내 간 손상 지표인 GOT, GPT 및 과산화 효소의 수치를 감소시켰으며, 산화적 스트레스의 생성을 억제함으로써 염증성 단백질의 발현을 조절하여 TAA로 인한 간 손상을 완화하는 것으로 생각된다. This study investigated the effect of Chaenomelis Fructus extract (CF) on thioacetamide (TAA)-induced acute liver injury in rats. Rats were divided into five treatment groups: Normal group (Normal, n=8), TAA-induced with distilled water group (Control, n=8), TAA-induced with silymarin 100 mg/kg group (Silymarin, n=8), TAA-induced with CF 100 mg/kg group (CF100, n=8), and TAA-induced with CF 200 mg/kg group (CF200, n=8). An animal model of acute liver injury was established via an injection of TAA (200 mg/kg of body weight, I.P). Silymarin and CF extracts were administrated (P.O.) simultaneously with TAA for 3 days. Levels of GOT (glutamic oxaloacetic transaminase), GPT (glutamic pyruvic transaminase), ammonia, and MPO (myeloperoxidase) were assessed in serum, and the expressions of NADPH oxidase and inflammatory related proteins were analyzed by western blot from liver tissue harvested during autopsy. Our results reveal that CF-administration significantly decreases the levels of serum GOT, GPT, ammonia, and MPO, effectively suppresses NADPH oxidase, and down-regulates the expressions of the NF-κB pathway proteins. These results indicate that administration of CF alleviates the liver injury by inhibiting NADPH oxidase and down-regulating the NF-κB pathway.

USB 장치 정보를 이용한 사용자 인증방안

이진해(Jin-Hae Lee),조인준(In-June Jo),김선주(Seon-Joo Kim) 한국콘텐츠학회 2017 한국콘텐츠학회논문지 Vol.17 No.7

ID/PW(Identifier/Password) 인증방식은 다양한 보안취약성이 존재함에도 사용이 편리하고 구축비용이 저렴하여 아직까지 폭 넓게 사용하고 있으며, 유추해내기 어려운 복잡한 패스워드의 사용과 주기적인 변경을 요구하고 있다. 하지만 사용자 입장에서는 복잡한 패스워드를 기억하고 주기적으로 변경하는 것은 매우 불편한 일이다. 이에 본 논문에서는 USB(Universal Serial Bus) 메모리를 활용하여 복잡한 패스워드를 주기적으로 변경할 필요가 없는 인증시스템을 제안하였다. 사용자 인증시마다 자동으로 재생성 되도록 하고 기존의 인증데이터는 재사용이 불가능하도록 설계하였다. 이를 바탕으로 ID/PW 인증시스템을 크게 고치지 않으면서 사용이 편리하고, 인증서 / 지문인식 수준의 보안성을 제공할 수 있다. Password-based authentication is vulnerable because of its low cost and convenience, but it is still widely used. In order to increase the security of the password-based user authentication method, the password is changed frequently, and it is recommended to use a combination of numbers, alphabets and special characters when generating the password. However, it is difficult for users to remember passwords that are difficult to create and it is not easy to change passwords periodically. Therefore, in this paper, we implemented a user authentication system that does not require a password by using the USB memory that is commonly used. Authentication data used for authentication is protected by USB data stored in USB memory using USB device information to improve security. Also, the authentication data is one-time and reusable. Based on this, it is possible to have the same security as the password authentication system and the security level such as certificate or fingerprint recognition.

애엽(艾葉) 추출물이 알코올성 위염에 미치는 효과

이진아,서정복,김진영,신미래,박해진,노성수,Lee, Jin A,Seo, Jeong Bok,Kim, Jin Young,Shin, Mi-Rae,Park, Hae-Jin,Roh, Seong-Soo 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.4

Objective: Alcohol is known to cause inflammation in the stomach by decreasing the protective substances of the gastric mucosa and increasing oxidative stress. The purpose of this study was to investigate the anti-inflammatory effect of Artemisiae Argyi Folium extract (AF) on alcohol-induced gastritis. Methods: The total polyphenol and flavonoid contents of AF were confirmed through an in vitro experiment. Radical scavenging activities were confirmed using DPPH and ABTS assays. In vivo experiments were conducted on mice divided into 5 groups (n=8): a normal group (Nor), an alcohol-induced gastritis group (Con), an alcohol-induced gastritis group administered 10 mg/kg sucralfate (SC), an alcohol-induced gastritis group administered 100 mg/kg AF (AFL), and an alcohol-induced gastritis group administered 200 mg/kg AF(AFH). The serum levels of reactive oxygen species (ROS) were determined, and protein expressions were confirmed in gastric tissues. Results: In alcohol-induced gastritis, AF alleviated damage to the gastric mucosa caused by alcohol. AF also decreased the serum ROS levels. Western blots showed that AF decreased the expression of NADPH oxidase and decreased the expression of the NF-κB pathway associated with inflammation. AF also decreased the expression of adhesion molecules and chemokine proteins, and increased the expression of anti-inflammatory proteins. Conclusions: AF not only reduced oxidative stress in alcohol-induced gastritis, but it also relieved gastric mucosal inflammation by regulating the expression of the NF-κB pathway.

대황-황금 혼합물이 만성 역류성 식도염에 미치는 효과

이진아,오민혁,신미래,노성수,박해진,Lee, Jin A,Oh, Min Hyuck,Shin, Mi-Rae,Roh, Seong-Soo,Park, Hae-Jin 한국생약학회 2022 생약학회지 Vol.53 No.1

강제수영실험을 통한 산수유 추출물의 항피로 효과

이진아(Jin A Lee),신미래(Mi-Rae Shin),노정숙(Jeong Sook Noh),박해진(Hae-Jin Park),노성수(Seong-Soo Roh) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.4

본 실험에서는 추출방법을 달리한 산수유 물 추출물(CFW)과 산수유 30% 에탄올 추출물(CFE)을 이용해 강제수영부하실험을 실시하여 산수유 추출물의 항피로 효과를 확인하였다. 강제수영부하실험 종료 후 수영시간 변화를 확인하였으며, 혈청을 이용하여 간 손상지표, 신장 손상지표 및 피로관련 지표를 측정하였다. 강제수영부하실험을 실시하여 시료 투여 전과 후의 수영시간을 측정한 결과, CFW군에서 0day 대비 7 days에서 23% 증가한 반면 CFE군에서는 15%감소하였다. 강제수영부하실험에서 CFW군에서 혈중 GOT, GPT 및 BUN 수치가 유의하게 감소하였으며, CFE군에서는 GPT와 BUN 수치가 유의하게 감소하였다. 항피로 관련 지표를 측정한 결과 CFW와 CFE 투여는 가자미근의 글리코겐 수치를 증가시켰으며, 특히 CFW 투여는 고강도 운동으로 증가한 LDH에 의해 D-lactate의 농도가 증가하는 것을 유의하게 억제하여 근피로를 경감시켰다. 또한, CFW군과 CFE군에서 혈중의 암모니아 수치가 유의하게 감소한 것을 확인하였으며, CFW 및 CFE 투여는 고강도 운동으로 인한 지방 소모로 TG 및 FFA의 수치를 유의하게 감소시켰다. 이상의 결과를 종합해보면 산수유 추출물은 항피로 효과를 나타냈으며, 특히 산수유 30% 에탄올 추출물보다 산수유물 추출물에서 더 뛰어난 결과를 나타냈다. 따라서 산수유물 추출물은 피로 관련 인자를 조절하여 피로 개선 효과를 나타내는 것으로 나타났으며, 이는 피로 개선을 위한 주요 소재가 될 것이라 판단된다. This study examined the effects of Corni Fructus administration on the exercise performance and fatigue accumulation in the forced swimming test (FST). The ICR mice were divided randomly into four groups: water-treated FST (control), 500 mg/kg of red ginseng-treated FST (RG), 500 mg/kg of water extract of Corni Fructus-treated FST(CFW), and 500 mg/kg of 30% EtOH extract of Corni Fructus-treated FST (CFE). After FST, an autopsy was performed, and the soleus muscle and serum were collected. The experimental result show that the running time increased in the CFW. In addition, the soleus muscle showed that glycogen was increased by CFW and CFE. Furthermore, CFW significantly regulated GOT (glutamic oxaloacetic transaminase), GPT (glutamic pyruvic transaminase), BUN (blood urea nitrogen), ammonia, LDH (lactate dehydrogenase), D-lactate, TG (triglyceride), and FFA (free fatty acid) in serum. On the other hand, CFE regulated the above factors but not significantly. Overall, CFW and CFE in FST are considered effective in preventing fatigue by controlling the liver enzyme, kidney enzyme, and fatigue-related factors, and the CFW is considered to be more effective than CFE.

說例: 만성 음주자의 약인성 간손상에 대한 가감청간탕(加減淸肝湯) 치험례

이진원 ( Jin Won Lee ),정유선 ( Yu Sun Jung ),김세란 ( Se Ran Kim ),최해윤 ( Hae Yun Choi ),장수영 ( Soo Young Jang ),신현철 ( Hyeon Cheol Shin ) 대구한의대학교 제한동의학술원 2012 東西醫學 Vol.37 No.2

Drug-induced liver injury caused by inappropriate treatments including western or herbal medicines, folk remedies, health functional foods, and so on has increased recently. However, there have been no conclusive treatments to it but withdrawal of the suspected medications. We have treated an alcohol induced chronic hepatitis patient with two different herbal medicines at three different times. Gagamcheonggan-tang, Gagamgalhwahaeseong-tang were used and we modified the drug dosage depending on the progresses. Gagamcheonggan-tang was more effective than Gagamgalhwahieseong-tang, and it also fasten the healing process than not using any medications. Therefore, we suggest that the appropriate use of herbal medicine might be a therapeutic modality for drug-induced liver injury patients and the drug dosage might have an impact on the effectiveness of treatment based on our observation of the patient`s condition and progress.

진피-황금 혼합물이 급성 역류성 식도염 흰쥐에 미치는 효과

이진아(Jin A Lee),신미래(Mi-Rae Shin),노성수(Seong-Soo Roh),박해진(Hae-Jin Park) 한국영양학회 2021 Journal of Nutrition and Health Vol.54 No.3

본 연구에서는 진피-황금 혼합물 (CS)이 급성 역류성 식도염에 미치는 식도 점막 보호 효과를 평가하기 위하여 CS를 경구투여한 후 수술을 통해 역류성 식도염을 유발하였으며, 실험 종료 후 혈액 채취 및 식도 조직을 적출하였다. 동물에게서 적출한 식도 점막의 손상 정도를 육안으로 확인한 결과 CS투여군에서 식도 점막의 손상이 유의하게 감소하였으며, H&E staining을 통해 관찰한 결과 마찬가지로 CS투여군에서 식도 상피의 탈락 및 염증세포의 침윤이 현저하게 감소한 것을 확인하였다. 혈액을 이용하여 역류성 식도염의 원인으로 유효하다고 알려진 ROS의 수치를 확인한 결과, CS투여군에서 ROS 수치가 유의적으로 감소하였으며, western blotting을 통해 NADPH oxidase인 NOX4, p47<SUP>phox</SUP>, p22<SUP>phox</SUP>의 발현을 확인한 결과, 마찬가지로 CS 투여군에서 유의하게 감소하였고, 특히 CS200투여군에서 Normal군과 비슷한 수치를 나타냈다. 또한, CS투여는 염증성 단백질인 MAPK와 NF-κB 경로를 유의적으로 억제하였을 뿐 아니라 tight junction 단백질인 claudin-1과 claudin-4의 발현을 유의하게 조절한 것을 확인하였다. 이상의 결과를 종합해보면 진피-황금 추출물은 산화적 스트레스를 억제함으로써 염증성 단백질의 발현을 조절할 뿐 아니라 tight junction 단백질의 발현을 조절하여 식도 점막을 보호하는 것으로 판단되나 역류성 식도염은 음식물의 섭취와 밀접한 관련이 있는 만큼 추후 동물의 식이 섭취량을 조사하는 등 세부적인 추가 연구가 필요할 것으로 보인다. Purpose: Reflux esophagitis is a disease caused by the reflux of stomach contents and stomach acid etc. into the esophagus due to defect in the lower esophageal sphincter and is currently increasing worldwide. This study was conducted to evaluate the effect of a mixture of Citrus Reticulata and Scutellariae Radix (CS) extract on acute reflux esophagitis in rats. Methods: Rats were divided into five groups for examination: normal group (Normal, n = 8), water-treated acute reflux esophagitis rats (Control, n = 8), tocopherol 30 mg/kg body weight-treated acute reflux esophagitis rats (Toco, n = 8), CS 100 mg/kg body weight-treated acute reflux esophagitis rats (CS100, n = 8), CS 200 mg/kg body weight-treated acute reflux esophagitis rats (CS200, n = 8). The experimental groups were administrated of each treatment compounds and after 90 min, acute reflux esophagitis was induced through surgery. Rats were sacrificed 5 h after surgery. We measured the level of reactive oxygen species (ROS) in serum and analyzed the expression of nicotinamide adenine dinucleotide phosphate, inflammatory, and tight junction-related proteins by western blot in the esophageal tissues. Results: CS administration significantly protected the esophageal mucosal damage due to reflux esophagitis, and the level of ROS in the serum was significantly reduced with CS administration as compared to Control. In addition, CS administration significantly suppressed mitogen-activated protein kinase (MAPK or MAP kinase) and nuclear factor-kappa B (NF-κB) pathways and increased protein expressions of tight junction protein. Conclusion: These results suggest that the CS not only regulates the expression of inflammatory proteins by inhibiting oxidative stress, but also reduces damage to the esophageal mucosa by inhibiting the expression of tight junction proteins.