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      • 지연시간과 회로 구조 변화를 고려한 증가적 타이밍 분석

        오장욱(Oh Jang Wook),한창호(Han Chang Ho) 한국정보처리학회 1999 정보처리학회논문지 Vol.6 No.8

        In this paper, we present techniques which perform incremental timing analysis using Timed Boolean Algebra that solves the false path problem and extracts the timing information in combinational circuits. Our algorithm sets histories of internal inputs that are substituted for internal output and extracts maximal delays through checking sensitizability of primary outputs. Once finding the sum of primitive delay terms, then it applies modified delay with referencing histories of primary output and it can extract maximal delays of primary outputs fast and efficiently. When the structure of circuit is changed, there is no need to compute the whole circuit again. We can process partial timing analysis of computing on the gates that are need to compute again. These incremental timing analysis methods are considered both delay changes and structure of circuit, and can reduce the costs of a trial and error in the circuit design.

      • KCI등재

        국내 지역별 미세먼지 농도 리스크 분석

        오장욱,임태진,Oh, Jang Wook,Lim, Tea Jin 한국안전학회 2017 한국안전학회지 Vol.32 No.5

        Millions of People die every year from diseases caused by exposure to outdoor air pollution. Especially, one of the most severe types of air pollution is fine particulate matter (PM10, PM2.5). South Korea also has been suffered from severe PM. This paper analyzes regional risks induced by PM10 and PM2.5 that have affected domestic area of Korea during 2014~2016.3Q. We investigated daily maxima of PM10 and PM2.5 data observed on 284 stations in South Korea, and found extremely high outlier. We employed extreme value distributions to fit the PM10 and PM2.5 data, but a single distribution did not fit the data well. For theses reasons, we implemented extreme mixture models such as the generalized Pareto distribution(GPD) with the normal, the gamma, the Weibull and the log-normal, respectively. Next, we divided the whole area into 16 regions and analyzed characteristics of PM risks by developing the FN-curves. Finally, we estimated 1-month, 1-quater, half year, 1-year and 3-years period return levels, respectively. The severity rankings of PM10 and PM2.5 concentration turned out to be different from region to region. The capital area revealed the worst PM risk in all seasons. The reason for high PM risk even in the yellow dust free season (Jun. ~ Sep.) can be inferred from the concentration of factories in this area. Gwangju showed the highest return level of PM2.5, even if the return level of PM10 was relatively low. This phenomenon implies that we should investigate chemical mechanisms for making PM2.5 in the vicinity of Gwangju area. On the other hand, Gyeongbuk and Ulsan exposed relatively high PM10 risk and low PM2.5 risk. This indicates that the management policy of PM risk in the west side should be different from that in the east side. The results of this research may provide insights for managing regional risks induced by PM10 and PM2.5 in South Korea.

      • KCI등재

        보건의료 교육기관에서 생물테러 관련 교육 현황조사 및 학습목표 개발

        이하경,천병철,이성은,오향순,왕순주,김지희,장욱,Lee, Ha-Gyung,Chun, Byung-Chul,Yi, Sung-Eun,Oh, Hyang-Soon,Wang, Sun-Ju,Kim, Jee-Hee,Sohn, Jang-Wook 대한예방의학회 2008 예방의학회지 Vol.41 No.4

        Objectives: Bioterrorism (BT) preparedness and response plans are particularly important among healthcare workers who will be among the first involved in the outbreak situations. This study was conducted to evaluate the current status of education for BT preparedness and response in health care-related colleges/junior colleges and to develop learning objectives for use in their regular curricula. Methods: We surveyed all medical colleges/schools, colleges/junior colleges that train nurses, emergency medical technicians or clinical pathologists, and 10% (randomly selected) of them that train general hygienists in Korea. The survey was conducted via mail from March to July of 2007. We surveyed 35 experts to determine if there was a consensus of learning objectives among healthcare workers. Results: Only 31.3% of medical colleges/schools and 13.3% of nursing colleges/junior colleges had education programs that included BT preparedness and responses in their curricula. The most common reason given for the lack of BT educational programs was 'There is not much need for education regarding BT preparedness and response in Korea'. None of the colleges/junior colleges that train clinical pathologists, or general hygienists had an education program for BT response. After evaluating the expert opinions, we developed individual learning objectives designed specifically for educational institutions. Conclusions: There were only a few colleges/junior colleges that enforce the requirement to provide education for BT preparedness and response in curricula. It is necessary to raise the perception of BT preparedness and response to induce the schools to provide such programs.

      • 국가직무능력표준 기반의 직무능력단위별 학습과정 구현

        임현지 ( Hyun-ji Im ),이병권 ( Byong-kwon Lee ),오장욱 ( Jang Wook Oh ),안형철 ( Hyoung Choul Ahn ),백정열 ( Jeong-yeol Baek ),김원태 ( Won-tae Kim ) 한국정보처리학회 2017 한국정보처리학회 학술대회논문집 Vol.24 No.1

        산업현장에서 직무를 수행하기 위해 요구되는 지식·기술·소양 등의 내용을 국가가 산업부분별 ·수준별로 체계화한 것을 국가직무능력표준이고, 국가적 차원에서 표준화했다. 본 연구에서는 국가직무능력표준의 능력단위별 학습모듈 기반으로 한 학습과정 설정과 학습을 구현했다.

      • KCI등재
      • KCI등재후보

        경구용 약독화 장티푸스 생균 백신의 면역원성과 안전성

        오미혜,신동한,피대훈,신영규,최병민,장욱,김익상 대한감염학회 2004 감염과 화학요법 Vol.36 No.1

        목적 : Salmonella typhi Ty21a 주로 만든 경구용 약독화 장티푸스 생균 백신 투여 후 위장관의 점막면역 유도를 통한 장티푸스 특이 IgA 항체 양전율과 백신 투여 후 발생한 이상 반응을 조사함으로 백신의 면역원성과 안전성에 대해 알아보고자 이 연구를 시행하였다. 재료 및 방법 : 2001년 7월부터 2002년 3월까지 고려대학교 의과대학 안산병원에서 건강한 6세 이상의 소아, 청소년 및 성인 지원자를 93명을 모집하여 장티푸스 생균 백신(지로티프 캅셀, 보령신약)을 1캅셀씩 2일 간격으로 3회 경구 투여하였다. 투여 시작 후 6, 8, 10일째에 혈액을 채취하여 혈중에서 장티푸스 특이 IgA 분비세포를 측정하는 ELISPOT(enzyme-linked immunospot) 방법으로 면역형성 유무를 검사하였다. 또한 2001년 7월부터 2001년 11월까지 고대안산병원을 포함한 전국 12개 기관에서 모집한 465명의 소아 및 성인남녀 지원자를 대상으로 백신 투여 후 발생한 이상 반응을 조사 분석하였다. 결과 : 1) 지원자 중 항체 양전율 연구를 마친 사람은 6-15세의 16세미만군 42명(남 : 22명, 여 : 20명), 16세이상군 51명(남 : 17명, 여 : 34명), 합계 93명(남 : 39명, 여 : 54명)이었으며, 평균 연령은 16세미만군 11.1±2.5세, 16세이상군 31.6±9.8세였다. 이상 반응 조사가 완료된 사람은 465명(남 : 187명, 여 : 278명)이었으며, 평균 연령은 31.3±16.9세였다. 2) 16세미만군의 항체 양전율은 73.8% (31/42명), 16세이상군의 양전율은 86.3%(44/51명)였으며, 양 군간에 통계적으로 유의한 차이는 없었다. 성, 연령, 알레르기력, 기존 질환, 병용약물 등 대상자의 제반 배경 인자 중에서 통계학적으로 유의하게 양전율에 영향을 미치는 요인은 없었다. 3) 이상 반응의 발현 증례율은 8.6% (40/465명)였으며 증상별로는 복통, 설사, 구역 등 위장관계 이상이 6.5% (30/465명), 무력감, 발열 등의 전신 이상이 1.3% (6/465명), 두통이 0.6% (3/465명), 피부발진이 0.2% (1/465명)에서 나타났다. 백신 복용 횟수에 따른 이상 반응 발현율은 1차 복용 후 5.2% (24/465명), 2차 복용 후 4.5% (21/462), 3차 복용 후 2.6% (12/461)로 처음 복용 후 유의하게 높았다(P<0.05). 대상자의 제반 배경 인자 중에서 통계학적으로 유의하게 이상 반응 발현율에 영향을 미치는 요인은 없었다. 결론 : 경구용 약독화 장티푸스 생균 백신은 장점막 면역유도를 통한 우수한 면역원성을 가지고 있으며, 이상 반응 발생률이 낮고 이상 증상이 경미하여 소아 및 성인 모두에 안전한 백신으로 판단된다. Background : This study is aimed at evaluating immunogenicity by measuring immunoglobulin A (lgA) seroconversion rate through common mucosal immune system and adverse reactions after vaccination of oral live attenuated Salmonella typhi (S. typhi) Ty21a vaccine in Korean population. Methods : A commercially available oral live attenuated vaccine of S. typhi strain Ty21a (Zerotyph® capsule, Boryung Biopharma Co., Seoul, Korea) was given to volunteers, children above 6 years, adolescents, and adults who have never infected with S. typhi nor received S. typhi vaccination. The vaccines were given in three doses, with two day interval between the doses. Seroconversion was determined by ELISPOT (enzyme-linked immunospot) assay. Adverse reactions after vaccination were evaluated in 12 institutions by direct interviewing with vaccinees. Results : A total of 93 volunteers for evaluation of seroconversion were enrolled. Seroconversion rate in the the below 16 year-old group was 73.8% (31/42) and that of over 16 year-old group was 86.3% (44/51), which was not statistically different. Adverse reaction were found in 8.6% (40/465). Gastrointestinal symptoms were most common (6.5%, 30/465). Adverse reactions were found in 5.2% (24/465) after 1st administration, 4.5% (21/462) after 2nd, and 2.6% (12/461) after 3rd. Frequency of adverse reactions was significantly higher after 1st administration (P<0.05). Conclusion : Oral live attenuated S. typhi vaccine, Zerotyph® capsule, had good immnuogenicity and safety through intestinal immune system.

      • KCI등재후보

        2007년 대한감염학회 권장 성인 예방접종 권장안

        강진한,김홍빈,장욱,이상오,정문현,정희진,최영화,최정현,최준용,최희정 대한감염학회 2008 감염과 화학요법 Vol.40 No.1

        In 2007, the Korean Society of Infectious Diseases recommended an immunization schedule for adults residing in Korea. This recommendation includes four categories: standard immunization for healthy persons, supplementary immunization for persons with underlying illnesses, recommendations for health-care personnel and for international travelers. The Standard Immunization Schedule consists of universal vaccination (tetanus-diphtheria/tetanus-diphtheria-pertussis (Td/Tdap); hepatitis A vaccine for persons aged 20s; human papilloma virus vaccine for women under 26 years old; meningococcal vaccine for military recruits and college students in dormitories; influenza vaccination for persons aged 50 years or more and pregnant women; and pneumococcal vaccination for persons aged 65 years or more) and catch-up vaccination (hepatitis A vaccine for persons aged 30s; hepatitis B vaccine, varicella and MMR vaccines for persons who have uncertain specific immunities). The Supplementary Immunization Schedule recommends 4 vaccines, i.e., pneumococcal, influenza, meningococcal, and Haemophilus influenzae type b, appropriate to the underlying illnesses, and confirmation of the presence of antibodies to hepatitis A and hepatitis B. The Recommendation for Health-Care Personnel includes universal vaccination (influenza and pertussis) and catch-up vaccination (hepatitis B, measles-mumps-rubella and varicella for seronegative health-care personnel). The Recommended Immunization for International Travelers focuses reinforcement of vaccinations for healthy persons and includes certain immunizations necessary for international travel (yellow fever, meningococcal, plaque, tick-borne encephalitis, and cholera). These guidelines can be seen at www.ksid.or.kr.

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