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우유 중 dexamethasone의 잔류 분석 및 휴약기간 설정 연구
박광일,진영배,김우현,김석,이후장,Park, Kwangil,Jin, Yeung Bae,Kim, Woohyun,Kim, Suk,Lee, Hu-Jang 대한수의학회 2022 대한수의학회지 Vol.62 No.2
This study investigated dexamethasone (DXM) residues in the milk from intramuscularly dosed dairy cows and established the withdrawal time (WT) of DXM in milk. Eighteen healthy Holstein cows were injected with 20 (DXM-1) or 40 mL (DXM-2) of a drug containing 1 mg/mL of DXM. After administering DXM, milk samples were collected from all cows at 12-hour intervals for five days. The DXM residue concentrations in milk were determined by liquid chromatography-tandem mass spectrometry. The correlation coefficient of the calibration curve was 0.9966, and the limits of detection and quantification (LOQ) were 0.03 and 0.1 ㎍/kg, respectively. The recoveries were 97.0% to 104.0%, and the coefficient of variations was less than 7.22%. After treatment, DXM in DXM-1 was detected above the LOQ in two milk samples at 36 hours and below the LOQ in all milk samples of DXM-2 at 48 hours. Using the WT calculation program WT 1.4, the withdrawal periods of DXM-1 and DXM-2 in milk were established to be two days. In conclusion, the developed analytical method is sensitive and reliable for detecting DXM in milk. The estimated WT of DXM in bovine milk is shorter than the current milk WT recommendation of three days for DXM in lactating dairy cows.
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하수슬러지의 전처리 방법에 따른 줄지렁이(Eisenia fetida savigny)의 섭식효율 및 생장
박광일,배윤환,Park, Kwang-ll,Bae, Yoon-Hwan 유기성자원학회 2003 유기물자원화 Vol.11 No.4
The effects of several factors such as heavy metals, living microorganims, high molecular conglomerator in sewage sludge were analysed. And the effects of the sewage sludges which were mixed with other organic waste such as paper mill sludge or night soil sludge upon the feeding rate and biomass of earthworm population were also estimated. The earthworm populations could not survive when newly produced sewage sludges were fed without any pretreatment. The contents of heavy metals were under the levels that could inhibit earthworm's growth. The living microorganisms and the high molecular conglomerator in the sewage sludge had no relations with ecotoxicological effects of sewage sludge upon the earthworm population. Sewage sludge which had been mixed with paper mill sludge and aged for more than 21 days showed no ecotoxicological effects on tiger worm(Eisenia fetida) population. And the feeding rate of earthworm population and the turnover rate of earthworm biomass were higher in those sewage sludges than in the sewage sludges pretreated by other ways.
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박광일,Park, Kwang-Il 한국생명보험의학회 2010 保險醫學會誌 Vol.29 No.1
The measurement of prostate specific antigen (PSA) in screening for prostate cancer is recently performed as a routine check-up in clinical medicine and insurance medicine. Several factors may affect serum PSA levels. As prostate size increases with increasing age, the PSA concentration also rises. Increasing body mass index (BMI) is associated with a lower mean PSA concentration. Inhibitors of 5-alpha-reductase such as finasteride and dutasteride produce a 50 percent or greater decrease in serum PSA during the first three months of therapy, which persists as long as the drug is continued. Men who are regularly taking non-steroidal antiinflammatory drugs (NSAIDs) or acetaminophen have lower PSA levels. Emerging concepts regarding PSA testing that may help refine the interpretation of an elevated concentration include: PSA density, PSA velocity, and Free versus complexed or bound PSA. With many insurance companies, PSA level has become part of a standard battery of blood tests, along with HIV, cholesterol, liver enzymes, and other predictors of premature death. But, there is no clear proof of benefit, so we have to monitor the value of PSA test as a prostate cancer screening test in insurance medicine.
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