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      • KCI등재

        호스피스 癌患者의 餘命 期間에 따른 症狀 및 삶의 질의 變化

        김건영(Kun Young Kim),최윤선(Youn Seon Choi),대균(Dae Gyun Kim),서상연(Sang-Yeon Suh) 대한임상노인의학회 2010 대한임상노인의학회지 Vol.11 No.2

        연구배경: 호스피스ㆍ완화의료로 의뢰된 말기 암환자의 여명 기간에 따른 증상과 삶의 질의 변화를 조사하여, 향후 말기 암환자를 위한 올바른 치료중재 결정에 도움이 되기 위해 본 연구를 시행 하였다. 방법: 말기 암으로 수도권 6개 종합병원에 호스피스ㆍ완화의료를 위해 입원 사망한 137명을 대상으로 하였다, 입원 시 작성한 MDASI-K 설문지를 통해 증상들과 이들이 삶의 질에 미치는 영향을 기록하였고, 여명 기간에 따른 증상의 빈도 및 중등도, 삶의 질에 미치는 영향, 여명 기간에 따른 ECOG 기능지수의 연관성을 분석하였다. 결과: 여명 기간에 따른 증상 빈도 및 삶의 질 저하의 대한 평균 점수는 MDASI-K 19가지 항목 중 17가지 부문에서 여명 기간이 짦아질수록 높았다. 신체적 증상 및 정신사회적 증상 모두 대부분의 항목에서 여명기간과 유의한 연관성을 보였다. ECOG기능점수 악화에 따라 여명 기간은 유의하게 감소하였다. 결론: 7개의 증상과 삶의 질에 지장을 주는 1개의 항목이 여명기간이 짦아짐에 따라 빈도가 증가하였다. 여명기간이 짧아질수록 11개 증상과 6개 삶의 질 관련 항목의 점수는 악화되었다. 말기 암환자 진료 시 보다 적극적인 증상조절이 필요하다. Background: Cancer had become the 1st leading cause of death in Korea since 1983. There were roughly 65,000 cancer deaths per year in 2006. Survival prediction is difficult even among experienced palliative care doctors. Appropriate symptom control and QoL are important in end of life. Methods: Eleven physicians of the Korean Palliative Medicine Research Group performed this study. We followed terminal cancer inpatients until their death between November 2006 and December 2007. A total 137 patients who completed a Korean version of MDASI before their death from 6 teaching hospitals were included in this cohort study. Basic data was obtained at the time of hospital admission. The subjects were divided into 3 groups according to length of survival. The first group A consists of patients who lived less than 14 days, group B patients lived between 15 and 34 days. Lastly, group C patients lived more than 35 days. Then symptom prevalence and severity, and quality of life were compared. Results: 46.7% were male. Mean age was 63.9 years old. The mean survival time was around 39 days. Survival duration was decreased by a lower ECOG score. There was no significant differences in survival duration according to age, type of primary cancer, or regular opioid use. Dry mouth, lack of appetite, fatigue were the most prevalent symptoms. General activity and mood were the most prevalent QoL impairments. There was no significant difference in prevalence by sex except sleep disturbance in which there was a higher frequency in females. There were seven items in the symptom category and one item in the QoL interference category where prevalence increased as length of survival was shortened with statistical significance. Dry mouth, lack of appetite, and fatigue were the most severe symptoms. Work, general activity, and walking were the most severe QoL impairments. 11 symptoms except remembering & numbness of tingling and all 6 QoL impairments were worsened by decreased survival duration. No significant difference in severity of both symptoms and QOL impairment was present by sex except three items. Conclusion: It is evident that prevalence and severity of symptoms was high in Korean terminal cancer patients. More active symptom management is needed.

      • SCOPUSKCI등재
      • 악성 체강삼출액의 세포학적 분석

        상표,배지연,박관규,건영,이상숙,장은숙,정숙,Kim, Sang-Pyo,Bae, Ji-Yeon,Park, Kwan-Kyu,Kwon, Kun-Young,Lee, Sang-Sook,Chang, Eun-Sook,Kim, Chung-Sook 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.2

        Eighty cases of malignant effusion were cytologically studied to elucidate the incidence of primary tumor site and cytologic characteristics of each tumor types. Eighty fluid specimens were composed of 43 ascitic, 35 pleural, and 2 pericardial effusion and primary tumor site had been confirmed by histology. The frequent primary sites were stomach(22 cases, 28%), lung(21 cases, 26%), ovary(11 cases, 14%), liver(7 cases, 9%), and breast (4 cases, 5%). The principal malignant tumors were adenocarcinoma (56 cases, 70%), squamous cell carcinoma (7 cases, 9%), liver cell carcinoma (7 cases, 9%), small cell carcinoma (4 cases, 5%), and non-Hodgkin's lymphoma (4 cases, 5%). The distinctive cytologic findings according to primary tumor types were as follows; the gastric adenocarcinomas were mainly characterized by isolated cells and irregular clusters sometimes with signet ring cells. Papillary serous cystadenocarcinoma of ovary showed frequently papillary clusters and occasional psammoma bodies. Breast carcinoma of ductal type showed cell balls with smooth margins. Colonic adenocarcinoma showed rather irregular clusters or palisading pattern of cylindrical cells. Metastatic squamous cell carcinoma, liver cell carcinoma, small cell carcinoma, and non-Hodgkln's lymphoma showed also characteristic features. These findings Indicate that the cytological features observed in the great majority of malignant effusion are similar to those of primary tumor types, which are very helpful to indentify the primary tumor site.

      • 기관지 폐포 세정액에서 뉴우모시스티스 카리니의 면역세포화학적 검출

        건영,조승제,상표,박관규,장은숙,정숙,Kwon, Kun-Young,Cho, Seung-Che,Kim, Sang-Pyo,Park, Kwan-Kyu,Chang, Eun-Sook,Kim, Chung-Sook 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.1

        Pneumocystis carinli is an established cause of pulmonary infections in immuno-compromised hosts. Several cytoiogical stains, such as Papanicolaou, Gomori methenamine sliver(GMS) and Diff-Quik have been used for detection of the organism, but occasionally can be laborious and, due to a degree of nonspecificity, may be misleading. We evaluated the diagnostic utility of immunocytochenmical stains that recognize P. carinii in bornchoalveolar lavage from experimentally Induced P. carinii pneumonia rats(n=15). In audition to routine stains for diagnosis by morphologic recognition of P. carinii on Papanicolaou, GMS and Diff-Quik stains, bronchoalveolar lavage samples were reacted with immunocytochemical stains using monoclonal antibodies(MAB) 092 and 902. In bronchoalveolar lavage P. carinii organisms were detected In 9 of 10 cases(90%) using each MAB 092 and 902, whereas GMS and Diff-Quik stains demonstrated P. carinii in 13(86%) and 11(73%) of 15 cases respectively. In lung tissue specimens(n=15) P. carinii organisms were well identified on GMS stain and immunohistochemical stains using MAB 092 and 902 in ail cases. We believe that the immunocytochemical staining using MAB 092 and/or 902 is a very useful and diagnostic tool In addition to GMS and Diff-Qulk stain to detect P. carinii organisms in bronchoalveolar lavage.

      • Pneumocystis carinii 폐렴의 기관지 폐포세정액: 세포학적 및 전자현미경적 소견

        건영,윤철희,상표,박관규,장은숙,Kwon, Kun-Young,Yun, Cheol-Hee,Kim, Sang-Pyo,Park, Kwan-Kyu,Chang, Eun-Sook 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.1

        The cytological and ultrastructural findings of Pneumocystis carinii(PC) obtained from rats by bronchoalveolar lavage (BAL) are described. All developmental forms of the PC organisms were obtained in the lavage fluid. Papanicolaou stain revealed conglomeration of PC as a foamy cast. The cystic walls of PC were well identified on Gomori's methenamine silver stain. Trophozoites and intracystic bodies were stained by Giemsa and Diff-Quik techniques. Some PC organisms were seen within the alveolar macrophages. Ultrastructurally, the cysts were almost circular in shape, and were nearly devoid of surface tubular extensions. The wall of the cyst was composed of an unit membrane, an intermediate electron lucent layer and an external electron dense layer The cysts frequently contained intracystic bodies, so called sporozoites. Occasionally empty or collapsed cysts with no intracystic bodies, and precysts were found. Trophozoites were variable in size and shape with abundant tubular extensions along the single electron dense pellicle. BAL is a useful method for concentrating the various morphologic forms of PC organisms, and is a rapid diagnostic method for PC pneumonia.

      • KCI등재

        서울시 도시환경정비사업 내 공개공지 활성화를 위한 제도개선에 관한 연구

        도경,김건영,Kim, Do-Kyong,Kim, Kun-Young 한국조경학회 2011 韓國造景學會誌 Vol.39 No.5

        지구단위계획에서는 형식적으로 조성되는 경직된 제도의 모습을 벗어나기 위하여 구역 내 총체적인 계획의 일부분으로 건물 세부 기준뿐만 아니라, 공개공지의 배치, 형태 및 포상에 대한 가이드라인을 제시하고 있다. 문제점을 가지고 있는 도시환경정비기본계획(2005년 수립)이 그동안 도심부의 여건 변화를 반영하기 위하여 재정비되면서 구역별 개발유도 지침에 공개공지 부문이 세분화 되었다. 이러한 제도가 공개공지계획에 있어 실효성 있는 제도인지 개정 전 후를 비교해 본 결과, 도시 및 주거 환경정비법 상 공개공지 관련 수립지침의 부재로 공개공지계획 시 공통적으로 지켜야 하는 건축법과 별반 다를 것이 없는 항목이 신설되어 개정되기 전과 괄목할만한 변경사항이 없다는 분석 내용이다. 지구단위계획과 비교 분석해 본 결과, 지구단위계획 상 공개공지계획은 상위법인 건축법, 서울시 건축조례와 동일한 조성 기준이 한가지만 존재하고, 대부분은 제1종지구단위계획수립지침을 통해 신설된 조성 기준들이다. 반면, 도시환경정비기본계획상 공개공지계획의 속성은 절반이 상위법인 건축법과 서울시 건축조례와 동일하거나 유사한 항목이다. 건축법과 같은 공통적으로 지켜야 하는 상위법에서는 설치기준 등과 같은 필수적인 요소들의 나열이라면, 하위법에서는 주변 환경과 공개공지의 적극적인 연계로 공개공지의 의의에 맞게 구체적이고, 실효성 있는 미시적인 측면의 조성 기준이 만들어져야 할 것이다. The district units planning suggests not only detailed standards of building as parts of the whole plan in the district but also a guideline of the arrangement, shape and pavement of the public open space, in order to move away from the rigid image of an institution which causes the formal creation of it. This triggered various problems. While the basic plan for adjustment of urban environments(established in 2005) was being reorganized in order to reflect changed conditions of the city center, the sector of public open space was subdivided according to the guidelines of development by district. We conducted a comparative analysis of conditions before and after the adjustment, so as to examine whether or not the reorganized institution is effective for the plan of public open spaces. The analysis showed that there was no remarkable change between the basic plan and the reorganized institution in that items which were not any different from the existing building codes were established due to lack of guidelines related to public open space under the law of urban and residential environmental improvement. Low regulations should set up criteria for establishment from a concrete, effective microscopic aspect appropriate to the significance of public open space by the linking of public open space and the surrounding environment, whereas high regulations such as building codes should specify essential components.

      • 종격동 내배엽동 종양의 세침흡인 세포학적 소견

        조갑래,상표,박관규,건영,장은숙,Cho, Kam-Rae,Kim, Sang-Pyo,Park, Kwan-Kyu,Kwon, Kun-Young,Chang, Eun-Sook 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.1

        Endodermal sinus tumor of the mediastinum is a very rare malignant tumor, usually affecting young adolescents, and its histologic findings are characteristic as that of gonadal germ cell origin. We describe the cytologic finding of fine needle aspiration of mediastinal endodermal sinus tumor in a 19-year-old male patient, comparing with tissue section. The tumor cells in smears were usually in tight clusters with large overlapping cells, which were arranged in a papillary or microacinar pattern, suggesting carcinoma. The tumor cells were large, round or oval with a small amount of cytoplasm which was occasionally vacuolated and had indistinct border. The nuclei were large, pleomorphic, and vesicular with large prominent nucleoli. The tissue sections showed typical findings of endodermal sinus tumor. Careful correlation of cytological findings and the serum alpha -fetoprotein level would be helpful to confirm the diagnosis.

      • 폐의 거대세포암종의 세포학적 소견

        윤철희,배지연,상표,건영,정숙,장은숙,Yun, Cheol-Hee,Bae, Ji-Yeon,Kim, Sang-Pyo,Kwon, Kun-Young,Kim, Chung-Sook,Chang, Eun-Sook 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.2

        Pulmonary giant cell carcinoma is one of the most highly malignant neoplasms of the lung. Although mixed malignant glandular or squamous components may be associated with a giant cell carcinoma, it is a distinct clinical and morphologic entity. We reviewed cytologic presentations of 6 cases of pulmonary giant ceil carcinoma. Cytologically, the single most characteristic feature of giant cell carcinoma was an extremely large, bizarre cancer cell engulfing numerous leukocytes. The nuclei of these cells showed occasional prominent nucleoli, and the cytoplasm was abundant. Giant cells were also seen in other types of pulmonary carcinoma, but the slant cells of this neoplasm could be differentiated from those encountered in undifferentiated large cell carcinoma and squamous cell carcinoma by the abundant cytoplasm, the presence of markedly enlarged nuclei, prominent nucleoli, and a significant degree of phagocytosis. In conclusion, precise diagnosis and classification of lung cancer is imperative because of proved correlation between cell type and prognosis.

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