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Pharmasol 基劑를 使用한 Indomethacin 結晶多形의 直腸吸收에 關한 硏究
이동호,김재백,Lee, D.H. 圓光大學校 藥品硏究所 1986 藥品硏究所報 Vol.1 No.1
Suppositories may be particulary important where a drug cannot be tolerated orally, where the patient cannot swallow, or where the drug may be decomposed or inactivated by the pH and enzyme present in the gastrointestinal tracts Rectal suppositories are used for the introduction of medicaments to be adsorbed into the circulatory system. In order to study on the bioavailability of Acetaminophen rectal suppository. we make two types of suppository; one is a new gelatin capsule (Rectocap) and the other is common suppository (Rectal suppository) After the rectal administration of Rectocap and Rectal suppository, we experiment the serum concentration of Acetaminophen by High Pressure Liquid Chromatography. In serum concentration, the Rectocap is higher and persisted longer than the Rectal suppository This greater serum concentration of Rectocap may be related to a variery of factors including point, the solubility chemical reactivity and the composition in the suppository bases.
갑상선 미세 유두암에서 종양 크기의 구분에 따른 임상병리학적 특징의 분석
조윤정,이동호,이상철,김세준,김정구,안창준,이관주,Yun-Jung Cho,M,D,Dong-Ho Lee,M,D,Sang-Chul Lee,M,D,Say-Jun Kim,M,D,Jung-Koo Kim,M,D,Chang-Joon Ahn,M,D,and Kwan-Ju Lee,M,D 대한갑상선-내분비외과학회 2010 The Koreran journal of Endocrine Surgery Vol.10 No.3
Purpose: Although the detected incidence of papillary thyroid microcarcinoma (PTMC) has increased with development of ultrasonography and fine-needle aspiration biopsy, the best treatment has not yet been established. Treatment decisions require information on many factors including lymph node metastasis, extrathyroidal extension, and bilaterality. With this aim, the present study analyzed clinicopathologic features of PTMC according to cut-off of tumor size. Methods: The clinicopathologic features of patients with PTMC between January 2007 and December 2009 were reviewed retrospectively from medical records. Patients were divided according to tumors lesser than or equal to cut-off (Group I) and tumors exceeding cut-off (Group II). Results: Both capsule invasion and lymphovascular invasion were significantly different at all cut-off diameters (5∼9 mm). Central node metastasis revealed a difference in all cut-off values except 8 mm. Extrathyroidal extension differed at all cut-off values except 5 mm. Bilaterality displayed a statistically significantdifference only at the 8 mm cut-off. Conclusion: A cut-off of 5 mm represents a safe value to discriminate less aggressive from aggressive treatment for PTMC. (Korean J Endocrine Surg 2010;10:152-156)
갑상선암 수술 중 발생하는 의도하지 않은 부갑상선 절제의 임상적 의의
김영균,김정구,이동호,이혜경<SUP>1<.SUP>,유영경,안창준,Young Gyun Kim,M.D.,Jeong Gu Kim,M.D.,Dong Ho Lee,M.D.,Hae Gyung Lee,M.D.<SUP>1<.SUP>,Young Kyoung Yoo,M.D. and Chang Joon Ahn,M.D. 대한갑상선-내분비외과학회 2006 The Koreran journal of Endocrine Surgery Vol.6 No.1
Purpose: Many surgeons intend to preserve all of the parathyroids during a thyroid operation; however, they have had the unpleasant experience of achieving unintentional parathyroidectomy. We studied the risk factors for unin-tentional parathyroidectomy and whether these unintentional parathyroidectomies caused symptomatic hypocalcemia. Methods: We conducted a retrospective review of the medical records and pathologic reports of 95 papillary carcinoma patients who underwent operations between January 1994 and December 2003. We statistically analyzed the correlation between unintentional parathyroidectomy and the risk factors such as tumor size, capsular invasion, including extra-thyroidal extension, and the operation method. Results: Of the total 95 procedures, 14 (14.7%) produced patho-logy reports stating that incidental parathyroid tissue was identified within the thyroidectomy specimen. The majority of the 14 reported cases contained only a single focus of inci-dental parathyroid tissue; however, one of these thyroidectomy specimens contained two foci of parathyroid tissue. The factors such as tumor size, capsular invasion and extensive surgery were not correlated with the prevalence of unintentional parathyroidectomy. There was no association of unintentional parathyroidectomy with postoperative hypocalcemia (P=.449).Conclusion: Unintentional parathyroidectomy is not associated with symptomatic postoperative hypocalcemia. The factors such as tumor size, capsular invasion or extensive surgery are not risk factors for unintentional parathyroidectomy. (Korean J Endocrine Surg 2006;6:17-21)
김민기,최영수,김기현,배자성,이동호,성기영,김정수,박우찬,Min-Ki Kim,M,D,Young-Soo Choi,M,D,Ki-Hyun Kim,M,D,Ja-Sung Bae,M,D,Dong-Ho Lee,M,D,Ki Young Sung,M,D,Jung-Soo Kim,M,D,and Woo-Chan Park,M,D 대한갑상선-내분비외과학회 2009 The Koreran journal of Endocrine Surgery Vol.9 No.1
Purpose: This study was performed to readjust the clinical implications of a nonrecurrent laryngeal nerve by assessing the reported Korean cases of a nonrecurrent laryngeal nerve. Methods: We analyzed the cases of nonrecurrent laryngeal nerve that have been reported in Korea between 1997 and 2008 by reviewing the literature. An internet search was conducted in the NDSL (National Digital Science Library) and the Korean Medical Database. Results: The data included 3 men and 25 women with an average age of 45.1 (age range: 28∼58). All the cases were right-sided, and the incidence rate was 0.38% and 0.86% in two articles, respectively. There was a type I variation in 4 cases (17.4%), type IIa in 19 cases (82.6%), and the others are unknown. Twenty-five cases (89.3%) had the vascular anomaly called arteria lusoria. Only 8 cases (28.6%) were preoperatively predicted as possibly having a nonrecurrent laryngeal nerve. Iatrogenic nerve injury developed in 1 case (3.57%) with a type I variation during the postoperative period. Conclusion: A similar tendency for the incidence rate, the genderratio, the type distribution and vascular anomaly was observed when comparing the Korean reports with those reports of overseas. The nonrecurrent laryngeal nerve can be preoperatively predicted if proper attention is given when vascular anomaly is noted on CT or USG, and injury will be avoided by intraoperatively following the standard operation technique. There is currently an increasing incidence of thyroid diseases, and so adequate attention must be given to the possibility of a nonrecurrent laryngeal nerve and its management. (Korean J Endocrine Surg 2009;9:24-29)
수술 전 갑상선 암의 측경부 림프절전이 예측을 위한 지수화된 전산화 단층촬영 소견의 임상적 의의
김영중,김지영<SUP>1<.SUP>,김용석,이관주,이동호,배자성,성기영,김정수,박우찬,Young Joong Kim,Jee Young Kim,Ph.D.<SUP>1<.SUP>,Young Suk Kim,Ph.D.,Kwan Ju Lee,Ph.D.,Dong Ho Lee,Ph.D.,Ja-Seong Bae,Ph.D.,Ki Young Sung,Ph.D.,Jeong Soo 대한갑상선-내분비외과학회 2011 The Koreran journal of Endocrine Surgery Vol.11 No.2
미세침흡인으로 얻은 갑상선 유두암 세포에서 p27 발현과 경부림프절 전이의 연관성
이관주,이정의<SUP>1<,SUP>,김정수,김태규<SUP>2<,SUP>,이상철,김정구,안창준,김세준,이동호,Kwan Ju Lee,M,D,Jung Hea Lee,M,D,<SUP>1<,SUP>,Jeong Soo Kim,M,D,Tai Gyu Kim,M,D,<SUP>2<,SUP>,Sang Chul Lee,M,D,Jeong Goo Kim,M,D,Chang-Joon 대한갑상선-내분비외과학회 2009 The Koreran journal of Endocrine Surgery Vol.9 No.3
Purpose: The p27 gene as a tumor suppressor gene is associated with colorectal cancer, gastric cancer and breast cancer. Some studies have shown a relationship between the underexpression of p27 and lymph node metastasis in papillary thyroid carcinoma. The aim of this study is to evaluate the relationship between a p27 expression of the papillary thyroid cancer cells obtained by fine needle aspiration (FNA) and cervical lymph node metastasis. Methods: This study included 60 patients with papillary thyroid cancer and who underwent total thyroidectomy or lobectomy. Central lymph node dissection was routinely done. Out of these patients, 30 patients underwent a FNA procedure during the operation. Immunohistochemical staining for p27 antibody was performed on the papillary thyroid cancer tissues and cells. Results: Cervical lymph node metastasis is correlated with the tumor size and lymphovascular invasion (P<0.001). The underexpression of p27 for the papillary thyroid cancer tissues and cells was associated with lymph node metastasis (P=0.009). Conclusion: An evaluation of the p27 expression for the papillary thyroid cancer cells obtained by FNA may be useful as a predictor for lymph node metastasis before surgery. (Korean J Endocrine Surg 2009;9:155-160)