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유화-확산법을 이용한 폴리스티렌 방향 나노 입자의 제조: 특성 및 방출 거동
이소민,손성옥,김윤미,이홍열,김민관,최진현,김한도,Lee, So-Min,Sohn, Sung-Ok,Kim, Yun-Mi,Lee, Hong-Youl,Kim, Min-Kwan,Choi, Jin-Hyun,Ghim, Han-Do 한국섬유공학회 2007 한국섬유공학회지 Vol.44 No.1
An attempt was carried out to suggest a nano-sized agent for durable fragrant finishing of fabrics. By adopting emulsification-diffusion method, we could prepare polystyrene (PS) aromatic nanoparticles (ANP) with lavender oil (LO) in core. Effects of process parameters on mean particle sire and its distribution of PS-ANPs were also examined. With controlled preparative condition, we could obtain PS-ANPs of diameters ranging 200 to 400 nm with narrow distribution. PS-ANPs were coated with poly(vinyl alcohol) layer to restrict the diffusion of LO from PS-ANPs. Sustained release properties of PS-ANPs were also evaluated.
델파이기법을 활용한 국가 공공(公共)백신 연구개발 정책수립 기초조사
이소민 ( Somin Lee1 ),여상구 ( Sanggu Yeo ),강신정 ( Shinjung Kang ),한순영 ( Soonyoung Han ),이상원 ( Sangwon Lee ) 한국보건행정학회 2015 보건행정학회지 Vol.25 No.2
Background: Vaccination is the most powerful and useful preparation against infectious diseases. However, developing vaccines costs a lot and requires extensive long-term efforts. Therefore, the government should research and develop vaccines with a national-level policy. To greatly enhance the success rate of vaccine development, the policy should be set up considering priorities such as the current status of domestic research, the importance for public health, the urgency of research. Methods: The Delphi technique was utilized to draft this survey, through a brainstorming stage, then two inquiries, and finally the final panel meeting where unresolved items were discussed, to draw the conclusion. Results: Among the results, firstly, the highest ranked item on centralized fields for vaccine development by the Ministry of Health was ‘self-sufficiency of vaccines.’ Secondly, ‘emerging infectious disease’ was most highly ranked in prioritized fields of vaccine development and research. Thirdly, for the vaccine that needs to be improved and developed further by the government to improve its efficacy and safety, BCG (Bacille de Calmette) for tuberculosis was ranked the highest on both types (intradermal and subcutaneous injection) from National Immunization Programme (NIP) and non-NIP. As for the high risk pathogens, ‘anthrax’ and ‘smallpox’ were first and second, consecutively. Lastly, ‘development and control of vaccine candidates’ was ranked the highest for the area in need for technique development in order to improve domestic vaccine’s research level. Conclusion: The results of this study will be put to good use as basic data for the national vaccine research and development (R&D) policy of the country. This study was first step and more studies should be carried out for the final decision of the national vaccine R&D priority.
이윤정,김언국,김혜윰,윤정주,이소민,이용표,이건목,강대길,이호섭,Lee, Yun Jung,Kim, Eon Kuk,Kim, Hye Yoom,Yoon, Jung Joo,Lee, So Min,Lee, Yong-Pyo,Lee, Geon Mok,Kang, Dae Gill,Lee, Ho Sub 대한한의학방제학회 2013 大韓韓醫學方劑學會誌 Vol.21 No.1
Objectives : Diabetes mellitus is the leading cause for vascular complications such as atherosclerosis. The present study is to investigate whether Doinseunggi-tang (DST) improves diabetic vascular dysfunction in type II diabetes. Methods : The db/db mice were treated with high fat/high cholesterol diet and DST (200 mg/kg/day) for 8 weeks. Results : DST significantly lowered blood glucose and systolic blood pressure. In addition, DST also markedly decreased total plasma cholesterol, triglyceride, and LDL-cholesterol, whereas increased the HDL-cholesterol. Vascular relaxation of aortic rings by acetylcholine or SNP was ameliorated by DST in a dose-dependent manner. Damage of vascular intima and hypertrophic of media was improved by DST. Immunohistological study revealed that DST attenuated the increase of ICAM-1, VCAM-1, and ET-1 expression in thoracic aorta. Conclusions : Taken together, DST suppressed hyperglycemia and diabetic vascular dysfunction in type II db/db mice. The present data suggests that Doinseunggi-tang may be prevent a development of diabetic atherosclerosis.
국가 화학물질 유해성정보 데이터베이스 구축 과정의 신뢰도 제고 방안에 관한 연구
이소민(Somin Lee),이민혁(Minhyeok Lee),강미진(Mijin Kang),권순광(Soon-Kwang Kwon),나진성(Jin-Sung Ra),박백수(Beaksoo Park) 한국환경보건학회 2020 한국환경보건학회지 Vol.46 No.4
Objectives: According to the Act on Registration, Evaluation, Etc. of Chemicals, new and existing chemicals must be registered by 2030. In addition, industries need to submit hazard data as an attachment during the registration process. Therefore, we constructed a nationwide chemical database to support small industry by providing hazard data and original sources. During the process, we developed a new standard procedure for minimizing errors and increasing reliability. Methods: We analyzed the categories of errors and the cause of the errors through the verification results of the 2019 project. We present an improved database construction methodology and system. Results: Errors are categorized according to their causative factors into simple, technical, and structural type errors. Simple errors arise simply because of decreased concentration or negligence in following the instructions. Technical errors are caused by a discrepancy between the professional field and the type of data. Structural errors indicate systemic errors such as incomplete forms on the excel database or ambiguity in the guidelines. Lessons from the errors collected in the 2019 project are used to update the procedures for database authorization and technical guidelines. The main update points are as follows; ‘supplementation of review process’, ‘giving regular training to external reviewers’, ‘giving additional information to authors, like physico-chemical properties of substances, degradability, etc.’, ‘amendment of excel form’, and ‘guideline upgrades’. Conclusions: We conducted this study with the aim of improving the accuracy and reliability of the database of hazard information for chemical substances. The new procedures and guidelines are now being used in the 2020 project for construction of a hazard information database for Korea.
신화 다시쓰기: 쇼의 『피그말리온』과 러셀의 『리타 교육하기』에 재해석된 창조 내러티브
이소민(Lee, Somin),박희본(Park, Heebon) 새한영어영문학회 2021 새한영어영문학 Vol.63 No.1
This paper examines George Bernard Shaw’s Pygmalion and Willy Russell’s Educating Rita in the context of feminism in British society in the early and late twentieth-century, focusing on how both playwrights revise the Pygmalion myth and reinterpret the Greek creation narrative. Shaw and Russell reflect the social and political changes in women’s status and empowerment in twentieth-century Britain. They break the silence of Galatea and give convincing voices to Eliza and Rita, the Galatea figures. While the improvement of women’s status and the subversion of the creator’s power are addressed in both adaptations, these rewritings also confirm the existence of a patriarchal society that continues to restrain the rights of women. In conclusion, the dramatic adaptations of the Pygmalion myth by Shaw and Russell are significant in that they reflect and represent changes in gender equality while indicating pre-existing suppression of women in British society.
학술 정보 기반 한의학 처방을 위한 확장 적응증 데이터베이스 구축
이소민(So-Min Lee),백연희(Yeon-Hee Baek),송상호(Sang-Ho Song),RETITI DIOP EMANE CHRISTOPHER,함선중(Xuan-Zhong Han),홍성연(Seong-Yeon Hong),김익수(Ik-Su Kim),임종태(Jong-Tea Lim),복경수(Kyoung-Soo Bok),MINH NHAT TRAN,QUYNH HO 한국콘텐츠학회 2021 한국콘텐츠학회논문지 Vol.21 No.8
의료의 질은 효과, 효율, 적절성, 과학적-기술적 측면 등과 같은 4가지로 정의할 수 있다. 과학적-기술적 측면의 질 관리를 위해 의료기관에서는 매년 보수교육의 형태로 최신 지견을 현장에 보급하고 있다. 하지만 최신 지견이 가장 빠르게 보급되는 연구 결과들을 단발성인 보수교육만으로 임상 현장에 충분히 보급하는 것에는 명백한 한계가 존재한다. 빅데이터, 인공지능과 같은 지능정보처리 기술이 의료 분야에 적용될 경우 기존에 문헌 조사 등으로 연구되어 적은 정보만으로 연구를 수행해야 했던 한계를 극복할 수 있다. 본 논문은 기존 약재 처방 적응증을 확장할 수 있는 근거가 되는 데이터베이스를 구축한다. 이를 위해 한의학 관련 국내외 논문 정보를 수집, 저장 관리, 분석하는 작업을 수행한다. 약재 처방전의 확장 적응증 콘텐츠 구축을 위한 한의학 근거문헌 데이터의 처리 및 분석 기법을 설계한다. 본 연구를 통해 한의학 의사결정지원시스템에서 근거기반 약재처방 주치 정보의 기본 콘텐츠로 활용할 수 있을 것이라 기대한다. The quality of medical care can be defined as four types such as effectiveness, efficiency, adequacy, and scientific-technical quality. For the management of scientific-technical aspects, medical institutions annually disseminate the latest knowledge in the form of conservative education. However, there is an obvious limit to the fact that the latest knowledge is distributed quickly enough to the clinical site with only one-time conservative education. If intelligent information processing technologies such as big data and artificial intelligence are applied to the medical field, they can overcome the limitations of having to conduct research with only a small amount of information. In this paper, we construct databases on which the existing medicine prescription adaptations can be extended. To do this, we collect, store, manage, and analyze information related to oriental medicine at domestic and abroad Journals. We design a processing and analysis technique for oriental medicine evidence research data for the construction of a database of oriental medicine prescription extended adaption. Results can be used as a basic content of evidence-based medicine prescription information in the oriental medicine-related decision support services.
이소민(So-Min Lee),변성우(Sung-Woo Byun),이석필(Seok-Pil Lee) 대한전기학회 2014 전기학회논문지 Vol.63 No.5
Recently, researches on analyzing relationship between the state of emotion and musical stimuli using EEG are increasing. A selection of feature vectors is very important for the performance of EEG pattern classifiers. This paper proposes a comparison of EEG feature vectors for emotion classification according to music listening. For this, we extract some feature vectors like DAMV, IAV, LPC, LPCC from EEG signals in each class related to music listening and compare a separability of the extracted feature vectors using Bhattacharyya distance. So more effective feature vectors are recommended for emotion classification according to music listening.