[인터뷰] “검사 27년, 후회는 없다” - ‘국민이 우스운가’ 검수완박 문자로 홍역 치른 조종태 광주고검장

조종태,김주미 법률방송 2022 법치와 자유 Vol.1 No.4

원인 미상의 설사와 복통으로 발현한 AL형 유전분증 1 예

조종태,윤성철 단국대학교 1998 論文集 Vol.32 No.-

Primary systemic amyloidosis (AL amyloidosis) is an uncommon disease characterized by the accumulation in vital organs of a fibrillar protein consisting of monoclonal immunoglobulin light chains. It is a plasma cell dyscrasia usually accompanied by a bone marrow plasmacytosis and an M component in the serum or urine. The presenting features of AL amyloidosis are protean and frequently nonspecific, but the diagnosis is rarely made until symptoms or signs referable to a particular organ appear. The amyloid deposits cause cardiac or renal dysfunction and, ultimately, death. We report a case of AL amyloidosis, presented with unexplained diarrhea and abdominal pain for eight months, documented by a renal biopsy, and review the previous literatures

혈액투석 치료를 받고 있는 말기신부전 환자에서 적혈구생성인자에 치료반응이 불량한 환자들의임상적 특징

조종태,박영선 대한신장학회 2004 대한신장학회잡지 Vol.23 No.1

Paraquat 중독환자의 임상적 고찰

조종태,박태진,윤성철 단국대학교 의과대학 1998 檀國醫大學術誌 Vol.2 No.1

한국형 출혈열 환자에서 분리한 한타 바이러스의 핵산 분석

조종태,윤성철,안규리,한진석,김성권,이정상 단국대학교 1998 論文集 Vol.33 No.-

Hemorrhagic fever with renal syndrome(HFRS)is an infectious disease showing diverse clinical manifestations according to different serotypes of hantavirus. On the assumption that the antigenicity, nucleotide and amino acid sequence diversity of hantaviruses, as well as immune response diversity of individual KHF patients may be present, this study was performed to analyse the genetic diversity of hantaviruses isolated from patients with KHF. In the 13 samples hantaviral RNAs were extracted, cDNAs of partial M segment were amplified by RT-PCR using genus-reactive primer, amplified cNNAs were analyzed by direct sequencing method, and then the nucleotide and deduced amino acid sequences were compared with previously known sequences of four serotypes of hantavirus isolated from rodent hosts and each other by the computer assistance. The results were as follows. The nucleotide and amino acid sequences of 11 samples among the 13 human isolates showed 90.3∼95.5%, 86.7∼97.9% the other 1 samples 82.7%, 71.9% homology respectively to those of Hantaan virus 76-118 strain, and another 1 sample showed 83.7%, 75.3% homology respectively to those of Seoul virus B1 strain isolated from rodent host. The nucleotide and amino acid sequences of 7 among 12 Hantaan samples showed differences within 5%, 10% respectively each other and high genetic similarities, but those of the oehr 5 among 12 Hantaan samples showed low genetic similarities each other. In conclusion, hantaviruese isolated from KHF patients showed genetic diversity compared with previously known hantaviruses isolated from rodent hosts.

혈액투석 환자에서 혈청 마그네슘 농도와 임상적 의의

조종태 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.5

Background : Hypermagnesemia may be implicated to have both harmful and beneficial effects in dialysis patients. It may contribute to osteomalacic renal osteodystrophy and suppression of parathyroid hormone. The purposes of this study were to analyze the serum magnesium concentration in hemodialysis patients, and to clarify the relationship between serum magnesium and intact parathyroid hormone concentration (iPTH) independently of other clinical parameters. Methods : Eighty-one patients (38 males and 43 females) with end-stage renal failure undergoing maintenance hemodialysis in Dankook University Hospital were included in this study. The mean age was 53+12 years and the duration of dialysis was 36k35 months. The underlying kidney disease was diabetic nephropathy in 24 patients (30%). The patients used a dialysate magnesium concentration of 1.5 mEq/L. The serum magnesium, iPTH and other clinical parameters were evaluated and analyzed. Results : The mean serum magnesium concentration was 2.78±0.45 mEq/L (range 1.50-3.95 mEq/L). Hypermagnesemia (defined as serum Mg >2.1 mEq/L) was found in 72 patients (89%). The mean iPTH was 128±224 pg/mL (range 3-1,344 pg/mL). The iPTH was significantly low, and the serum aluminum concentration was significantly high in patients (n=28) with more severe hypermagnesemia (defined as serum Mg >3.0 mEq/L). The serum magnesium, aluminum and calcium concentration have significant negative correlations with iPTH respectively (r=-0.27, -0.31, -0.28, p<0.05) in patients (n=55) with relative hypoparathyroidism (defined as iPTH <120 pg/mL). Conclusion : Hypermagnesemia was common in hemodialysis patients. High serum aluminum concentration should be considered in patients with moderate to severe hypermagnesemia. Furthermore, hypermagnesemia as well as high serum aluminum and calcium concentration may have a suppressive effect on FTH in patients with relative hypoparathyroidism or adynamic bone disease. 목 적 : 혈액투석 환자에서 고마그네슘혈증은 신성골이양증에 관여할 수도 있다는 부정적 측면과 부갑상선호르몬 상승을 억제할 수도 있다는 긍정적 측면이 보고되고 있지만 분명한 임상적 의의는 잘 알려져 있지 않다. 따라서 본 연구의 목적은 혈액투석 환자에서 혈청 마그네슘 농도와 부갑상선호르몬과의 관계를 각종 임상적 지표들과 함께 분석하여 혈액투석 환자에서 혈청 마그네슘 농도와 임상적 의의를 규명하는 것이다. 방 법 : 현재 단국대학교병원에서 말기신부전으로 혈액투석 (투석액의 마그네슘 농도는 1.5 mEq/L) 치료 중인 환자 81명 (연령은 53±12세, 남녀비는 38:43, 투석기간은 36±35개월, 원인신질환은 당뇨병성신증이 30%)을 대상으로 혈청 마그네슘과 부갑상선호르몬 농도 및 각종 임상적 지표들을 연속해서 측정하여 분석하였다. 결 과 : 혈청 마그네슘 농도는 2.78±0.45 mEq/L (범위 1.50-3.95 mEq/L)이었고 고마그네슘혈증 (serum Mg >2.1 mEq/L)은 72명 (89%)이었으며 부갑상선호르몬 농도 (intact PTH)는 128±224 pg/mL (범위 3-1,344 pg/mL)이었다. 중등도 이상의 고마그네슘혈증 (serum Mg ≥3.0 mEq/L)이 있는 군 (n=28)에서 혈청 부갑상선호르몬 농도가 의미있게 낮았고 알루미늄 농도는 의미있게 높았다. 상대적 부갑상선기능저하증 (iPTH <120 pg/mL)이 있는 군 (n=55)의 혈청 마그네슘, 알루미늄 및 칼슘 농도가 의미있게 높았고 alkaline phosphatase는 의미있게 낮았으며 혈청 마그네슘, 알루미늄 및 칼슘 농도는 부갑상선호르몬 농도와 각각 음의 상관관계 (r=-0.27, -0.31, -0.28, p<0.05)를 보였고 다중회귀분석결과 혈청 부갑상선호르몬 농도를 예견할 수 있었다 (multiple r=0.39, p<0.05). 결 론 : 혈액투석 환자에서 고마그네슘혈증은 흔한 현상이고 중등도 이상의 고마그네슘혈증이 동반됐을 경우에는 고알루미늄혈증이 동반됐을 가능성을 생각해볼 필요가 있다. 또한 상대적 부갑상선기능저하증이 있는 환자들에게는 높은 농도의 혈청 마그네슘이 부갑상선호르몬의 생성 혹은 분비를 억제하는 효과가 있는 것으로 사료된다. 이러한 결과는 혈액투석 환자에서 고마그네슘혈증이 무력성 골질환과 같은 신성골이양증의 발병에 관여할 가능성을 시사한다.

모자간에 발생한 선천성 신성요붕증

조종태,송탁호 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.5

Most cases of congenital nephrogenic diabetes insipidus (NDI) are transmitted in an X-linked recessive manner and are caused by mutations in the vasopressin type 2 receptor (AVPR2) genes on the long arm of the X chromosome (Xq28). In these cases, female carriers are usually asymptomatic, and most patients are male. X-linked NDI is a rare hereditary disease with an estimated prevalence and incidence of approximately four to nine per one million males. Although several cases of congenital NDI diagnosed in the childhood were reported in Korea, there were few reports about congenital NDI diagnosed in the adult and documented by the mutational analysis. We have experienced two cases of congenital NDI developing in the mother and the son, diagnosed in the adult, and confirmed to be caused by mutation (R113W) in AVPR2 gene. Therefore, we report these cases with a brief review of the literature. 요붕증 (diabetes insipidus)은 다량의 희석된 소변을 특징으로 하는 질환이다. 이러한 상태는 항이뇨호르몬 (AVP; arginine vasopressin) 분비장애에 의한 것 (중추성요붕증)이거나 항이뇨호르몬에 신장 집합관 반응장애에 의한 것 (신성요붕증)이다.

혈액투석을 받고 있는 말기 신질환에서 Calcitriol(Rocaltrol^(�))의 효과

조종태,엄재호,안규리,한진석,김성권,이정상 최신의학사 1992 最新醫學 Vol.35 No.4

혈액투석을 받는 말기신부전 환자중에서 에리트로포에틴에 치료반응이 불량한 환자들의 임상적 특징

조종태,박영선 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.1

Background:The main pathogenic factor causing anemia in chronic renal failure is the erythropoietin deficiency. However, there are some patients showing poor responses to erythropoietin administration. The purposes of this study were to analyze the clinical parameters of poor responders to erythropoietin among ESRD patients undergoing hemodialysis, and to clarify the major potential factors accounting for poor responses to erythropoietin therapy. Methods:Eighty-one patients with end-stage renal failure undergoing hemodialysis were included in this study. Poor responders to erythropoietin, defined as patients requiring erythropoietin doses more than 200 U/kg/week subcutaneously to correct anemia, were identified. The hematocrit, erythropoietin dose, erythropoietin resistance index (ERI), and other clinical parameters in 77 patients requiring erythropoietin administration were evaluated and analyzed. Results:Poor responses to erythropoietin were found in 16 patients (20.8%) among 77 patients requiring erythropoietin administration. Serum iron, total iron binding capacity (TIBC), transferrin saturation (TSAT), and albumin concentration were significantly decreased (p<0.05), and increased CRP (≥0.5 mg/dL) was more frequent in poor responders (p<0.01). The independent factor affecting on ERI was TIBC (R=0.44, p<0.01). However, there were no significant difference between poor and good responders in age, gender, duration of dialysis, underlying renal disease, use of ACE inhibitor, dose of dialysis (Kt/V), serum parathyroid hormone, and aluminum concentration. Conclusion:TIBC seems to be a predicting factor accounting for poor response to erythropoietin among ESRD patients undergoing hemodialysis. 목 적:만성신부전에 동반되는 빈혈의 주요 원인은 신장에서 생성되는 적혈구생성인자 (erythropoietin)의 결핍이다. 그러나 일부 만성신부전 환자 중에서 적혈구생성인자 투여에도 불구하고 빈혈이 개선되지 않거나 비교적 고용량을 투여하여야 반응하는 경우가 있다. 이러한 적혈구생성인자에 불충분한 반응의 원인으로 여러 요인들이 거론되고 있으나 아직 이론이 있는 부분이 있다. 따라서 본 연구의 목적은 혈액투석 치료를 받고 있는 말기신부전 환자에서 적혈구생성인자에 치료반응이 불량한 환자들의 임상소견을 분석하여 불량한 반응을 보이는데 관여하는 주요 요인들을 규명하는 것이다. 방 법:현재 말기신부전으로 혈액투석을 정기적으로 받고 있는 환자 81명 (연령은 52.0±11.7세, 남녀비는 41:40, 투석기간은 37.3±36.5개월, 원인신질환은 당뇨병성신증이 33%) 중에서 적혈구생성인자에 치료반응이 불량한 환자 (빈혈을 교정하기 위해서 피하 적혈구생성인자를 200 U/kg/week 이상 필요로 하는 환자)들을 분류하고 대상환자 81명 중 적혈구생성인자 투여를 필요로 하는 환자 77명을 대상으로 헤마토크리트, 적혈구생성인자 투여량, 적혈구생성인자 저항지수 및 각종 임상적 지표들을 분석하였다. 결 과:적혈구생성인자에 치료반응이 불량한 환자는 20.8% (16/77)이었고, 혈청 철분, 총철분결합능, transferrin saturation (이하 TSAT로 약기함) 및 알부민 등이 통계적으로 의미있게 감소하였으며, C-반응성단백 증가 (≥0.5 mg/dL)가 관찰되는 경우가 의미있게 많았다 (p< 0.05). 이들 가운데 혈청 총철분결합능은 적혈구생성인자 저항지수를 독립적으로 예견할 수 있었다 (R=0.44, p<0.01). 그러나 투석기간, 원인신질환, angiotensin converting enzyme (이하 ACE로 약기함) 억제제 사용 여부, 투석량 (Kt/V), 혈중 부갑상선호르몬 및 알루미늄 농도 등은 의미있는 차이가 없었다.

한국형출혈열에서 한탄 바이러스 항체역가의 변화유형에 따른 임상적 차이

조종태,윤성철 檀國大學校 出版部 1999 論文集 Vol.34 No.3