정책 - 2010년 사료정책방향

안규정,An, Gyu-Jeong 한국사료협회 2010 飼料 Vol.42 No.-

배합사료정책 - 우리나라 사료 정책의 방향

안규정,An, Gyu-Jeong 한국사료협회 2010 飼料 Vol.44 No.-

특집 - 사료 내 항생제 사용 금지 대처방안은? - 사료첨가용 항생제 사용 감축현황 및 추진계획

안규정,An, Gyu-Jeong 한국계육협회 2010 월간 닭고기 Vol.16 No.4

사료정책 - 사료공장 HACCP 중심의 사료관리법 개정사항

안규정,An, Gyu-Jeong 한국사료협회 2009 飼料 Vol.39 No.-

무허가축사 적법화 추진 및 향후 추진방향

안규정,An, Gyu-Jeong 한국낙농육우협회 2017 낙농·육우 Vol.37 No.3

양계산업 당면 현안문제 및 해결방안 - 알기 쉬운 무허가 축사 개선세부실시요령

안규정,An, Gyu-Jeong 대한양계협회 2016 월간 양계 Vol.48 No.8

DUCK's Column - 사료첨가용 항생제 사용 감축현황 및 추진계획

안규정,An, Gyu-Jeong 한국오리협회 2010 오리마을 Vol.83 No.-

Tsutsugamushi병 42예의 임상적 고찰(1987~1990)

박명재 ( Park Myeong Jae ),고경식 ( Go Gyeong Sig ),안규정 ( An Gyu Jeong ),정호연 ( Jeong Ho Yeon ),이태원 ( Lee Tae Won ),서환조 ( Seo Hwan Jo ) 대한내과학회 1992 대한내과학회지 Vol.42 No.6

연구배경 : 국내에서 가을철에 호발하는 급성 발열성 질환인 쭈쭈가무시병의 임상적 고찰을 통하여 이 질환을 이해함에 있다. 방법 : 1987년부터 1990년까지 경희대학병원에 입원하여 임상양상 및 간접면역형광항체법으로 확진된 Tsutsugamushi병 42예에 대한 의무기록지를 검토하였다. 결과 : 1) 1987년부터 1990년까지 총 42명 환자의 연도별 발생빈도는 각각 12, 8, l3, 9명이었다. 2) 월별발생빈도는 10월과 11월에 집중적으로 발생하였다(95.2%). 3) 대부분의 환자(69%)는 농촌 거주자였고 거주지 및 여행지는 전국에 걸쳐 분포하였다. 4) 성별발생분포는 42예의 환자 중 여자가 30명, 남자는 12명이였고 남여의 비율은 1 : 2.5로 여자가 더 많았다. 5) 발병연령은 8세에서 79세까지 분포되었고 40~70대 사이에 많이 발생하였으며(83.4%) 60대가 가장 많았다 (42.9%). 6) 가장 흔한 임상증세는 발열 및 오한이였다(97.6%). 7) 발진 및 가피는 각각 23예(54.8%), 22예(52.4%)에서 관찰되었다. 8) 간비종대 및 임파선종대는 각각 19예(45.2%), 5예(11.9%)에서 관찰되었다. 9) 검사실 소견은 SGOT의 상승 33예(78.6%), SGPT의 상승 29예(69.0%), alkaline phosphatase의 상승 20예(47.6%), LDH의 상승 11예(26.2%) 등이 관찰되었다. 담백뇨와 저알부민혈중도 각각 29예(69.0%), 20예 (47.6%)에서 관찰되었다. 10) 치료는 대부분 doxycycline이나 chloram-phenicol로 하였고 효과는 우수하였다. 11) 치료시작후 평균 3.6일이내 열이 떨어졌으며 1예의 사망자가 있었다. 결론 : 쭈쭈가무시병은 10, 11월에 한국에서 호발하는 중요한 급성 열성 질환이다. Background To define the clinical characteristics of Tsutsugamushi disease. Methods: We analyzed 42 cases of Tsutsugamushi disease admitted to Kyung Hee University Hospital between 1987 and 1990. Tsutsugamushi disease was diagnosed by indirect immunofluorescent antibody test. Results: 1) Among a total of 42 cases, the number of yearly incidence from the year of 1987 to 1990 were 12, 8, 13, 9, respectively. 2) In terms of the monthly incidence rate during 4 years, it demonstrated the high incidence especially between October and November (95.2%). 3) The most of patients (69%) resided in rural area. The residential and traveling areas were distributed in nationwide. 4) Among them, 30 cases were female and 12 cases in male. The ratio of male and female was 12.5, indicating that the rate of incidence was predominantly high in female. 5) The age distribution ranged from 8 to 79 year old. The high incidence of age was between the 40`s and 70`s (83.4%). The 60`s was most prevalent in age (42.9%). 6) The most frequent symptom was fever and chills. (97.6%) 7) Rash and eschar were observed in 54.8% (23 of 42), 52.4% (22 of 42) respectively. 8) Hepatosplenomegaly and lymphadenopathy were also observed in 45.2% (19 of 421, 11.9% (5 of 42) respectively. 9) The laboratory findings were observed the elevation of SGOT in 78.6% (33 of 42), SGPT in 69.0% (29 of 42). alkaline phosphatase in 47.6% (20 of 42) and LDH in 26.2% (11 of 42). Albuminuria and hypoalbuminemia were also observed in 69.0% (29 of 42), 47.6% (20 of 42) respectively. 10) The therapheutic efficacy of doxycycline and chloramphenicol was excellent. 11) The mean duration of fever following treatment was 3.6 days and 1 case of mortality was founded. Conclueion: Tsutsugamushi disease is one of the important acute febrile illnesses with the high incidence between October and November in Korea.

임신 중 진단되어 분만 후 부신피질선종을 제거한 쿠싱증후군 1예

조정수,전재석,안규정,김병준,권성호,이은규,최원욱,박상원,이원미 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.5

임신과 동반하는 쿠싱증후군은 매우 드물며 임신자체가 쿠싱증후군과 유사한 임상양상을 보이고 생화학적으로도 그 감별은 쉽지 않다. 뇌하수체의존성 쿠싱증후군이 자연적으로 발생하는 쿠싱증후군의 가장 많은 원인을 차지하는 것과 달리, 임신과 동반되는 경우 전체의 약 반수에서 부신피질선종이 그 원인으로 알려져 있다. 그 치료로 임신 2기 중 수술적 치료가 권고되고 있으나 코티졸 생성을 감소시키는 약물치료를 포함한 보존적 치료를 분만 때까지 시행하고, 분만 후 수술적 치료를 시행하여 산모와 태아에 좋은 결과를 보인 예들 또한 보고되고 있다. 저자 등은 임신 25주 에 고혈압, 심부전으로 인한 폐부종, 당뇨병 등으로 내원하여, 내분비학적 검사와 방사선학적 검사에 의해 부신피질선종에 의한 쿠싱증후군으로 진단된 후 심부전 치료, 혈압 및 혈당조절, 스테로이드생성 억제제 등 보존적 치료를 유지하여 분만 후 부신피질선종을 제거한 산모 1예를 경험하였다. Pregnancy is rare in women with Cushing's syndrome, as the associated infertility is related to excess cortisol and/or androgen. However, approximately 100 such cases have been reported, with 50% due to an adrenal cortical adenoma. Establishing a diagnosis and cause can be difficult. Clinically, striae, hypertension and gestational diabetes are common features in pregnancy, with hypertension and diabetes being the most common signs of Cushing's syndrome in pregnant women. Furthermore, biochemically, a normal pregnancy is associated with a several fold increase in plasma cortisol, as the increased cortisol production rate also increases the cortisol binding protein. Untreated, the condition results in high maternal and fetal morbidity and mortality. An adrenal or pituitary adenoma should be excised, but a metyrapone, which is not teratogenic, has been effective in controlling many cases of excess cortisol. Here, a case of Cushing's syndrome, complicating a pregnancy due to an adrenal cortical adenoma, with thorough obstetric and medical management, including a metyrapone, which was adrenalectomized after delivery, is reported (J Kor Soc Endocrinol 18:489∼495, 2003).

말단비대증을 동반한 뇌하수체 선종들의 면역조직화학적 및 임상적 특성의 비교

이명식,김성훈,김광원,민용기,고은미,정재훈,김경아,안규정,김병준,김진석,이문규,김종현,서연림,나동규 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.3

Background: It assumed that plurihormonal pituitary adenomas in acromegaly, which were immunohistochemically stained with other pituitary hormones in addition to GH and prolactin, would be originated from poorly differentiated cells. Therefore, we speculated that they might have higher growth rates and worse prognosis than monohormonal adenomas. To verify this speculation, we analyzed the frequency of plurihormonal adenomas and compared the clinical parameters and radiological invasiveness between plurihormonal adenoma and GH-prolactin adenoma in acromegaly. Methods: We studied 38 patients with acromegaly (22 males and 16 females, mean age 40.7 years) who were underwent surgical removal of pituitary adenomas by TSA from January 1995 to February 1998. We performed immunohistochemical staining in these tumors using avidinbiotin peroxidase complex method. An adenoma was considered as immunoreactive when above 50 percents of tumor cells were stained with anti-hormonal antibodies. Invasiveness of tumors were evaluated by preoperative MRI findings on the basis of Hardys classification. Results: The frequencies of plurihormonal and GH-prolactin adenomas were 42% and 58%, respectively. Plurihormonal adenoma included an adenoma which was not stained with prolactin, but with GH and other hormones. Prolactin immunoreactivity was found in 97%(37/38) of the tumors. Immunoreactivities to FSH, ACTH, LH, and TSH were found in 37.8%, 13.1%, 2.6% and 2.7%, respectively. There were no significant differences in age, basal serum GH and IGF-1 concentrations between plurihormonal and GH-prolactin adenomas. There were also no significant differences in response to TRH & LH stimulation tests and somatostatin & bromocriptine suppression tests between two groups. There were no differences in radiological invasiveness between two groups (plurihormonal adenoma, grade I 2, grade II 3, grade III 7, grade IV 4; GH-prolactin adenoma, grade I 3, grade II 6, grade III 9, grade IV 4). Conclusion: Plurihormonal adenomas were 44% and immunoreactivity to prolactin was 97% in pituitary adenomas in acromegaly. There were no significant differences in clinical parameters and radiological invasiveness between plurihormonal and GH-prolactin adenomas in acromegaly (J Kor Soc Endocrinol 13:324-330, 1998).