트리테이스프로텍트 ^®정(라미프릴 10mg)에 대한 라미프린 ^®정의 생물학적동등성

오수연,조종태,김형건,김윤균,Oh, Soo-Yeon,Cho, Jong-Tae,Kim, Hyung-Gun,Kim, Yoon-Gyoon 한국약제학회 2008 Journal of Pharmaceutical Investigation Vol.38 No.1

To evaluate the bioequivalence of two ramipril formulations, a standard 2-way randomized cross-over study was conducted in twenty-six healthy male Korean volunteers. A single oral dose of 10 mg of test formulation $Ramiprin^{(R)}$ (tablet) or reference formulation Tritace $Protect^{(R)}$ (tablet) was administered with one-week washout period. Plasma concentrations of ramipril were assayed over a period of 12 hr with a well validated method using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The values of area under the plasma concentration-time curve, from time zero to last sampling time $(AUC_t)$ and from time zero to time infinity $(AUC_{inf})$ were $77.45{\pm}44.78\;and\;78.96{\pm}45.64$ for test, and $70.30{\pm}42.27\;and\;71.99{\pm}43.55ng\;hr/mL$ for reference formulation, respectively. Similarly, maximum concentration $(C_{max})$ and elimination half-life $(t_{1/2})$ were $65.61{\pm}19.96ng/mL$ and $2.15{\pm}0.75hr$ for test, and $63.63{\pm}25.50ng/mL$ and $2.16{\pm}0.73hr$ for reference formulations, respectively. Time to reach maximum concentration $(T_{max})$ for the test and the reference, were $0.51{\pm}0.22hr\;and\;0.52{\pm}0.18hr$, respectively. The parametric 90% confidence intervals on the mean of the differences between the two formulations (test-reference) of the log-transformed values of $AUC_t\;and\;C_{max}$ were 1.03 to 1.19 and 0.98 to 1.17, respectively. The overall results indicate that the two formulations are bioequivalent and can be prescribed interchangeably.

유방암 여성 환자의 림프부종에 대한 림프배액맛사지의 효과

오수연,김현아,정광조,김정선,조종관,유화승,Oh, Soo-Yeon,Kim, Hyeon-Ah,Jung, Kwang-Jo,Kim, Jung-Sun,Cho, Chong-Kwan,Yoo, Hwa-Seung 대한암한의학회 2007 大韓癌韓醫學會誌 Vol.12 No.1

Objective: We have the purpose of evaluating the effects of lymphatic massage on lymphoedema in breast cancer patients. Method: The patient who has in condition of lymphoedema after the breast cancer therapy is taken massages with aroma oil for 5 days. We measured the upper arm circumference and edema index before and after the therapy. We also measure the edema index of normal arm to compare with the abnormal one. Results: We gave 4 patients the decongestive lymphatic therapy and now present the positive conclusion. 3cases of the 4 showed decrease of circumferences and edema index. It means that the edematous condition getting better during these therapy. Conclusion: Lymphatic massage with aroma therapy may have effectiveness on lymphoedema in breast cancer patients. but further advanced clinical trials are needed.

Risk Factors of Atrophic Gastritis and Intestinal Metaplasia in First-Degree Relatives of Gastric Cancer Patients Compared with Age-Sex Matched Controls

오수연,김나영,윤혁,최윤진,이주엽,박경준,김희진,강규근,오동현,서아영,이재우,신철민,박영수,Jane C Oh,이동호,정현채 대한암예방학회 2013 Journal of cancer prevention Vol.18 No.2

Background: To identify whether first-degree relatives (FDRs) of gastric cancer (GC) patients have increased risk for atrophicgastritis (AG) and intestinal metaplasia (IM) in relation to other risk factors of GC. Methods: The study cohort consisted of 224 pairs of age-sex matched controls and FDRs. AG and IM in the gastric mucosa werescored histologically using the updated Sydney classification. Risk of having AG and IM was studied by comparing FDRs to controls. Impacts of age, H. pylori infection, smoking, dietary and socioeconomic factors on the presence of AG and IM were studied. Results: In multivariate regression analysis, FDRs had adjusted OR of 2.69 (95% CI 1.06-6.80, P=0.037) for antral IM in malepopulation. Adjusted OR for antral AG and IM were 9.28 (95% CI 4.73-18.18, P<0.001) and 7.81 (95% CI 3.72-16.40, P<0.001)for the H. pylori infected subjects in total population. Getting old by 5 years increased the ORs of having AG and IM byapproximately 1.25 fold (P<0.001). Spicy food increased the OR of antral IM by 2.28 fold (95% CI 1.36-3.84, P=0.002). Conclusions: Family history of GC was an independent risk factor for antral IM in male in our study, which could be one reasonfor the increase of gastric cancer in the family member of gastric cancer. It could be an evidence for the necessity of frequentendoscopy in the presence of family history of GC compared to general population in male.

소아에서의 치루 및 항문 주위 농양의 임상적 고찰

오수연,최금자,Oh, Soo-Youn,Choi, Kum-Ja 대한소아외과학회 2002 소아외과 Vol.8 No.2

To evaluate the clinical characteristics and results of treatment of fistula-in-ano and perianal abscess in childhood, we analyzed 95 cases of fistula-in-ano and/or perianal abscess seen in childhood, between January 1995 and June 2001 at the Department of General Surgery of Ewha Womans University Mokdong Hospital. Perianal abscess was in 25 patients, anal fistula in 62 and combined disease (perianal fistula and abscess) in 8. Male predominance was noted (95%). Median age was 8 months and 78% of cases were presented under the age of 1 year. Median duration of symptoms was 60 days. Twenty four abscesses (77%) and 18 lesions (72%) of combined disease (n=25) were located on both lateral sides of the anus, and fistulas located on both lateral sides were 33 (53%). Multiplicity of the lesion was noted in 25% of cases. Sixteen percent of abscess, 81% of fistula and 88% of combination group have had previous perianal abscesses. The perianal abscesses were treated with incision and currettage and fistulas were treated with fistulotomy or fistulectomy. There were no recurrent diseases and no complications after surgical treatment. Although the progresses of the perianal abscess and fistula in ano in childhood may be self-limitied, surgical management was safe and curable.

유한상태기계에 기반한 확장된 I-O 모델링 방법론

오수연,왕지남,김기형,김강석,Oh, Soo-Yeon,Wang, Gi-Nam,Kim, Ki-Hyung,Kim, Kangseok 한국시뮬레이션학회 2016 한국시뮬레이션학회 논문지 Vol.25 No.4

최근 자동 생산 시스템은 PLC (Programmable Logic Controller) 제어 프로그램을 일반적으로 사용하고 있다. 생산제품의 수명 주기가 길지 않기 때문에 공법과 라인 및 설비 변경이 자주 일어난다. 대부분, 기존 공정을 바탕으로 이루어지고 설비의 위치 및 제어정보를 수정한다. PLC 제어 프로그램 또한 기존 공정을 바탕으로 수정이 이루어진다. 새로운 제어 프로그램을 검증하기 위해서는 실제 생산 시스템을 구축하기 전에 가상의 공간에서 실제 공정과 같이 구성하여 순차적으로 공정이 진행되는 지 확인할 수 있는 방법이 필요하다. 본 연구는 순차제어(sequential control)와 병목현상 처리에 유용한 Timed-FSA를 기반으로 하는 논리적인 모델링 방법을 사용한다. 기존에 연구되었던 I-O 모델링과 I-O 모델링에서 요구되었던 하나의 설비에 다양한 상태의 정의를 통해 사용자의 시간과 공수를 절감하기 위한 기존 모델링에 페트리네트의 토큰(Petri Nets Coloured Token) 개념을 추가한 확장된 I-O 모델링 방법을 제안한다. 예제 설비를 통하여 사용자의 모델링 시간을 절감하는 실험과 사용자 평가를 통해 제안하는 확장된 I-O 모델링의 편의성을 검증한다. Recently manufacturing companies have used PLC control programs popularly for their automated production systems. Since the life cycle of production process is not so long, the change of the production lines occur frequently. Most of changes happen with modification of the position information and control process of the equipment. PLC control program is also modified based on the fundamental process. Therefore, to verify new PLC program by configuring virtual space according to real environment is needed. In this paper we show a logical modeling method, based on Timed-FSA useful for sequence control and dead-lock prevention. There is a problem wasting user's labor and time when defining a variety of states in a device. To overcome this problem, we propose an extended I-O model based on existing methods by adding a token concept of Petri Nets. Also we will show the usability of the extended I-O modeling through user study.

국내 우주환경 자료 보유 현황: 태양·행성간 공간

오수연,이진이,한국우주과학회 태양우주환경분과,Oh, Suyeon,Lee, Jin-Yi,Division of Solar and Space Environment of KSSS, 한국우주과학회 2021 우주기술과 응용 Vol.1 No.2

The Solar and Space Environment Division of the Korean Space Science Society investigated the use and possession of ground and satellite observations and models of solar and planetary data operated by domestic research institutes and universities. Based on the findings, we would like to introduce observational instruments, data, and models in solar and interplanetary fields in this paper to improve understanding and use of each data and explore opportunities for interdisciplinary research. The ground and satellite observations, which require a lot of investment, were mainly held by research institutes (National Meteorological Satellite Center, Polar Research Institute, Korean Space Weather, Korea Astronomy and Space Science Institute and KAIST Satellite Research Institute), and model development was overwhelmingly carried out at Kyung Hee University. In solar and interplanetary fields, we introduce Fast Imaging Solar Spectrograph (FISS), neutron monitors, and the analysis models [for the Solar Dynamics Observatory/Atmospheric Imaging Assembly (SDO/AIA) and Hinode/X-Ray Telescope (XRT) observations] in nonequilibrium ionization state as representatives. Survey on solar and interplanetary fields can be downloaded from the website of the Korean Space Science Society (http://ksss.or.kr/). The paper makes know the importance of long-term and continuous management of space science-related materials, and hopes to contribute to enhancing the status of domestic space science data by utilizing locally produced data by various personnel participating in space science research. 한국우주과학회 태양우주환경분과에서 국내 연구소와 대학에서 운영 중인 태양 및 행성간의 자료를 지상관측기, 위성 및 모델에 대한 보유 및 활용에 대한 조사를 실시하였다. 조사 결과를 바탕으로 각 자료에 대한 이해와 활용도를 높이고, 분야 간 융합 연구 기회를 모색하고자 본 논문에서 태양 및 행성간 분야의 관측 자료와 모델을 소개하고자 한다. 투자가 많이 필요한 지상 관측기 및 위성 분야는 주로 연구소(국가기상위성센터, 극지연구소, 우주전파센터, 한국천문연구원 및 KAIST 인공위성연구소)에서 자료를 보유하고 있었으며, 모델 개발은 경희대학교에서 압도적으로 수행하였다. 태양 및 행성간 분야에서 고속태양분광기(Fast Imaging Solar Spectrograph, FISS), 우주선 중성자 관측기 및 이온화 비평형 상태 Solar Dynamics Observatory/Atmospheric Imaging Assembly(SDO/AIA)와 Hinode/X-Ray Telescope(XRT) 온도 대응 함수 모델을 대표로 소개한다. 태양 및 행성간 분야의 자료에 대한 조사 내용은 한국우주과학회 홈페이지에서 다운로드할 수 있다(http://ksss.or.kr/). 이 논문이 우주과학 관련 자료에 대한 장기적이고 연속적인 관리에 대한 중요성을 인식하며, 우주과학 연구에 참여하는 다양한 인력들이 참조하여 국내에서 생산되고 있는 자료를 활용하여 국내 우주과학 자료의 위상을 높이는 데 기여하기를 희망한다.

주조티타늄과 기계절삭티타늄 코핑의 변연적합성에 관한 연구

오수연,방몽숙,양홍서,박상원,박하옥,Oh Su-Yeon,Vang Mong-Sook,Yang Hong-So,Park Sang-Won,Park Ha-Ok 대한치과보철학회 2006 대한치과보철학회지 Vol.44 No.1

Statement of problem: The titanium has advantages of a high biocompatibility, a corrosion resistence, low density, and cheep price, so it is focused as a substituted alloy But it is quite difficult to cast with the tranditional method due to the high melting point, reacivity with element at, elevated temperature. By using the CAD-CAM system for the crown construction, it is possible to reduce the errors while proceeding the wax-up, investing, and casting procedure Purpose: The purposes of this study were to measure the marginal adaptation of the casting titanium coping and machine-milled titanium coping according to the casting methods and the marginal configurations. Material and method: The marginal configurations were used chamfer shoulder, and beveled shoulder. The total 30 copings were used, and these are divided into 6 groups according to the manufacturing method and marginal configuration. The gap between margin of the model and the restoration was measured with 3-dimensional measuring microscope. Results: The following results were obtained; 1. casting gold coping demonstrated the best marginal seal, followed by casting titanium coping finally machine-milled titanium copings. 2. In casting titanium coping, chamfer demonstrated the best marginal seal, followed by shoulder and beveled shoulder. There was no significantly difference in shoulder and beveled shoulder. But all margin form has clinically acceptable 3. In machine-milled titanium copings, chamfer demonstrated the best marginal seal, followed by shoulder and beveled shoulder. Beveled shoulder show large and uneven marginal gap Conclusions: Above result revealed that marginal adaptation of the titanim coping is avail able in the clinical range, it can be used as an alternative metal and it is prefered especially in chamfer or shoulder margin during implant superstructure fabrication. But there should be more research on machine-milled titanium in order to use it in the clinics.

제스트릴^®정(리시노프릴, 10 mg)에 대한 리시헥살^®정의 생물학적동등성

오수연,디펜드라 쿠마 아리얼,조종태,김형건,김윤균,Oh, Soo-Yeon,Aryal Dipendra Kumar,Cho, Jong-Tae,Kim, Hyung-Gun,Kim, Yoon-Gyoon 한국약제학회 2006 Journal of Pharmaceutical Investigation Vol.36 No.4

Lisinopril is one of the angiotensin-converting enzyme inhibitors, which have been used for treatment of hypertension and heart failure. The aim of this study was to evaluate the bioequivalence of two lisinopril tablet, $Lisihexal^{\circledR}$ and $Zestril^{\circledR}$ as a test and reference, respectively. The study was came out on 28 healthy male Korean volunteers in $2{\times}2$ crossover design. An analytical method with LC-MS-MS was developed for the quantification of lisinopril and enalapril(IS) using SPE method. The condition was selective, sensitive and precise in human plasma, that was enough for the pharmacokinetic study of lisinopril. The pharmacokinetic parameters such as $AUC_t,\;AUC_{inf},\;C_{max},\;T_{max}\;and\;t_{1/2}$ were calculated and ANOVA test was used for the statistical analysis of the parameters using log transformed $AUC_t,\;AUC_{inf}\;and\;C_{max}$. $t_{1/2}$ of test and reference drugs were calculated $11.4{\pm}5.1\;and\;16.1{\pm}9.9\;hr$, respectively. The 90% confidence intervals of $AUC_t,\;AUC_{inf}\;and\;C_{max}$ were log 0.9245$\sim$log 1.0603, log 0.9270$\sim$log 1.0601 and log 0.9548$\sim$log 1.1009, within the acceptable range of log 0.8 to log 1.25 by KFDA bioequivalence criteria. Two medications of lisinopril were evaluated bioequivalent and thus may be prescribed interchangeably.

단보 : 제스트릴(R)정(리시노프릴, 10 mg)에 대한 리시헥살(R)정의 생물학적동등성

오수연 ( Soo Yeon Oh ),디펜드라쿠마아리얼 ( Dipendra Kumar Aryal ),조종태 ( Jong Tae Cho ),김형건 ( Hyung Gun Kim ),김윤균 ( Yoon Gyoon Kim ) 한국약제학회 2006 Journal of Pharmaceutical Investigation Vol.36 No.4

창자 가로절단-재문합 실험모델에서 창자신경계통의 형태계측학적 변화

오수연(Soo-Youn Oh),박웅채(Ung-Chae Park),김경래(Kyung-Rae Kim),왕준호(Jun-Ho Wang),이재동(Jae-Dong Lee),김순제(Soon-Je Kim),송우철(Wu-Chul Song),박승화(Seung-Hwa Park) 대한체질인류학회 2007 해부·생물인류학 (Anat Biol Anthropol) Vol.20 No.1

작은창자의 손상 후 시간경과에 따른 재생과정에서 근육층신경얼기와 제1형 카할사이질세포가 각각 어떻게 변화하는지를 살펴보고자 돌창자 가로절단-재문합 실험모델을 제작하여 형태계측학적 방법으로 비교분석 하였다. 형태계측학적 분석을 하기위해 Sprague Dawley계 성숙흰쥐의 돌창자를 가로절단한 후 재문합시킨 실험군과 가로절단을 하지 않고 개복 후 봉합수술만을 시행한 대조군에서 수술 후 3일, 7일, 15일, 30일군의 근육층신경얼기와 제1형 카할사이질세포의 변화를 영상분석기를 이용하여 계수하고 통계처리 하였다. 작은창자의 가로절단으로 인한 손상효과는 근육층신경얼기와 제1형 카할사이질세포에서 동시에 일어났으며 손상부위를 중심으로 앞쪽과 뒤쪽(구강쪽과 항문쪽) 양 방향으로 고르게 나타났다. 손상효과는 수술 후 3일군과 7일군에서 가장 심하게 나타나 근육층신경얼기의 경우 신경세포의 형태적 변성과 아울러 세포수가 약 40% 감소하였다. 제1형 카할사이질세포는 세포수가 20~37% 감소하였으며 대부분 세포의 세포질에는 많은 공포가 형성되어 있었다. 수술 후 15일 이후부터는 재생이 일어나기 시작하여 근육층신경얼기에서 신경세포의 감소정도는 20~25%로 줄어들었으며 세포의 염색정도나 형태가 정상으로 회복되는 양상을 보였다. 제1형 카할사이질세포 수의 감소정도도 13~20%로 줄어들었으며 세포질 내 공포가 형성된 세포의 수도 감소하였다. 수술 후 30일군에서 근육층신경얼기를 이루는 신경세포의 형태는 대조군과 유사하였으며 신경세포의 수는 수술 면을 기준으로 구강쪽과 항문쪽에서 각각 12.3%, 15.6% 씩 감소하여 (p<0.01) 정상으로의 완전한 회복은 이루어지지 않았다. 제1형 카할사이질세포 수는 구강쪽과 항문쪽에서 각각 7.5%, 4.2%씩 감소하였으나 유의한 차이는 없었으며(p>0.01) 세포 형태도 정상이었다. 이로서 작은창자의 가로절단으로 인한 손상효과는 근육층신경얼기에서 좀 더 심하게 나타나며 정상으로의 회복도 제1형 카할사이질세포에 비해 더디게 나타남을 알 수 있었다. This study was performed to investigate the morphometric changes of myenteric plexus and type 1 interstitial cells of Cajal (ICC-I) in regeneration process of small intestine transection. Sprague Dawley rats (200~250 g) were anesthetized with ether; then the full thickness of ileal wall were semitransected; and subsequent end-to-end anastomosis were performed by using 6-0 silk suture thread. Sham-operated rats, which only underwent the laparotomy, were used for control group. Experimental animals were sacrificed at 3 days, 7 days, 15 days, and 30 days after the operation. In each group myenteric plexus and ICC-Is were prepared by histochemical method (NADH-TR stain for myenteric plexus, ZIO stain for ICC-Is) and cell numbers were counted by image analyzer (Image plus pro-5.0, Media Cybermedics, USA). Degeneration of myenteric neurons and ICC-Is occurred simultaneously and it was similar in oral and anal to the site of transection. Degeneration effects were most prominent at 3 days and 7 days after intestinal transection. In myenteric plexus, many neurons had degenerated appearances and about 40% of them were lost. Most of ICC-Is had cytoplasmic vacuoles and 20~37% of the cells were lost. At 15 days after transection, there were no more degeneration in myenteric neurons (20~25% cell loss) and ICC-Is (20~13% cell loss). At 30 days after transection, numbers of myenteric neurons were not recovered as that of the control group. However numbers of ICC-Is were as similar as that of the control group. In conclusion, we confirmed that degeneration effects of intestinal transection are more severe in myenteric plexus than in ICC-Is, and recovery of cell loss occurs more slowly in myenteric plexus.