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윤현수(Hyeon Soo Yoon),이미화(Me Hwa Lee),이수진(Su Jin Lee),김건영(Kun Young Kim),유연표(Yun Pyo You),정도영(Do Young Jung),노경환(Gyoung Hwan Roh),한현영(Hyun Young Han),박성규(Sung Kyu Park),최덕례(Duck Yeii Choi) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.2
Pyogenic liver abscess is a serious clinical disease with severe complications in 10-20% of the cases. Metastatic septic endophthalmitis is a rare complication associated with liver abscess. Despite appropriate treatment, the outcome is devastating. We experienced a case of pyogenic liver abscess complicated with endophthalmitis. The bacterial organism cultured from liver abscess was Klebsiella pneumoniae. Treatment of this patient was composed of percutaneous drainage under ultrasonographic guidance, systemic and intravitreal antibiotic therapy. After treatment for 6 weeks, the liver abscess was resolved completely, but the visual outcome was very poor despite intensive treatment. We report a case of pyogenic liver abscess complicated with endophthalmitis. (Korean J Gastroenterol 2001;38:120-123)
윤현수(Hyeon-soo Yoon) 한국중원언어학회 2009 언어학연구 Vol.0 No.15
The objective of this paper is to verify the relation between the loss of inflection and grammatical change in English and the influence of structural conservation on the change. There were various occurrences of grammatical changes in English as its rich inflection gradually declined; Nouns with the dative case began to appear in the subject position of the passives in late OE period, and preteritive-present verbs obtained the feature of modal auxiliary. These phenomena arose from the loss of inflection. After morphological difference between dative and accusative disappeared, (S) (V) DO IO construction became unworkable. As a result, the preposition to came into use in front of IO. Choi(2003) claims that infinitives with to could maintain its original usage as noun. In the same way the preposition to in front of IO seems to have been taken up to keep using (S) (V) DO IO construction. Consequently, the loss of inflection triggered grammatical change and caused word order change ultimately, but on the other hand, the tendency to conserve the structure or meaning of previous stages performed its part in the process of the change.
배아줄기세표의 인슐린 분비세포로의 유도 분화에 대한 연구
성지혜,임천규,최혜원,이형송,신현상,전진현,윤현수,궁미경,Sung, Ji-Hye,Lim, Chun-Kyu,Choi, Hye-Won,Lee, Hyoung-Song,Shin, Hyeon-Sang,Jun, Jin-Hyun,Yoon, Hyun-Soo,Koong, Mi-Kyoung 대한생식의학회 2004 Clinical and Experimental Reproductive Medicine Vol.31 No.4
Objective: Embryonic stem (ES) cells could be differentiated into the specific cell types by alternation of culture condition and modification of gene expression. This study was performed to evaluate the differentiation protocol for mouse and human ES cells to insulin secreting cells. Methods: Undifferentiated mouse (JH-I) and human (Miz-hESI) ES cells were cultured on STO feeder layer, and embryoid bodies (EBs) were formed by suspension culture. For the differentiation, EBs were cultured by sequential system with three stage protocol. The differentiating ES cells were collected and marker gene expressions were analyzed by seIni-quantitative RT-PCR in each stage. Amount of secreted insulin levels in culture media of human ES cells were measured by human insulin specific RIA kit. Results: During the differentiation process of human ES cells, GATA-4, a-fetoprotein, glucose transporter-2 and Ngn-3 expression were increased whereas OctA was decreased progressively. Insulin and albuInin mRNAs were expressed from stage IT in mouse ES cells and from stage III in human ES cells. We detected 3.0~7.9 IlU/rnl secretion of insulin from differentiated human ES cells by in vitro culture for 36 days. Conclusion: The sequential culture system could induce the differentiation of mouse and human ES cells into insulin secreting cells. This is the fIrst report of differentiation of human ES cells into insulin secreting cells by in vitro culture with serum and insulin free medium.
증례 : 순환기 ; 한약에 의한 급성 신부전 후 동시 발병한 급성 심근경색과 위궤양 출혈
강기운 ( Ki Woon Kang ),이경진 ( Kyung Jin Lee ),윤현수 ( Hyeon Soo Yoon ),조용수 ( Yong Soo Cho ),김시범 ( Si Bum Kim ),이상 ( Sahng Lee ),정성희 ( Sung Hee Jung ) 대한내과학회 2010 대한내과학회지 Vol.78 No.3
급성 신부전, 급성 심근경색과 위궤양 출혈은 특히 고령의 환자에게 높은 이환율, 사망률과 관련이 되는 질환이다. 이 세 질환 중에 어느 한 질환의 발병으로 인해 나머지 다른 질환이 발병될 수 있다고 보고가 되어 있지만 세 질환이 동시에 발병하는 경우는 드물다. 저자들은 한약인 감초와 알로에가 포함된 건강식품만을 10일간 복용한 후에 발생한 전신 허약으로 입원한 92세 남자 환자를 보고하였다. 입원 후에 환자는 6시간 차이로 급성 심근경색과 위궤양 출혈이 Acute renal failure, acute myocardial infarction (AMI), and gastric ulcer bleeding (GUB) are associated with high rates of morbidity and mortality, especially in older patients. The development of each of these conditions can be followed by the development
황체호르몬 수용체의 발현이 저반응 환자군의 임신에 미치는 영향
이정복,도병록,김은수,김명희,천은경,정현정,노성일,김문규,윤현수,Lee, Jung-Bok,Do, Byung-Rok,Kim, Eun-Soo,Kim, Myung-Hee,Chun, Eun-Kyung,Jeong, Hyeon-Jeong,Roh, Sung-Il,Kim, Moon-Kyoo,Yoon, Hyun-Soo 대한생식의학회 2004 Clinical and Experimental Reproductive Medicine Vol.31 No.2
Objectives: To investigate the effect of LH receptor in folliculogenesis, we confirm the expression level of LH receptor (LH-R) mRNA in human granulosa cells (GCs) and its expression levels were analyzed by comparison to embryo developmental rate and pregnancy rate. Materials and Methods: GCs were obtained at the time of oocyte retrieval from the patients undergoing IVF-ET program. The patients were divided into two groups: Group I (n=20) is poor responder (retrieved oocyte(s)$\leq$3ea), Group II (n=80) is normal responder (retrieved oocytes>3ea). After the extraction of total RNA, semiquantitative RT-PCR was performed and the expression level of LH-R mRNA was normalized by $\beta$-actin. Statistical analysis was performed by using $X^2$ test, Student's t-test and Pearson correlation. Results: In Group II, the relative values of LH-R mRNA (0.680 vs. 0.463, p<0.005) and pregnancy rate (54.7% vs. 23.1%, p<0.05) were significantly higher than in Group I. Number of retrieved oocyte(s) was gradually increased when the expression of LH-R mRNA was increased (p<0.05). But the quality of retrieved oocyte and transferred embryo were not related with the expression of LH-R mRNA. When the pregnancy rate was compared with FSH only group and FSH combined with hMG group in the ovarian stimulation protocol, FSH combined with hMG group was significantly higher than FSH only group in Group I (37.5% vs. 0%), and the expression of LH-R mRNA was significantly higher in hMG combined group than FSH only group (p<0.05). Conclusion: Expression level of LH-R mRNA has important role in ovarian function related with the response to gonadotrophin in human folliculogenesis. Furthermore these data might provide the evidence that additional use of hMG is helpful to poor responders.
정도영(Do Young Jung),이수진(Su Jin Lee),이미화(Me Hwa Lee),최덕례(Duck Yeii Choi),박성규(Sung Kyu Park),윤현수(Hyeon Soo Yoon),김건영(Kun Young Kim),한현영(Hyun Young Han),강동욱(Dong Wuk Kang) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.6
Pyogenic liver abscess is a serious clinical problem, which gives rise to complication in 30-50% of the cases. Spontaneous subcapsular hemorrhage is a rare complication associated with liver abscess. A 30-year-old woman was admitted with right upper quadrant abdominal pain, febrile sensation, and myalgia for 3 days. A septated 6×6 ㎎ sized ill-defined round and low-density lesion with hematoma was observed in subcapsular area of both hepatic lobe. Hepatic arteriography showed stretching of the branches of the right hepatic artery without extravasation of the contrast material. Ultrasono-guided percutaneous transhepatic aspiration was performed for subcapsular hematoma. The aspirates had blood count of WBC 58,500/㎣, hemoglobin of 7.8 g/dL, and platelet of 20,000/㎣. The aspirates of low density lesion was pus, in which Klebsiella pneumoniae was isolated. Liver biopsy was performed around the abscess and there was no evidence of hepatic neoplasia. After treatment of antibiotics for six weeks and percutaneous transhepatic drainage, she recovered completely. We report a rare case of pyogenic liver abscess complicated with spontaneous subcapsular hemorrhage. (Korean J Gastroenterol 2001;38:449-452)
윤현수 청주대학교 대학원 1999 우암논총 Vol.22 No.-
In this paper I have researched inverted sentences in Old English period. Inverted sentences are distributed very extensively in ASC which is a typical prose in Old English. The reason the inverted sentences are found in large numbers in Old English is that word order was not restricted as much as in modem English because inflection was abundant in Old English. The other reason rhythm and stress and they are closely interrelated with theme-rheme order. English has a strong tendency to place rhythmically heavy constituents at the end of the clause. On the contrary, the short unstressed constituents tend to occur at the first place of the clause. In each of these inversion type; that is, preposed adverbs of place and time, preposed adjectives, and preposed pronouns, the preposed elements become thematic and the inverted subjects become rhematic. Theme-rheme order, that is, the inverted order was kept well in Old English and the purpose of inversion was to stress the subject at the end of the clause.
박성규,유진우,이수진,한현영,강동욱,장희철,이미화,윤현수,최덕례 대한소화기내시경학회 2000 Clinical Endoscopy Vol.21 No.1
Idiopathic Myelofibrosis (IMF), a clonal disorder of a multipotent hemtopoietic progenitor cell of unknown etiology, is characterized by massive splenomegaly, leukoerythroblastic blood changes, and bone marrow fibrosis. Portal hypertension occurs in approximately 10% of patients with IMF. Alsom there mey be bleeding from esophageal varices. A 59-year-old woman was admitted with intermittent abdominal distension and melena. An esophagogastroduodenoscopy revealed extensive esophageal varices with red colored signs, and subsequently esophageal variceal ligation was performed. Marked splenomegaly and ascites was observed through abdominal US and MRI scan. Bone marrow biopsy revealed an increase in reticulin and fibrosis. Extramedullary hematopoiesis and sinusoidal change were observed in the liver biopsy specimen. This case of IMF causing an esophageal variceal hemorrhage is herein reported.