록각(鹿角)의 Adjuvant 관절염(關節炎)에 대한 실험적(實驗的) 연구(硏究)

신지원,박재영,박희수,Shin, Ji-Won,Park, Jai-Young,Park, Hee-Soo 대한약침학회 2002 Journal of pharmacopuncture Vol.5 No.1

Objective: To investigate effects of Cervi Cornu on Adjuvant Athritis in rats, the edema inhibit rate, the anaJgesic effects, the number of WBC, RA facter, Platelet, the quantity of CRP, total protein, albumin and globuline in the blood serum were measured in the arthritis part. Results: The results obtained as fonows ; 1. After arthritis of Sprague dawley(SD) rats was induced by injecting Freund's complete adjuvant for 2 weeks, any treatment was not for Control group, acupunctured for Treat Ⅰ group. normal saJine was ora] administrated for the Treat Ⅱ group, Cervi Cornu Ex. was oral administrated for Treat Ⅲ, and Cervi Cornu Herbal-acupullcture was injected for Trea Ⅳ group during 2 weeks every other day. Selected point was on pressure pain point in both groups. And then the edema inhibit rate were checked. The edema inhibit rate was $46.03\%$ in Treat I group, $43.24\%$ Treat IV group, $37.44\%$ in Treat III. there was significance in the edema inhibit rate between Control group and Treat group, in order of Treat Ⅰ, Ⅳ, Ⅲ.(p<0.05) 2. The analgesic effects was $7.58{\pm}1.80$(${\times}10$gm) in Control group. $11.00{\pm}1.10$(${\times}10$gm) in Treat Ⅰ group. $99.92{\pm}1.28$(${\times}10$gm) in Treat Ⅲ group and $14.67{\pm}1.03$(${\times}10$gm) in Treat Ⅳ group. There was significance in the analgesic effects between Control group and Treat group(p<0.05) 3. The number of WBC was $14.72{\pm}1.48$(${\times}10^3$㎕) in control Group, $10.26{\pm}1.13$(${\times}10^3$㎕) in Treat Ⅰ group, $11.00{\pm}1.13$(${\times}103$㎕) in Treat Ⅱ Group and $9.63{\pm}1.75$(${\times}10^3$㎕) in Treat Ⅳ group. There was significance in the number of WBC between Control group and Treat group(p<0.05) 4. The content of total protein in the blood serum were $6.13{\pm}0.05$g/dl in control group, $5.73{\pm}0.14$g/dl in Treat I group, $5.88{\pm}0.13$g/dl in Treat Ⅲ group and $5.90{\pm}0.13$g/dl in Treat IV group. There was significance in The content of total protein in the blood serum between Control group and Treat group(p<0.05) 5. The contests of albumin in the blood serum were $2.32{\pm}0.12$g/dl in the Control group, $2.35{\pm}0.05$g/dl in Treat Ⅰ group, $2.35{\pm}0.05$g/dl in Treat Ⅱ group, $2.30{\pm}0.06$g/dl in Treat Ⅲ group, $2.42{\pm}0.08$g/dl in Treat IV group. There was no significance in The content of albumin in the blood serum between Control group and Treat group(p<0.05) 6. The contests of globulin in the blood semm were $3.68{\pm}0.08$g/dl in the Control group, $3.43{\pm}0.12$g/dl in Treat Ⅰ group, $3.55{\pm}0.10$g/dl in Treat IV group. There was significance in The content of globulin in the blood serum between Control group and Treat group(p<0.05) 7. The numbers of RA factor were $3.47{\pm}0.54$IU/ml in Control group and $2.38{\pm}0.50$IU/ml in Treat Ⅱ group. There was significance inThe numbers of RA factor between Control group and Treat group(p<0.05) 8. The numbers of platelet were $1126.33{\pm}1126.33{\pm}85.93{times}10^3$/㎕ in Control group, $1043.33{\pm}80.80{times}10^3$/㎕ in Treat Ⅰ group, $1116.82{\pm}77.93{times}10^3$/㎕ in Treat Ⅱ group, $1164.17{\pm}94.02{times}10^3$/㎕l in Treat Ⅲ group, $1076.67{\pm}54.84{times}10^3$/㎕ in Treat Ⅳ group. There was no significance in The numbers of platelet between Control group and Treat group(p<0.05) 9. The quantity of CRP were $0.05{\pm}0.01$mg/ml in Control group, $0.05{\pm}0.01$mg/ml in Treat Ⅰ group, $0.06{\pm}0.01$mg/ml in Treat Ⅱ group, $0.05{\pm}0.00$mg/ml in Treat Ⅲ g

이상치에 근거한 선택적 실현변동성 예측 방법

신지원,신동완,Shin, Ji Won,Shin, Dong Wan 한국통계학회 2017 응용통계연구 Vol.30 No.3

실현변동성(RVs)이 지속적인 장기기억성과 상당히 큰 이상치의 존재로 인해 정상계열과 비정상계열의 경계에 위치한다는 것에 주목하였다. 실현변동성을 예측하기 위해 실현변동성 이상치 관측 유무에 따라 heterogeneous autoregressive (HAR) 모형과 integrated HAR (IHAR) 모형을 번갈아 사용하는 새로운 방법을 제안하였고, 이 방법을 IHAR-O-HAR라 칭하였다. 예측력 비교는 주요 지수인 S&P 500, Nasdaq과 Nikkei 225의 실현변동성 데이터를 이용하였으며 표본 외 예측력 비교에서 새로운 IHAR-O-HAR 방법은 RW 방법, HAR 방법이나 IHAR 방법의 예측력보다 우수함을 확인하였다. We note that the dynamics of realized volatilities (RVs) are near the boundary between stationarity and non-stationarity because RVs have persistent long-memory and are often subject to fairly large outlying values. To forecast realized volatility, we consider a new method that adaptively use models with and without unit root according to the abnormality of observed RV: heterogeneous autoregressive (HAR) model and the Integrated HAR (IHAR) model. The resulting method is called the IHAR-O-HAR method. In an out-of-sample forecast comparison for the realized volatility datasets of the 3 major indexes of the S&P 500, the NASDAQ, and the Nikkei 225, the new IHAR-O-HAR method is shown superior to the existing HAR and IHAR method.

(γ-Aminobutyric acid를 생산하는 Lactobacillus brevis AML15의 분리 및 특성

신지원,김동걸,이용우,이형석,신기선,최충식,권기석,Shin, Ji-Won,Kim, Dong-Geol,Lee, Yong-Woo,Lee, Hyoung-Seok,Shin, Kee-Sun,Choi, Chung-Sig,Kwon, Gi-Seok 한국생명과학회 2007 생명과학회지 Vol.17 No.7

국내해안의 젓갈과 김치류로부터 86종의 GABA 생산균주를 분리하였다. 분리된 균주들을 Thin layer chromatography를 이용하여 GABA 생성능이 우수한 AML15, AML45-1, AML72의 3종의 균주를 선발하였다. 선별된 3종의 균주의 아미노산 분석 결과 GABA 생성능이 가장 우수한 AML15 균주를 본 실험에 사용하였다. AML15의 분류학적 위치를 규명하기 위하여 16S ribosomal DNA 영역의 부분염기서열 분석을 실시하였다. 165 rDNA 분석결과 Lactobacillus brevis ATCC 367과 99%의 유사도를 나타내어 L. brevis AML15로 명명하였다. MRS 배지에 최종 전환 농도로 설정된 5%(w/v) monosodium glutamic acid를 첨가하고 배지의 초기 pH를 4.0, 5.0과 6.0으로 조정하여 배양한 결과 배지의 초기 pH가 5.0일 때 GABA 생성능이 가장 높게 조사되었다. GABA 생산배지에 GAD 효소활성에 조효소로 작용하는 PLP를 0. 10. 50과 100 ${\mu}M$의 농도로 첨가하여 아미노산 분석결과 PLP를 10${\mu}M$ 첨가하였을 때 10,424 $nM/{\mu}$l의 GABA가생산되었다. PLP를 첨가하지 않았을 때보다 PLP 첨가 후 GABA 생성이 증가됨을 확인할 수 있었다. For the screening of ${\gamma}-aminobutyric$ acid (CABA)-producing bacteria, 86 bacterial strains which produce GABA were isolated from Kimchi and Salted fisk .Among these, three strains designated AML15, AML45-1, AML72 with relatively high GABA productivity were selecled by thin layer chromatography (TLC). To elucidate the relationship between isolated strains and the genus Lactobacillus, their 16S rDNA sequence were examined. The result of their DNA sequences showed 99% similarity with Lactobacillus brevis ATCC 367. On the basis of the these results, isolated strains were identified as Lactobacillus brevis and designated L. brevis AML15. In order to determine the optimum conditions for GABA production, the isolated strains were cultivated in pyridoxal phosphate (PLP) and monosodium glutami. acid (MSG). Results showed that L. brevis AML15 had the highest CABA productivity with 10,424 $nM/{\mu}l$ concentration in MRS broth containing 5% (w/v) MSG and 10 ${\mu}M$ PLP at pH 5.0. The results imply that L. brevis AML15 has the potential to be developed as a strain for GABA hyper-production.

Polyurethane과 Poly(Ethylene Oxide)를 이용한 hybrid 나노섬유 지지체의 제작

신지원,신호준,허수진,김지희,황영미,김동화,신정욱,Shin, Ji-Won,Shin, Ho-Jun,Heo, Su-Jin,Kim, Ji-Hee,Hwang, Young-Mi,Kim, Dong-Hwa,Shin, Jung-Woog 대한의용생체공학회 2006 의공학회지 Vol.27 No.5

The object of this study is to investigate the potential of dual-electrospun polymer based structure for vascular tissue engineering, especially for the medium or small sue blood vessels. Polyurethane(PU), which is known to be biocompatible in this area, was electrospun with poly(ethylene oxide) (PEO). Concentration of PU was fixed at 20wt%, while that of PEO was set from 15 to 35wt%. Morphological features were observed by SEM image and measurement of porosity and cellular responses were tested before and after extracting PEO from the hybrid scaffolds by immersing the scaffolds into distilled water. The diameter of PEO fibers were ranged from 200nm to 500nm. The lower concentration of PEO tended to show beads. The porosity of the scaffolds after extracting PEO was highly increased with higher concentration of PEO as expected. Also, higher proliferation rate of smooth muscle cells was observed at higher concentration of PEO than at the lower concentration and without PEO. As conclusions, this dual electrospinning technique combined with PU and PEO is expected to overcome the current barrier of cell penetration by providing more space for cells to proliferation.

기계적 자극이 다층 구조의 나노파이버 지지체의 평활근 세포에 미치는 영향

신지원,김동화,허수진,김수향,김영직,신정욱,Shin, Ji-Won,Kim, Dong-Hwa,Heo, Su-Jin,Kim, Su-Hyang,Kim, Young-Jick,Shin, Jung-Woog 대한의용생체공학회 2008 의공학회지 Vol.29 No.1

The object of this study is to investigate the effects of intermittent cyclic stretching on the smooth muscle cells (SMCs) seeded onto aligned multi-layered fibrous scaffold. To make multi-layered fibrous scaffold, polyurethane (PU) and poly(ethylene oxide) (PEO) were electrospun alternatively, then were immersed into distilled water to extract PEO. Various types of scaffolds were fabricated depending on fiber directions, i.e., aligned or randomly oriented. The direction of stretching was either parallel or vertical to the fiber direction for the aligned scaffolds. The stretching was also applied to the randomly aligned scaffolds. The duration of stretching was 2 min with 15 min resting period. During the stretching, the maximum and minimum strain was adjusted to be 10 and 7%, respectively with the frequency of 1 Hz. The bioactivities of cells on the scaffolds were assessed by quantifying DNA, collagen, and glycosaminoglycan (GAG) levels. And the cell morphology was observed by staining F-actin. SMCs under parallel stretching to the fiber direction responded more positively than those in other conditions. From the results, we could explain the morphological effect of a substrate on cellular activities. In addition the synergistic effects of substrate and mechanical stimuli effects were confirmed.

노인의 주도적인 SNS 활동을 통한 소통증진 프로그램에 대한 평가연구

신지원(Shin, Ji Won),권지성(Kwon, Jisung) 한국사회복지학회 2015 한국사회복지학회 학술대회 자료집 Vol.2015 No.4

국제이주와 동안아지역연구의 초국가적 공간에 대한 고찰

신지원 ( Ji Won Shin ) 전남대학교 사회과학연구소 2014 현대사회과학연구 Vol.18 No.-

이 논문은 ``초국가적 공간``에 있어 국제이주연구와 동남아지역연구의 연관성을 고찰하고 이주와 동남아지역 통합연구를 통하여 접근될 수 있는 연구과제들을 조명한다. 국제인구이동의 역동성과 유형의 다양화를 통해 한국을 포함한 아시아 국가들은 기존에 경험하지 못한 ``초국가적 공간``을 경험하고 있다. 이주의 과정에 영향을 미치는 모든 요소들과 요소들 간의 연결고리, 그러한 요소들로 인해 이주가 발생한 맥락을 파악하는 데 있어 총체적 접근은 매우 중요하며, 시공간을 초월한 이주민들을 수용하고 있는 한국내 이주연구는 동남아지역연구와 밀접한 연관성을 가진다. 현재까지 이주관련 연구에서 나타나는 학문적편향은 이주과정에 대한 환원주의적 접근 결과를 가져오고, 이는 이주의 단편적 경험에 초점을 둔 연구로 귀결되는 경향을 보여 왔다. 이 논문에서는 이주와 동남아 통합연구에 있어 초국가적 접근방식의 중요성을 살펴보고 기존 이주연구의 한계를 극복할 수 있는 연구의 방향성을 고찰한다. This paper examines the ways in which the studies of international migration and Southeast Asia are closely related and prospertive _ areas that cou1d be compatibly expIoted through integrative approaches. The dynamics and diversification of international migration enable South Korea and other Asian countries to unprecedenredl.y experience ``transnational spaces``. In order to explain such experiences it is important for migration Te``leal``Cb to take on holistic approaches that consider different factors fadJjtatlng migratory processes, the causal nexus between the factors and the context causing migration based on those factors. It is also CNciaI for migration research to understand the process of _ beyond _ and space. Aro>nIingly, _ research in Korea where the majority of the migrant population is from Southeast Asia bas close relevance to the regional studies of Southeast Asia. Migration studies are hitherto tended to be biased by being trapped in methodological nationalism. Taking a nation-state as an analytical unit and setting state borders as societal boundaries, migration scholars have inclined to bounded thinking and their approaches been oontained _ a single society. Consldedng a proUferation of recuning and circulatory patterns of international migration, leading to diverse migratory experiences as well as multifaceted cu1tuntl1ntetactlons, research approaches centred on the nation-state are by far limited to understand contemporary migration trends. This paper discusses the importance of transnational approaclres in the lnlegmtive studies of atlgm_ and Southeast Asia and prospeelive research that could move beyond the limitations of current migration research in Korea.

축제방문동기가 축제이미지, 만족, 그리고 재방문의도에 미치는 영향: 도심 음식축제 방문객을 중심으로

신지원 ( Shin Ji Won ),이상묵 ( Lee Sang Mook ) 한국이벤트컨벤션학회 2021 이벤트 컨벤션 연구 Vol.17 No.1

Purpose - The purpose of this study is to investigate the effect of the participants' motivation, festival image, festival satisfaction and revisit intention focused on consumers who visited the city food festival. Research Design, data, and methodology -Design, data, and methodology -Online surveys were distributed to consumers who visited the city food festival from September to October 2020 through text messages, e-mails, and social media. A total of 313 respondents responded, but a total of 260 respondents were used for the survey excluding consumers who did not visit the city food festival and 53 respondents who were unfaithful. Frequency analysis was performed to understand the general characteristics and demographic characteristics of respondents using the SPSS 25.0 statistical program for people who have visited the city festival, and confirmatory factor analysis and structural equation model using AMOS 23.0 was employed. Result - In this study, the hypothesis of the influence relationship between the motive of visiting the festival, the image of the festival, the satisfaction of the festival, and the intention to revisit were verified. Specifically, the motivating factor for visit was composed of a pursuit factor and an incentive factor, and the causal relationship between these two motive factors was directly or indirectly influenced by the image and satisfaction of the city food festival. Conclusions - The results of this study provided meaningful implications for establishing future marketing strategies for festival-related industries and participating organizations which are facing many difficulties.

논의 및 과학 글쓰기 관련 국내 과학 교육 연구 동향 분석

신지원 ( Ji Won Shin ),최애란 ( Ae Ran Choi ) 한국과학교육학회 2014 한국과학교육학회지 Vol.34 No.2

본 연구에서는 국내에서 발표된 논의 및 과학 글쓰기 관련 논문을 대상으로 연구 문제, 연구 대상, 연구 방법 및 논의 및 과학 글쓰기 활동 적용 방식과 어떠한 측면에서 그 결과를 분석하고 있는지 알아봄으로써 논의 및 과학 글쓰기 관련 연구의 동향을 살펴보고 후속 연구의 방향을 제시하고자 한다. 2004년부터 2013년까지 논의 및 과학 글쓰기 관련 연구 118편을 수집하여 분석하였다. 최근 10년간 논의 및 과학 글쓰기 관련 연구는 점점 증가하는 추세이고 2008년 이후에 관련 연구가 활성화되고 있다는 것을 알 수 있었다. 교수·학습 전략을 개발, 논의 및 과학 글쓰기 활동에 대한 내용 분석, 그 효과 분석의 순으로 연구 문제가 선정된 것으로 나타났다. 초등학생과 중학생을 대상으로 한 연구에 비해 예비 교사 및 현장 교사를 대상으로 한 연구와 고등학생을 대상으로 한 연구는 적었다. 연구 방법은 양적 연구, 질적 연구, 혼합 연구가 비교적 고르게 적용되고 있었다. 또한 연구 대상에게 논의 및 과학 글쓰기 관련 사전 교육을 진행하거나 관련 자료를 제시한 연구가 증가하고 있었다. 논의 및 과학 글쓰기 적용 후에 학생들의 과학에 대한 태도를 분석한 연구가 많았는데, 과학 개념, 과학 탐구 능력, 비판적 사고력 향상 등의 분석에 좀 더 초점을 두어야 할 것이다. 많은 연구에서 논의 구조와 논의 과정 또는 과학 글쓰기에 포함된 내용과 글쓰기의 형태 분석을 해왔다. 향후에는 논의의 수준 또는 과학 글쓰기에 포함된 과학 개념을 함께 분석하는 연구가 활발하게 진행되기를 제안한다. The purpose of this study is to investigate trends in research studies on scientific argument and writing in Korea. 118 research studies published from 2004 to 2013 have been collected and analyzed. Many of the research studies focused on developing teaching strategies, analyzing contents of scientific argument and writing, and effects on student learning. More than half of the studies were conducted with elementary and middle school students while studies with pre-service, in-service teachers or high school students were relatively rare. Most research studies were conducted within regular school hour context and participants were given relevant information/education prior to argument and writing activities. Many research have analyzed student growth in scientific attitudes and we would suggest that further studies should investigate student growth in scientific concepts, scientific inquiry, and critical thinking. The structure and process of argument or the content and form of writing have been analyzed. The quality of argument and scientific concepts embedded in argument and writing should be investigated more in future researches.

성인학습에서의 한국화 채색화 표현방법 탐색을 통한 예술적 자기표현 과정 연구 - 예술의전당 성인 아카데미 수업 사례를 중심으로

신지원 (Ji-Won Shin) 한국문화교육학회 2022 문화예술교육연구 Vol.17 No.6

The purpose of this study is to show how lifelong adult art learning sessions can derive one's improvement in art expression methods and sense of achievement by verifying Korean painting expression methods. To validate, seven non art major students from Seoul Arts Center Korean Art Class were selected and participated in three programs: topic expression activities, convergence expression activities, and experience expanding and explanatory. Then, an in-depth interview was conducted to review and analyze participants' motivation to participate in classes, difficulties in practical expressions, and changes and expression before and after exploring various expression programs. As a result, the following conclusions were drawn. First, participants gradually improved their art expression method. Second, participants' sense of accomplishment and confidence were strengthened, and they could reflect on themselves much more. Lastly, social emotions and health function vitality were improved through art expression activities. This study is meaningful in analyzing one’s growth result and demonstrating participants' diverse competencies by applying Korean painting to adult learning programs for the expansion of cultural enjoyment classes. 본 연구는 한국화 채색화 표현방법 탐색을 통해 성인의 예술적 자기표현 양상과 그에 대한 개인적 성취감이 어떻게 발현되는지 검토함으로써 평생학습 차원에서의 성인 미술학습이 가지는 교육적 의의를 도출하는 데 목적을 두었다. 이를 위해 예술의전당 성인 아카데미 한국화(채색화)반에서, 미술을 전공하지 않은 7명의 연구 참여자를 대상으로 주제 표현활동, 융합 표현활동, 경험을 표현하고 확장하기 등 세 가지 프로그램을 진행하면서 연구 참여자들이 경험한 수업참여 동기, 실기표현에서의 어려움과 극복해야 할 점, 그리고 다양한 표현방법 탐색 전후의 변화와 소감 등에 대한 심층면담을 통해 자료수집과 분석을 행하였다. 그 결과, 다음과 같은 결론을 도출하였다. 첫째, 세 가지 프로그램을 통해 성인 참여자들의 한국화 표현기능이 점차 향상되었다. 둘째, 예술적 자기표현 방법을 다양하게 탐색하는 과정 속에서 연구 참여자들의 성취감과 자신감이 증진되었으며, 자기통찰을 경험할 수 있었다. 셋째, 예술 표현활동을 통해 사회정서, 건강기능 활력에도 도움이 되었다. 이상을 통해 한국화 채색화 분야를 문화향유 계층 확대를 위한 성인학습 프로그램에 적용하여 개인적인 성장의 결과를 분석하고 참여자들의 다양한 역량을 도출하였다는 점에 본 연구의 의의가 있다.